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  3. 疾病研究領域 動物 其他類
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  5. Cantharidin

Cantharidin  (Synonyms: 斑蝥素; 班蝥酸酐; 斑蝥酸酐)

目錄號: HY-N0209 純度: 99.54%
COA 產(chǎn)品使用指南

斑蝥素 (Cantharidin) 是從芫菁科和擬天?？浦蟹蛛x到的天然毒素，對害蟲具有毒害作用。

MCE 的所有產(chǎn)品僅用作科學研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務

Cantharidin Chemical Structure

Cantharidin Chemical Structure

CAS No. : 56-25-7

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規(guī)格 價格 是否有貨 數(shù)量
25 mg ￥500
In-stock
50 mg ￥800
In-stock
100 mg ￥1050
In-stock
500 mg ￥4200
詢價
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5 g   詢價  

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Customer Review

    Cantharidin purchased from MCE. Usage Cited in: Oncol Lett. 2018 May;15(5):6527-6532.  [Abstract]

    Cantharidin (CTD) enhances A549 cells autophagy. Western blotting of autophagy associated proteins LC3 I , LC3 II, Beclin 1 and p62 are analyzed.

    Cantharidin purchased from MCE. Usage Cited in: Biochem Pharmacol. 2017 Aug 15;138:49-60.  [Abstract]

    Blockade of AMPK signals by AMPK α2 siRNA or AMPK inhibitor (Dorsomorphin; 2.5 μM, pretreatment 2 hours) treatment counteracts the apoptotic effects of Cantharidin at 2.5 μM. Data are representative of at least two independent experiments. Blocking AMPK signaling by knockdown of AMPK or Dorsomorphin (AMPK kinase inhibitor) treatment markedly reverses the apoptotic effect of Cantharidin, indicating that AMPK activation is required for the anti-HCC activity of Cantharidin.

    Cantharidin purchased from MCE. Usage Cited in: Biochem Pharmacol. 2017 Aug 15;138:49-60.  [Abstract]

    Dose-dependent effects of Cantharidin on AMPK-related signaling in three HCC cell lines. The phosphorylation of AMPK is markedly upregulated, and so is its downstream effector phospho-ULK1, whereas PP5 expression is not affected after Cantharidin treatment.

    Cantharidin purchased from MCE. Usage Cited in: Lung Cancer. 2017 Oct;112:81-89.  [Abstract]

    Dose-and time-dependent effects of Cantharidin on p-AMPK, PARP, and Caspase 9. Cells are treated with Cantharidin at indicated concentrations for 24 hours or 2.5 μM Cantharidin for different time durations. The protein levels are analyzed with indicated antibodies.

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻

    生物活性

    Cantharidin, a natural toxin isolated from beetles in the families Meloidae and Oedemeridae, has been reported to be toxic to some pests, including the diamondback moth[1].

    細胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    143B GI50
    10 μM
    Compound: cantharidin
    Inhibition of growth after 72 hr continuous exposure to test compounds in Osteosarcoma 143B tumor cell lines
    Inhibition of growth after 72 hr continuous exposure to test compounds in Osteosarcoma 143B tumor cell lines
    		[PMID: 11881984]
    143B IC50
    10 μM
    Compound: 1
    Inhibitory activity against tumor osteosarcoma cell line 143B after 72 hr continuous exposure to compound
    Inhibitory activity against tumor osteosarcoma cell line 143B after 72 hr continuous exposure to compound
    		[PMID: 10937725]
    A2780 GI50
    10 μM
    Compound: cantharidin
    Inhibition of growth after 72 hr continuous exposure to test compounds in Ovarian A2780 tumor cell lines
    Inhibition of growth after 72 hr continuous exposure to test compounds in Ovarian A2780 tumor cell lines
    		[PMID: 11881984]
    A2780 IC50
    10 μM
    Compound: 1
    Inhibitory activity against ovarian tumor cell line A2780 after 72 hr continuous exposure to compound
    Inhibitory activity against ovarian tumor cell line A2780 after 72 hr continuous exposure to compound
    		[PMID: 10937725]
    A2780 GI50
    4.4 μM
    Compound: 1
    Cytotoxicity against human A2780 cells after 72 hrs by MTT assay
    Cytotoxicity against human A2780 cells after 72 hrs by MTT assay
    		[PMID: 20153915]
    A2780 GI50
    4.4 μM
    Compound: 1
    Cytotoxicity against human A2780 cells after 72 hrs by MTT assay
    Cytotoxicity against human A2780 cells after 72 hrs by MTT assay
    		[PMID: 17606377]
    A-431 GI50
    2.9 μM
    Compound: 1
    Cytotoxicity against human A431 cells after 72 hrs by MTT assay
    Cytotoxicity against human A431 cells after 72 hrs by MTT assay
    		[PMID: 20153915]
    A-431 GI50
    2.9 μM
    Compound: 1
    Cytotoxicity against human A431 cells after 72 hrs by MTT assay
    Cytotoxicity against human A431 cells after 72 hrs by MTT assay
    		[PMID: 17606377]
    ADDP cell line GI50
    11 μM
    Compound: cantharidin
    Inhibition of growth after 72 hr continuous exposure to test compounds in Ovarian ADDP tumor cell lines
    Inhibition of growth after 72 hr continuous exposure to test compounds in Ovarian ADDP tumor cell lines
    		[PMID: 11881984]
    ADDP cell line IC50
    11 μM
    Compound: 1
    Inhibitory activity against ovarian tumor cell line ADDP after 72 hr continuous exposure to compound
    Inhibitory activity against ovarian tumor cell line ADDP after 72 hr continuous exposure to compound
    		[PMID: 10937725]
    BE(2)-C GI50
    3.7 μM
    Compound: 1
    Cytotoxicity against human BE(2)-C cells after 72 hrs by MTT assay
    Cytotoxicity against human BE(2)-C cells after 72 hrs by MTT assay
    		[PMID: 20153915]
    BE(2)-C GI50
    3.7 μM
    Compound: 1
    Cytotoxicity against human BE2C cells after 72 hrs by MTT assay
    Cytotoxicity against human BE2C cells after 72 hrs by MTT assay
    		[PMID: 17606377]
    Bone marrow cell IC50
    6.5 μg/mL
    Compound: 1; CTD
    Cytotoxicity against human Bone marrow cell assessed as cell growth inhibition by MTS assay
    Cytotoxicity against human Bone marrow cell assessed as cell growth inhibition by MTS assay
    		[PMID: 33454654]
    DU-145 GI50
    2.1 μM
    Compound: 1
    Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
    Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
    		[PMID: 20153915]
    DU-145 GI50
    2.1 μM
    Compound: 1
    Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
    Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
    		[PMID: 17606377]
    HCT-116 IC50
    9 μM
    Compound: 1; CTD
    Anticancer activity against human HCT-116 cells assessed as cell growth inhibition by MTT assay
    Anticancer activity against human HCT-116 cells assessed as cell growth inhibition by MTT assay
    		[PMID: 33454654]
    HCT-116 IC50
    9 μM
    Compound: 1
    Inhibitory activity against colon tumor cell line HCT116 after 72 hr continuous exposure to compound
    Inhibitory activity against colon tumor cell line HCT116 after 72 hr continuous exposure to compound
    		[PMID: 10937725]
    Hepatocyte IC50
    21 μM
    Compound: 1
    Cytotoxicity against rat hepatocyte cells after 48 hrs by MTT assay
    Cytotoxicity against rat hepatocyte cells after 48 hrs by MTT assay
    		[PMID: 20691337]
    HepG2 IC50
    11 μM
    Compound: 1
    Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 20691337]
    HepG2 IC50
    19.1 μM
    Compound: 1; CTD
    Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
    Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
    		[PMID: 33454654]
    HL-60 IC50
    2.7 μM
    Compound: 1; CTD
    Anticancer activity against human HL-60 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
    Anticancer activity against human HL-60 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
    		[PMID: 33454654]
    HT-29 GI50
    3.2 μM
    Compound: 1
    Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
    Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
    		[PMID: 20153915]
    HT-29 GI50
    3.2 μM
    Compound: 1
    Cytotoxicity against human HT29 cells after 72 hrs by MTT assay
    Cytotoxicity against human HT29 cells after 72 hrs by MTT assay
    		[PMID: 17606377]
    HT-29 IC50
    6.4 μM
    Compound: 1; CTD
    Anticancer activity against human HT-29 cells assessed as cell growth inhibition by MTT assay
    Anticancer activity against human HT-29 cells assessed as cell growth inhibition by MTT assay
    		[PMID: 33454654]
    HT-29 GI50
    6.4 μM
    Compound: cantharidin
    Inhibition of growth after 72 hr continuous exposure to test compounds in colon HT-29 tumor cell lines
    Inhibition of growth after 72 hr continuous exposure to test compounds in colon HT-29 tumor cell lines
    		[PMID: 11881984]
    HT-29 IC50
    6.4 μM
    Compound: 1
    Inhibitory activity against colon tumor cell line HT-29 after 72 hr continuous exposure to compound
    Inhibitory activity against colon tumor cell line HT-29 after 72 hr continuous exposure to compound
    		[PMID: 10937725]
    KB 3-1 IC50
    2.7 μM
    Compound: 1; CTD
    Anticancer activity against human KB 3-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
    Anticancer activity against human KB 3-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
    		[PMID: 33454654]
    MCF7 GI50
    7.5 μM
    Compound: 1
    Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 20153915]
    MCF7 GI50
    7.5 μM
    Compound: 1
    Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 17606377]
    NCI-H460 GI50
    3.3 μM
    Compound: 1
    Cytotoxicity against human H460 cells after 72 hrs by MTT assay
    Cytotoxicity against human H460 cells after 72 hrs by MTT assay
    		[PMID: 20153915]
    NCI-H460 GI50
    3.3 μM
    Compound: 1
    Cytotoxicity against human H460 cells after 72 hrs by MTT assay
    Cytotoxicity against human H460 cells after 72 hrs by MTT assay
    		[PMID: 17606377]
    SK-HEP1 IC50
    34 μM
    Compound: 1
    Cytotoxicity against human SKHEP1 cells after 48 hrs by MTT assay
    Cytotoxicity against human SKHEP1 cells after 48 hrs by MTT assay
    		[PMID: 20691337]
    SW480 GI50
    4.5 μM
    Compound: 1
    Cytotoxicity against human SW480 cells after 72 hrs by MTT assay
    Cytotoxicity against human SW480 cells after 72 hrs by MTT assay
    		[PMID: 20153915]
    SW480 GI50
    4.5 μM
    Compound: 1
    Cytotoxicity against human SW480 cells after 72 hrs by MTT assay
    Cytotoxicity against human SW480 cells after 72 hrs by MTT assay
    		[PMID: 17606377]
    體外研究
    (In Vitro)

    Cantharidin 處理人紅細胞 48 小時可顯著增加膜聯(lián)蛋白-V 結合細胞的百分比 (≥10 μg/mL)，顯著降低前向散射 (≥25 μg/mL)，顯著增加[Ca2+]i (≥25 μg /mL)，但并未顯著改變神經(jīng)酰胺豐度或 ROS[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    196.20

    Formula

    C10H12O4
    CAS 號
    性狀

    固體

    顏色

    White to off-white

    中文名稱

    斑蝥素；班蝥酸酐；斑蝥酸酐
    結構分類
    初始來源

    Cantharides
    運輸條件

    Room temperature in continental US; may vary elsewhere.
    儲存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性數(shù)據(jù)
    細胞實驗： 

    DMSO 中的溶解度 : 20 mg/mL (101.94 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

    配制儲備液
    濃度 溶劑體積 質量 1 mg 5 mg 10 mg
    1 mM 5.0968 mL 25.4842 mL 50.9684 mL
    5 mM 1.0194 mL 5.0968 mL 10.1937 mL
    查看完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

    • 摩爾計算器

    • 稀釋計算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動物實驗：

    請根據(jù)您的 實驗動物和給藥方式 選擇適當?shù)娜芙夥桨浮?

    以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
    ——為保證實驗結果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的工作液，建議您現(xiàn)用現(xiàn)配，當天使用；
    以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

    • 方案 一

      請依序添加每種溶劑： 10% DMSO    90% Corn Oil

      Solubility: ≥ 2 mg/mL (10.19 mM); 澄清溶液

      此方案可獲得 ≥ 2 mg/mL（飽和度未知）的澄清溶液，此方案實驗周期在半個月以上的動物實驗酌情使用。

      以 1 mL 工作液為例，取 100 μL 20.0 mg/mL 的澄清 DMSO 儲備液加到 900 μL玉米油中，混合均勻。

    動物溶解方案計算器
    請輸入動物實驗的基本信息：

    給藥劑量

    mg/kg

    動物的平均體重

    g

    每只動物的給藥體積

    μL

    動物數(shù)量

    只
    由于實驗過程有損耗，建議您多配一只動物的量
    請輸入您的動物體內(nèi)配方組成：
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    如果您的動物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過 2%。
    方案所需 助溶劑 包括：DMSO， ，均可在 MCE 網(wǎng)站選購。 ，Tween 80，均可在 MCE 網(wǎng)站選購。
    計算結果
    工作液所需濃度 : mg/mL
    儲備液配制方法 : mg 藥物溶于 μL  DMSO（母液濃度為 mg/mL）。
    您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，以下方案僅供參考，如有需要，請與 MCE 中國技術支持聯(lián)系。
    動物實驗體內(nèi)工作液的配制方法 : 取 μL DMSO 儲備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。
    連續(xù)給藥周期超過半月以上，請謹慎選擇該方案。
    請確保第一步儲備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱 （超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。
    純度 & 產(chǎn)品資料

    純度: 99.54%

    參考文獻

    完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 5.0968 mL 25.4842 mL 50.9684 mL 127.4210 mL
    5 mM 1.0194 mL 5.0968 mL 10.1937 mL 25.4842 mL
    10 mM 0.5097 mL 2.5484 mL 5.0968 mL 12.7421 mL
    15 mM 0.3398 mL 1.6989 mL 3.3979 mL 8.4947 mL
    20 mM 0.2548 mL 1.2742 mL 2.5484 mL 6.3711 mL
    25 mM 0.2039 mL 1.0194 mL 2.0387 mL 5.0968 mL
    30 mM 0.1699 mL 0.8495 mL 1.6989 mL 4.2474 mL
    40 mM 0.1274 mL 0.6371 mL 1.2742 mL 3.1855 mL
    50 mM 0.1019 mL 0.5097 mL 1.0194 mL 2.5484 mL
    60 mM 0.0849 mL 0.4247 mL 0.8495 mL 2.1237 mL
    80 mM 0.0637 mL 0.3186 mL 0.6371 mL 1.5928 mL
    100 mM 0.0510 mL 0.2548 mL 0.5097 mL 1.2742 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    產(chǎn)品名稱：
    Cantharidin
    目錄號：
    HY-N0209
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