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  2. 天然產(chǎn)物
  3. 疾病研究領(lǐng)域 植物 黃酮類 酚類
  4. 癌癥 其他科 二氫黃酮 多酚類
  5. Kuwanon E

Kuwanon E  (Synonyms: 桑皮酮 E)

目錄號: HY-N3514 純度: ≥96.0%
COA 產(chǎn)品使用指南

Kuwanon E 是從桑樹中分到的黃酮類化合物，對人單核細胞白血病細胞系具有細胞毒性，并降低 IL-1β 的水平。

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Kuwanon E Chemical Structure

Kuwanon E Chemical Structure

CAS No. : 68401-05-8

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥2500
In-stock
5 mg 現(xiàn)貨 詢價
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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Kuwanon E is a flavonoid isolated from Morus alba, cytotoxic to human monocytic leukemic cell lines, and reduces the level of IL-1β[1].

IC50 & Target

Kuwanon E shows cytotoxic activity against THP-1 human monocytic leukemic cell line, with an IC50 of 4.0±0.08 μM[1].
細胞效力
(Cellular Effect)
Cell Line Type Value Description References
BJ EC50
> 10 μM
Compound: 13
Cytotoxicity against human BJ cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human BJ cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
CCRF-CEM EC50
> 10 μM
Compound: 13
Cytotoxicity against human CEM cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human CEM cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
HeLa EC50
> 10 μM
Compound: 13
Cytotoxicity against human HeLa cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human HeLa cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
MCF7 EC50
> 10 μM
Compound: 13
Cytotoxicity against human MCF7 cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human MCF7 cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
RPMI-8226 EC50
> 10 μM
Compound: 13
Cytotoxicity against human RPMI8226 cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human RPMI8226 cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
THP-1 EC50
> 10 μM
Compound: 13
Cytotoxicity against human THP1 cells after 72 hrs by erythosin B staining method
Cytotoxicity against human THP1 cells after 72 hrs by erythosin B staining method
[PMID: 20192247]
THP-1 IC50
4 μM
Compound: 4
Cytotoxicity against human THP1 cells after 24 hrs by WST1 assay
Cytotoxicity against human THP1 cells after 24 hrs by WST1 assay
[PMID: 24901948]
U-266 EC50
> 10 μM
Compound: 13
Cytotoxicity against human U266 cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human U266 cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
分子量

424.49

Formula

C25H28O6
CAS 號
性狀

固體

顏色

Off-white to light brown

中文名稱

桑黃酮 E；桑酮 E；桑皮酮 E
結(jié)構(gòu)分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

純度 & 產(chǎn)品資料

純度: ≥96.0%

參考文獻

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Kuwanon E
目錄號：
HY-N3514
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