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  1. Anti-infection
  2. Bacterial Antibiotic
  3. Amikacin disulfate

Amikacin disulfate  (Synonyms: 阿米卡星硫酸鹽; BAY 41-6551 disulfate)

目錄號(hào): HY-B0509B 純度: ≥98.0%
COA 產(chǎn)品使用指南 技術(shù)支持

Amikacin disulfate (BAY 41-6551 disulfate) 是一種氨基糖苷類抗生素,也是一種卡那霉素的半合成類似物。Amikacin disulfate 具有殺菌作用,直接作用于 30S 和 50S 細(xì)菌核糖體亞基,可抑制蛋白質(zhì)合成。Amikacin disulfate 對(duì)大多數(shù)革蘭氏陰性細(xì)菌 (Gram-negative bacteria) (包括慶大霉素和妥布霉素抗性菌株) 非常有效。Amikacin disulfate 還抑制易感諾卡氏菌和非結(jié)核分枝桿菌引起的感染。

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Amikacin disulfate Chemical Structure

Amikacin disulfate Chemical Structure

CAS No. : 39831-55-5

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Customer Review

Other Forms of Amikacin disulfate:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Amikacin disulfate (BAY 41-6551 dissulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin disulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin disulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin disulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria[1][2].

IC50 & Target

Aminoglycoside

 

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
Vero IC50
> 6.25 μg/mL
Compound: Amikacin
Cytotoxicity against monkey Vero cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against monkey Vero cells assessed as decrease in cell viability after 72 hrs by MTT assay
[PMID: 28552337]
Vero IC50
> 62.5 μg/mL
Compound: Amikacin
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
[PMID: 23352268]
體外研究
(In Vitro)

Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused by Nocardia asteroides, Mycobacterium avium-intracellulare, and certain species of "rapid-growing" mycobacteria (that is, M. chelonae and M. fortuitumi)[1].
Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD50 value of 453 μM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

體內(nèi)研究
(In Vivo)

Amikacin (320 mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats in vivo[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Fischer 344 rats (40-50-day-old)[3]
Dosage: 320?mg/kg
Administration: Subcutaneous injection; daily; for 10 days
Result: Induced hearing loss in rats.
Clinical Trial
分子量

781.76

Formula

C22H47N5O21S2

CAS 號(hào)
性狀

固體

顏色

White to off-white

中文名稱

阿米卡星硫酸鹽;丁胺卡那霉素硫酸鹽

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn): 

H2O 中的溶解度 : 100 mg/mL (127.92 mM; 超聲助溶)

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 1.2792 mL 6.3958 mL 12.7916 mL
5 mM 0.2558 mL 1.2792 mL 2.5583 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液;一旦配成溶液,請(qǐng)分裝保存,避免反復(fù)凍融造成的產(chǎn)品失效
儲(chǔ)備液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲(chǔ)存時(shí),請(qǐng)?jiān)?個(gè)月內(nèi)使用,-20°C儲(chǔ)存時(shí),請(qǐng)?jiān)?個(gè)月內(nèi)使用。

* 備注:如您選擇水作為儲(chǔ)備液,請(qǐng)稀釋至工作液后,再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物實(shí)驗(yàn):

以下溶解方案,請(qǐng)直接配制工作液。建議現(xiàn)用現(xiàn)配,在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比; 如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象,可以通過(guò)加熱和/或超聲的方式助溶。

  • 方案 一

    請(qǐng)依序添加每種溶劑: PBS

    Solubility: 50 mg/mL (63.96 mM); 澄清溶液; 超聲助溶

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息:

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

由于實(shí)驗(yàn)過(guò)程有損耗,建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
該產(chǎn)品水溶性佳,請(qǐng)具體參考實(shí)測(cè) 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
您所需的儲(chǔ)備液濃度超過(guò)該產(chǎn)品的實(shí)測(cè)溶解度,如有需要,請(qǐng)與 MCE 中國(guó)技術(shù)支持聯(lián)系。
純度 & 產(chǎn)品資料
參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液;一旦配成溶液,請(qǐng)分裝保存,避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲(chǔ)存時(shí),請(qǐng)?jiān)?個(gè)月內(nèi)使用,-20°C儲(chǔ)存時(shí),請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.2792 mL 6.3958 mL 12.7916 mL 31.9791 mL
5 mM 0.2558 mL 1.2792 mL 2.5583 mL 6.3958 mL
10 mM 0.1279 mL 0.6396 mL 1.2792 mL 3.1979 mL
15 mM 0.0853 mL 0.4264 mL 0.8528 mL 2.1319 mL
20 mM 0.0640 mL 0.3198 mL 0.6396 mL 1.5990 mL
25 mM 0.0512 mL 0.2558 mL 0.5117 mL 1.2792 mL
30 mM 0.0426 mL 0.2132 mL 0.4264 mL 1.0660 mL
40 mM 0.0320 mL 0.1599 mL 0.3198 mL 0.7995 mL
50 mM 0.0256 mL 0.1279 mL 0.2558 mL 0.6396 mL
60 mM 0.0213 mL 0.1066 mL 0.2132 mL 0.5330 mL
80 mM 0.0160 mL 0.0799 mL 0.1599 mL 0.3997 mL
100 mM 0.0128 mL 0.0640 mL 0.1279 mL 0.3198 mL

* 備注:如您選擇水作為儲(chǔ)備液,請(qǐng)稀釋至工作液后,再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Amikacin disulfate
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