成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

  2. Anti-infection Immunology/Inflammation Autophagy
  3. Parasite Toll-like Receptor (TLR) SARS-CoV Autophagy
  4. Hydroxychloroquine sulfate

Hydroxychloroquine sulfate  (Synonyms: 硫酸羥氯喹; HCQ sulfate)

目錄號: HY-B1370 純度: 99.95%
COA 產(chǎn)品使用指南

Hydroxychloroquine sulfate (HCQ sulfate) 是一種合成的抗瘧疾劑，也可以抑制 Toll 樣受體 7/9 (TLR7/9) 信號傳導。Hydroxychloroquine sulfate 有效抑制 SARS-CoV-2 感染。

MCE 的所有產(chǎn)品僅用作科學研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務

Hydroxychloroquine sulfate Chemical Structure

Hydroxychloroquine sulfate Chemical Structure

CAS No. : 747-36-4

1.  客戶無需承擔相應的運輸費用。

2.  同一機構（單位）同一產(chǎn)品試用裝僅限申領一次，同一機構（單位）一年內

     可免費申領三個不同產(chǎn)品的試用裝。

3.  試用裝只面向終端客戶。

規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in Water ￥550
In-stock
50 mg ￥500
In-stock
100 mg ￥700
In-stock
200 mg ￥1120
In-stock
500 mg   詢價  
1 g   詢價  

* Please select Quantity before adding items.

Customer Review

Other Forms of Hydroxychloroquine sulfate:

MCE 顧客使用本產(chǎn)品發(fā)表的 57 篇科研文獻

查看 Parasite 亞型特異性產(chǎn)品:

查看 Toll-like Receptor (TLR) 亞型特異性產(chǎn)品:

  • 生物活性

  • 實驗參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].

IC50 & Target

TLR7

 

Plasmodium

 

TLR9

 

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
Vero C1008 CC50
> 40 μM
Compound: Hydroxychloroquine sulfate
Cytotoxicity (CC50) determination in Vero E6 cells measured by fluorescence (OD590nm)
Cytotoxicity (CC50) determination in Vero E6 cells measured by fluorescence (OD590nm)
10.1101/2020.04.03.023846
Vero C1008 CC50
>> 50 μM
Compound: Hydroxychloroquine Sulfate
CC50 determination at MOI 0.004 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in Vero E6 cells
CC50 determination at MOI 0.004 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in Vero E6 cells
10.1101/2020.03.25.008482
Vero C1008 CC50
>> 50 μM
Compound: Hydroxychloroquine Sulfate
CC50 determination at MOI 0.01 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in Vero E6 cells
CC50 determination at MOI 0.01 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in Vero E6 cells
10.1101/2020.03.25.008482
Vero C1008 IC50
11.17 μM
Compound: Hydroxychloroquine Sulfate
IC50 determination at MOI 0.01 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in SARS-CoV-2 infected Vero E6 cells
IC50 determination at MOI 0.01 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in SARS-CoV-2 infected Vero E6 cells
10.1101/2020.03.25.008482
Vero C1008 EC50
4.17 μM
Compound: Hydroxychloroquine sulfate
Antiviral efficacy against SARS-CoV-2 (strain BavPat1) in Vero E6 cells assessed by inhibition of viral RNA replication measured by RT-PCR after 2 days
Antiviral efficacy against SARS-CoV-2 (strain BavPat1) in Vero E6 cells assessed by inhibition of viral RNA replication measured by RT-PCR after 2 days
10.1101/2020.04.03.023846
Vero C1008 IC50
9.21 μM
Compound: Hydroxychloroquine Sulfate
IC50 determination at MOI 0.004 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in SARS-CoV-2 infected Vero E6 cells
IC50 determination at MOI 0.004 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in SARS-CoV-2 infected Vero E6 cells
10.1101/2020.03.25.008482
體外研究
(In Vitro)

Hydroxychloroquine sulfate 是一種從 4-氨基喹啉衍生而來的合成抗瘧藥；幾十年來，它一直被用于處理一些風濕性疾病，例如類風濕性關節(jié)炎 (RA)[1]。
Hydroxychloroquine sulfate 或 chloroquine 對細胞內 pH 值也沒有可測量的影響，盡管這些濃度可以抑制 DNA 或 RNA 配體誘導的 TLR9 或 7 信號傳導[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內研究
(In Vivo)

硫酸羥氯喹用于處理狼瘡，硫酸羥氯喹及其類似物氯喹均抑制 TLR7 和 9 信號[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

433.95

Formula

C18H28ClN3O5S
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

硫酸羥氯喹；硫酸羥基氯喹
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性數(shù)據(jù)
細胞實驗： 

H2O 中的溶解度 : 110 mg/mL (253.49 mM; 超聲加熱助溶)

DMSO 中的溶解度 : 100 mg/mL (230.44 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 2.3044 mL 11.5221 mL 23.0441 mL
5 mM 0.4609 mL 2.3044 mL 4.6088 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物實驗：

以下溶解方案，請直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶。

  • 方案 一

    請依序添加每種溶劑： PBS

    Solubility: 100 mg/mL (230.44 mM); 澄清溶液; 超聲助溶

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
該產(chǎn)品水溶性佳，請具體參考實測 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，如有需要，請與 MCE 中國技術支持聯(lián)系。
純度 & 產(chǎn)品資料

純度: 99.99%

參考文獻
Animal Administration
[2]

MRL/lpr mice are dosed orally five times a week with 20 or 60 mg/kg E6446 or 60 mg/kg Hydroxychloroquine sulfate beginning at 5 weeks of age. CB 4564 is administered at 50 mg/kg i.p. every 10 days. A serum sample is taken immediately before the beginning of treatment to monitor changes in autoreactive antibodies. Subsequently, serum samples are collected approximately monthly and analyzed for anti-dsDNA by ELISA after 1:500 dilution. Body weights and urine samples are taken at the same interval, and proteinuria is assessed. Anti-nuclear antibodies (ANA) are assessed using commercially available HEp2 slide kits, with serum diluted to 1:100 in kit buffer. ANA scores are read blinded[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.3044 mL 11.5221 mL 23.0441 mL 57.6103 mL
5 mM 0.4609 mL 2.3044 mL 4.6088 mL 11.5221 mL
10 mM 0.2304 mL 1.1522 mL 2.3044 mL 5.7610 mL
15 mM 0.1536 mL 0.7681 mL 1.5363 mL 3.8407 mL
20 mM 0.1152 mL 0.5761 mL 1.1522 mL 2.8805 mL
25 mM 0.0922 mL 0.4609 mL 0.9218 mL 2.3044 mL
30 mM 0.0768 mL 0.3841 mL 0.7681 mL 1.9203 mL
40 mM 0.0576 mL 0.2881 mL 0.5761 mL 1.4403 mL
50 mM 0.0461 mL 0.2304 mL 0.4609 mL 1.1522 mL
60 mM 0.0384 mL 0.1920 mL 0.3841 mL 0.9602 mL
80 mM 0.0288 mL 0.1440 mL 0.2881 mL 0.7201 mL
100 mM 0.0230 mL 0.1152 mL 0.2304 mL 0.5761 mL

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的產(chǎn)品:

Your information is safe with us. * Required Fields.

   產(chǎn)品名稱：

  

* 需求量：

* 客戶姓名：

 

* Email：

* 電話：

 

* 公司或機構名稱：

   留言給我們：

Bulk Inquiry

Inquiry Information

產(chǎn)品名稱：
Hydroxychloroquine sulfate
目錄號：
HY-B1370
需求量：