成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

  2. Anti-infection Immunology/Inflammation NF-κB Apoptosis Autophagy
  3. Bacterial Toll-like Receptor (TLR) NF-κB Apoptosis Autophagy Antibiotic
  4. Physcion

Physcion  (Synonyms: 大黃素甲醚; Parietin; Rheochrysidin)

目錄號(hào): HY-N0108 純度: 99.10%
COA 產(chǎn)品使用指南

Physcion (Parietin) 是從中藥大黃中得到的蒽醌類(lèi)物質(zhì)，是具有口服有效性和血腦屏障透過(guò)性的 6-磷酸葡萄糖酸脫氫酶 (6-phosphogluconate dehydrogenase) 抑制劑，IC50 和 Kd 值分別為 38.5 μM 和 26.0 μM。同時(shí)，Physcion 也是 TLR4/NF-kB 信號(hào)通路抑制劑，具有抗炎、抗菌、抗癌作用，可誘導(dǎo)癌細(xì)胞凋亡 (Apoptosis) 和自噬 (Autophagy)。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Physcion Chemical Structure

Physcion Chemical Structure

CAS No. : 521-61-9

1.  客戶無(wú)需承擔(dān)相應(yīng)的運(yùn)輸費(fèi)用。

2.  同一機(jī)構(gòu)（單位）同一產(chǎn)品試用裝僅限申領(lǐng)一次，同一機(jī)構(gòu)（單位）一年內(nèi)

     可免費(fèi)申領(lǐng)三個(gè)不同產(chǎn)品的試用裝。

3.  試用裝只面向終端客戶。

規(guī)格 價(jià)格 是否有貨 數(shù)量
5 mg ￥312
In-stock
10 mg ￥500
In-stock
25 mg ￥1000
In-stock
50 mg ￥1750
In-stock
100 mg ￥3000
In-stock
200 mg   詢價(jià)  
500 mg   詢價(jià)  

* Please select Quantity before adding items.

Customer Review

Other Forms of Physcion:

查看 Toll-like Receptor (TLR) 亞型特異性產(chǎn)品:

查看 NF-κB 亞型特異性產(chǎn)品:

查看 Antibiotic 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Physcion (Parietin), an anthraquinone derivative derived from the traditional Chinese medicine rhubarb, is an effective oral active 6-phosphogluconate dehydrogenase inhibitor with blood-brain barrier permeability, with IC50 and Kd values of 38.5 μM and 26.0 μM, respectively. Additionally, Physcion is an inhibitor of the <>bTLR4/NF-κB signaling pathway, exhibiting anti-inflammatory, antibacterial, and anticancer effects, and can induce Apoptosis and Autophagy in cancer cells[1][2][3][4][5].

IC50 & Target

TLR4

 

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 100 μg/mL
Compound: 6
Antiproliferative activity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26995526]
A549 IC50
1.5 μM
Compound: 80
Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay
[PMID: 33691166]
HCT-116 IC50
19 μM
Compound: 2
Cytotoxicity against MDR1 Pgp under-expressing human HCT116 cells after 24 hrs by MTT assay
Cytotoxicity against MDR1 Pgp under-expressing human HCT116 cells after 24 hrs by MTT assay
[PMID: 17949858]
HepG2 IC50
77.3 μM
Compound: 2
Cytotoxicity against MDR1 Pgp overexpressing human HepG2 cells after 24 hrs by MTT assay
Cytotoxicity against MDR1 Pgp overexpressing human HepG2 cells after 24 hrs by MTT assay
[PMID: 17949858]
HT-29 IC50
> 100 μg/mL
Compound: 6
Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26995526]
HUVEC IC50
> 100 μg/mL
Compound: 6
Antiproliferative activity against human HUVEC cells assessed as growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against human HUVEC cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26995526]
MCF7 IC50
> 100 μg/mL
Compound: 6
Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26995526]
NCI-H157 IC50
3 μM
Compound: 80
Antiproliferative activity against human NCI-H157 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human NCI-H157 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay
[PMID: 33691166]
體外研究
(In Vitro)

Physcion (10 或 20 μM，48 小時(shí)) 誘導(dǎo)人鼻咽癌 (CNE2 細(xì)胞) 的細(xì)胞凋亡和自噬[2]。
Physcion (10-40 μM，24 小時(shí)) 在 SH-SY5Y 細(xì)胞中減弱了 OGD/R (oxygen-glucose deprivation/reperfusion) 誘導(dǎo)的神經(jīng)元損傷及炎癥反應(yīng)[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[2]

Cell Line: The nasopharyngeal carcinoma cell line CNE2
Concentration: 10 or 20 μM
Incubation Time: 48 h
Result: Induced apoptosis in CNE2 cells in a dose-dependent manner.

Western Blot Analysis[2]

Cell Line: The nasopharyngeal carcinoma cell line CNE2
Concentration: 10 or 20 μM
Incubation Time: 48 h
Result: Significantly increased the level of LC3B-II, which means physcion induced autophagy in CNE2 cells.

Western Blot Analysis[3]

Cell Line: Oxygen-glucose deprivation/reperfusion (OGD/R)-induced SH-SY5Y cells
Concentration: 40 μM
Incubation Time: 24 h
Result: Significantly reversed the OGD/R-induced upregulation of TLR4, p-p65, and p-IκB expression.
體內(nèi)研究
(In Vivo)

Physcion (20 or 40 mg/kg，口服，每日一次共 7 天) 通過(guò)抑制 TLR4/NF-kB 信號(hào)通路，在腦缺血再灌注誘導(dǎo)的 SD 大鼠模型中發(fā)揮神經(jīng)保護(hù)作用[3]。
Physcion (4 或 9 mg/kg，口服，每日一次共 6 天) 可在 SPF 雞中有效減輕由 Chlamydia psittaci 6 BCE 引起的感染癥狀[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ischemia-reperfusion (I/R)-induced focal cerebral ischemia model in SD rats[3]
Dosage: 20 or 40 mg/kg
Administration: Oral gavage (p.o.), once daily for 7 days
Result: Significantly reduced the brain water content and the NSS (Neurological Severity Score) in I/R rats, compared to I/R group.
Obviously decreased areas of infarction compared to I/R group.
Animal Model: SPF chickens (21 days old) infected intra-laryngeally with Chlamydia psittaci 6 BCE[4]
Dosage: 4 or 9 mg/kg
Administration: Oral gavage (p.o.), once daily for 6 days
Result: Dose-dependently alleviated respiratory distress, air sac and lung lesions, and bacterial load in the spleen in infected chickens.
分子量

284.26

Formula

C16H12O5
CAS 號(hào)
性狀

固體

顏色

Yellow to orange

中文名稱

大黃素甲醚
結(jié)構(gòu)分類(lèi)
初始來(lái)源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 3.33 mg/mL (11.71 mM; ultrasonic and warming and adjust pH to 9 with NaOH and heat to 60°C; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

THF 中的溶解度 : 2.5 mg/mL (8.79 mM; 超聲助溶 (<60°C))

DMF 中的溶解度 : 1 mg/mL (3.52 mM; 超聲助溶)

Ethanol 中的溶解度 : < 1 mg/mL (insoluble)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 3.5179 mL 17.5895 mL 35.1791 mL
5 mM 0.7036 mL 3.5179 mL 7.0358 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.10%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMF / THF / DMSO 1 mM 3.5179 mL 17.5895 mL 35.1791 mL 87.9477 mL
THF / DMSO 5 mM 0.7036 mL 3.5179 mL 7.0358 mL 17.5895 mL
DMSO 10 mM 0.3518 mL 1.7590 mL 3.5179 mL 8.7948 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的產(chǎn)品:

Your information is safe with us. * Required Fields.

   產(chǎn)品名稱：

  

* 需求量：

* 客戶姓名：

 

* Email：

* 電話：

 

* 公司或機(jī)構(gòu)名稱：

   留言給我們：

Bulk Inquiry

Inquiry Information

產(chǎn)品名稱：
Physcion
目錄號(hào)：
HY-N0108
需求量：