Isoniazid (Synonyms: 異煙肼; INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide)

目錄號(hào): HY-B0329 純度: 99.91%: FAQs
Data Sheet SDS COA 產(chǎn)品使用指南

摩爾計(jì)算器

Isoniazid (INH) 是一種前體，必須被細(xì)菌過(guò)氧化氫酶 KatG 激活。Isoniazid 對(duì)快速分裂的分枝桿菌具有殺菌作用，并具有抗菌活性。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Isoniazid Chemical Structure

CAS No. : 54-85-3

1. 客戶無(wú)需承擔(dān)相應(yīng)的運(yùn)輸費(fèi)用。

2. 同一機(jī)構(gòu)（單位）同一產(chǎn)品試用裝僅限申領(lǐng)一次，同一機(jī)構(gòu)（單位）一年內(nèi)

可免費(fèi)申領(lǐng)三個(gè)不同產(chǎn)品的試用裝。

3. 試用裝只面向終端客戶。

規(guī)格	價(jià)格	是否有貨
10 mM * 1 mL in DMSO	￥550	In-stock
100 mg	￥500	In-stock
200 mg		詢價(jià)
500 mg		詢價(jià)

or 大包裝詢價(jià)

* Please select Quantity before adding items.

Customer Review

Other Forms of Isoniazid:

Isoniazid-d₄ In-stock
Isoniazid (Standard) 詢價(jià)

MCE 顧客使用本產(chǎn)品發(fā)表的 4 篇科研文獻(xiàn)

•Front Bioeng Biotechnol. 2022 Mar 17;10:826093. [Abstract]
•ACS Chem Biol. 2021 Dec 15. [Abstract]
•Biotechnol Bioeng. 2021 Sep 3. [Abstract]
•Res Sq. 2024 Sep 2:rs.3.rs-4926508. [Abstract]

Isoniazid 相關(guān)產(chǎn)品

•相關(guān)化合物庫(kù):

•同靶點(diǎn)產(chǎn)品:

•同靶點(diǎn)蛋白產(chǎn)品:

查看 Antibiotic 亞型特異性產(chǎn)品:

查看所有亞型

Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

生物活性
純度 & 產(chǎn)品資料
參考文獻(xiàn)

生物活性

Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity^[1]^[2]^[3]^[4].

細(xì)胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 450 μM Compound: Isoniazid	Cytotoxicity against Homo sapiens (human) A549 cells after 72 hr by MTT assay Cytotoxicity against Homo sapiens (human) A549 cells after 72 hr by MTT assay	10.1007/s00044-012-0112-0
A549	IC₅₀	> 450 μM Compound: Isoniazid	Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 27214509]
A549	IC₅₀	> 450 μM Compound: Isoniazid	Cytotoxicity against human A549 assessed as inhibition of cell proliferation by MTT assay Cytotoxicity against human A549 assessed as inhibition of cell proliferation by MTT assay	[PMID: 25771110]
A549	IC₅₀	> 450 μM Compound: INH	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 24292339]
BMDM	CC₅₀	100 μg/mL Compound: Isoniazid	Cytotoxicity against Swiss mouse BMDM assessed as reduction in cell viability after 24 hrs by MTS assay Cytotoxicity against Swiss mouse BMDM assessed as reduction in cell viability after 24 hrs by MTS assay	[PMID: 28712709]
CHO	CC₅₀	256 μM Compound: INH	Cytotoxicity against CHO cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against CHO cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31525660]
HCT-8	EC₅₀	> 100 μM Compound: INH	Toxicity against human HCT8 cells after 72 hrs by XTT assay Toxicity against human HCT8 cells after 72 hrs by XTT assay	[PMID: 20060303]
HepG2	IC₅₀	> 1 mM Compound: INH	Cytotoxicity against human HepG2 cells measured after overnight incubation by MTT assay Cytotoxicity against human HepG2 cells measured after overnight incubation by MTT assay	[PMID: 21855181]
HepG2	IC₅₀	> 1 mM Compound: INH, Isoniazid	Cytotoxicity against human HepG2 cells by MTT assay Cytotoxicity against human HepG2 cells by MTT assay	[PMID: 22018878]
HepG2	IC₅₀	> 250 μM Compound: INH	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay	[PMID: 24953953]
HepG2	IC₅₀	> 250 μM Compound: INH	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 25593095]
HepG2	IC₅₀	> 250 μM Compound: INH	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after overnight incubation by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after overnight incubation by MTT assay	[PMID: 31401536]
HepG2	IC₅₀	> 5000 μM Compound: INH	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by MTS assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by MTS assay	[PMID: 29679902]
J774.1	IC₅₀	> 400 μM Compound: V, Isnz	Cytotoxicity against mouse J774.1 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against mouse J774.1 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 23202852]
J774.A1	IC₅₀	> 100 μM Compound: INH	Cytotoxicity against mouse J774A1 cells assessed as cell viability after 24 hrs by Trypan blue exclusion assay Cytotoxicity against mouse J774A1 cells assessed as cell viability after 24 hrs by Trypan blue exclusion assay	[PMID: 24611928]
J774.A1	IC₅₀	> 64 μg/mL Compound: INH	Cytotoxicity against mouse J774.A1 cells after 48 hrs by MTT assay Cytotoxicity against mouse J774.A1 cells after 48 hrs by MTT assay	[PMID: 36150342]
Macrophage	IC₅₀	> 100 μM Compound: INH	Cytotoxicity against mouse bone marrow derived macrophage assessed as growth inhibition after 48 hrs by MTS assay Cytotoxicity against mouse bone marrow derived macrophage assessed as growth inhibition after 48 hrs by MTS assay	[PMID: 23454512]
MRC5	CC₅₀	> 10 μg/mL Compound: INH	Cytotoxicity against human MRC5 cells after 24 hrs Cytotoxicity against human MRC5 cells after 24 hrs	[PMID: 26254828]
MT4	CC₅₀	> 100 μM Compound: Isoniazid	Cytotoxicity of compound against mock-infected MT-4 cells was evaluated by MTT assay Cytotoxicity of compound against mock-infected MT-4 cells was evaluated by MTT assay	[PMID: 15006398]
PBMC	IC₅₀	169 μg/mL Compound: INH	Cytotoxicity against PBMC (unknown origin) assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against PBMC (unknown origin) assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25908515]
PBMC	IC₅₀	4.67 mM Compound: INH	Cytotoxicity against human PBMC measured after overnight incubation by MTT assay Cytotoxicity against human PBMC measured after overnight incubation by MTT assay	[PMID: 21855181]
PBMC	IC₅₀	4.67 mM Compound: INH, Isoniazid	Cytotoxicity against human PBMC by MTT assay Cytotoxicity against human PBMC by MTT assay	[PMID: 22018878]
PBMC	IC₅₀	71.68 μg/mL Compound: INZ	Cytotoxicity against human PBMC assessed as reduction in cell growth after 72 hrs by MTT assay Cytotoxicity against human PBMC assessed as reduction in cell growth after 72 hrs by MTT assay	[PMID: 32977201]
Peritoneal macrophage cell	IC₅₀	> 100 μg/mL Compound: 3	Cytotoxicity against C57BL/6 mouse peritoneal macrophages assessed as cell viability by lactate dehydrogenase release assay Cytotoxicity against C57BL/6 mouse peritoneal macrophages assessed as cell viability by lactate dehydrogenase release assay	[PMID: 26725953]
RAW264.7	IC₅₀	> 400 μg/mL Compound: INH	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25908515]
RAW264.7	GI₅₀	21900 μM Compound: INH	Cytotoxicity against mouse RAW264.7 cells assessed as growth inhibition after 48 hrs by trypan blue assay Cytotoxicity against mouse RAW264.7 cells assessed as growth inhibition after 48 hrs by trypan blue assay	10.1039/C3MD00251A
THP-1	IC₅₀	> 25 μg/mL Compound: INH	Cytotoxicity against human THP1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human THP1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 31557610]
THP-1	IC₅₀	> 3649 μM Compound: INH	Cytotoxicity against human THP1 cells after 72 hrs by MTT assay Cytotoxicity against human THP1 cells after 72 hrs by MTT assay	[PMID: 21309577]
THP-1	IC₅₀	0.0024 μg/mL Compound: Isoniazid	Anti-tubercular activity against rifampicin, isoniazid, ethambutol and pyrazinamide-sensitive dormant phage of Mycobacterium tuberculosis H37Ra ATCC 25177 infected in human THP1 cells by neutral red assay Anti-tubercular activity against rifampicin, isoniazid, ethambutol and pyrazinamide-sensitive dormant phage of Mycobacterium tuberculosis H37Ra ATCC 25177 infected in human THP1 cells by neutral red assay	[PMID: 26299346]
THP-1	IC₅₀	0.0024 μg/mL Compound: Isoniazid	Anti-tubercular activity against rifampicin, isoniazid, ethambutol and pyrazinamide-sensitive active phage of Mycobacterium tuberculosis H37Ra ATCC 25177 infected in human THP1 cells by neutral red assay Anti-tubercular activity against rifampicin, isoniazid, ethambutol and pyrazinamide-sensitive active phage of Mycobacterium tuberculosis H37Ra ATCC 25177 infected in human THP1 cells by neutral red assay	[PMID: 26299346]
THP-1	IC₅₀	100 μM Compound: INH	Cytotoxicity against human THP-1 cells assessed as cell viability measured after 96 hrs by MTT assay Cytotoxicity against human THP-1 cells assessed as cell viability measured after 96 hrs by MTT assay	[PMID: 34242760]
THP-1	IC₅₀	547 μM Compound: INH	Cytotoxicity against human THP1 cells assessed as growth inhibition after 24 to 48 hrs by MTT assay Cytotoxicity against human THP1 cells assessed as growth inhibition after 24 to 48 hrs by MTT assay	[PMID: 29529504]
Vero	IC₅₀	> 100 μg/mL Compound: INH	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS-PMS assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS-PMS assay	[PMID: 24087924]
Vero	IC₅₀	> 100 μM Compound: INH	Cytotoxicity against african green monkey Vero cells assessed as growth inhibition after 24 hrs by MTS assay Cytotoxicity against african green monkey Vero cells assessed as growth inhibition after 24 hrs by MTS assay	[PMID: 23454512]
Vero	IC₅₀	> 100 μM Compound: INH	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 23886691]
Vero	IC₅₀	> 100 μM Compound: INH	Cytotoxicity against african green monkey Vero cells assessed as cell growth after 48 hrs by hemocytometry Cytotoxicity against african green monkey Vero cells assessed as cell growth after 48 hrs by hemocytometry	[PMID: 20961671]
Vero	IC₅₀	> 12 μg/mL Compound: INH	Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero cells assessed as inhibition of cell viability after 96 hr by MTT assay Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero cells assessed as inhibition of cell viability after 96 hr by MTT assay	10.1007/s00044-012-0074-2
Vero	IC₅₀	> 128 μM Compound: INH	Cytotoxicity against african green monkey Vero cells after 72 hrs by CellTiter assay Cytotoxicity against african green monkey Vero cells after 72 hrs by CellTiter assay	[PMID: 22391032]
Vero	IC₅₀	> 128 μM Compound: INH	Cytotoxicity against african green monkey Vero cells after 72 hrs by Cell titer assay Cytotoxicity against african green monkey Vero cells after 72 hrs by Cell titer assay	[PMID: 19271749]
Vero	IC₅₀	> 128 μM Compound: INH	Cytotoxicity against african green monkey Vero cells by tetrazolium dye reduction assay Cytotoxicity against african green monkey Vero cells by tetrazolium dye reduction assay	[PMID: 24084159]
Vero	IC₅₀	> 130.5 μM Compound: Isoniazid	Cytotoxicity against african green monkey Vero after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero after 72 hrs by MTT assay	[PMID: 20576327]
Vero	IC₅₀	> 200 μg/mL Compound: INH	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30145051]
Vero	IC₅₀	> 200 μg/mL Compound: isoniazid	Cytotoxicity against Vero cells after 48 hrs by XTT method Cytotoxicity against Vero cells after 48 hrs by XTT method	[PMID: 17888665]
Vero	IC₅₀	> 200 μM Compound: INH	Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay	[PMID: 24836065]
Vero	IC₅₀	> 450 μM Compound: Isoniazid	Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero cells after 72 hr by MTT assay Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero cells after 72 hr by MTT assay	10.1007/s00044-012-0112-0
Vero	IC₅₀	> 450 μM Compound: Isoniazid	Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero cells after 72 hr by MTT assay Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero cells after 72 hr by MTT assay	10.1007/s00044-011-9646-9
Vero	IC₅₀	> 450 μM Compound: Isoniazid	Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell proliferation by MTT assay Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell proliferation by MTT assay	[PMID: 25771110]
Vero	IC₅₀	> 450 μM Compound: INH	Cytotoxicity against african green monkey Vero cells by MTT assay Cytotoxicity against african green monkey Vero cells by MTT assay	[PMID: 24292339]
Vero	IC₅₀	> 454.7 μM Compound: INH	Inhibition of mammalian Vero cell viability at 6.25 and 62.5 ug/ml by MTT assay Inhibition of mammalian Vero cell viability at 6.25 and 62.5 ug/ml by MTT assay	[PMID: 16303302]
Vero	IC₅₀	> 455.69 μM Compound: Isoniazid	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability measured after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 33482292]
Vero	CC₅₀	> 455.73 μM Compound: INH	Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay	[PMID: 21840711]
Vero	CC₅₀	> 455.73 μM Compound: INH	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 21320779]
Vero	CC₅₀	> 455.73 μM Compound: Isoniazid	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 20615698]
Vero	IC₅₀	> 455.77 μM Compound: isoniazid	Cytotoxicity against Vero cells after 72 hrs by MTT assay Cytotoxicity against Vero cells after 72 hrs by MTT assay	[PMID: 17276683]
Vero	CC₅₀	> 455.8 μM Compound: Isoniazid	Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero cells assessed as cell viability after 72 hr by MTT assay Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero cells assessed as cell viability after 72 hr by MTT assay	10.1007/s00044-011-9638-9
Vero	IC₅₀	> 455.8 μM Compound: INH	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 19942326]
Vero	IC₅₀	> 455.8 μM Compound: isoniazid	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 19131245]
Vero	CC₅₀	> 455.8 μM Compound: INH	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 18502542]
Vero	IC₅₀	> 455.8 μM Compound: INH	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 18304818]
Vero	IC₅₀	> 455.8 μM Compound: isoniazid	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 18078756]
Vero	IC₅₀	> 455.8 μM Compound: INH, isoniazid	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 18068979]
Vero	IC₅₀	> 455.8 μM Compound: INH	Cytotoxicity against Vero cells after 72 hrs by MTT assay Cytotoxicity against Vero cells after 72 hrs by MTT assay	[PMID: 17960928]
Vero	IC₅₀	> 456 μM Compound: INH	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 21978838]
Vero	CC₅₀	> 50 μg/mL Compound: INH	Cytotoxicity against african green monkey Vero cells after 72 hrs by CellTiterGlo assay Cytotoxicity against african green monkey Vero cells after 72 hrs by CellTiterGlo assay	[PMID: 22691154]
Vero	CC₅₀	> 50 μM Compound: INH	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 33010635]
Vero	IC₅₀	> 50 μM Compound: 51	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by tetrazolium dye assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by tetrazolium dye assay	[PMID: 28094223]
Vero	IC₅₀	> 500 μg/mL Compound: Isoniazid	Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay	[PMID: 19232450]
Vero	CC₅₀	> 500 μM Compound: INH, Isoniazid	Cytotoxicity against african green monkey Vero cells after 72 hrs by Cell titer Glo luminescent cell viability assay Cytotoxicity against african green monkey Vero cells after 72 hrs by Cell titer Glo luminescent cell viability assay	[PMID: 21570839]
Vero	IC₅₀	> 6.25 μg/mL Compound: Isoniazid	Cytotoxicity against monkey Vero cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against monkey Vero cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 28552337]
Vero	IC₅₀	> 62.5 μg/mL Compound: Isoniazid	Cytotoxicity against African green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 24721315]
Vero	IC₅₀	> 62.5 μg/mL Compound: Isoniazid	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 23352268]
Vero	IC₅₀	> 62.5 μg/mL Compound: INH	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 23122863]
Vero	IC₅₀	> 62.5 μg/mL Compound: Isoniazid	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 22749825]
Vero	IC₅₀	> 62.5 μg/mL Compound: INH	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 20056418]
Vero	IC₅₀	> 64 μg/mL Compound: INH	Cytotoxicity against African green monkey Vero cells after 48 hrs by MTT assay Cytotoxicity against African green monkey Vero cells after 48 hrs by MTT assay	[PMID: 36150342]
Vero	CC₅₀	> 7000 μM Compound: INH	Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay	[PMID: 27241693]
Vero	CC₅₀	> 7300 μM Compound: INH	Cytotoxicity in African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity in African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31350124]
Vero	CC₅₀	125 μg/mL Compound: INH	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 28720502]
Vero	CC₅₀	125 μg/mL Compound: INH	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 28646656]
Vero	CC₅₀	128 μg/mL Compound: Isoniazid	Cytotoxicity against African green monkey Vero cells incubated for 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells incubated for 72 hrs by MTT assay	[PMID: 31352245]
Vero	CC₅₀	128 μg/mL Compound: INH	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30025351]
Vero	CC₅₀	128 μg/mL Compound: INH	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29227930]
Vero	IC₅₀	128 μM Compound: INH	Cytotoxicity against african green monkey Vero cells after 72 hrs Cytotoxicity against african green monkey Vero cells after 72 hrs	[PMID: 19757815]
Vero	CC₅₀	1459.85 μM Compound: 1NH	Cytotoxicity against african green monkey Vero C1008 cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero C1008 cells after 72 hrs by MTT assay	[PMID: 21917452]
Vero	CC₅₀	1470 μM Compound: INH	Cytotoxicity against African green monkey Vero C1008 cells after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero C1008 cells after 72 hrs by MTT assay	[PMID: 24095091]
Vero	CC₅₀	199 μg/mL Compound: Isoniazid	Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero C1008 cells assessed as cell viability after 72 hr by MTT assay Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero C1008 cells assessed as cell viability after 72 hr by MTT assay	10.1007/s00044-012-0043-9
Vero	CC₅₀	256 μg/mL Compound: INH	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30690301]
Vero	CC₅₀	256 μM Compound: INH	Cytotoxicity against African green monkey Vero cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 30992202]
Vero	CC₅₀	256 μM Compound: INH	Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay	[PMID: 30296686]
Vero	CC₅₀	32 μg/mL Compound: INH	Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay	[PMID: 29407980]
Vero	CC₅₀	5833.5 μM Compound: Isoniazid	Cytotoxicity against african green monkey Vero C1008 cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero C1008 cells after 72 hrs by MTT assay	[PMID: 20138519]
Vero	IC₅₀	62.5 μg/mL Compound: INH	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 19879757]
Vero	CC₅₀	6282.8 μM Compound: INH	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assat Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assat	[PMID: 21146257]

體外研究
(In Vitro)

Isoniazid (INH) 是一種前體藥物，必須被結(jié)核分枝桿菌中稱為 KatG的細(xì)菌過(guò)氧化氫酶-過(guò)氧化物酶激活^[1]。
KatG 將等煙?；cNADH偶聯(lián)形成等煙?；?NADH 復(fù)合物。該復(fù)合物與稱為 InhA 的烯酰-?；d體蛋白還原酶緊密結(jié)合，從而阻斷天然烯酰-AcpM 底物和脂肪酸合成酶的作用。該過(guò)程抑制分枝桿菌細(xì)胞壁所需的分枝菌酸的合成。KatG 激活 Isoniazid 會(huì)產(chǎn)生一系列自由基，包括一氧化氮，這也被證明對(duì)另一種抗分枝桿菌前藥 PA-824 的作用很重要^[2]^[3]。
Isoniazid 對(duì)快速分裂的分枝桿菌有殺菌作用，對(duì)生長(zhǎng)緩慢的分枝桿菌有抑菌作用^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

137.14

Formula

C₆H₇N₃O

CAS 號(hào)

54-85-3

性狀

固體

顏色

White to off-white

中文名稱

異煙肼

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)

細(xì)胞實(shí)驗(yàn)：

DMSO 中的溶解度 : 50 mg/mL (364.59 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

H₂O 中的溶解度 : 33.33 mg/mL (243.04 mM; 超聲助溶)

配制儲(chǔ)備液

濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg

1 mM	7.2918 mL	36.4591 mL	72.9182 mL
5 mM	1.4584 mL	7.2918 mL	14.5836 mL
10 mM	0.7292 mL	3.6459 mL	7.2918 mL

查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

* 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

摩爾計(jì)算器
稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

濃度 _(start)

體積 _(start)

濃度 _(final)

體積 _(final)

動(dòng)物實(shí)驗(yàn)：

以下溶解方案，請(qǐng)直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的方式助溶。

方案一

請(qǐng)依序添加每種溶劑： PBS
Solubility: 150 mg/mL (1093.77 mM); 澄清溶液; 超聲助溶

動(dòng)物溶解方案計(jì)算器

請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只

由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量

計(jì)算結(jié)果

工作液所需濃度 : mg/mL

該產(chǎn)品水溶性佳，請(qǐng)具體參考實(shí)測(cè) 水 / PBS / Saline 中的溶解度數(shù)據(jù)。

您所需的儲(chǔ)備液濃度超過(guò)該產(chǎn)品的實(shí)測(cè)溶解度，如有需要，請(qǐng)與 MCE 中國(guó)技術(shù)支持聯(lián)系。

純度 & 產(chǎn)品資料

純度: 99.91%

選擇批次：

Data Sheet (630 KB) SDS (537 KB)

COA (286 KB) LCMS (93 KB)

產(chǎn)品使用指南 (1538 KB)

參考文獻(xiàn)

[1]. Suarez, J., et al., An oxyferrous heme/protein-based radical intermediate is catalytically competent in the catalase reaction of Mycobacterium tuberculosis catalase-peroxidase (KatG). J Biol Chem, 2009. 284(11): p. 7017-29. [Content Brief]

[2]. Timmins, G.S., et al., Nitric oxide generated from isoniazid activation by KatG: source of nitric oxide and activity against Mycobacterium tuberculosis. Antimicrob Agents Chemother, 2004. 48(8): p. 3006-9. [Content Brief]

[3]. Singh, R., et al., PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release. Science, 2008. 322(5906): p. 1392-5. [Content Brief]

[4]. Ahmad, Z., et al., Biphasic kill curve of isoniazid reveals the presence of drug-tolerant, not drug-resistant, Mycobacterium tuberculosis in the guinea pig. J Infect Dis, 2009. 200(7): p. 1136-43. [Content Brief]

Isoniazid 相關(guān)分類

Infection

完整儲(chǔ)備液配制表

可選溶劑	濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	7.2918 mL	36.4591 mL	72.9182 mL	182.2955 mL
	5 mM	1.4584 mL	7.2918 mL	14.5836 mL	36.4591 mL
	10 mM	0.7292 mL	3.6459 mL	7.2918 mL	18.2295 mL
	15 mM	0.4861 mL	2.4306 mL	4.8612 mL	12.1530 mL
	20 mM	0.3646 mL	1.8230 mL	3.6459 mL	9.1148 mL
	25 mM	0.2917 mL	1.4584 mL	2.9167 mL	7.2918 mL
	30 mM	0.2431 mL	1.2153 mL	2.4306 mL	6.0765 mL
	40 mM	0.1823 mL	0.9115 mL	1.8230 mL	4.5574 mL
	50 mM	0.1458 mL	0.7292 mL	1.4584 mL	3.6459 mL
	60 mM	0.1215 mL	0.6077 mL	1.2153 mL	3.0383 mL
	80 mM	0.0911 mL	0.4557 mL	0.9115 mL	2.2787 mL
	100 mM	0.0729 mL	0.3646 mL	0.7292 mL	1.8230 mL

* 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isoniazid54-85-3INH Isonicotinic acid hydrazide Isonicotinic hydrazide異煙肼BacterialAutophagyMitophagyAntibioticMitochondrial AutophagyKatGmycobacteriatuberculostaticInhibitorinhibitorinhibit

產(chǎn)品名稱：			* 需求量：
* 客戶姓名：			* Email：
* 電話：			* 公司或機(jī)構(gòu)名稱：
留言給我們：

產(chǎn)品名稱：			* Lot #：
* 客戶姓名：			* Email：
電話：			* 部門：
* 公司或機(jī)構(gòu)名稱：
留言給我們：

MedChemExpress (MCE) 只為有資質(zhì)的科研機(jī)構(gòu)、醫(yī)藥企業(yè)基于科學(xué)研究或藥證申報(bào)的用途提供醫(yī)藥研發(fā)服務(wù)，不為任何個(gè)人或者非科研性質(zhì)的、非用于藥證申報(bào)使用等其他用途提供服務(wù)。	站點(diǎn)地圖隱私聲明
滬ICP備15051369號(hào)-4 上海工商滬公網(wǎng)安備31011502019417 滬(浦)應(yīng)急管危經(jīng)許[2021]201709(QFYS) 營(yíng)業(yè)執(zhí)照（三證合一）
Copyright ? 2013-2025 MedChemExpress. All Rights Reserved.

成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Isoniazid (Synonyms: 異煙肼; INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide)

Customer Review

Other Forms of Isoniazid:

MCE 顧客使用本產(chǎn)品發(fā)表的 4 篇科研文獻(xiàn)

Isoniazid 相關(guān)產(chǎn)品

•相關(guān)化合物庫(kù):

•同靶點(diǎn)產(chǎn)品:

•同靶點(diǎn)蛋白產(chǎn)品:

查看 Antibiotic 亞型特異性產(chǎn)品:

生物活性

純度 & 產(chǎn)品資料

參考文獻(xiàn)

摩爾計(jì)算器

稀釋計(jì)算器

Isoniazid 相關(guān)分類

完整儲(chǔ)備液配制表

Keywords:

您最近查看的產(chǎn)品:

熱門區(qū)域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
郵箱 *

Sorry, but the email address you supplied was invalid.

成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Isoniazid (Synonyms: 異煙肼; INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide)

Customer Review

Other Forms of Isoniazid:

Isoniazid 相關(guān)抗體

MCE 顧客使用本產(chǎn)品發(fā)表的 4 篇科研文獻(xiàn)

Isoniazid 相關(guān)產(chǎn)品

•相關(guān)化合物庫(kù):

•同靶點(diǎn)產(chǎn)品:

•同靶點(diǎn)蛋白產(chǎn)品:

查看 Antibiotic 亞型特異性產(chǎn)品:

生物活性

純度 & 產(chǎn)品資料

參考文獻(xiàn)

Isoniazid 相關(guān)抗體:

摩爾計(jì)算器

稀釋計(jì)算器

Isoniazid 相關(guān)分類

完整儲(chǔ)備液配制表

Keywords:

您最近查看的產(chǎn)品:

Request for HNMR Report

Request for HNMR Report

熱門區(qū)域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z