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  2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Anti-infection
  3. Reactive Oxygen Species Bacterial Endogenous Metabolite
  4. Protocatechualdehyde

Protocatechualdehyde  (Synonyms: 原兒茶醛; Catechaldehyde; Protocatechuic aldehyde; Rancinamycin IV)

目錄號(hào): HY-N0295 純度: 99.98%
COA 產(chǎn)品使用指南

Protocatechualdehyde (Catechaldehyde) 是從 Salvia miltiorrhiza 中分離出來(lái)的一種天然多酚化合物，具有多種生物活性，可作為抗氧化、抗衰老、抗菌消炎劑被廣泛應(yīng)用于多個(gè)醫(yī)學(xué)領(lǐng)域。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Protocatechualdehyde Chemical Structure

Protocatechualdehyde Chemical Structure

CAS No. : 139-85-5

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥137
In-stock
25 mg ￥125
In-stock
50 mg ￥185
In-stock
100 mg ￥268
In-stock
500 mg ￥536
In-stock
1 g ￥778
In-stock
5 g ￥1863
In-stock
10 g   詢價(jià)  
50 g   詢價(jià)  

* Please select Quantity before adding items.

Customer Review

Other Forms of Protocatechualdehyde:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Protocatechualdehyde (Catechaldehyde), a natural polyphenol compound isolated from the roots of radix Salviae Miltiorrhizae, is associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging, an antibacterial and anti-inflammatory agent[1].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 10 μM
Compound: 22
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 25710081]
A549 IC50
3.1 μM
Compound: 17
Cytotoxicity against human A549 cells after 4 days by MTT assay
Cytotoxicity against human A549 cells after 4 days by MTT assay
[PMID: 24359303]
A549 GI50
42 μM
Compound: 2
Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay
[PMID: 25752525]
B16-4A5 IC50
17 μM
Compound: 36
Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells after 72 hrs
Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells after 72 hrs
[PMID: 20189399]
Bel-7402 IC50
3.7 μM
Compound: 17
Cytotoxicity against human Bel7402 cells after 4 days by MTT assay
Cytotoxicity against human Bel7402 cells after 4 days by MTT assay
[PMID: 24359303]
BMDM IC50
15 μM
Compound: 6
Inhibition of M-CSF/RANKL-induced osteoclast differentiation in C57BL/6 mouse bone marrow macrophage assessed as reduction in multinucleated TRAP+ cells incubated for 6 days with fresh media replacement on day 3 and measured on day 6 by TRAP staining-base
Inhibition of M-CSF/RANKL-induced osteoclast differentiation in C57BL/6 mouse bone marrow macrophage assessed as reduction in multinucleated TRAP+ cells incubated for 6 days with fresh media replacement on day 3 and measured on day 6 by TRAP staining-base
[PMID: 31257875]
BV-2 IC50
> 100 μM
Compound: 26
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay
[PMID: 28911817]
DLD-1 IC50
70 μM
Compound: 4
Cytotoxicity against human DLD1 cells after 96 hrs by MTT assay
Cytotoxicity against human DLD1 cells after 96 hrs by MTT assay
[PMID: 15387639]
HBL-100 GI50
> 100 μM
Compound: 2
Antiproliferative activity against human HBL100 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HBL100 cells after 48 hrs by sulforhodamine B assay
[PMID: 25752525]
HeLa GI50
49 μM
Compound: 2
Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay
[PMID: 25752525]
HepG2 2.2.15 EC50
2.46 μg/mL
Compound: 61
Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV e antigen secretion by ELISA
Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV e antigen secretion by ELISA
[PMID: 24549242]
HepG2 2.2.15 EC50
3.94 μg/mL
Compound: 61
Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV surface antigen secretion by ELISA
Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV surface antigen secretion by ELISA
[PMID: 24549242]
HepG2 2.2.15 IC50
4.17 μg/mL
Compound: 61
Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV DNA production by quantitative RT-PCR analysis
Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV DNA production by quantitative RT-PCR analysis
[PMID: 24549242]
K562 IC50
> 10 μM
Compound: 22
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
[PMID: 25710081]
KB IC50
> 10 μM
Compound: 17
Cytotoxicity against human KB cells after 4 days by MTT assay
Cytotoxicity against human KB cells after 4 days by MTT assay
[PMID: 24359303]
N9 IC50
> 100 μM
Compound: 31
Antineuroinflammatory activity in mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
Antineuroinflammatory activity in mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
[PMID: 28073678]
SW1573 GI50
54 μM
Compound: 2
Antiproliferative activity against human SW1573 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human SW1573 cells after 48 hrs by sulforhodamine B assay
[PMID: 25752525]
T47D GI50
> 100 μM
Compound: 2
Antiproliferative activity against human T47D cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human T47D cells after 48 hrs by sulforhodamine B assay
[PMID: 25752525]
WiDr GI50
> 100 μM
Compound: 2
Antiproliferative activity against human WiDr cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human WiDr cells after 48 hrs by sulforhodamine B assay
[PMID: 25752525]
體外研究
(In Vitro)

Protocatechualdehyde (PCA) (50、100 μM，24/48 小時(shí)) 處理的 MCF-7 細(xì)胞在 24 小時(shí)內(nèi)顯著降低細(xì)胞增殖 11% 和 20%，在 48 小時(shí)內(nèi)分別降低 22% 和 27%[2]。
Protocatechualdehyde (50、100 μM，24 小時(shí)) 處理的 MCF-7 細(xì)胞在 50 μM 和 100 μM 的濃度下分別增加了 1.9 倍和 2.6 倍。PCA 抑制雌激素受體 (ER) 陽(yáng)性 (MCF-7) 乳腺癌細(xì)胞的增殖，但不抑制 ER 陰性 (MDA-MB-231) 乳腺癌細(xì)胞的增殖[2]。
Protocatechualdehyde (0、100、200 μM，在 HCT116 和 SW480 細(xì)胞中作用 48 小時(shí)) 影響 HDAC 的酶活性，觀察到 PCA 處理以劑量依賴性方式抑制 HDAC 活性[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: Human breast cancer cell (MCF-7 and MDA-MB-231)
Concentration: 0, 5, 10, 25, 50, and 100 μM
Incubation Time: 24, 48 hours
Result: Inhibited MCF-7 cells cell growth.

Apoptosis Analysis[2]

Cell Line: Human breast cancer cell (MCF-7 and MDA-MB-231)
Concentration: 0, 5, 10, 25, 50, and 100 μM
Incubation Time: 24, 48 hours
Result: Increased apoptosis in MCF-7 cells.
分子量

138.12

Formula

C7H6O3
CAS 號(hào)
性狀

固體

顏色

Light yellow to brown

中文名稱

原兒茶醛
結(jié)構(gòu)分類
初始來(lái)源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : ≥ 50 mg/mL (362.00 mM; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 7.2401 mL 36.2004 mL 72.4008 mL
5 mM 1.4480 mL 7.2401 mL 14.4802 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物實(shí)驗(yàn)：

請(qǐng)根據(jù)您的 實(shí)驗(yàn)動(dòng)物和給藥方式 選擇適當(dāng)?shù)娜芙夥桨浮?

以下溶解方案都請(qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：
——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的方式助溶

  • 方案 一

    請(qǐng)依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (18.10 mM); 澄清溶液

    此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

    以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水 定容至 1 mL。

    生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
  • 方案 二

    請(qǐng)依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (18.10 mM); 澄清溶液

    此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

    以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液 中，混合均勻。

    2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。
動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
請(qǐng)輸入您的動(dòng)物體內(nèi)配方組成：
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
如果您的動(dòng)物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過(guò) 2%。
方案所需 助溶劑 包括：DMSO， ，均可在 MCE 網(wǎng)站選購(gòu)。 ，Tween 80，均可在 MCE 網(wǎng)站選購(gòu)。
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
儲(chǔ)備液配制方法 : mg 藥物溶于 μL  DMSO（母液濃度為 mg/mL）。

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

您所需的儲(chǔ)備液濃度超過(guò)該產(chǎn)品的實(shí)測(cè)溶解度，以下方案僅供參考，如有需要，請(qǐng)與 MCE 中國(guó)技術(shù)支持聯(lián)系。
動(dòng)物實(shí)驗(yàn)體內(nèi)工作液的配制方法 : 取 μL DMSO 儲(chǔ)備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。
連續(xù)給藥周期超過(guò)半月以上，請(qǐng)謹(jǐn)慎選擇該方案。
請(qǐng)確保第一步儲(chǔ)備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱 （超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。
純度 & 產(chǎn)品資料

純度: 99.98%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 7.2401 mL 36.2004 mL 72.4008 mL 181.0020 mL
5 mM 1.4480 mL 7.2401 mL 14.4802 mL 36.2004 mL
10 mM 0.7240 mL 3.6200 mL 7.2401 mL 18.1002 mL
15 mM 0.4827 mL 2.4134 mL 4.8267 mL 12.0668 mL
20 mM 0.3620 mL 1.8100 mL 3.6200 mL 9.0501 mL
25 mM 0.2896 mL 1.4480 mL 2.8960 mL 7.2401 mL
30 mM 0.2413 mL 1.2067 mL 2.4134 mL 6.0334 mL
40 mM 0.1810 mL 0.9050 mL 1.8100 mL 4.5251 mL
50 mM 0.1448 mL 0.7240 mL 1.4480 mL 3.6200 mL
60 mM 0.1207 mL 0.6033 mL 1.2067 mL 3.0167 mL
80 mM 0.0905 mL 0.4525 mL 0.9050 mL 2.2625 mL
100 mM 0.0724 mL 0.3620 mL 0.7240 mL 1.8100 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Protocatechualdehyde
目錄號(hào)：
HY-N0295
需求量：