Arbutin (Synonyms: 熊果苷; β-Arbutin)

目錄號(hào): HY-N0192 純度: 99.76%: FAQs
Data Sheet SDS COA 產(chǎn)品使用指南技術(shù)支持

Arbutin (β-Arbutin) 是一種廣泛存在的天然多酚，具有抗氧化，抗炎和抗腫瘤特性。是黑色素細(xì)胞中酪氨酸酶 (tyrosinase) 的競(jìng)爭(zhēng)性抑制劑，對(duì)單酚酶的 K_i^app 值為 1.42 mM；對(duì)二酚酶 K_i^app 的值為 0.9 mM。Arbutin 也用作脫色劑。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Arbutin Chemical Structure

CAS No. : 497-76-7

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規(guī)格	價(jià)格	是否有貨
10 mM * 1 mL in DMSO	￥500	In-stock
500 mg	￥400	In-stock
5 g	￥550	In-stock
10 g	￥910	In-stock
50 g		詢價(jià)

or 大包裝詢價(jià)

* Please select Quantity before adding items.

Customer Review

Other Forms of Arbutin:

Arbutin (Standard) In-stock
Arbutin-d₄ 詢價(jià)

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)

•FEBS Open Bio. 2021 Jan;11(1):289-299. [Abstract]

Arbutin 相關(guān)產(chǎn)品

•相關(guān)化合物庫(kù):

•同靶點(diǎn)產(chǎn)品:

•同靶點(diǎn)蛋白產(chǎn)品:

生物活性
純度 & 產(chǎn)品資料
參考文獻(xiàn)

生物活性

Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase, with K_i^app values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents^[1]. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties^[2]^[3].

IC₅₀ & Target

Human Endogenous Metabolite

細(xì)胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
B16	IC₅₀	116 μM Compound: Arbutin	Inhibition of melanogenesis in theophylline-stimulated mouse B16-4A5 cells after 72 hrs Inhibition of melanogenesis in theophylline-stimulated mouse B16-4A5 cells after 72 hrs	[PMID: 19615910]
B16	IC₅₀	120 μM Compound: Arbutin	Inhibition of alpha-MSH -stimulated melanogenesis in mouse B16 cells assessed as melanin release after 3 days Inhibition of alpha-MSH -stimulated melanogenesis in mouse B16 cells assessed as melanin release after 3 days	[PMID: 21388810]
B16	IC₅₀	140 μM Compound: Arbutin	Inhibition of melanin production in alpha-MSH stimulated mouse B16 cells after 72 hrs by spectrophotometry Inhibition of melanin production in alpha-MSH stimulated mouse B16 cells after 72 hrs by spectrophotometry	[PMID: 23623417]
B16	IC₅₀	1550 μM Compound: 2	Inhibition of tyrosinase activity in alpha-MSH-stimulated mouse B16 cells using L-tyrosine as substrate Inhibition of tyrosinase activity in alpha-MSH-stimulated mouse B16 cells using L-tyrosine as substrate	[PMID: 21429753]
B16	IC₅₀	180 μM Compound: Arbutin	Antimelanogenic activity at alpha-MSH-stimulated mouse melanoma B16 cells after 3 days by spectrophotometry Antimelanogenic activity at alpha-MSH-stimulated mouse melanoma B16 cells after 3 days by spectrophotometry	[PMID: 22217872]
B16	IC₅₀	180 μM Compound: Arbutin	Inhibition of alpha-MSH-induced melanin production in mouse B16 cells after 3 days Inhibition of alpha-MSH-induced melanin production in mouse B16 cells after 3 days	[PMID: 21601449]
B16	IC₅₀	180 μM Compound: arbutin	Inhibition of alpha-MSH-induced melanin production in mouse B16 cells after 72 hrs Inhibition of alpha-MSH-induced melanin production in mouse B16 cells after 72 hrs	[PMID: 20097083]
B16	IC₅₀	180 μM Compound: Arbutin	Inhibition of alpha-MSH-induced melanin production in mouse B16 cells after 72 hrs Inhibition of alpha-MSH-induced melanin production in mouse B16 cells after 72 hrs	[PMID: 20044259]
B16	IC₅₀	247 μM Compound: Arbutin	Inhibition of melanin production in alpha-MSH-stimulated mouse B16 cells incubated for 24 hrs followed by alpha-MSH stimulation for 72 hrs in presence of compound Inhibition of melanin production in alpha-MSH-stimulated mouse B16 cells incubated for 24 hrs followed by alpha-MSH stimulation for 72 hrs in presence of compound	[PMID: 29526485]
B16	IC₅₀	64 μM Compound: Arbutin	Inhibition of alpha-MSH-stimulated melanogenesis in mouse B16 cells assessed as reduction in melanin production incubated for 3 days Inhibition of alpha-MSH-stimulated melanogenesis in mouse B16 cells assessed as reduction in melanin production incubated for 3 days	[PMID: 31387790]
B16	IC₅₀	67.9 μg/mL Compound: Arbutin	Inhibition of alpha-MSH-stimulated melanogenesis in mouse B16 cells assessed as melanin release after 72 hrs Inhibition of alpha-MSH-stimulated melanogenesis in mouse B16 cells assessed as melanin release after 72 hrs	[PMID: 22450129]
B16	IC₅₀	99 μM Compound: 2	Inhibition of alpha-MSH-induced melanin synthesis in mouse B16 cells grown in a 5% CO2-95% air atmosphere after 3 days Inhibition of alpha-MSH-induced melanin synthesis in mouse B16 cells grown in a 5% CO2-95% air atmosphere after 3 days	[PMID: 21429753]
B16-4A5	IC₅₀	> 1000 μM Compound: Arbutin	Inhibition of theophylline-stimulated mouse B16-4A5 cell proliferation assessed as cell viability after 68 hrs by WST8 assay Inhibition of theophylline-stimulated mouse B16-4A5 cell proliferation assessed as cell viability after 68 hrs by WST8 assay	[PMID: 19615910]
B16-4A5	IC₅₀	174 μM Compound: Arutin	Inhibition of melanogenesis in mouse B16-4A5 cells after 72 hrs by spectrophotometry Inhibition of melanogenesis in mouse B16-4A5 cells after 72 hrs by spectrophotometry	[PMID: 23270663]
B16-4A5	IC₅₀	174 μM Compound: arbutin	Inhibition of melanogenesis in theophylline-stimulated mouse B16-4A5 cells after 72 hrs by microplate reader analysis Inhibition of melanogenesis in theophylline-stimulated mouse B16-4A5 cells after 72 hrs by microplate reader analysis	[PMID: 25987378]
B16-4A5	IC₅₀	174 μM Compound: Arbutin	Inhibition of melanogenesis in mouse B16-4A5 cells after 72 hrs by spectrophotometry relative to control Inhibition of melanogenesis in mouse B16-4A5 cells after 72 hrs by spectrophotometry relative to control	[PMID: 24601675]
B16-4A5	IC₅₀	174 μM Compound: Arbutin	Inhibition of theophylline-induced melanogenesis in mouse B16-4A5 cells after 72 hrs by spectrophotometric analysis relative to control Inhibition of theophylline-induced melanogenesis in mouse B16-4A5 cells after 72 hrs by spectrophotometric analysis relative to control	[PMID: 23376010]
B16-4A5	IC₅₀	174 μM Compound: Arbutin	Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells after 72 hrs Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells after 72 hrs	[PMID: 20189399]
B16-F1	IC₅₀	122 μM Compound: Arbutin	Inhibition of melanin production in C57BL/6J mouse B16-F1 cells incubated for 5 days Inhibition of melanin production in C57BL/6J mouse B16-F1 cells incubated for 5 days	[PMID: 27720556]
B16-F1	IC₅₀	148.3 μM Compound: Arbutin	Antimelanogenic activity in mouse B16-F1 cells assessed as reduction in alpha-MSH-stimulated melanin production preincubated for 72 hrs followed by alpha-MSH-stimulation and measured after 2 hrs Antimelanogenic activity in mouse B16-F1 cells assessed as reduction in alpha-MSH-stimulated melanin production preincubated for 72 hrs followed by alpha-MSH-stimulation and measured after 2 hrs	[PMID: 30446440]
B16-F10	IC₅₀	391.2 μM Compound: Arbutin	Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 72 hrs by XTT assay Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 72 hrs by XTT assay	[PMID: 27720556]
Melan-a	IC₅₀	98.05 μM Compound: Arbutin	Inhibition of melanin formation in mouse Melan-a cells after 5 days by ELISA Inhibition of melanin formation in mouse Melan-a cells after 5 days by ELISA	[PMID: 20022495]

體外研究
(In Vitro)

Arbutin (0.3-5.4 mM；24 小時(shí)、48 小時(shí)、72 小時(shí)；B16 小鼠黑色素瘤細(xì)胞) 以時(shí)間和劑量依賴性方式抑制 B16 小鼠黑色素瘤細(xì)胞的活力^[2]。
Arbutin (1.4-5.4 mM；24 小時(shí)) 以 5.4 mM的劑量增加處理的 B16 鼠黑色素瘤細(xì)胞的凋亡率^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	B16 murine melanoma cells
Concentration:	0.3 mM, 0.7 mM, 1.4 mM, 2.1 mM, 2.9 mM, 3.6 mM, 5.4 mM
Incubation Time:	24 hours, 48 hours or 72 hours
Result:	Inhibited the viability of B16 murine melanoma cells in a time- and dose-dependent manner.

Apoptosis Analysis^[2]

Cell Line:	B16 murine melanoma cells
Concentration:	1.4 mM, 2.9 mM, 5.4 mM
Incubation Time:	24 hours
Result:	Caused apoptosis in 19.3% of the cells.

體內(nèi)研究
(In Vivo)

Arbutin (50 mg/kg、100 mg/kg；口服；每天；17 天；雄性 C57BL/6 小鼠) 預(yù)處理對(duì) ISO 誘導(dǎo)的小鼠心臟肥大具有顯著的保護(hù)作用^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6 mice ( 20-25 g)^[3]
Dosage:	50 mg/kg, 100 mg/kg
Administration:	Oral administration; every day; for 17 days
Result:	Ameliorated the ISO-induced myocardial injury.

分子量

272.25

Formula

C₁₂H₁₆O₇

CAS 號(hào)

497-76-7

性狀

固體

顏色

White to off-white

中文名稱

熊果苷；熊果酚甙；熊果素；熊果葉甙；楊梅葉甘

結(jié)構(gòu)分類

Phenols

初始來(lái)源

微生物

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

溶解性數(shù)據(jù)

細(xì)胞實(shí)驗(yàn)：

DMSO 中的溶解度 : ≥ 50 mg/mL (183.65 mM; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

H₂O 中的溶解度 : 33.33 mg/mL (122.42 mM; 超聲助溶)

* "≥" means soluble, but saturation unknown.

配制儲(chǔ)備液

濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg

1 mM	3.6731 mL	18.3655 mL	36.7309 mL
5 mM	0.7346 mL	3.6731 mL	7.3462 mL
10 mM	0.3673 mL	1.8365 mL	3.6731 mL

查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用。

* 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

摩爾計(jì)算器
稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

濃度 _(start)

體積 _(start)

濃度 _(final)

體積 _(final)

動(dòng)物實(shí)驗(yàn)：

請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥方式選擇適當(dāng)?shù)娜芙夥桨浮?

以下溶解方案都請(qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：
——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的方式助溶

方案一

請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.18 mM); 澄清溶液

此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。
以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水定容至 1 mL。
生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
方案二

請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.18 mM); 澄清溶液

此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。
以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液中，混合均勻。
2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。
方案三

請(qǐng)依序添加每種溶劑： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (9.18 mM); 澄清溶液

此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液，此方案實(shí)驗(yàn)周期在半個(gè)月以上的動(dòng)物實(shí)驗(yàn)酌情使用。
以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 900 μL玉米油中，混合均勻。

以下溶解方案，請(qǐng)直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的方式助溶。

方案一

請(qǐng)依序添加每種溶劑： PBS
Solubility: 100 mg/mL (367.31 mM); 澄清溶液; 超聲助溶

動(dòng)物溶解方案計(jì)算器

請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只

由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量

計(jì)算結(jié)果

工作液所需濃度 : mg/mL

該產(chǎn)品水溶性佳，請(qǐng)具體參考實(shí)測(cè) 水 / PBS / Saline 中的溶解度數(shù)據(jù)。

您所需的儲(chǔ)備液濃度超過(guò)該產(chǎn)品的實(shí)測(cè)溶解度，如有需要，請(qǐng)與 MCE 中國(guó)技術(shù)支持聯(lián)系。

純度 & 產(chǎn)品資料

純度: 99.76%

選擇批次：

Data Sheet (638 KB) SDS (394 KB)

COA (192 KB) HNMR (140 KB) RP-HPLC (205 KB) MS (71 KB)

產(chǎn)品使用指南 (1538 KB)

參考文獻(xiàn)

[1]. Garcia-Jimenez A, et al. Action of tyrosinase on alpha and beta-arbutin: A kinetic study. PLoS One. 2017 May 11;12(5):e0177330. [Content Brief]

[2]. Jiang L, et al. Investigation of the pro-apoptotic effects of arbutin and its acetylated derivative on murinemelanoma cells. Int J Mol Med. 2018 Feb;41(2):1048-1054. [Content Brief]

[3]. Nalban N, et al. Arbutin Attenuates Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting TLR-4/NF-κB Pathway in Mice. Cardiovasc Toxicol. 2019 Sep 4. [Content Brief]

Arbutin 相關(guān)分類

完整儲(chǔ)備液配制表

可選溶劑	濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	3.6731 mL	18.3655 mL	36.7309 mL	91.8274 mL
	5 mM	0.7346 mL	3.6731 mL	7.3462 mL	18.3655 mL
	10 mM	0.3673 mL	1.8365 mL	3.6731 mL	9.1827 mL
	15 mM	0.2449 mL	1.2244 mL	2.4487 mL	6.1218 mL
	20 mM	0.1837 mL	0.9183 mL	1.8365 mL	4.5914 mL
	25 mM	0.1469 mL	0.7346 mL	1.4692 mL	3.6731 mL
	30 mM	0.1224 mL	0.6122 mL	1.2244 mL	3.0609 mL
	40 mM	0.0918 mL	0.4591 mL	0.9183 mL	2.2957 mL
	50 mM	0.0735 mL	0.3673 mL	0.7346 mL	1.8365 mL
	60 mM	0.0612 mL	0.3061 mL	0.6122 mL	1.5305 mL
	80 mM	0.0459 mL	0.2296 mL	0.4591 mL	1.1478 mL
	100 mM	0.0367 mL	0.1837 mL	0.3673 mL	0.9183 mL

* 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Arbutin497-76-7β-Arbutin熊果苷熊果酚甙熊果素熊果葉甙楊梅葉甘TyrosinaseEndogenous MetaboliteInhibitorinhibitorinhibit

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Arbutin (Synonyms: 熊果苷; β-Arbutin)

Customer Review

Other Forms of Arbutin:

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)