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  2. Epigenetics PI3K/Akt/mTOR Anti-infection
  3. AMPK Bacterial
  4. Galegine hydrochloride

Galegine hydrochloride 

目錄號: HY-N0930B 純度: 98.45%
COA 產品使用指南

Galegine hydrochloride, 一種胍衍生物，有助于小鼠減輕體重。胍類是從 G. officinalis 中提取的化合物，產生雙胍、二甲雙胍和苯甲雙胍。Galegine hydrochloride 激活 3T3-L1 脂肪細胞、L6 肌管、H4IIE 大鼠肝癌和 HEK293 人腎細胞系中的 AMPK。Galegine hydrochloride 具有抗菌活性，對金黃色葡萄球菌菌株 (Staphylococcus aureus) 的最低抑菌濃度為 4 mg/L。

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Galegine hydrochloride Chemical Structure

Galegine hydrochloride Chemical Structure

CAS No. : 2368870-39-5

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規(guī)格 價格 是否有貨 數(shù)量
5 mg ￥1600
In-stock
10 mg ￥2800
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Customer Review

  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice. Guanidine hydrochloride is the compound derived from G. officinalis, which gave rise to the biguanides, metformin and phenformin. Galegine hydrochloride activates AMPK in 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines. Galegine hydrochloride has antibacterial activity, with minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains[1][2].

體外研究
(In Vitro)

Pre-treatment with Galegine hydrochloride (10?μM-3?mM; 5?h) produces a concentration-dependent stimulation of insulin-independent glucose uptake by 3T3-L1 adipocytes without any effect on cell viability. Incubation with Galegine hydrochloride (1?μM-1?mM, 5?h) produces a concentration-dependent stimulation of glucose uptake into L6 myotubes, again without any effect on cell viability[1].
Galegine hydrochloride (0.3-300?μM; 24 hours) produced a slight reduction in basal glycerol release and a more marked reduction in isoprenaline-stimulated glycerol release from 3T3-L1 adipocytes. Incubation of H4IIE rat hepatoma cells with Galegine hydrochloride (10 or 300?μM) for up to 6?hours produces a time-dependent activation of AMPK measured in cell lysates, with maximal activation at 360?min and twofold activation still evident at 24?hous in the presence of 300?μM Galegine hydrochloride. The effect of 300?ΜM Galegine hydrochloride is markedly greater than that of 10?μM. Incubation with Galegine hydrochloride for 1?hour produces a concentration-dependent activation of AMPK in both 3T3L-1 adipocytes and L-6 myotubes. Galegine hydrochloride also produces a concentration-dependent activation of the enzyme in a human kidney cell line (HEK293)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內研究
(In Vivo)

Galegine hydrochloride (63 mg/kg; feed; daily for 11 days) produces a significant reduction in body weight[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male BALB/c mice[1]
Dosage: 63 mg/kg
Administration: feed; daily for 11 days
Result: Produced a significant reduction in body weight.
分子量

163.65

Formula

C6H14ClN3
CAS 號
性狀

固體

顏色

White to off-white

結構分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性數(shù)據(jù)
細胞實驗： 

H2O 中的溶解度 : 43.33 mg/mL (264.77 mM; 超聲助溶)

DMSO 中的溶解度 : 5.2 mg/mL (31.78 mM; 超聲助溶; 吸濕的 DMSO 對產品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 6.1106 mL 30.5530 mL 61.1060 mL
5 mM 1.2221 mL 6.1106 mL 12.2212 mL
查看完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
該產品水溶性佳，請具體參考實測 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
您所需的儲備液濃度超過該產品的實測溶解度，如有需要，請與 MCE 中國技術支持聯(lián)系。
純度 & 產品資料
參考文獻

完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 6.1106 mL 30.5530 mL 61.1060 mL 152.7651 mL
5 mM 1.2221 mL 6.1106 mL 12.2212 mL 30.5530 mL
10 mM 0.6111 mL 3.0553 mL 6.1106 mL 15.2765 mL
15 mM 0.4074 mL 2.0369 mL 4.0737 mL 10.1843 mL
20 mM 0.3055 mL 1.5277 mL 3.0553 mL 7.6383 mL
25 mM 0.2444 mL 1.2221 mL 2.4442 mL 6.1106 mL
30 mM 0.2037 mL 1.0184 mL 2.0369 mL 5.0922 mL
H2O 40 mM 0.1528 mL 0.7638 mL 1.5277 mL 3.8191 mL
50 mM 0.1222 mL 0.6111 mL 1.2221 mL 3.0553 mL
60 mM 0.1018 mL 0.5092 mL 1.0184 mL 2.5461 mL
80 mM 0.0764 mL 0.3819 mL 0.7638 mL 1.9096 mL
100 mM 0.0611 mL 0.3055 mL 0.6111 mL 1.5277 mL

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產品名稱：
Galegine hydrochloride
目錄號：
HY-N0930B
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