Oleanonic acid (Synonyms: 3-Oxooleanolic acid)

目錄號: HY-N1487 純度: 99.63%: FAQs
Data Sheet SDS COA 產(chǎn)品使用指南

摩爾計算器

Oleanonic acid (3-Oxooleanolic acid) 是一種可口服的三萜，具有抗炎和抗蟲活性。Oleanonic acid 在體外可改善 Amyloid-β 前體蛋白誘導(dǎo)的氧化應(yīng)激、自噬缺陷、鐵死亡、線粒體損傷和內(nèi)質(zhì)網(wǎng)應(yīng)激，在體內(nèi)可改善大鼠的心肌肥厚。

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Oleanonic acid Chemical Structure

CAS No. : 17990-42-0

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規(guī)格	價格	是否有貨
10 mM * 1 mL in DMSO	￥550	In-stock
50 mg	￥500	In-stock
100 mg		詢價
200 mg		詢價

or 大包裝詢價

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Other Forms of Oleanonic acid:

Oleanonic acid (Standard) 詢價

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻

•Pharmacol Res. 2024 May 9:204:107208. [Abstract]

Oleanonic acid 相關(guān)產(chǎn)品

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HIV HIV-1 HIV-2

生物活性
純度 & 產(chǎn)品資料
參考文獻

生物活性

Oleanonic acid (3-Oxooleanolic acid) is an orally available triterpene that has anti-inflammatory and insecticidal properties. In vitro, oleanonic acid can improve oxidative stress, autophagy defects, ferroptosis, mitochondrial damage, and endoplasmic reticulum stress induced by Amyloid-β, and in vivo, it can alleviate myocardial hypertrophy in rats^[1]^[2]^[3]^[4]^[5].

IC₅₀ & Target

HIV-1

細(xì)胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 20 μg/mL Compound: Oleanonic acid	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 21106454]
A549	IC₅₀	49.5 μM Compound: 4a	Cytotoxicity against human A549 cells incubated for 72 hrs by MTS assay Cytotoxicity against human A549 cells incubated for 72 hrs by MTS assay	[PMID: 31677446]
BJ	IC₅₀	> 50 μM Compound: 4a	Cytotoxicity against human BJ cells incubated for 72 hrs by MTS assay Cytotoxicity against human BJ cells incubated for 72 hrs by MTS assay	[PMID: 31677446]
Ca9-22	IC₅₀	18.04 μg/mL Compound: Oleanonic acid	Cytotoxicity against human Ca9-22 cells by MTT assay Cytotoxicity against human Ca9-22 cells by MTT assay	[PMID: 21106454]
CCRF-CEM	IC₅₀	15.1 μM Compound: 4a	Cytotoxicity against human CCRF-CEM cells incubated for 72 hrs by MTS assay Cytotoxicity against human CCRF-CEM cells incubated for 72 hrs by MTS assay	[PMID: 31677446]
H9	EC₅₀	0.11 μg/mL Compound: 27	Cytotoxicity against mock-infected human H9 cells after 4 days Cytotoxicity against mock-infected human H9 cells after 4 days	[PMID: 9748372]
H9	IC₅₀	0.8 μg/mL Compound: 27	Antiviral activity against HIV1 3B in human H9 cells after 4 days by p24 antigen ELISA Antiviral activity against HIV1 3B in human H9 cells after 4 days by p24 antigen ELISA	[PMID: 9748372]
HCT-116	IC₅₀	> 50 μM Compound: 4a	Cytotoxicity against p53 knockout human HCT116 cells incubated for 72 hrs by MTS assay Cytotoxicity against p53 knockout human HCT116 cells incubated for 72 hrs by MTS assay	[PMID: 31677446]
HCT-116	IC₅₀	45.1 μM Compound: 4a	Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTS assay Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTS assay	[PMID: 31677446]
Hep 3B2	IC₅₀	> 20 μg/mL Compound: Oleanonic acid	Cytotoxicity against human Hep3B cells by MTT assay Cytotoxicity against human Hep3B cells by MTT assay	[PMID: 21106454]
HepG2	IC₅₀	> 20 μg/mL Compound: Oleanonic acid	Cytotoxicity against human HepG2 cells by MTT assay Cytotoxicity against human HepG2 cells by MTT assay	[PMID: 21106454]
J774.A1	IC₅₀	38.8 μM Compound: 3	Inhibition of LPS-induced NO production in mouse J774A1 cells compound preincubated for 1 hr before LPS treatment by Griess reaction Inhibition of LPS-induced NO production in mouse J774A1 cells compound preincubated for 1 hr before LPS treatment by Griess reaction	[PMID: 25113933]
J774.A1	IC₅₀	87.72 μM Compound: 3	Cytotoxicity against mouse J774A1 cells assessed as cell viability by MTT assay relative to control Cytotoxicity against mouse J774A1 cells assessed as cell viability by MTT assay relative to control	[PMID: 25113933]
K562	IC₅₀	> 50 μM Compound: 4a	Cytotoxicity against human K562 cells incubated for 72 hrs by MTS assay Cytotoxicity against human K562 cells incubated for 72 hrs by MTS assay	[PMID: 31677446]
MCF7	IC₅₀	> 20 μg/mL Compound: Oleanonic acid	Cytotoxicity against human MCF7 cells by MTT assay Cytotoxicity against human MCF7 cells by MTT assay	[PMID: 21106454]
MDA-MB-231	IC₅₀	> 20 μg/mL Compound: Oleanonic acid	Cytotoxicity against human MDA-MB-231 cells by MTT assay Cytotoxicity against human MDA-MB-231 cells by MTT assay	[PMID: 21106454]
MRC5	IC₅₀	> 50 μM Compound: 4a	Cytotoxicity against human MRC5 cells incubated for 72 hrs by MTS assay Cytotoxicity against human MRC5 cells incubated for 72 hrs by MTS assay	[PMID: 31677446]
RAW264.7	IC₅₀	38.5 μM Compound: 3	Inhibition of LPS-induced NO production in mouse RAW264.7 cells compound preincubated for 1 hr before LPS treatment by Griess reaction Inhibition of LPS-induced NO production in mouse RAW264.7 cells compound preincubated for 1 hr before LPS treatment by Griess reaction	[PMID: 25113933]
RAW264.7	IC₅₀	89.6 μM Compound: 3	Cytotoxicity mouse RAW264.7 cells assessed as cell viability by MTT assay relative to control Cytotoxicity mouse RAW264.7 cells assessed as cell viability by MTT assay relative to control	[PMID: 25113933]
U2OS	IC₅₀	48.5 μM Compound: 4a	Cytotoxicity against human U2OS cells incubated for 72 hrs by MTS assay Cytotoxicity against human U2OS cells incubated for 72 hrs by MTS assay	[PMID: 31677446]

體外研究
(In Vitro)

Oleanonic acid 抑制 HIV-1 體外感染 PBMC，自然感染 PBMC 和單核細(xì)胞/巨噬細(xì)胞的 EC₅₀ 分別為 22.7 mM，24.6 mM 和 57.4 mM。除此之外，它可以抑制鼠腹腔白細(xì)胞產(chǎn)生白三烯 B4，IC₅₀ 為 17 μM^[2]。
Oleanonic acid 對克氏蜱和亞馬遜蜱具有較強的抗蟲活性，IC₅₀ 分別為 18.5 μM 和 29.9 μM^[3]。
Oleanonic acid (0-45 μM，24 h) 在苯腎上腺素 (PE) 處理的心肌細(xì)胞中抑制 NF-κB 轉(zhuǎn)錄活性的升高，并以濃度依賴的方式降低肥厚基因如心房利鈉因子 (ANF) 和腦利鈉肽 (BNP) 的 mRNA 表達^[4]。
Oleanonic acid (15 μM，24 h) 抑制心肌細(xì)胞 Thr410 位點蛋白激酶 PKCζ 的磷酸化，然后在 PE 處理的心肌細(xì)胞中降低 NF-κB 的激活^[4]。
Oleanonic acid (1-5 μM，48 h) 在 SH-SY5Y 細(xì)胞中降低 APP 表達，降低氧化應(yīng)激誘導(dǎo)的損傷，修復(fù)細(xì)胞自噬缺陷，抑制鐵死亡^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[4]

Cell Line:	NRCMs
Concentration:	0, 5, 15, 45 μM
Incubation Time:	24 h
Result:	Inhibited NF-κB transcriptional activity and reduced the expression of hypertrophic genes such as Atrial Natriuretic Factor (ANF) and Brain Natriuretic Peptide (BNP).

Western Blot Analysis^[4]

Cell Line:	NRCMs
Concentration:	15 μM
Incubation Time:	24 h
Result:	Inhibited the phosphorylation of the Thr410 site protein kinase PKCζ, and suppressed NF-κB.

Western Blot Analysis^[5]

Cell Line:	SH-SY5Y, SH-SY5Y-APP
Concentration:	1, 2.5, 5 μM
Incubation Time:	48 h
Result:	Reduced APP expression, inhibited mTOR phosphorylation, increased autophagy markers ATG5 and LC3-II, suppressed Nrf2 and HO-1, and restored the levels of GPX4, NCOA, and COX2.

體內(nèi)研究
(In Vivo)

Oleanonic acid (15-45 mg/kg，口服，每天，8 周) 在大鼠中抑制 PKCζ-NF-κB 信號通路，有效改善心肌肥厚^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	AAC rats^[4]
Dosage:	15, 45 mg/kg; daily; 8 weeks
Administration:	Oral
Result:	Reduced heart size and visibly decreased the thickness of the left ventricular wall, and in a dose-dependent manner, there was also a reduction in myocardial cell diameter and the heart weight to body weight ratio (HW/BW) under 400x HE staining.

分子量

454.68

Formula

C₃₀H₄₆O₃

CAS 號

17990-42-0

性狀

固體

顏色

White to off-white

中文名稱

齊墩果酮酸

結(jié)構(gòu)分類

初始來源

運輸條件

Room temperature in continental US; may vary elsewhere.

儲存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

溶解性數(shù)據(jù)

細(xì)胞實驗：

DMSO 中的溶解度 : 50 mg/mL (109.97 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液

濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg

1 mM	2.1993 mL	10.9967 mL	21.9935 mL
5 mM	0.4399 mL	2.1993 mL	4.3987 mL
10 mM	0.2199 mL	1.0997 mL	2.1993 mL

查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

摩爾計算器
稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

濃度 _(start)

體積 _(start)

濃度 _(final)

體積 _(final)

動物實驗：

請根據(jù)您的實驗動物和給藥方式選擇適當(dāng)?shù)娜芙夥桨浮?

以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
——為保證實驗結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實驗的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

方案一

請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.50 mM); 澄清溶液

此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。
以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水定容至 1 mL。
生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
方案二

請依序添加每種溶劑： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (5.50 mM); 懸濁液; 超聲助溶

此方案可獲得 2.5 mg/mL的均勻懸濁液，懸濁液可用于口服和腹腔注射。
以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液中，混合均勻。
2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。
方案三

請依序添加每種溶劑： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.50 mM); 澄清溶液

此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液，此方案實驗周期在半個月以上的動物實驗酌情使用。
以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 900 μL玉米油中，混合均勻。

動物溶解方案計算器

請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

每只動物的給藥體積

μL

動物數(shù)量

只

由于實驗過程有損耗，建議您多配一只動物的量

請輸入您的動物體內(nèi)配方組成：

DMSO +

Tween-80 +

Saline

如果您的動物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過 2%。

方案所需 助溶劑 包括：DMSO，，均可在 MCE 網(wǎng)站選購。，Tween 80，均可在 MCE 網(wǎng)站選購。

計算結(jié)果

工作液所需濃度 : mg/mL

儲備液配制方法 : mg 藥物溶于 μL DMSO（母液濃度為 mg/mL）。

您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，以下方案僅供參考，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。

動物實驗體內(nèi)工作液的配制方法 : 取 μL DMSO 儲備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。

連續(xù)給藥周期超過半月以上，請謹(jǐn)慎選擇該方案。

請確保第一步儲備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱（超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。

純度 & 產(chǎn)品資料

純度: 99.63%

選擇批次：

Data Sheet (656 KB) SDS (393 KB)

COA (290 KB) HNMR (286 KB) RP-HPLC (244 KB) MS (72 KB)

產(chǎn)品使用指南 (1538 KB)

參考文獻

[1]. Giner-Larza EM et al.Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity.Eur J Pharmacol.Sep 28;428(1):137-43.doi:10.1016/S0014-2999(01)01290-0(2001) [Content Brief]

[2]. Fabio Mengoni.Anti-HIV Activity of Oleanolic Acid on Infected Human Mononuclear Cells.Planta Med 68(2): 111-114.DOI: 10.1055/s-2002-20256(2002) [Content Brief]

[3]. Cristiano S. FUNARI, et al. Oleanonic acid from Lippia lupulina (Verbenaceae).shows strong in vitro antileishmanial and antitrypanosomal activity. Acta Amazonica. 46 (4) .Oct-Dec 2016

[4]. Hui Gao, et al. Oleanonic acid ameliorates pressure overload-induced cardiac hypertrophy in rats: The role of PKCζ-NF-κB pathway. Mol Cell Endocrinol. 2018 Jul 15:470:259-268. [Content Brief]

[5]. Liqing Tao, et al. Oleanonic acid ameliorates mutant Aβ precursor protein-induced oxidative stress, autophagy deficits, ferroptosis, mitochondrial damage, and ER stress in vitro. Biochim Biophys Acta Mol Basis Dis. 2024 Dec;1870(8):167459. [Content Brief]

Oleanonic acid 相關(guān)分類

完整儲備液配制表

可選溶劑	濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1993 mL	10.9967 mL	21.9935 mL	54.9837 mL
	5 mM	0.4399 mL	2.1993 mL	4.3987 mL	10.9967 mL
	10 mM	0.2199 mL	1.0997 mL	2.1993 mL	5.4984 mL
	15 mM	0.1466 mL	0.7331 mL	1.4662 mL	3.6656 mL
	20 mM	0.1100 mL	0.5498 mL	1.0997 mL	2.7492 mL
	25 mM	0.0880 mL	0.4399 mL	0.8797 mL	2.1993 mL
	30 mM	0.0733 mL	0.3666 mL	0.7331 mL	1.8328 mL
	40 mM	0.0550 mL	0.2749 mL	0.5498 mL	1.3746 mL
	50 mM	0.0440 mL	0.2199 mL	0.4399 mL	1.0997 mL
	60 mM	0.0367 mL	0.1833 mL	0.3666 mL	0.9164 mL
	80 mM	0.0275 mL	0.1375 mL	0.2749 mL	0.6873 mL
	100 mM	0.0220 mL	0.1100 mL	0.2199 mL	0.5498 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Oleanonic acid (Synonyms: 3-Oxooleanolic acid)

Other Forms of Oleanonic acid:

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻