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  2. Anti-infection
  3. Bacterial Antibiotic
  4. Clinafloxacin

Clinafloxacin  (Synonyms: 克林沙星; AM-1091; CI-960; PD 127391)

目錄號: HY-B0536 純度: 98.34%
COA 產品使用指南 技術支持

Clinafloxacin (AM 1091) 是一種高效廣譜氟喹諾酮類抗生素 (antibiotic)，對革蘭氏陽性、革蘭氏陰性和厭氧病原體均有抑制活性。Clinafloxacin 對金黃色葡萄球菌的 DNA 促旋酶 (DNA gyrase) 和拓撲異構酶 IV (topoisomerase IV) 有抑制作用，IC50 值分別為 0.92 μg/ml 和 1.62 μg/ml。

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Clinafloxacin Chemical Structure

Clinafloxacin Chemical Structure

CAS No. : 105956-97-6

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規(guī)格 價格 是否有貨 數(shù)量
5 mg ￥245
In-stock
10 mg ￥385
In-stock
25 mg ￥665
In-stock
50 mg ￥980
In-stock
100 mg ￥1470
In-stock
200 mg   詢價  
500 mg   詢價  

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Customer Review

Other Forms of Clinafloxacin:

  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

Clinafloxacin (AM 1091) is a potent and broad-spectrum fluoroquinolone antibiotic, has inhibitory activity against gram-positive, gram-negative bacterias, and anaerobic pathogens in vitro[1]. Clinafloxacin is against DNA gyrase and topoisomerase IV of?S. aureus with IC50 values of 0.92 μg/ml and 1.62 μg/ml, respectively[2].

IC50 & Target

Quinolone

 

體外研究
(In Vitro)

Clinafloxacin exhibits activity against S. pneumonia with an MIC of 1μg/ml for the parC-gyrA mutants[2].
Clinafloxacin hydrochloride has antibacterial activities against target-altered mutant strains of?S. aureus. It against Wild type S. aureus, gyrA?mutant S. aureus and gyrA?mutant S. aureus with MIC values of 0.016 μg/ml, 0.063 μg/ml and 0.915 μg/ml, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內研究
(In Vivo)

Clinafloxacin is very effective for the therapy of penicillin-resistant, ciprofloxacin-susceptible pneumococcal meningitis in the rabbit model.
With the CS strain (2349)(Clinafloxacin MIC=0.12 μg/ml), at a dose of 10 mg/kg and 20 mg/kg per day Clinafloxacin achieves an initial reduction at 6 hr. Both are bactericidal at this point but presents regrowth at 24 hr, and the final reduction at 24 hr in mean log cfu/ml is 22.30 and 23.83, respectively. However, With the CR strain (4371)(Clinafloxacin MIC=0.5 μg/ml), Clinafloxacin even at 20 mg/kg per day does not decrease bacterial titers at any time point in this rabbit model of meningitis[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

365.79

Formula

C17H17ClFN3O3
CAS 號
性狀

固體

顏色

Light yellow to brown

中文名稱

克林沙星
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 100 mg/mL (273.38 mM; 超聲助溶; 吸濕的 DMSO 對產品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 2.7338 mL 13.6690 mL 27.3381 mL
5 mM 0.5468 mL 2.7338 mL 5.4676 mL
查看完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內使用， -20°C儲存時，請在1年內使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
純度 & 產品資料

純度: 98.34%

參考文獻

Clinafloxacin 相關分類

完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內使用， -20°C儲存時，請在1年內使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7338 mL 13.6690 mL 27.3381 mL 68.3452 mL
5 mM 0.5468 mL 2.7338 mL 5.4676 mL 13.6690 mL
10 mM 0.2734 mL 1.3669 mL 2.7338 mL 6.8345 mL
15 mM 0.1823 mL 0.9113 mL 1.8225 mL 4.5563 mL
20 mM 0.1367 mL 0.6835 mL 1.3669 mL 3.4173 mL
25 mM 0.1094 mL 0.5468 mL 1.0935 mL 2.7338 mL
30 mM 0.0911 mL 0.4556 mL 0.9113 mL 2.2782 mL
40 mM 0.0683 mL 0.3417 mL 0.6835 mL 1.7086 mL
50 mM 0.0547 mL 0.2734 mL 0.5468 mL 1.3669 mL
60 mM 0.0456 mL 0.2278 mL 0.4556 mL 1.1391 mL
80 mM 0.0342 mL 0.1709 mL 0.3417 mL 0.8543 mL
100 mM 0.0273 mL 0.1367 mL 0.2734 mL 0.6835 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產品名稱：
Clinafloxacin
目錄號：
HY-B0536
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