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  2. Anti-infection
  3. Bacterial Antibiotic
  4. Sparfloxacin

Sparfloxacin  (Synonyms: 司帕沙星; CI-978; AT-4140)

目錄號: HY-B0308 純度: 99.93%
COA 產(chǎn)品使用指南

Sparfloxacin (CI-978) 是氟喹諾酮類抗菌素。

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Sparfloxacin Chemical Structure

Sparfloxacin Chemical Structure

CAS No. : 110871-86-8

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規(guī)格 價格 是否有貨 數(shù)量
100 mg ￥200
In-stock
500 mg ￥400
In-stock
1 g   詢價  
5 g   詢價  

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Customer Review

Other Forms of Sparfloxacin:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Sparfloxacin (CI-978) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity[1].

IC50 & Target

Quinolone

 

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO IC50
88.8 μM
Compound: sparfloxacin
Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits
Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits
[PMID: 23812503]
HEK293 IC50
> 250 μM
Compound: Sparfloxacin
Binding affinity to human ERG F656A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -120 mV by patch clamp method
Binding affinity to human ERG F656A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -120 mV by patch clamp method
[PMID: 23711922]
HEK293 IC50
> 250 μM
Compound: Sparfloxacin
Binding affinity to human ERG Y652A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method
Binding affinity to human ERG Y652A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method
[PMID: 23711922]
HEK293 IC50
127.6 μM
Compound: Sparfloxacin
Binding affinity to human ERG Y652A tandem dimeric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method
Binding affinity to human ERG Y652A tandem dimeric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method
[PMID: 23711922]
HEK293 IC50
21.7 μM
Compound: Sparfloxacin
Binding affinity to wild type human ERG expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method
Binding affinity to wild type human ERG expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method
[PMID: 23711922]
HEK293 IC50
33.6 μM
Compound: Sparfloxacin
Binding affinity to human ERG F656A tandem dimeric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -120 mV by patch clamp method
Binding affinity to human ERG F656A tandem dimeric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -120 mV by patch clamp method
[PMID: 23711922]
HEK293 IC50
46.9 μM
Compound: Sparfloxacin
Binding affinity to human ERG S624A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method
Binding affinity to human ERG S624A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method
[PMID: 23711922]
NIH3T3 IC50
122 μM
Compound: Sparfloxacin
Inhibition of mouse NIH/3T3 cell proliferation by MTT assay
Inhibition of mouse NIH/3T3 cell proliferation by MTT assay
[PMID: 19595598]
體外研究
(In Vitro)

Sparfloxacin (CI-978) shows broad and potent antibacterial activity. Its MICs for 90% of the strains tested are 0.1 to 0.78 μg/ml against gram-positive organisms, such as members of the genera Staphylococcus , Streptococcus and Enterococcus , and 0.0125 to 1.56 μg/ml against gram-negative organisms, such as members of the family Enterobacteriaceae and the genera Pseudomona . Its MICs are 0.025 to 0.78 μg/ml against glucose nonfermenters, 0.2 to 0.78 μg/ml against anaerobes, 0.0125 to 0.05 μg/ml against Legionella. Sparfloxacin (CI-978) showed good oral efficacy against systemic infections with Staphylococcus aureus , Streptococcus pyogenes , Streptococcus pneumoniae , Escherichia coli , and Pseudomonas aeruginosa in mice[1]. Sparfloxacin targets DNA gyrase and inhibits DNA synthesis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

392.40

Formula

C19H22F2N4O3
CAS 號
性狀

固體

顏色

Light yellow to yellow

中文名稱

司帕沙星
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)
細(xì)胞實驗： 

0.1 M NaOH 中的溶解度 : 50 mg/mL (127.42 mM; ultrasonic and adjust pH to 11 with NaOH)

DMSO 中的溶解度 : 5 mg/mL (12.74 mM; 超聲助溶 (<60°C); 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.5484 mL 12.7421 mL 25.4842 mL
5 mM 0.5097 mL 2.5484 mL 5.0968 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.93%

參考文獻(xiàn)

Sparfloxacin 相關(guān)分類

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO / 0.1 M NaOH 1 mM 2.5484 mL 12.7421 mL 25.4842 mL 63.7105 mL
5 mM 0.5097 mL 2.5484 mL 5.0968 mL 12.7421 mL
10 mM 0.2548 mL 1.2742 mL 2.5484 mL 6.3711 mL
0.1 M NaOH 15 mM 0.1699 mL 0.8495 mL 1.6989 mL 4.2474 mL
20 mM 0.1274 mL 0.6371 mL 1.2742 mL 3.1855 mL
25 mM 0.1019 mL 0.5097 mL 1.0194 mL 2.5484 mL
30 mM 0.0849 mL 0.4247 mL 0.8495 mL 2.1237 mL
40 mM 0.0637 mL 0.3186 mL 0.6371 mL 1.5928 mL
50 mM 0.0510 mL 0.2548 mL 0.5097 mL 1.2742 mL
60 mM 0.0425 mL 0.2124 mL 0.4247 mL 1.0618 mL
80 mM 0.0319 mL 0.1593 mL 0.3186 mL 0.7964 mL
100 mM 0.0255 mL 0.1274 mL 0.2548 mL 0.6371 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Sparfloxacin
目錄號：
HY-B0308
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