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  1. Immunology/Inflammation Stem Cell/Wnt Apoptosis Autophagy
  2. COX Wnt Apoptosis Autophagy
  3. Ginkgetin

Ginkgetin  (Synonyms: 銀杏雙黃酮)

目錄號: HY-N0889 純度: 99.86%
COA 產(chǎn)品使用指南

Ginkgetin 是一種從銀杏葉中分離得到的雙黃酮。Ginkgetin 具有抗腫瘤,抗炎,神經(jīng)保護,抗真菌的作用。Ginkgetin 也是一種有效的 Wnt 信號抑制劑,IC50 值為 5.92 μM。

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Ginkgetin Chemical Structure

Ginkgetin Chemical Structure

CAS No. : 481-46-9

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ¥1869
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1 mg ¥571
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5 mg ¥1500
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10 mg ¥2400
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25 mg ¥5300
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Customer Review

Other Forms of Ginkgetin:

查看 COX 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Ginkgetin, a biflavone, is isolated from Ginkgo biloba leaves. Ginkgetin exhibit anti-tumor, anti-inflammatory, neuroprotective, anti-fungal activities. Ginkgetin is also a potent inhibitor of Wnt signaling, with an IC50 of 5.92 μΜ[1][2][3][4][5].

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
OVCAR-3 IC50
1.8 μg/mL
Compound: 1
Growth inhibition of human OVCAR-3 cells after 48 hrs
Growth inhibition of human OVCAR-3 cells after 48 hrs
[PMID: 9134745]
體外研究
(In Vitro)

Ginkgetin (2.5-20 μM; 48 h) inhibits the growth of Daoy and D283 cell lines, and induces G2/M cell cycle arrest in Daoy cells[2].
Ginkgetin (20-40 μM; 24 h) significantly activates the apoptosis of osteosarcoma cells in a concentration-dependent manner[3].
Ginkgetin (10-20 μM; 3-24 h) down-regulated the expression of Wnt target genes without affecting the expression of β-catenin in medulloblastoma cells[2].
Ginkgetin (1-10 μM; 24 or 48 h) significantly inhibits the VEGF-induced endothelial cell proliferation, migration, and wound recovery in a concentration-dependent manner[1].
Ginkgetin (5-10 μM; 48 h) induces autophagy responsible for cell death in A549[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Daoy and D283 cell lines
Concentration: 2.5, 5, 10, 20 μM
Incubation Time: 48 hours
Result: Inhibited the cell growth, with IC50s of 14.65 and 15.81 μM for Daoy and D283 cells, respectively.

Apoptosis Analysis[3]

Cell Line: Osteosarcoma cells
Concentration: 20, 30, 40 μM
Incubation Time: 24 hours
Result: Markedly induced the apoptosis of osteosarcoma cells in a concentration-dependent manner.

Cell Cycle Analysis[2]

Cell Line: Daoy cells
Concentration: 2.5, 5, 10, 20 μM
Incubation Time: 24 hours
Result: Increased G2/M phase, compared with that of control, indicating a G2/M cell phase arrest.

Cell Cycle Analysis[2]

Cell Line: Daoy and D283 cell lines
Concentration: 10, 20 μM
Incubation Time: 3, 6, 12, 24 hours
Result: Attenuated the expression of Wnt target genes, Axin2, cyclin D1 and survivin at 20 μM for 24 h in Daoy cells.
Unaffected the level of total β-catenin and diminished the level of β-catenin phosphorylation in a time- and concentration-dependent manner.
體內(nèi)研究
(In Vivo)

Ginkgetin (25-100 mg/kg; i.p. 2 hours after the onset of ischemia) exerts anti-inflammatory effects on cerebral ischemia/reperfusion-induced injury in a rat model via the TLR4/NF-κB signaling pathway[4].
Ginkgetin (30 mg/kg; intragastrically once per day for 42 d) suppresses tumor growth in A549 cells bearing nude mice[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (200-220 g)[4]
Dosage: 25, 50, 100 mg/kg
Administration: I.p. 2 hours after the onset of ischemia
Result: Reduced the neurological de?cit score.
Suppressed the expression of NF-κB, TLR4 and IκBαin ischemic penumbra cortex, and inhibited the degradation of IκBα.
Decreased the expressions of ICAM-1, COX-2, and iNOS.
Downregulated downstream in?ammatory factor PGE2 and TNF-α expression.
Decreased IL-1β, IL-6, IL-8, and IL-10 protein expression.
分子量

566.51

Formula

C32H22O10

CAS 號
性狀

固體

顏色

Light yellow to yellow

中文名稱

銀杏素;白果雙黃酮;銀杏雙黃酮;銀杏黃素

結(jié)構(gòu)分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.

儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細胞實驗: 

DMSO 中的溶解度 : ≥ 20.83 mg/mL (36.77 mM; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響,請使用新開封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 1.7652 mL 8.8260 mL 17.6519 mL
5 mM 0.3530 mL 1.7652 mL 3.5304 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液;一旦配成溶液,請分裝保存,避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C儲存時,請在2年內(nèi)使用, -20°C儲存時,請在1年內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物實驗:

以下溶解方案,請直接配制工作液。建議現(xiàn)用現(xiàn)配,在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比; 如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象,可以通過加熱和/或超聲的方式助溶。

  • 方案 一

    請依序添加每種溶劑: 50% PEG300    50% Saline

    Solubility: 2 mg/mL (3.53 mM); 懸濁液; 超聲加熱助溶

  • 方案 二

    請依序添加每種溶劑: 0.5% CMC-Na/saline water

    Solubility: 2 mg/mL (3.53 mM); 懸濁液; 超聲助溶 (<60°C)

動物溶解方案計算器
請輸入動物實驗的基本信息:

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

由于實驗過程有損耗,建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.86%

參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液;一旦配成溶液,請分裝保存,避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C儲存時,請在2年內(nèi)使用, -20°C儲存時,請在1年內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7652 mL 8.8260 mL 17.6519 mL 44.1298 mL
5 mM 0.3530 mL 1.7652 mL 3.5304 mL 8.8260 mL
10 mM 0.1765 mL 0.8826 mL 1.7652 mL 4.4130 mL
15 mM 0.1177 mL 0.5884 mL 1.1768 mL 2.9420 mL
20 mM 0.0883 mL 0.4413 mL 0.8826 mL 2.2065 mL
25 mM 0.0706 mL 0.3530 mL 0.7061 mL 1.7652 mL
30 mM 0.0588 mL 0.2942 mL 0.5884 mL 1.4710 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱:
Ginkgetin
目錄號:
HY-N0889
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