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  2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. trans-Trimethoxyresveratrol

trans-Trimethoxyresveratrol  (Synonyms: trans-trismethoxy Resveratrol; E-Resveratrol Trimethyl Ether; Tri-O-methylresveratrol)

目錄號(hào): HY-N1408 純度: 99.62%
COA 產(chǎn)品使用指南 技術(shù)支持

Trans-Trimethoxyresveratrol是Resveratrol(RSV)的衍生物，與Resveratrol(RSV)相比，它可能是一個(gè)更有效的抗炎,抗血管新生的化合物。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

trans-Trimethoxyresveratrol Chemical Structure

trans-Trimethoxyresveratrol Chemical Structure

CAS No. : 22255-22-7

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥390
In-stock
50 mg ￥350
In-stock
100 mg ￥600
In-stock
200 mg   詢價(jià)  
500 mg   詢價(jià)  

* Please select Quantity before adding items.

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Trans-Trimethoxyresveratrol is a derivative of Resveratrol (RSV),and it may be a more potent anti-inflammatory, antiangiogenic and vascular-disrupting agent when compared with resveratrol. In vitro: The in vitro study of resveratrol and trans-Trimethoxyresveratrol showed rather weak cytotoxic effects on three cancer cell lines (HepG2, MCF-7, and MDA-MB-231), which contradicted a previous study reporting that resveratrol inhibited MCF-7 cells with an IC50 of about 10 μM. This discrepancy might be explained by the fact that the measurements were made 24 h after drug treatment, whereas the measurements of the previous study were taken 6 days after. The fact that the cytotoxic effect of trans-Trimethoxyresveratrol was lower than that of resveratrol is surprising, because in many studies, trans-Trimethoxyresveratrol is the most active analogue of resveratrol , although resveratrol shows much stronger antioxidant effects than that of trans-Trimethoxyresveratrol.[1] In vivo: Zebrafish embryos offer great advantage over their adults as well as other in vivo models because of the external development and optical transparency during their first few days, making them invaluable in the inspection of developmental processes. These unique advantages can even be made more useful when specific cell types are labeled with fluorescent probes. Zebrafish embryo in vivo, suggests that trans-Trimethoxyresveratrol has both more potent antiangiogenic activity and more importantly, stronger specific cytotoxic effects on endothelial cells than does resveratrol.[1]

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
BT-549 IC50
15.6 μM
Compound: 3
Cytotoxicity against human BT549 cells assessed as growth inhibition measured after 48 hrs by XTT assay
Cytotoxicity against human BT549 cells assessed as growth inhibition measured after 48 hrs by XTT assay
[PMID: 23547843]
BXPC-3 GI50
0.35 μg/mL
Compound: 1b
Growth inhibition of human BxPC3 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human BxPC3 cells after 48 hrs by sulforhodamine B assay
[PMID: 19719153]
Caco-2 IC50
11.95 μM
Compound: 9
Cytotoxicity against human Caco-2 cells after 3 days by [3H]thymidine incorporation assay
Cytotoxicity against human Caco-2 cells after 3 days by [3H]thymidine incorporation assay
[PMID: 20627379]
DU-145 GI50
1.5 μg/mL
Compound: 1b
Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay
[PMID: 19719153]
HCT-116 IC50
5.7 μM
Compound: 8E
Cytotoxicity against human HCT116 cells after 24 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 24 hrs by MTT assay
[PMID: 21215623]
HEK293 IC50
28.3 μM
Compound: 5H6
Inhibition of TNFalpha induced NF-kappaB activation in human 293 cells after 24 hrs by luciferase reporter gene assay
Inhibition of TNFalpha induced NF-kappaB activation in human 293 cells after 24 hrs by luciferase reporter gene assay
[PMID: 18487053]
HeLa IC50
13.3 μM
Compound: 3
Cytotoxicity against human HeLa cells assessed as growth inhibition measured after 48 hrs by XTT assay
Cytotoxicity against human HeLa cells assessed as growth inhibition measured after 48 hrs by XTT assay
[PMID: 23547843]
HepG2 IC50
> 100 μM
Compound: TMS; 66
Anticancer activity against human HepG2 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
Anticancer activity against human HepG2 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
[PMID: 32485531]
HT-29 IC50
14 μM
Compound: TMS; 66
Anticancer activity against human HT-29 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
Anticancer activity against human HT-29 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
[PMID: 32485531]
HT-29 IC50
16.1 μM
Compound: 9
Cytotoxicity against human HT-29 cells after 3 days by [3H]thymidine incorporation assay
Cytotoxicity against human HT-29 cells after 3 days by [3H]thymidine incorporation assay
[PMID: 20627379]
IMR-90 IC50
2.1 μM
Compound: 8E
Cytotoxicity against human IMR90 cells after 24 hrs by MTT assay
Cytotoxicity against human IMR90 cells after 24 hrs by MTT assay
[PMID: 21215623]
K562 IC50
6.39 μM
Compound: TMRV
Cytotoxicity against Homo sapiens (human) K562 cells assessed as growth inhibition after 48 hr by MTT assay
Cytotoxicity against Homo sapiens (human) K562 cells assessed as growth inhibition after 48 hr by MTT assay
10.1007/s00044-012-0159-y
KB IC50
10.3 μM
Compound: 2
Cytotoxicity against human KB cells after 48 hrs
Cytotoxicity against human KB cells after 48 hrs
[PMID: 17000031]
KB IC50
17.7 μM
Compound: 3
Cytotoxicity against human KB cells assessed as growth inhibition measured after 48 hrs by XTT assay
Cytotoxicity against human KB cells assessed as growth inhibition measured after 48 hrs by XTT assay
[PMID: 23547843]
LLC-PK1 IC50
20 μM
Compound: 3
Cytotoxicity against pig LLC-PK1 cells assessed as growth inhibition measured after 48 hrs by XTT assay
Cytotoxicity against pig LLC-PK1 cells assessed as growth inhibition measured after 48 hrs by XTT assay
[PMID: 23547843]
MCF7 IC50
1.1 μM
Compound: 8E
Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
[PMID: 21215623]
MCF7 IC50
8.41 μM
Compound: TMRV
Cytotoxicity against Homo sapiens (human) MCF7 cells assessed as growth inhibition after 48 hr by MTT assay
Cytotoxicity against Homo sapiens (human) MCF7 cells assessed as growth inhibition after 48 hr by MTT assay
10.1007/s00044-012-0159-y
NCI-H460 GI50
0.62 μg/mL
Compound: 1b
Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay
[PMID: 19719153]
SF-268 GI50
0.56 μg/mL
Compound: 1b
Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay
[PMID: 19719153]
SK-BR-3 IC50
111.8 μM
Compound: TMS; 66
Anticancer activity against human SK-BR-3 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
Anticancer activity against human SK-BR-3 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
[PMID: 32485531]
SK-MEL IC50
12.2 μM
Compound: 3
Cytotoxicity against human SK-MEL cells assessed as growth inhibition measured after 48 hrs by XTT assay
Cytotoxicity against human SK-MEL cells assessed as growth inhibition measured after 48 hrs by XTT assay
[PMID: 23547843]
SK-OV-3 IC50
55.5 μM
Compound: 3
Cytotoxicity against human SKOV3 cells assessed as growth inhibition measured after 48 hrs by XTT assay
Cytotoxicity against human SKOV3 cells assessed as growth inhibition measured after 48 hrs by XTT assay
[PMID: 23547843]
SW480 IC50
54 μM
Compound: 3
Antiproliferative activity against human SW480 cells assessed as cell viability using propidium iodide staining after 48 hrs
Antiproliferative activity against human SW480 cells assessed as cell viability using propidium iodide staining after 48 hrs
[PMID: 20395019]
Vero IC50
26.7 μM
Compound: 3
Cytotoxicity against african green monkey Vero cells assessed as growth inhibition measured after 48 hrs by XTT assay
Cytotoxicity against african green monkey Vero cells assessed as growth inhibition measured after 48 hrs by XTT assay
[PMID: 23547843]
分子量

270.32

Formula

C17H18O3
CAS 號(hào)
性狀

固體

顏色

White to off-white

結(jié)構(gòu)分類
初始來源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : ≥ 50 mg/mL (184.97 mM; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

* "≥" means soluble, but saturation unknown.

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 3.6993 mL 18.4966 mL 36.9932 mL
5 mM 0.7399 mL 3.6993 mL 7.3986 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物實(shí)驗(yàn)：

請(qǐng)根據(jù)您的 實(shí)驗(yàn)動(dòng)物和給藥方式 選擇適當(dāng)?shù)娜芙夥桨浮?

以下溶解方案都請(qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：
——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

  • 方案 一

    請(qǐng)依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (9.25 mM); 澄清溶液

    此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

    以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水 定容至 1 mL。

    生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
  • 方案 二

    請(qǐng)依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (9.25 mM); 澄清溶液

    此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

    以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液 中，混合均勻。

    2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。
動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量
請(qǐng)輸入您的動(dòng)物體內(nèi)配方組成：
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
如果您的動(dòng)物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過 2%。
方案所需 助溶劑 包括：DMSO， ，均可在 MCE 網(wǎng)站選購。 ，Tween 80，均可在 MCE 網(wǎng)站選購。
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
儲(chǔ)備液配制方法 : mg 藥物溶于 μL  DMSO（母液濃度為 mg/mL）。
您所需的儲(chǔ)備液濃度超過該產(chǎn)品的實(shí)測(cè)溶解度，以下方案僅供參考，如有需要，請(qǐng)與 MCE 中國技術(shù)支持聯(lián)系。
動(dòng)物實(shí)驗(yàn)體內(nèi)工作液的配制方法 : 取 μL DMSO 儲(chǔ)備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。
連續(xù)給藥周期超過半月以上，請(qǐng)謹(jǐn)慎選擇該方案。
請(qǐng)確保第一步儲(chǔ)備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱 （超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。
純度 & 產(chǎn)品資料
參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6993 mL 18.4966 mL 36.9932 mL 92.4830 mL
5 mM 0.7399 mL 3.6993 mL 7.3986 mL 18.4966 mL
10 mM 0.3699 mL 1.8497 mL 3.6993 mL 9.2483 mL
15 mM 0.2466 mL 1.2331 mL 2.4662 mL 6.1655 mL
20 mM 0.1850 mL 0.9248 mL 1.8497 mL 4.6241 mL
25 mM 0.1480 mL 0.7399 mL 1.4797 mL 3.6993 mL
30 mM 0.1233 mL 0.6166 mL 1.2331 mL 3.0828 mL
40 mM 0.0925 mL 0.4624 mL 0.9248 mL 2.3121 mL
50 mM 0.0740 mL 0.3699 mL 0.7399 mL 1.8497 mL
60 mM 0.0617 mL 0.3083 mL 0.6166 mL 1.5414 mL
80 mM 0.0462 mL 0.2312 mL 0.4624 mL 1.1560 mL
100 mM 0.0370 mL 0.1850 mL 0.3699 mL 0.9248 mL
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產(chǎn)品名稱：
trans-Trimethoxyresveratrol
目錄號(hào)：
HY-N1408
需求量：