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  2. NF-κB Stem Cell/Wnt JAK/STAT Signaling Apoptosis
  3. NF-κB STAT Wnt β-catenin Bcl-2 Family Apoptosis
  4. Cardamonin

Cardamonin  (Synonyms: 豆蔻明; Cardamomin; Alpinetin chalcone)

目錄號(hào): HY-N0279 純度: 98.38%
COA 產(chǎn)品使用指南

Cardamonin 是一種黃酮類(lèi)化合物，并針對(duì)各種信號(hào)分子、轉(zhuǎn)錄因子、細(xì)胞因子和酶，可抑制 mTOR、NF-κB、Akt、STAT3、Wnt/β-catenin 和 COX-2，其表現(xiàn)出抗癌、抗炎、抗微生物和抗糖尿病的活性。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Cardamonin Chemical Structure

Cardamonin Chemical Structure

CAS No. : 18956-16-6

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥748
In-stock
5 mg ￥680
In-stock
10 mg ￥1160
In-stock
50 mg ￥3500
In-stock
100 mg   詢(xún)價(jià)  
200 mg   詢(xún)價(jià)  

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Customer Review

Other Forms of Cardamonin:

    Cardamonin purchased from MCE. Usage Cited in: Biomed Pharmacother. 2020 Feb;122:109547.  [Abstract]

    Cardamonin promotes the Nrf2-ARE regulated cytoprotective genes in HL-1 cells dependent on Nrf2. western blot analysis were used to determine Nrf2, HO1, NQO1 and GCLM expression levels in HL-1 cells treated with the indicated concentrations of CAR (0, 25, 50 and 100 μM) for 24 h.

    Cardamonin purchased from MCE. Usage Cited in: Biomed Pharmacother. 2020 Feb;122:109547.  [Abstract]

    Cardamonin promotes the Nrf2-ARE regulated cytoprotective genes in HL-1 cells dependent on Nrf2. Western blot analysis of Nrf2, HO1, NQO1 and GCLM.

    查看 NF-κB 亞型特異性產(chǎn)品:

    查看 STAT 亞型特異性產(chǎn)品:

    查看 Bcl-2 Family 亞型特異性產(chǎn)品:

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities[1][2].

    細(xì)胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    CCRF-CEM IC50
    ≤ 10 μM
    Compound: 64
    Cytotoxicity in human CCRF-CEM cells by resazurin reduction assay
    Cytotoxicity in human CCRF-CEM cells by resazurin reduction assay
    		[PMID: 28793973]
    DLD-1 IC50
    41.8 μM
    Compound: 6
    Cytotoxicity against human DLD1 cells co-transfected with Sac1 after 24 hrs
    Cytotoxicity against human DLD1 cells co-transfected with Sac1 after 24 hrs
    		[PMID: 19682913]
    L929 IC50
    2 nM
    Compound: PAP-1
    Inhibition of human voltage-gated potassium channel Kv1.3 expressed in L929 cells by whole-cell patch clamp assay
    Inhibition of human voltage-gated potassium channel Kv1.3 expressed in L929 cells by whole-cell patch clamp assay
    		[PMID: 20971642]
    RAW264.7 IC50
    11.48 μM
    Compound: 8a
    Anti-inflammatory activity in Mus musculus (mouse) RAW264.7 cells assessed as inhibition of IFN-gamma/LPS-induced NO production after 17 to 20 hr by Griess assay
    Anti-inflammatory activity in Mus musculus (mouse) RAW264.7 cells assessed as inhibition of IFN-gamma/LPS-induced NO production after 17 to 20 hr by Griess assay
    		10.1007/s00044-011-9706-1
    RAW264.7 IC50
    2.2 μM
    Compound: Cardamonin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins followed by LPS stimulation for 12 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins followed by LPS stimulation for 12 hrs by Griess assay
    		[PMID: 28688956]
    RAW264.7 IC50
    2.2 μM
    Compound: Cardamonin
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells pretreated for 30 mins followed by LPS challenge measured after 12 hrs by Griess assay
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells pretreated for 30 mins followed by LPS challenge measured after 12 hrs by Griess assay
    		[PMID: 28011215]
    體外研究
    (In Vitro)

    Cardamonin (5-40 μM, 24 or 48 h) treatment inhibits gastric cancer cell growth[3].
    Cardamonin (10-30 μM, 24 or 48 h) treatment can regulate the expression of apoptosis relative protein[3].
    Cardamonin (10-30 μM, 24 or 48 h) treatment can inhibit STAT3 phosphorylation[3].
    Cardamonin (0-100 μM, 24 h) treatment improves the anti-oxidative capacity in HL-1 cells[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[3]

    Cell Line: AGS, MGC-803, BGC-823 cells
    Concentration: 5, 10, 20, 30, 40 μM
    Incubation Time: 24 or 48 hours
    Result: Inhibited cell growth in a concentration-dependent manner.

    Western Blot Analysis[3]

    Cell Line: AGS, MGC-803, BGC-823 cells
    Concentration: 10, 20, 30 μM
    Incubation Time: 24 or 48 hours
    Result: Down-regulated Bcl-2, increased Bax protein expression, and increased the protein expression levels of Caspase-3.

    Western Blot Analysis[3]

    Cell Line: AGS cells
    Concentration: 10, 20, 30 μM
    Incubation Time: 24 or 48 hours
    Result: Suppressed the phosphorylation level of STAT3.

    Western Blot Analysis[4]

    Cell Line: HL-1 cells
    Concentration: 0, 25, 50, 100 μM
    Incubation Time: 24 hours
    Result: Showed anti-oxidant effects in doxorubicin-stimulated cardiomyocytes.
    體內(nèi)研究
    (In Vivo)

    Cardamonin (oral gavage; 20, 40 or 80 mg/kg; once) treatments alleviates doxorubicin-induced cardiotoxicity and inhibits apoptosis in doxorubicin-challenged mice[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male C57BL/6 J mice (8 weeks old, 20-22 g)[4]
    Dosage: 20, 40 or 80 mg/kg
    Administration: Oral gavage; 20, 40 or 80 mg/kg; once
    Result: Rescued the reduction of LVEF% and LVFS% by doxorubicin, reduced the increasement of serum LDH, CK-MB and Tn-T levels by doxorubicin in a dose-dependent manner, improved doxorubicin-induced histological changes, and attenuated collagen accumulation in cardiac sections by doxorubicin in a dose-dependent manner.
    Animal Model: Male C57BL/6 J mice (8 weeks old, 20-22 g)[4]
    Dosage: 20, 40 or 80 mg/kg
    Administration: Oral gavage; 20, 40 or 80 mg/kg; once
    Result: Rescued Bcl-2, and inhibited Bax and Caspase-3 cleavage in heart tissues from doxorubicin-challenged mice.
    分子量

    270.28

    Formula

    C16H14O4
    CAS 號(hào)
    性狀

    固體

    顏色

    Light yellow to yellow

    中文名稱(chēng)

    豆蔻明；豆蔻素；豆寇明
    結(jié)構(gòu)分類(lèi)
    初始來(lái)源
    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲(chǔ)存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    溶解性數(shù)據(jù)
    細(xì)胞實(shí)驗(yàn)： 

    DMSO 中的溶解度 : 125 mg/mL (462.48 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

    配制儲(chǔ)備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 3.6999 mL 18.4993 mL 36.9987 mL
    5 mM 0.7400 mL 3.6999 mL 7.3997 mL
    查看完整儲(chǔ)備液配制表

    * 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用。

    • 摩爾計(jì)算器

    • 稀釋計(jì)算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動(dòng)物實(shí)驗(yàn)：

    請(qǐng)根據(jù)您的 實(shí)驗(yàn)動(dòng)物和給藥方式 選擇適當(dāng)?shù)娜芙夥桨浮?

    以下溶解方案都請(qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：
    ——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
    以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的方式助溶

    • 方案 一

      請(qǐng)依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.17 mg/mL (8.03 mM); 澄清溶液

      此方案可獲得 ≥ 2.17 mg/mL（飽和度未知）的澄清溶液。

      以 1 mL 工作液為例，取 100 μL 21.7 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水 定容至 1 mL。

      生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
    動(dòng)物溶解方案計(jì)算器
    請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

    給藥劑量

    mg/kg

    動(dòng)物的平均體重

    g

    每只動(dòng)物的給藥體積

    μL

    動(dòng)物數(shù)量

    只
    由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
    請(qǐng)輸入您的動(dòng)物體內(nèi)配方組成：
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    如果您的動(dòng)物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過(guò) 2%。
    方案所需 助溶劑 包括：DMSO， ，均可在 MCE 網(wǎng)站選購(gòu)。 ，Tween 80，均可在 MCE 網(wǎng)站選購(gòu)。
    計(jì)算結(jié)果
    工作液所需濃度 : mg/mL
    儲(chǔ)備液配制方法 : mg 藥物溶于 μL  DMSO（母液濃度為 mg/mL）。
    您所需的儲(chǔ)備液濃度超過(guò)該產(chǎn)品的實(shí)測(cè)溶解度，以下方案僅供參考，如有需要，請(qǐng)與 MCE 中國(guó)技術(shù)支持聯(lián)系。
    動(dòng)物實(shí)驗(yàn)體內(nèi)工作液的配制方法 : 取 μL DMSO 儲(chǔ)備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。
    連續(xù)給藥周期超過(guò)半月以上，請(qǐng)謹(jǐn)慎選擇該方案。
    請(qǐng)確保第一步儲(chǔ)備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱 （超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。
    純度 & 產(chǎn)品資料

    純度: 98.38%

    參考文獻(xiàn)

    完整儲(chǔ)備液配制表

    * 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.6999 mL 18.4993 mL 36.9987 mL 92.4967 mL
    5 mM 0.7400 mL 3.6999 mL 7.3997 mL 18.4993 mL
    10 mM 0.3700 mL 1.8499 mL 3.6999 mL 9.2497 mL
    15 mM 0.2467 mL 1.2333 mL 2.4666 mL 6.1664 mL
    20 mM 0.1850 mL 0.9250 mL 1.8499 mL 4.6248 mL
    25 mM 0.1480 mL 0.7400 mL 1.4799 mL 3.6999 mL
    30 mM 0.1233 mL 0.6166 mL 1.2333 mL 3.0832 mL
    40 mM 0.0925 mL 0.4625 mL 0.9250 mL 2.3124 mL
    50 mM 0.0740 mL 0.3700 mL 0.7400 mL 1.8499 mL
    60 mM 0.0617 mL 0.3083 mL 0.6166 mL 1.5416 mL
    80 mM 0.0462 mL 0.2312 mL 0.4625 mL 1.1562 mL
    100 mM 0.0370 mL 0.1850 mL 0.3700 mL 0.9250 mL
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    產(chǎn)品名稱(chēng)：
    Cardamonin
    目錄號(hào)：
    HY-N0279
    需求量：