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  2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Betaine chloride

Betaine chloride  (Synonyms: 鹽酸甜菜堿)

目錄號: HY-N0739 純度: ≥98.0%
COA 產(chǎn)品使用指南

Betaine hydrochloride 是許多食物中發(fā)現(xiàn)的天然化合物，也是一種可維持正常 DNA 甲基化模式的活性甲基供體。

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Betaine chloride Chemical Structure

Betaine chloride Chemical Structure

CAS No. : 590-46-5

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Other Forms of Betaine chloride:

  • 生物活性

  • 實驗參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Betaine hydrochloride is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns.

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

體外研究
(In Vitro)

It is found that proliferation of HeLa cells is inhibited significantly upon exposure to increasing Betaine hydrochloride levels with the MTT test (p<0.05). The percentage of S phase cells in the low dose groups (<5 mg/mL) are distinctly higher than in high dose groups, and the rates of Sub-G1 phase are the opposite (p<0.05). A high concentration of Betaine hydrochloride (>5.0 mg/mL) significantly promotes the apoptosis of HeLa cells (p<0.01). SOD activities of the low dose groups are slightly higher than the control group (p<0.05), and there are obvious synchronicity and correlation among the expression of promoting apoptosis genes Bax, P53, Caspase 3 and apoptosis suppression gene Bcl-2. In response to an apoptosis-inducing stimulus, p53 and cyclin D1 can be activated with blockage of the cell cycle at G1/S or S/G2 checkpoints[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Liver-to-body weight ratio is attenuated by Betaine hydrochloride supplementation. When Betaine hydrochloride is added to the alcohol-containing liquid diet, both hepatic triglyceride (TG) accumulation and liver injury are significantly reduced. Betaine hydrochloride supplementation attenuates epididymal fat pad mass loss induced by chronic alcohol feeding. Betaine hydrochloride supplementation prevents the depletion of S-adenosylhomocysteine (SAM) and reduces the increase in S-adenosylhomocysteine (SAH), thereby improving the methylation state of the adipose tissue[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

153.61

Formula

C5H12ClNO2
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

鹽酸甜菜堿；甜菜堿鹽酸鹽
結(jié)構(gòu)分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性數(shù)據(jù)
細胞實驗： 

H2O 中的溶解度 : 100 mg/mL (651.00 mM; 超聲助溶)

DMSO 中的溶解度 : 5 mg/mL (32.55 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 6.5100 mL 32.5500 mL 65.0999 mL
5 mM 1.3020 mL 6.5100 mL 13.0200 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
該產(chǎn)品水溶性佳，請具體參考實測 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
純度 & 產(chǎn)品資料

純度: ≥98.0%

參考文獻
Cell Assay
[1]

Cytotoxic effects of Betaine hydrochloride are evaluated by MTT assays. Briefly, 5×103 HeLa or MCF-10A cells/well are seeded in a 96-well plate and cultured overnight. Then, different concentrations of Betaine hydrochloride (from 0 to 100 mg/mL) are added to each well, and the MTT assay is performed at 24, 48, 72 and 96 h after incubation. Cu/Zn-SOD activities are detected using the superoxide dismutase Assay Kit according to the manufacturer’s instructions[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[2]

Male C57BL/6 mice weighing 25±0.5 g are used in this study. Animals are randomly assigned to four groups (n=6 to 8 per group) and pair-fed a modified Lieber-DeCarli alcohol (AF) or isocaloric maltose dextrin control liquid diet (PF) for 5 weeks with a stepwise feeding procedure. The ethanol content starts at 30% of total calories and gradually increases up to 36% in the last week. Betaine hydrochloride is administered as a supplement in the liquid diets (both PF and AF) at a concentration of 0.5% (w/v), simultaneously with the alcohol. All animals have access to diet and water ad libitum. At the end of the experiment, the mice are killed after being deprived of food for 4?h, and the plasma, liver and epididymal fat pad samples are harvested for assays[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 6.5100 mL 32.5500 mL 65.0999 mL 162.7498 mL
5 mM 1.3020 mL 6.5100 mL 13.0200 mL 32.5500 mL
10 mM 0.6510 mL 3.2550 mL 6.5100 mL 16.2750 mL
15 mM 0.4340 mL 2.1700 mL 4.3400 mL 10.8500 mL
20 mM 0.3255 mL 1.6275 mL 3.2550 mL 8.1375 mL
25 mM 0.2604 mL 1.3020 mL 2.6040 mL 6.5100 mL
30 mM 0.2170 mL 1.0850 mL 2.1700 mL 5.4250 mL
H2O 40 mM 0.1627 mL 0.8137 mL 1.6275 mL 4.0687 mL
50 mM 0.1302 mL 0.6510 mL 1.3020 mL 3.2550 mL
60 mM 0.1085 mL 0.5425 mL 1.0850 mL 2.7125 mL
80 mM 0.0814 mL 0.4069 mL 0.8137 mL 2.0344 mL
100 mM 0.0651 mL 0.3255 mL 0.6510 mL 1.6275 mL

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Betaine chloride
目錄號：
HY-N0739
需求量：