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  2. Metabolic Enzyme/Protease Apoptosis
  3. Endogenous Metabolite Apoptosis
  4. L-SelenoMethionine

L-SelenoMethionine  (Synonyms: L-硒代蛋氨酸)

目錄號(hào): HY-B1000A 純度: 99.82%
COA 產(chǎn)品使用指南

L-SelenoMethionine 是 Selenomethionine 的 L-異構(gòu)體，是硒的主要天然食物形式。L-SelenoMethionine 是一種癌癥化學(xué)預(yù)防劑，可以通過(guò)飲食補(bǔ)充降低癌癥的發(fā)生率并誘導(dǎo)癌細(xì)胞凋亡。L-SelenoMethionine 還可以增加谷胱甘肽過(guò)氧化物酶的表達(dá)。

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L-SelenoMethionine Chemical Structure

L-SelenoMethionine Chemical Structure

CAS No. : 3211-76-5

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in Water ￥440
In-stock
100 mg ￥400
In-stock
500 mg ￥1200
In-stock
1 g   詢價(jià)  
5 g   詢價(jià)  

* Please select Quantity before adding items.

Other Forms of L-SelenoMethionine:

MCE 顧客使用本產(chǎn)品發(fā)表的 2 篇科研文獻(xiàn)

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

L-SelenoMethionine, an L-isomer of Selenomethionine, is a major natural food-form of selenium. L-SelenoMethionin is a cancer chemopreventive agent that can reduce cancer incidence by dietary supplementation and induce apoptosis of cancer cells. L-SelenoMethionine also can increase expression of glutathione peroxidase[1][2][3].

IC50 & Target

Microbial Metabolite

 

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
65 μM
Compound: 3
Anticancer activity against human A549 cells assessed as cell growth inhibition measured after 6 days by SRB assay
Anticancer activity against human A549 cells assessed as cell growth inhibition measured after 6 days by SRB assay
[PMID: 34217061]
DU-145 IC50
40 μM
Compound: 3
Anticancer activity against human DU-145 cells assessed as cell growth inhibition measured after 6 days by SRB assay
Anticancer activity against human DU-145 cells assessed as cell growth inhibition measured after 6 days by SRB assay
[PMID: 34217061]
HT-29 IC50
130 μM
Compound: 3
Anticancer activity against human HT-29 cells assessed as cell growth inhibition measured after 6 days by SRB assay
Anticancer activity against human HT-29 cells assessed as cell growth inhibition measured after 6 days by SRB assay
[PMID: 34217061]
UACC-375 IC50
50 μM
Compound: 3
Anticancer activity against human UACC-375 cells assessed as cell growth inhibition measured after 6 days by SRB assay
Anticancer activity against human UACC-375 cells assessed as cell growth inhibition measured after 6 days by SRB assay
[PMID: 34217061]
體外研究
(In Vitro)

L-SelenoMethionine (1-500 μM; 24-72 h) is selectively inhibits the growth of prostate cancer cells, compared with normal cells[2].
? L-SelenoMethionine (500 μM; 48 h) induce apoptosis in prostate cancer cells[2].
? L-SelenoMethionine (500 μM; 48 h) causes an increase in arrest in the G2-M phase of the cell cycle selectively in prostate cancer cells[2].
? L-SelenoMethionine (5 μM; 24 h) mitigates gene expression associated with the cellular stress response from 10 cGy irradiation[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt)
Concentration: 1, 5, 10, 50, 100, 500 μM
Incubation Time: 24, 48, 72 hours
Result: Inhibited the growth of prostate cancer cells, with a lower IC50 (1-90 μM) at 72 h than normal prostate cells (>500 μM).

Apoptosis Analysis[2]

Cell Line: Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt)
Concentration: 500 μM
Incubation Time: 48 hours
Result: Exhibited the highest level of DNA condensation in androgen-responsive LNCaP carcinoma cells, followed by PC-3 and DU145 cells.
Exhibited the nicked-end DNA labeling in prostate cancer cells.
Promoted the PARP cleavage in prostate cancer cells.

Cell Cycle Analysis[2]

Cell Line: Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt)
Concentration: 500 μM
Incubation Time: 48 hours
Result: Increased the sub-G0-G1 cell fraction of LNCaP (41.5%), PC-3 (12.1%), and DU145 cells (11.2%).
Caused a significant increases in G2 cells , particularly in LNCaP (13%), PC-3 (32%), and DU145 (20%) cells.

RT-PCR[3]

Cell Line: Human thyroid epithelial cells (HTori-3)
Concentration: 5 μM
Incubation Time: 24 hours
Result: Downregulated the CDC6, GADD45A, FAS and ATF3 in irradiated cells.
體內(nèi)研究
(In Vivo)

L-SelenoMethionine (0.06-12 μg/g diet; p.o. for 3 d) partially or completely prevent the decrease in the serum or plasma levels of total antioxidants in rats exposed to gamma rays, protons or HZE particles[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

196.11

Formula

C5H11NO2Se
CAS 號(hào)
性狀

固體

顏色

White to off-white

中文名稱

L-硒代蛋氨酸
結(jié)構(gòu)分類
初始來(lái)源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

H2O 中的溶解度 : 14.29 mg/mL (72.87 mM; 超聲助溶)

DMSO 中的溶解度 : 1 mg/mL (5.10 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 5.0992 mL 25.4959 mL 50.9918 mL
5 mM 1.0198 mL 5.0992 mL 10.1984 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用。

* 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物實(shí)驗(yàn)：

以下溶解方案，請(qǐng)直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的方式助溶。

  • 方案 一

    請(qǐng)依序添加每種溶劑： PBS

    Solubility: 9.09 mg/mL (46.35 mM); 澄清溶液; 超聲助溶 (<60°C)

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.82%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 5.0992 mL 25.4959 mL 50.9918 mL 127.4795 mL
5 mM 1.0198 mL 5.0992 mL 10.1984 mL 25.4959 mL
H2O 10 mM 0.5099 mL 2.5496 mL 5.0992 mL 12.7479 mL
15 mM 0.3399 mL 1.6997 mL 3.3995 mL 8.4986 mL
20 mM 0.2550 mL 1.2748 mL 2.5496 mL 6.3740 mL
25 mM 0.2040 mL 1.0198 mL 2.0397 mL 5.0992 mL
30 mM 0.1700 mL 0.8499 mL 1.6997 mL 4.2493 mL
40 mM 0.1275 mL 0.6374 mL 1.2748 mL 3.1870 mL
50 mM 0.1020 mL 0.5099 mL 1.0198 mL 2.5496 mL
60 mM 0.0850 mL 0.4249 mL 0.8499 mL 2.1247 mL

* 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
L-SelenoMethionine
目錄號(hào)：
HY-B1000A
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