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  2. Metabolic Enzyme/Protease NF-κB Apoptosis Cytoskeleton Cell Cycle/DNA Damage
  3. Endogenous Metabolite NF-κB TNF Receptor FOXO Microtubule/Tubulin
  4. D-chiro-Inositol

D-chiro-Inositol  (Synonyms: D-手性肌醇)

目錄號(hào): HY-N3021 純度: ≥98.0%
COA 產(chǎn)品使用指南

D-chiro-Inositol 是一種肌醇的差向異構(gòu)體，具有改善糖代謝、抗腫瘤、抗炎和抗氧化的活性。D-chiro-Inositol 通過(guò)改善膽汁酸分泌和減輕氧化應(yīng)激，有效緩解膽汁淤積。它通過(guò)模擬胰島素的作用來(lái)改善胰島素抵抗，降低高血糖和循環(huán)胰島素水平，減少血清雄激素，并改善 X 綜合征的一些代謝異常。此外，D-chiro-Inositol 可誘導(dǎo)促炎因子 (如 Nf-κB) 和細(xì)胞因子 (如 TNF-α) 的減少，從而發(fā)揮抗炎作用。D-chiro-Inositol 可用于肝硬化、乳腺癌、2 型糖尿病和多囊卵巢綜合征的研究。

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D-chiro-Inositol Chemical Structure

D-chiro-Inositol Chemical Structure

CAS No. : 643-12-9

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規(guī)格 價(jià)格 是否有貨 數(shù)量
5 mg ￥187
In-stock
10 mg ￥300
In-stock
50 mg ￥500
In-stock
100 mg   詢價(jià)  
200 mg   詢價(jià)  

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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

D-chiro-Inositol is a stereoisomer of inositol that exhibits activities such as improving glucose metabolism, anti-tumor effects, anti-inflammatory properties, and antioxidant activity. D-chiro-Inositol effectively alleviates cholestasis by enhancing bile acid secretion and reducing oxidative stress. D-chiro-Inositol improves insulin resistance, lowers hyperglycemia and circulating insulin levels, reduces serum androgen levels, and ameliorates some metabolic abnormalities associated with X syndrome by mimicking the action of insulin. Additionally, D-chiro-Inositol can induce a reduction in pro-inflammatory factors (such as Nf-κB) and cytokines (such as TNF-α), thereby exerting anti-inflammatory effects. D-chiro-Inositol may be used in the study of liver cirrhosis, breast cancer, type 2 diabetes, and polycystic ovary syndrome[1][2][3][4][5][6][7][8][9].

IC50 & Target

Human Endogenous Metabolite

 

體外研究
(In Vitro)

D-chiro-Inositol (0.1-10 μmol, 3 h) 改善 Palmitoleic acid (HY-W011873) 處理的 HepG2 細(xì)胞的糖代謝，抑制了 FOXO1 的活性[3]。
D-chiro-Inositol (1-40 mM, 48 h) 抑制了乳腺癌細(xì)胞 MDA-MB-231 的生長(zhǎng)[4]。
D-chiro-Inositol (0.125-1 mM, 24 和 48 h) 可調(diào)節(jié) 3T3-L1 脂肪細(xì)胞的 GSH/GSSG 比值，降低細(xì)胞的促炎狀態(tài)[9]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR[3]

Cell Line: PA-treated HepG2 cells
Concentration: 0.1-10 μmol
Incubation Time: 3 h
Result: Increased the mRNA expression levels of PEPCK and G6 Pase in HepG2 cells.

Western Blot Analysis[3]

Cell Line: PA-treated HepG2 cells
Concentration: 0.1-10 μmol
Incubation Time: 3 h
Result: Inhibited the downregulation of IR β and p85 subunit expression levels and restored the phosphorylation levels of IRS-2, AKT and FOXO1.

Cell Proliferation Assay[4]

Cell Line: MDA-MB-231 cells
Concentration: 1, 5, 10, 20 and 40 mM
Incubation Time: 48 h
Result: The cell proliferation abilities decreased by 18.3%, 17.2%, 17.5%, 18.4% and 24.9%, respectively.
體內(nèi)研究
(In Vivo)

D-chiro-Inositol (150 mg/kg; p.o.; 每天 1 次持續(xù) 2 周) 減輕膽汁淤積模型大鼠的肝臟膽汁酸積累，降低肝臟損傷和纖維化的嚴(yán)重程度[2]。
D-chiro-Inositol (50 mg/kg; i,g.; 每天 1 次持續(xù) 8 周) 增強(qiáng)高脂肪飲食小鼠葡萄糖耐量，降低肝臟中脂質(zhì)積累[3]。
D-chiro-Inositol (500 和 1000 mg/kg; p.o.; 每天 1 次持續(xù) 45 天) 抑制小鼠異種移植瘤模型中腫瘤的生長(zhǎng)[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat model of cholestasis induced by bile duct ligation [2]
Dosage: 150 mg/kg
Administration: Oral gavage (p.o.) Once a day for 2 weeks
Result: Reduced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in rats, and alleviates bile duct hyperplasia, parenchymal necrosis and fibrosis.
Increased total bile acid (TBA) levels in serum and bile and decreased total bile acid (TBA) levels in the liver.
Increased the expression of genes encoding bile acid transporters BSEP (Abcb11) and MRP2 (Abcc2) in liver tissue.
Decreased liver CD68 and NF-κB levels, serum and liver MDA levels, and significantly increased serum and liver superoxide dismutase activity.
Animal Model: High-fat diet mice [3]
Dosage: 50 mg/kg
Administration: i.g.; once a day for 8 weeks
Result: Reduces hepatic DAG production and prevents PKCε ectopic translocation to the membrane, thereby inhibiting PKCε activation.
Increased the low levels of IRβ and PI3Kp85 and reversed the downregulation of IRS-2 and AKT phosphorylation levels.
Animal Model: Female nude mice xenograft tumor model[4]
Dosage: 500 和 1000 mg/kg
Administration: p.o.; once a day for 45 days
Result: The tumor growth inhibition rates were 22.1% and 67.6%, respectively.
分子量

180.16

Formula

C6H12O6
CAS 號(hào)
性狀

固體

顏色

White to off-white

中文名稱

D-手性肌醇
結(jié)構(gòu)分類
初始來(lái)源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

H2O 中的溶解度 : 75 mg/mL (416.30 mM; 超聲助溶)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 5.5506 mL 27.7531 mL 55.5062 mL
5 mM 1.1101 mL 5.5506 mL 11.1012 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

* 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物實(shí)驗(yàn)：

以下溶解方案，請(qǐng)直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的方式助溶。

  • 方案 一

    請(qǐng)依序添加每種溶劑： PBS

    Solubility: 100 mg/mL (555.06 mM); 澄清溶液; 超聲助溶

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
該產(chǎn)品水溶性佳，請(qǐng)具體參考實(shí)測(cè) 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
您所需的儲(chǔ)備液濃度超過(guò)該產(chǎn)品的實(shí)測(cè)溶解度，如有需要，請(qǐng)與 MCE 中國(guó)技術(shù)支持聯(lián)系。
純度 & 產(chǎn)品資料

純度: ≥98.0%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.5506 mL 27.7531 mL 55.5062 mL 138.7655 mL
5 mM 1.1101 mL 5.5506 mL 11.1012 mL 27.7531 mL
10 mM 0.5551 mL 2.7753 mL 5.5506 mL 13.8766 mL
15 mM 0.3700 mL 1.8502 mL 3.7004 mL 9.2510 mL
20 mM 0.2775 mL 1.3877 mL 2.7753 mL 6.9383 mL
25 mM 0.2220 mL 1.1101 mL 2.2202 mL 5.5506 mL
30 mM 0.1850 mL 0.9251 mL 1.8502 mL 4.6255 mL
40 mM 0.1388 mL 0.6938 mL 1.3877 mL 3.4691 mL
50 mM 0.1110 mL 0.5551 mL 1.1101 mL 2.7753 mL
60 mM 0.0925 mL 0.4626 mL 0.9251 mL 2.3128 mL
80 mM 0.0694 mL 0.3469 mL 0.6938 mL 1.7346 mL
100 mM 0.0555 mL 0.2775 mL 0.5551 mL 1.3877 mL

* 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

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