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  2. GPCR/G Protein Membrane Transporter/Ion Channel
  3. Prostaglandin Receptor Potassium Channel
  4. Saikogenin D

Saikogenin D  (Synonyms: 皂苷元 D)

目錄號: HY-N4237 純度: 98.95%
COA 產(chǎn)品使用指南

Saikogenin D 分離自 Bupleurum chinense ，具有抗炎作用。Saikogenin D 激活環(huán)氧合酶，將花生四烯酸轉(zhuǎn)化為環(huán)氧二十烷酸和二羥基二十碳三烯酸，其代謝產(chǎn)物繼而抑制前列腺素E2 (PGE2) 的產(chǎn)生。 由于細胞內(nèi) Ca2+ 的釋放，Saikogenin D 導致 [Ca2+]i 升高。

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Saikogenin D Chemical Structure

Saikogenin D Chemical Structure

CAS No. : 5573-16-0

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥1400
In-stock
5 mg ￥2900
In-stock
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50 mg   詢價  

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Customer Review

查看 Prostaglandin Receptor 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Saikogenin D is isolated from?Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca2+]i due to Ca2+ release from intracellular stores[1][2].

IC50 & Target

EP

 

體外研究
(In Vitro)

Saikogenin D (1-20 μM) inhibits PGE2 production induced by the Ca2+ ionophore A23187 in a concentration-dependent manner with an IC50 value of 3 μM in C6 rat glioma cells[1].
Saikogenin D (10-100 μM) elevates [Ca2+]i in a concentration-dependent manner with a EC50 value of 35 μM in the presence or absence of extracellular Ca2+ in C6 rat glioma cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

472.70

Formula

C30H48O4
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

皂苷元 D
結(jié)構分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

純度 & 產(chǎn)品資料
參考文獻

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產(chǎn)品名稱：
Saikogenin D
目錄號：
HY-N4237
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