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  2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. Microcystin-LR

Microcystin-LR  (Synonyms: Cyanoginosin-LR; MC-LR; Toxin T 17 (Microcystis aeruginosa))

目錄號(hào): HY-P0072
COA 產(chǎn)品使用指南

Microcystin-LR 是蛋白磷酸酶 1 型和 2A 型 (PP1/2A) 的有效抑制劑，其 IC50 值分別為 1.7 nM，0.04 nM。

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Microcystin-LR Chemical Structure

Microcystin-LR Chemical Structure

CAS No. : 101043-37-2

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規(guī)格 價(jià)格 是否有貨 數(shù)量
50 μg (0.5 mM * 100 μL in Ethanol) ￥2150
In-stock
100 μg (0.5 mM * 200 μL in Ethanol) ￥3650
In-stock

* Please select Quantity before adding items.

Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Microcystin-LR is a potent inhibitor of type 1 and type 2A protein phosphatases (PP1 and PP2A), with IC50s of 1.7 nM and 0.04 nM, respectively.

IC50 & Target

IC50: 1.7 nM (PP1), 0.04 nM (PP2A)[1].
體外研究
(In Vitro)

Microcystins are toxic molecules produced by cyanobacterial blooms due to water eutrophication[2]. Microcystin-LR proves to be a potent inhibitor of type 1 (IC50=1.7 nM) and type 2A (IC50= 0.04 nM) protein phosphatases. Microcystin-LR inhibits the activity of both type 1 and type 2A phosphatases >10-fold more potently than okadaic acid under the same conditions. Type 2A protein phosphatases in dilute mammalian cell extracts are found to be completely inhibited by 0.5 nM microcystin-LR while type 1 protein phosphatases are only slightly affected at this concentration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

995.17

Formula

C49H74N10O12
CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

Sequence Shortening

ADALD-{Bas}-R-{Oaa}-D-{Ggu}
中文名稱

微囊藻毒素-LR
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

Ethanol 中的溶解度 : 0.5 mg/mL (0.50 mM; 超聲助溶)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 98.0%

參考文獻(xiàn)
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Microcystin-LR
目錄號(hào)：
HY-P0072
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