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  2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. Ethyl ferulate

Ethyl ferulate  (Synonyms: 阿魏酸乙酯)

目錄號(hào): HY-N0061 純度: 99.89%
COA 產(chǎn)品使用指南 技術(shù)支持

Ethyl ferulate 是從川芎分離得到的阿魏酸的天然親酯衍生物，可誘導(dǎo)血紅素氧合酶 1 (HO-1)，保護(hù)大鼠神經(jīng)元免受氧化應(yīng)激。Ethyl ferulate也能夠保護(hù)神經(jīng)元免受 β 淀粉樣肽(1-42)導(dǎo)致的全身性的氧化應(yīng)激和神經(jīng)毒性。

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Ethyl ferulate Chemical Structure

Ethyl ferulate Chemical Structure

CAS No. : 4046-02-0

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Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥330
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500 mg ￥300
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1 g ￥500
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5 g   詢價(jià)  
10 g   詢價(jià)  

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Customer Review

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Ethyl ferulate, a naturally lipophilic derivative of ferulic acid originally derived from Rhizoma Chuanxiong, induces heme oxygenase-1 (HO-1) and protects rat neurons against oxidative stress[1]. Ethyl ferulate also protects neurons against amyloid β peptide (1-42)-induced oxidative stress and neurotoxicity[2].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 GI50
1.2 μM
Compound: 11
Growth inhibition of human A549 cells by Sulforhodamine B assay
Growth inhibition of human A549 cells by Sulforhodamine B assay
[PMID: 21106458]
A549 IC50
12.5 μM
Compound: 1b
Cytotoxicity against human A549 cells after 72 hrs by alamar blue assay
Cytotoxicity against human A549 cells after 72 hrs by alamar blue assay
[PMID: 22954735]
Calu-1 IC50
> 50 μM
Compound: 1b
Cytotoxicity against human Calu1 cells after 72 hrs by alamar blue assay
Cytotoxicity against human Calu1 cells after 72 hrs by alamar blue assay
[PMID: 22954735]
HeLa IC50
2.13 μM
Compound: 1b
Cytotoxicity against human HeLa cells after 72 hrs by alamar blue assay
Cytotoxicity against human HeLa cells after 72 hrs by alamar blue assay
[PMID: 22954735]
HeLa GI50
52.8 μM
Compound: 11
Growth inhibition of human HeLa cells by Sulforhodamine B assay
Growth inhibition of human HeLa cells by Sulforhodamine B assay
[PMID: 21106458]
HOP-62 IC50
26.8 μM
Compound: 1b
Cytotoxicity against human HOP62 cells after 72 hrs by alamar blue assay
Cytotoxicity against human HOP62 cells after 72 hrs by alamar blue assay
[PMID: 22954735]
LOX IMVI IC50
> 50 μM
Compound: 1b
Cytotoxicity against human LOXIMVI cells after 72 hrs by alamar blue assay
Cytotoxicity against human LOXIMVI cells after 72 hrs by alamar blue assay
[PMID: 22954735]
M14 IC50
> 50 μM
Compound: 1b
Cytotoxicity against human M14 cells after 72 hrs by alamar blue assay
Cytotoxicity against human M14 cells after 72 hrs by alamar blue assay
[PMID: 22954735]
MCF7 GI50
86.3 μM
Compound: 11
Growth inhibition of human MCF7 cells by Sulforhodamine B assay
Growth inhibition of human MCF7 cells by Sulforhodamine B assay
[PMID: 21106458]
MT4 CC50
> 10 μM
Compound: 9
Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 3 days by CytoTox-Glo assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 3 days by CytoTox-Glo assay
[PMID: 26756779]
MT4 EC50
> 10 μM
Compound: 9
Antiviral activity against HIV1 NL4-3 infected in human MT4 cells assessed as reduction in viral replication measured on day 3 post infection by luciferase reporter gene assay
Antiviral activity against HIV1 NL4-3 infected in human MT4 cells assessed as reduction in viral replication measured on day 3 post infection by luciferase reporter gene assay
[PMID: 26756779]
NCI-H1299 IC50
36.8 μM
Compound: 1b
Cytotoxicity against human NCI-H1299 cells after 72 hrs by alamar blue assay
Cytotoxicity against human NCI-H1299 cells after 72 hrs by alamar blue assay
[PMID: 22954735]
NCI-H157 IC50
32.3 μM
Compound: 1b
Cytotoxicity against human NCI-H157 cells after 72 hrs by alamar blue assay
Cytotoxicity against human NCI-H157 cells after 72 hrs by alamar blue assay
[PMID: 22954735]
NCI-H1792 IC50
25.6 μM
Compound: 1b
Cytotoxicity against human NCI-H1792 cells after 72 hrs by alamar blue assay
Cytotoxicity against human NCI-H1792 cells after 72 hrs by alamar blue assay
[PMID: 22954735]
NCI-H460 IC50
29.1 μM
Compound: 1b
Cytotoxicity against human H460 cells after 72 hrs by alamar blue assay
Cytotoxicity against human H460 cells after 72 hrs by alamar blue assay
[PMID: 22954735]
Platelet IC50
193.2 μM
Compound: Ethyl ferulate
Anti-platelet activity in rabbit platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 5 mins at 37 degC by aggregometry
Anti-platelet activity in rabbit platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 5 mins at 37 degC by aggregometry
10.1039/C4MD00022F
SK-N-SH GI50
22.3 μM
Compound: 11
Growth inhibition of human SK-N-SH cells by Sulforhodamine B assay
Growth inhibition of human SK-N-SH cells by Sulforhodamine B assay
[PMID: 21106458]
體外研究
(In Vitro)

Ethyl ferulate (1-50 μM，6 或 24 小時(shí)) 可增加星形膠質(zhì)細(xì)胞和海馬神經(jīng)元中的 HO 活性、HO-1 mRNA 和蛋白質(zhì)表達(dá)[1]。
Ethyl ferulate (5 μM，12 小時(shí)) 通過誘導(dǎo) HO-1[1] 保護(hù)大鼠海馬神經(jīng)元免受 GOX 誘導(dǎo)的細(xì)胞死亡。
Ethyl ferulate (10-50 μM，24 小時(shí))可保護(hù)原代神經(jīng)元細(xì)胞免受 Aβ-肽 (1-42) 誘導(dǎo)的細(xì)胞毒性、3-NT 形成、ROS 積累和脂質(zhì)過氧化作用[2] .
Ethyl ferulate (20-160 μM，24 小時(shí)) 可保護(hù) RPE 細(xì)胞免受 CoCl2 (150 μM) 誘導(dǎo)的細(xì)胞活力降低[5]。
Ethyl ferulate (40 μM，24 小時(shí)) 通過激活 Nrf-2 通路并減少 RPE 細(xì)胞中 ROS 的生成來抑制 CoCl2 誘導(dǎo)的 VEGFA 表達(dá)[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[5]

Cell Line: RPE cells (induced by 150 μM CoCl2 for 12 h)
Concentration: 40 μM
Incubation Time: 2 h
Result: Increased Nrf-2 expression and nuclear translocation.
Decreased Keap-1 expression, Aand increased HO-1 and NQO-1 expression.
Reduced hypoxia-induced HIF-1α and VEGFA expression.
體內(nèi)研究
(In Vivo)

Ethyl ferulate (15-50 mg/kg，腹腔注射，每天兩次，持續(xù) 5 天) 可抑制 LPS 誘導(dǎo)的小鼠急性肺損傷[3][4]。
Ethyl ferulate (0.05-0.2 μg，玻璃體內(nèi)給藥，1 μL/眼) 抑制氧誘導(dǎo)視網(wǎng)膜病變小鼠模型中的視網(wǎng)膜新生血管[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS (0.5 mg/kg)-induced acute lung injury mice model[3]
Dosage: 15 and 30 mg/kg
Administration: i.p., twice a day for 5 days
Result: Reduced leukocyte infiltration.
Reduced MPO activity, mRNA levels and secretion of TNF-α and IL-6.
分子量

222.24

Formula

C12H14O4
CAS 號(hào)
性狀

固體

顏色

White to off-white

中文名稱

阿魏酸乙酯
結(jié)構(gòu)分類
初始來源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : ≥ 100 mg/mL (449.96 mM; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 4.4996 mL 22.4982 mL 44.9964 mL
5 mM 0.8999 mL 4.4996 mL 8.9993 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物實(shí)驗(yàn)：

請(qǐng)根據(jù)您的 實(shí)驗(yàn)動(dòng)物和給藥方式 選擇適當(dāng)?shù)娜芙夥桨浮?

以下溶解方案都請(qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：
——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

  • 方案 一

    請(qǐng)依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (11.25 mM); 澄清溶液

    此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

    以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水 定容至 1 mL。

    生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
  • 方案 二

    請(qǐng)依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (11.25 mM); 澄清溶液

    此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

    以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液 中，混合均勻。

    2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。

掃碼獲得
動(dòng)物溶解方案

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量
請(qǐng)輸入您的動(dòng)物體內(nèi)配方組成：
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
如果您的動(dòng)物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過 2%。
方案所需 助溶劑 包括：DMSO， PEG300/PEG400，Tween 80，均可在 MCE 網(wǎng)站選購。
純度 & 產(chǎn)品資料

純度: 99.89%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4996 mL 22.4982 mL 44.9964 mL 112.4910 mL
5 mM 0.8999 mL 4.4996 mL 8.9993 mL 22.4982 mL
10 mM 0.4500 mL 2.2498 mL 4.4996 mL 11.2491 mL
15 mM 0.3000 mL 1.4999 mL 2.9998 mL 7.4994 mL
20 mM 0.2250 mL 1.1249 mL 2.2498 mL 5.6245 mL
25 mM 0.1800 mL 0.8999 mL 1.7999 mL 4.4996 mL
30 mM 0.1500 mL 0.7499 mL 1.4999 mL 3.7497 mL
40 mM 0.1125 mL 0.5625 mL 1.1249 mL 2.8123 mL
50 mM 0.0900 mL 0.4500 mL 0.8999 mL 2.2498 mL
60 mM 0.0750 mL 0.3750 mL 0.7499 mL 1.8748 mL
80 mM 0.0562 mL 0.2812 mL 0.5625 mL 1.4061 mL
100 mM 0.0450 mL 0.2250 mL 0.4500 mL 1.1249 mL

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Ethyl ferulate
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HY-N0061
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