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  2. Apoptosis Autophagy
  3. Apoptosis Autophagy
  4. Physalin B

Physalin B  (Synonyms: 酸漿苦味B)

目錄號: HY-N7695 純度: 96.98%
COA 產(chǎn)品使用指南 技術(shù)支持

Physalin B 是 Cape gooseberry 中主要的甾體活性成分之一，通過調(diào)節(jié) p53 依賴的凋亡途徑，誘導乳腺癌細胞周期阻滯和誘導凋亡 (apoptosis)。Physalin B 抑制人結(jié)腸癌細胞泛素-蛋白酶體通路并誘導不完全自噬反應。

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Physalin B Chemical Structure

Physalin B Chemical Structure

CAS No. : 23133-56-4

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥2520
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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Physalin B, one of the major active steroidal constituents of Cape gooseberry, induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway. Physalin B inhibits the ubiquitin-proteasome pathway and induces incomplete autophagic response in human colon cancer cells in vitro[1][2].

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
11.9 μM
Compound: 18
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
[PMID: 35608269]
HeLa IC50
2 μM
Compound: 1
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
[PMID: 16562828]
HeLa IC50
37.5 μM
Compound: PB-1
Inhibition of TNFalpha-induced IkappaBalpha (unknown origin) phosphorylation expressed in human HeLa cells pretreated 30 mins before TNFalpha addition measured up to 120 mins by ELISA in presence of proteasome inhibitor MG-132
Inhibition of TNFalpha-induced IkappaBalpha (unknown origin) phosphorylation expressed in human HeLa cells pretreated 30 mins before TNFalpha addition measured up to 120 mins by ELISA in presence of proteasome inhibitor MG-132
[PMID: 24900739]
HeLa IC50
6.07 μM
Compound: PB-1
Inhibition of TNFalpha-induced NF-kappaB activation (unknown origin) expressed in human HeLa cells pretreated 30 mins before TNFalpha addition after 7 hrs by luciferase reporter gene assay
Inhibition of TNFalpha-induced NF-kappaB activation (unknown origin) expressed in human HeLa cells pretreated 30 mins before TNFalpha addition after 7 hrs by luciferase reporter gene assay
[PMID: 24900739]
HepG2 IC50
11.7 μM
Compound: 18
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
[PMID: 35608269]
MCF7 IC50
1 μM
Compound: 6
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured after 24 to 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured after 24 to 72 hrs by MTT assay
[PMID: 33586438]
MCF7 IC50
11.2 μM
Compound: 18
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
[PMID: 35608269]
NCI-H460 IC50
0.9 μM
Compound: 6
Cytotoxicity against human NCI-H460 cells assessed as cell growth inhibition measured after 24 to 72 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells assessed as cell growth inhibition measured after 24 to 72 hrs by MTT assay
[PMID: 33586438]
PC-3 IC50
1 μM
Compound: 6
Cytotoxicity against human PC-3 cells assessed as cell growth inhibition measured after 24 to 72 hrs by MTT assay
Cytotoxicity against human PC-3 cells assessed as cell growth inhibition measured after 24 to 72 hrs by MTT assay
[PMID: 33586438]
SF-268 IC50
0.6 μM
Compound: 6
Cytotoxicity against human SF-268 cells assessed as cell growth inhibition measured after 24 to 72 hrs by MTT assay
Cytotoxicity against human SF-268 cells assessed as cell growth inhibition measured after 24 to 72 hrs by MTT assay
[PMID: 33586438]
SGC-7901 IC50
12.1 μM
Compound: 18
Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
[PMID: 35608269]
WI-38 IC50
3.3 μM
Compound: 6
Cytotoxicity against human WI-38 cells assessed as cell growth inhibition measured after 24 to 72 hrs by MTT assay
Cytotoxicity against human WI-38 cells assessed as cell growth inhibition measured after 24 to 72 hrs by MTT assay
[PMID: 33586438]
分子量

510.53

Formula

C28H30O9
CAS 號
性狀

固體

顏色

Off-white to light yellow

中文名稱

酸漿苦味B
結(jié)構(gòu)分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

純度 & 產(chǎn)品資料
參考文獻

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Physalin B
目錄號：
HY-N7695
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