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  2. Anti-infection
  3. Fungal Parasite Bacterial
  4. 5,7,3',4'-Tetramethoxyflavone

5,7,3',4'-Tetramethoxyflavone  (Synonyms: 木犀草素四甲醚)

目錄號(hào): HY-N7030 純度: 98.66%
COA 產(chǎn)品使用指南

5,7,3',4'-Tetramethoxyflavone 是可以從 M. exotica 中分離得到的一種具有口服活性的多甲氧基黃酮，具有多種生物活性，包括抗真菌、抗瘧疾、抗分支桿菌和抗炎活性。5,7,3',4'-Tetramethoxyflavone 可通過(guò)靶向 β-catenin 發(fā)揮軟骨保護(hù)作用。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

5,7,3',4'-Tetramethoxyflavone Chemical Structure

5,7,3',4'-Tetramethoxyflavone Chemical Structure

CAS No. : 855-97-0

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥610
In-stock
10 mg ￥550
In-stock
25 mg ￥900
In-stock
50 mg ￥1450
In-stock
100 mg   詢價(jià)  
200 mg   詢價(jià)  

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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

5,7,3',4'-Tetramethoxyflavone, an orally active polymethoxyflavones (PMFs) that can be isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling[1].

IC50 & Target

Plasmodium

 

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
RAW264.7 IC50
3.13 μM
Compound: 3y
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated PGE2 production by ELISA
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated PGE2 production by ELISA
[PMID: 28408221]
RAW264.7 IC50
32.5 μM
Compound: 3y
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production by ELISA
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production by ELISA
[PMID: 28408221]
RAW264.7 IC50
73.94 μM
Compound: 3y
Cytotoxicity against mouse RAW264.7 cells by MTT assay
Cytotoxicity against mouse RAW264.7 cells by MTT assay
[PMID: 28408221]
體外研究
(In Vitro)

5,7,3',4'-Tetramethoxyflavone (5-20 μg/mL, 24 h) 抑制軟骨細(xì)胞中 EP2、EP4、bcatenin 和 COX-2 基因的表達(dá)[1]。
5,7,3',4'-Tetramethoxyflavone (5-20 μg/mL, 48 h) 抑制軟骨細(xì)胞中 EP/cAMP/PKA 信號(hào)通路和 β-catenin 信號(hào)通路蛋白的表達(dá)[1]。
5,7,3',4'-Tetramethoxyflavone (5-20 μg/mL, 4 h) 通過(guò)調(diào)節(jié)IRE1α保護(hù)軟骨細(xì)胞免于凋亡[2]。
5,7,3',4'-Tetramethoxyflavone (5-20 μg/mL, 4 h) 可逆轉(zhuǎn) IRE1α 缺乏導(dǎo)致的內(nèi)質(zhì)網(wǎng) (ER) 應(yīng)激基因的表達(dá)模式[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Line:
Concentration:
Incubation Time:
Result:

Western Blot Analysis[2]

Cell Line: Chondrocytes
Concentration: 5-20 μg/mL
Incubation Time: 4 h
Result: Increased the protein level of Bcl-2 and XBP1s.
Decreased the expression of pro-apoptotic factors CHOP/caspase-3 and stress kinase JNK.
體內(nèi)研究
(In Vivo)

5,7,3',4'-Tetramethoxyflavone (25-100 mg/kg, 灌胃) 在大鼠體內(nèi)表現(xiàn)出軟骨保護(hù)活性[1]。
5,7,3',4'-Tetramethoxyflavone (5-20 mg/kg; 靜脈注射, 口服) 在大鼠中絕對(duì)生物利用度為 14.3 %[3]。
1.19
藥代動(dòng)力學(xué)分析[3]

Route Dose (mg/kg) AUC (min μg/mL) AUC/Dose (min/mL) t1/2 (h) Tmax (h) Cmax (ng/mL) Bioavailability (%)
i.v. 5 161.49 ± 58.78 0.1154 ± 0.0420 62.85 ± 27.92 / / 14.3
p.o. 50 231.43 ± 71.87 0.0165 ± 0.0051 273.76 ± 90.23 190.34 ± 24.50 0.79 ± 0.30 /

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat knee OA model[1]
Dosage: 25-100 mg/kg
Administration: i.g.
Result: Decreased the contents of IL-1b, TNF-a, and PGE2 in a dose-dependent manner.
Decreases the expression of the inflammatory cytokines in rat knee osteoarthritis (OA) synovial fluid (SF) lavages.
Inhibited chondrocytes hypertrophy and decreased the cartilage thickness.
Exhibited down regulation of b-catenin in a dose-dependent manner.
分子量

342.35

Formula

C19H18O6
CAS 號(hào)
性狀

固體

顏色

White to off-white

中文名稱

木犀草素四甲醚
結(jié)構(gòu)分類
初始來(lái)源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 8.33 mg/mL (24.33 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.9210 mL 14.6049 mL 29.2099 mL
5 mM 0.5842 mL 2.9210 mL 5.8420 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.15%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9210 mL 14.6049 mL 29.2099 mL 73.0247 mL
5 mM 0.5842 mL 2.9210 mL 5.8420 mL 14.6049 mL
10 mM 0.2921 mL 1.4605 mL 2.9210 mL 7.3025 mL
15 mM 0.1947 mL 0.9737 mL 1.9473 mL 4.8683 mL
20 mM 0.1460 mL 0.7302 mL 1.4605 mL 3.6512 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
5,7,3',4'-Tetramethoxyflavone
目錄號(hào)：
HY-N7030
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