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  2. Anti-infection
  3. Virus Protease
  4. Glycyrrhizic acid

Glycyrrhizic acid  (Synonyms: 甘草酸; Glycyrrhizin)

目錄號: HY-N0184 純度: 99.84%
COA 產(chǎn)品使用指南

Glycyrrhizic acid 是甘草里面的活性成分三萜皂苷，為 HMGB1 的拮抗劑，有用于腫瘤、糖尿病等研究的潛力。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Glycyrrhizic acid Chemical Structure

Glycyrrhizic acid Chemical Structure

CAS No. : 1405-86-3

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥550
In-stock
50 mg ￥500
In-stock
100 mg ￥700
In-stock
500 mg ￥2100
In-stock
1 g   詢價(jià)  
5 g   詢價(jià)  

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Customer Review

Other Forms of Glycyrrhizic acid:

    Glycyrrhizic acid purchased from MCE. Usage Cited in: Cell Prolif. 2020 Jun;53(6):e12829.  [Abstract]

    Protein levels of pro-caspase-1 + p10 + p12, GADMD, IL-1β, IL-18 and NLRP3 are detected by Western blotting. Glycyrrhizin inhibits pyroptosis in TNF-α-induced M1 macrophages.

    • 生物活性

    • 實(shí)驗(yàn)參考方法

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Glycyrrhizic acid is a triterpenoid saponinl, acting as a direct HMGB1 antagonist, with anti-tumor, anti-diabetic activities.

    細(xì)胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    ECV-304 IC50
    > 119 μM
    Compound: Glycyrrhizinic acid
    Cytotoxicity against human ECV304 cells after 72 hrs by MTT assay
    Cytotoxicity against human ECV304 cells after 72 hrs by MTT assay
    		[PMID: 24084294]
    ECV-304 IC50
    > 238 μM
    Compound: Glycyrrhizinic acid
    Membrane toxicity against human ECV304 cells after 2 hrs by LDH release assay
    Membrane toxicity against human ECV304 cells after 2 hrs by LDH release assay
    		[PMID: 24084294]
    HEK293 IC50
    0.015 μM
    Compound: glycyrrhizic acid
    Inhibition of mouse liver microsome 11betaHSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay
    Inhibition of mouse liver microsome 11betaHSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay
    		[PMID: 19574056]
    HEK293 IC50
    0.4 nM
    Compound: glycyrrhizinic acid
    Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay
    Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay
    		[PMID: 22360639]
    HEK293 IC50
    0.7 nM
    Compound: glycyrrhizinic acid
    Inhibition of human 11beta-HSD2 expressed in human HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay
    Inhibition of human 11beta-HSD2 expressed in human HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay
    		[PMID: 22148241]
    HEK293 EC50
    1 nM
    Compound: Glycyrrhizic acid
    Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA
    Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA
    		[PMID: 22440625]
    HEK293 IC50
    1 nM
    Compound: glycyrrhizic acid
    Inhibition of human microsomal 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay
    Inhibition of human microsomal 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay
    		[PMID: 19564108]
    HEK293 EC50
    10 nM
    Compound: Glycyrrhizic acid
    Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA
    Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA
    		[PMID: 22440625]
    HEK293 IC50
    10 nM
    Compound: glycyrrhizic acid
    Inhibition of human microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay
    Inhibition of human microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay
    		[PMID: 19564108]
    HEK293 IC50
    18.6 nM
    Compound: glycyrrhizinic acid
    Inhibition of human 11beta-HSD1 expressed in human HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay
    Inhibition of human 11beta-HSD1 expressed in human HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay
    		[PMID: 22148241]
    HEK293 IC50
    29.5 nM
    Compound: glycyrrhizinic acid
    Inhibition of mouse 11beta-HSD1 expressed in human HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay
    Inhibition of mouse 11beta-HSD1 expressed in human HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay
    		[PMID: 22148241]
    HEK293 IC50
    3 nM
    Compound: glycyrrhizinic acid
    Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay
    Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay
    		[PMID: 22360639]
    HEK293 IC50
    6 nM
    Compound: glycyrrhizinic acid
    Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay
    Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay
    		[PMID: 22360639]
    HEK293 EC50
    8 nM
    Compound: Glycyrrhizic acid
    Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA
    Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA
    		[PMID: 22440625]
    HEK293 IC50
    8 nM
    Compound: glycyrrhizic acid
    Inhibition of mouse microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay
    Inhibition of mouse microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay
    		[PMID: 19564108]
    Hepatocyte IC50
    > 200 μM
    Compound: glycyrrizhin
    Hepatoprotective activity against D-galactosamine/TNFalpha-induced cell death in primary cultured mouse hepatocytes treated for 30 mins before TNFalpha challenge measured after 18 hrs by MTT assay
    Hepatoprotective activity against D-galactosamine/TNFalpha-induced cell death in primary cultured mouse hepatocytes treated for 30 mins before TNFalpha challenge measured after 18 hrs by MTT assay
    		[PMID: 11277757]
    Hepatocyte IC50
    82.4 μM
    Compound: glycyrrhizin
    Hepatoprotective activity in mouse hepatocytes assessed inhibition of D-galactosamine/TNFalpha-induced cell death dosed administered before 30 mins of TNFalpha challenge measured after 18 hrs
    Hepatoprotective activity in mouse hepatocytes assessed inhibition of D-galactosamine/TNFalpha-induced cell death dosed administered before 30 mins of TNFalpha challenge measured after 18 hrs
    		[PMID: 11325227]
    MDCK EC50
    15.2 μM
    Compound: 15
    Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 25801933]
    MDCK EC50
    364.6 μM
    Compound: 1, GL
    Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 25801933]
    MDCK IC50
    39.6 μM
    Compound: 112
    Antiviral activity against Influenza A virus A/WSN/33(H1N1) infected in dog MDCK cells preincubated with virus for 15 mins followed by cells addition measured at 36 hrs post infection
    Antiviral activity against Influenza A virus A/WSN/33(H1N1) infected in dog MDCK cells preincubated with virus for 15 mins followed by cells addition measured at 36 hrs post infection
    		[PMID: 26841168]
    Raji IC50
    381 μM
    Compound: 8
    Inhibition of TPA-induced EBV-early antigen activation in human Raji cells after 48hrs by indirect immunofluorescence technique
    Inhibition of TPA-induced EBV-early antigen activation in human Raji cells after 48hrs by indirect immunofluorescence technique
    		[PMID: 19131254]
    RAW264.7 ED50
    70 μM
    Compound: 1, GL
    Inhibition of HMGB1 in mouse RAW264.7 cells assessed as LPS-induced TNFalpha release treated for 2 hrs prior to LPS-challenge measured after 16 hrs by ELISA
    Inhibition of HMGB1 in mouse RAW264.7 cells assessed as LPS-induced TNFalpha release treated for 2 hrs prior to LPS-challenge measured after 16 hrs by ELISA
    		[PMID: 23199028]
    Vero C1008 CC50
    > 100 μM
    Compound: 1; GL
    Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in survival rate measured after 48 hrs by MTT assay
    Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in survival rate measured after 48 hrs by MTT assay
    		[PMID: 31519375]
    體外研究
    (In Vitro)

    Glycyrrhizic acid 顯示出一系列抗癌相關(guān)的藥理活性，如廣譜抗癌能力、抵抗化療和放療引起的組織毒性、藥物吸收促進(jìn)作用和抗多藥耐藥 (MDR) 機(jī)制，作為藥物輸送系統(tǒng)中的載體材料[1]。
    在分泌GLP-1的腸道NCI-H716細(xì)胞中，Glycyrrhizic acid 促進(jìn)GLP-1分泌，鈣水平顯著升高。Glycyrrhizic acid 可通過激活TGR5促進(jìn)GLP-1分泌[2]。
    Glycyrrhizic acid 可在 37°C 下形成穩(wěn)定透明的低分子量水凝膠 (LMWHs) 以納米團(tuán)簇為微觀結(jié)構(gòu)的生理磷酸鹽緩沖液 (PBS)[4]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    體內(nèi)研究
    (In Vivo)

    在鏈脲佐菌素誘導(dǎo)的 1 型糖尿病大鼠 (STZ 處理的大鼠) 中，Glycyrrhizic acid 增加血漿 GLP-1 的水平，而氨苯蝶啶在足以抑制 Takeda G 蛋白偶聯(lián)受體 5 (TGR5) 的劑量下被阻斷[1]。
    Glycyrrhizic acid (Glycyrrhizic acid；50 mg/kg，ip) 顯著降低小鼠體內(nèi) TgAb、HMGB1、TNF-α、IL-6、IL-1β 的水平[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    822.93

    Formula

    C42H62O16
    CAS 號
    性狀

    固體

    顏色

    White to off-white

    中文名稱

    甘草酸；甘草皂甙；甘草甜素；強(qiáng)力寧；甘草皂苷
    結(jié)構(gòu)分類
    初始來源
    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性數(shù)據(jù)
    細(xì)胞實(shí)驗(yàn)： 

    DMSO 中的溶解度 : 100 mg/mL (121.52 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

    H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

    配制儲備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 1.2152 mL 6.0759 mL 12.1517 mL
    5 mM 0.2430 mL 1.2152 mL 2.4303 mL
    查看完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時(shí)，請?jiān)?個(gè)月內(nèi)使用，-20°C儲存時(shí)，請?jiān)?個(gè)月內(nèi)使用。

    • 摩爾計(jì)算器

    • 稀釋計(jì)算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動(dòng)物實(shí)驗(yàn)：

    請根據(jù)您的 實(shí)驗(yàn)動(dòng)物和給藥方式 選擇適當(dāng)?shù)娜芙夥桨浮?

    以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
    ——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
    以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

    • 方案 一

      請依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (3.04 mM); 澄清溶液

      此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

      以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水 定容至 1 mL。

      生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
    • 方案 二

      請依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (3.04 mM); 澄清溶液

      此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

      以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液 中，混合均勻。

      2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。
    動(dòng)物溶解方案計(jì)算器
    請輸入動(dòng)物實(shí)驗(yàn)的基本信息：

    給藥劑量

    mg/kg

    動(dòng)物的平均體重

    g

    每只動(dòng)物的給藥體積

    μL

    動(dòng)物數(shù)量

    只
    由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量
    請輸入您的動(dòng)物體內(nèi)配方組成：
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    如果您的動(dòng)物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過 2%。
    方案所需 助溶劑 包括：DMSO， ，均可在 MCE 網(wǎng)站選購。 ，Tween 80，均可在 MCE 網(wǎng)站選購。
    計(jì)算結(jié)果
    工作液所需濃度 : mg/mL
    儲備液配制方法 : mg 藥物溶于 μL  DMSO（母液濃度為 mg/mL）。
    您所需的儲備液濃度超過該產(chǎn)品的實(shí)測溶解度，以下方案僅供參考，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
    動(dòng)物實(shí)驗(yàn)體內(nèi)工作液的配制方法 : 取 μL DMSO 儲備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。
    連續(xù)給藥周期超過半月以上，請謹(jǐn)慎選擇該方案。
    請確保第一步儲備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱 （超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。
    純度 & 產(chǎn)品資料

    純度: 99.84%

    參考文獻(xiàn)
    Animal Administration
    [3]

    Mice[3]
    NOD.H-2h4 mice are fed in the animal house until 4 weeks of age. A total of 24 male mice are then randomly separated into three different groups (n=8 per group). Mice in the control group are given sterile water without supplement. Mice in the iodine supplement (NaI) group are given 0.005% NaI in the drinking water. Mice in the NaI+Glycyrrhizic acid group are treated with 50 mg/kg Glycyrrhizic acid once daily for 4 weeks, administered via intraperitoneal injection after 8 weeks of iodine supplementation. Thyroid tissues are removed surgically under anesthesia, washed with cold saline, blotted on filter paper and weighed using an electronic balance. The thyroid gland tissues are then stored at -80°C until use[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    參考文獻(xiàn)

    完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時(shí)，請?jiān)?個(gè)月內(nèi)使用，-20°C儲存時(shí)，請?jiān)?個(gè)月內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.2152 mL 6.0759 mL 12.1517 mL 30.3793 mL
    5 mM 0.2430 mL 1.2152 mL 2.4303 mL 6.0759 mL
    10 mM 0.1215 mL 0.6076 mL 1.2152 mL 3.0379 mL
    15 mM 0.0810 mL 0.4051 mL 0.8101 mL 2.0253 mL
    20 mM 0.0608 mL 0.3038 mL 0.6076 mL 1.5190 mL
    25 mM 0.0486 mL 0.2430 mL 0.4861 mL 1.2152 mL
    30 mM 0.0405 mL 0.2025 mL 0.4051 mL 1.0126 mL
    40 mM 0.0304 mL 0.1519 mL 0.3038 mL 0.7595 mL
    50 mM 0.0243 mL 0.1215 mL 0.2430 mL 0.6076 mL
    60 mM 0.0203 mL 0.1013 mL 0.2025 mL 0.5063 mL
    80 mM 0.0152 mL 0.0759 mL 0.1519 mL 0.3797 mL
    100 mM 0.0122 mL 0.0608 mL 0.1215 mL 0.3038 mL
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    產(chǎn)品名稱：
    Glycyrrhizic acid
    目錄號：
    HY-N0184
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