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  2. Autophagy Anti-infection Immunology/Inflammation
  3. Parasite Autophagy SARS-CoV Toll-like Receptor (TLR) HIV Antibiotic
  4. Chloroquine

Chloroquine 是一種廣泛用于瘧疾和類風(fēng)濕性關(guān)節(jié)炎的抗炎試劑。Chloroquine 是自噬 (autophagy) 和 Toll 樣受體 (TLRs) 的抑制劑。Chloroquine 有效抑制 SARS-CoV-2 (COVID-19) 感染 (EC50=1.13 μM)。

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Chloroquine Chemical Structure

Chloroquine Chemical Structure

CAS No. : 54-05-7

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10 mM * 1 mL in DMSO ￥550
In-stock
50 mg ￥350
In-stock
100 mg ￥500
In-stock
200 mg ￥875
In-stock
500 mg ￥1750
In-stock
1 g   詢價(jià)  
5 g   詢價(jià)  

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Customer Review

Other Forms of Chloroquine:

MCE 顧客使用本產(chǎn)品發(fā)表的 675 篇科研文獻(xiàn)

WB
Proliferation Assay
IF

    Chloroquine purchased from MCE. Usage Cited in: Immun Inflamm Dis. 2023 Apr 12; 11:e830.

    Chloroquine (10?μM; 30 min) reverses the effect of OmpA on autophagy by inhibiting the expression of Beclin1 and LC3II/I while increasing the expression of P62 in BMDCs.

    Chloroquine purchased from MCE. Usage Cited in: Immun Inflamm Dis. 2023 Apr 12; 11:e830.

    Chloroquine (10?μM; 30 min) reverses the effect of OmpA on autophagy by inhibiting the expression of LC3 in BMDCs.

    Chloroquine purchased from MCE. Usage Cited in: Prostate. 2019 Jan;79(1):44-53.  [Abstract]

    Treatment with sub-dose of Everolimus (10 nM), together with CQ (5 μM) increases the levels of Bax and cleaved PARP, and decreases the levels of Bcl-2 expression in both PC3 and LNPER cells.

    Chloroquine purchased from MCE. Usage Cited in: Oncogene. 2018 May;37(22):2936-2952.  [Abstract]

    IPZ-treated U87 and U251 cells are treated with or without Baf-A1 (5 nM), CQ (40 μM), or MG132 (1 μM) for 48 h, followed by western blots.

    Chloroquine purchased from MCE. Usage Cited in: Biomed Pharmacother. 2018 Dec;109:1617-1627.  [Abstract]

    GFP-LC3B-expressing LX-2 cells are treated with DMSO, 3-MA (10 mM), or Chloroquine (30 μM) alone or in the presence of Carvedilol (CVD, 10 μM) for 24 h. The conversion of LC3B-I to LC3B-II is evaluated using immunoblotting.

    Chloroquine purchased from MCE. Usage Cited in: Int J Mol Med. 2018 May;41(5):2535-2544.  [Abstract]

    MC3T3-E1 cells are treated with AICAR (10 μM) in the presence or absence of 3-MA (5 mM) or CQ (10 μM) for 24 h, after which western blot analysis is conducted.

    Chloroquine purchased from MCE. Usage Cited in: Sci Rep. 2018 Mar 7;8(1):4108.  [Abstract]

    L02 cells exposed to PA (200 μM) with different concentrations of Rapamycin (Rapa) or Chloroquine (CQ) for 24 h. Palmitate (PA) induced higher protein expression of LC3 II/I and p62 compared with control as indicated by western blot.

    Chloroquine purchased from MCE. Usage Cited in: Acta Biochim Biophys Sin (Shanghai). 2018 Feb 1;50(2):144-155.  [Abstract]

    Raw264.7 macrophages treated without or with Rapamycin (1 μΜ) or Chloroquine (20 μΜ) for 48 h. Western blot shows the protein expression levels of Atg5, Beclin1, LC3, and p62/SQSMT1.

    Chloroquine purchased from MCE. Usage Cited in: J Pharmacol Exp Ther. 2018 Oct;367(1):20-27.  [Abstract]

    Protein expression of LC3B and p62 in Panc-1 cells treated with Carboxamidotriazole (CAI) and/or Chloroquine (CQ).

    Chloroquine purchased from MCE. Usage Cited in: Biochem Biophys Res Commun. 2018 Sep 5;503(2):501-507.  [Abstract]

    Western blot analysis of autophagy markers and LAMP2 in mice with AAV-vaspin and Chloroquine (CQ) pretreatment after I/R (1d).

    Chloroquine purchased from MCE. Usage Cited in: Neurosci Lett. 2018 Aug 24;682:112-117.  [Abstract]

    After treatment of CDDP with or without the autophagy inhibitor CQ, the expression of LC3-II in the CQ+CDDP group is less than that in the CQ group but is higher than that in the CDDP group at 24 h and 96 h.

    Chloroquine purchased from MCE. Usage Cited in: Cell Physiol Biochem. 2018;48(6):2318-2336.  [Abstract]

    Cells are treated with Rapamycin (Rp; 10 μM)+Eicosapentaenoic acid (EPA; 40 μM) with or without Chloroquine (CQ; 5 μM) for 48 h. Cell extracts are prepared and subjected to western blot analysis.

    Chloroquine purchased from MCE. Usage Cited in: EBioMedicine. 2017 May;19:49-59.  [Abstract]

    mCherry-GFPLC3 puncta analysis in SPC-A-1 cells. Cells are transfected with mCherry-GFP-LC3 plasmid and incubated for 6 h. Next, cells are pretreated with or without Chloroquine (50 μM) for 1 h followed by stimulation of 5 μM Flu for 24 h or 36 h. Scale bar, 10 μm and 2 μm (magnified graph). The lysosomal inhibitor Chloroquine (CQ) raises the lysosomal pH and increases the autophagic flux.

    Chloroquine purchased from MCE. Usage Cited in: Sci Rep. 2017 Jun 7;7(1):2929.  [Abstract]

    p53 and Cell apoptosis. MCF7 and MDA-MB-231 cells are treated with 80?μM ω-3 FFAs, 20?μM ATRA alone or in combination for 48?h. The expression of PARP and p53 protein. β-Actin is used as an internal control.

    Chloroquine purchased from MCE. Usage Cited in: Oncotarget. 2017 Nov 22;8(65):109135-109150.  [Abstract]

    Cells are treated with RA (20 μM) plus ω-3 PUFAs (80 μM) with or without CQ (5 μM) for 24 h. Cell extracts are prepared and subjected to western blotting analysis.

    Chloroquine purchased from MCE. Usage Cited in: Acta Biochim Biophys Sin (Shanghai). 2016 Dec;48(12):1075-1084.  [Abstract]

    The change of LC3 is analyzed by western blotting after 6 h hypoxia in the presence or absence of Chloroquine of WDR26-overexpressing H9c2 cells.

    Chloroquine purchased from MCE. Usage Cited in: Tumour Biol. 2016 Jul;37(7):8811-24.  [Abstract]

    Assays for autophagy activity. Immunoblot analysis for LC3B. Compared with the Lenti-NC cells, the Lenti-CD44v6 cells display a higher intensity of autophagy flux but not steady-state levels when treated with 5-FU (*P<0.001).

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    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

    IC50 & Target[1][2][3][5]

    Plasmodium

     

    Malaria

     

    TLRs

     

    SARS-COV-2

     

    HIV-1

     

    細(xì)胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    184B5 IC50
    63.08 μM
    Compound: Chloroquine
    Antiproliferative activity against human 184B5 cells after 72 hrs by SRB assay
    Antiproliferative activity against human 184B5 cells after 72 hrs by SRB assay
    		[PMID: 26602827]
    184B5 IC50
    76.13 μM
    Compound: CQ
    Cytotoxicity against human 184B5 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human 184B5 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 28586716]
    184B5 GI50
    76.13 μM
    Compound: Chloroquine
    Cytotoxicity against human 184B5 cells after 48 hrs by SRB assay
    Cytotoxicity against human 184B5 cells after 48 hrs by SRB assay
    		[PMID: 20106668]
    184B5 GI50
    76.13 μM
    Compound: CQ
    Cytotoxicity against human 184B5 cells after 48 hrs by SRB assay
    Cytotoxicity against human 184B5 cells after 48 hrs by SRB assay
    		[PMID: 19804979]
    A-431 ED50
    > 20 μg/mL
    Compound: chloroquine
    Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay
    Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay
    		[PMID: 8450319]
    A549 IC50
    100 μM
    Compound: Chloroquine
    Anticancer activity against human A549 cells assessed as cell growth inhibition measured for 72 hrs by MTT assay
    Anticancer activity against human A549 cells assessed as cell growth inhibition measured for 72 hrs by MTT assay
    		[PMID: 34303874]
    BEAS-2B IC50
    3.07 μM
    Compound: Chloroquine
    Anticancer activity against human BEAS-2B cells assessed as cell growth inhibition measured for 72 hrs by MTT assay
    Anticancer activity against human BEAS-2B cells assessed as cell growth inhibition measured for 72 hrs by MTT assay
    		[PMID: 34303874]
    BHK-21 CC50
    > 20 μM
    Compound: 1; CQ
    cytotoxicity against golden hamster BHK-21 cells incubated for 72 hrs by MTT assay
    cytotoxicity against golden hamster BHK-21 cells incubated for 72 hrs by MTT assay
    		[PMID: 32845145]
    BT-474 IC50
    > 1000 μM
    Compound: 29; CQ
    Cytotoxicity against human BT474 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human BT474 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 29211480]
    BT-483 GI50
    10.2 μM
    Compound: CQ
    Growth inhibition of human BT-483 cells after 48 hrs by MTT assay in presence of 10% FBS supplemented DMEM medium
    Growth inhibition of human BT-483 cells after 48 hrs by MTT assay in presence of 10% FBS supplemented DMEM medium
    		[PMID: 19748786]
    BXPC-3 IC50
    25 μM
    Compound: CQ, Lys01
    Antiproliferative activity against human BxPC3 cells after 72 hrs by SRB method
    Antiproliferative activity against human BxPC3 cells after 72 hrs by SRB method
    		[PMID: 25699157]
    Caco-2 GI50
    38.67 μM
    Compound: CQ, 1
    Antiproliferative activity against human Caco2 cells after 2 days by sulforhodamine B assay
    Antiproliferative activity against human Caco2 cells after 2 days by sulforhodamine B assay
    		[PMID: 24184076]
    CCRF-CEM IC50
    23 μM
    Compound: 1, CQ
    Cytotoxicity against human CEM cells assessed as inhibition of cell proliferation by Coulter counter analysis
    Cytotoxicity against human CEM cells assessed as inhibition of cell proliferation by Coulter counter analysis
    		[PMID: 26114811]
    CHO CC50
    155 μM
    Compound: Chloroquine
    Cytotoxicity against CHO cells assessed as cell viability after 24 hrs by MTT assay
    Cytotoxicity against CHO cells assessed as cell viability after 24 hrs by MTT assay
    		[PMID: 25791675]
    CHO IC50
    35.8 μM
    Compound: CQ
    Cytotoxicity against CHO cells by MTT assay
    Cytotoxicity against CHO cells by MTT assay
    		[PMID: 26832222]
    CHO IC50
    57.84 μM
    Compound: CQ
    Cytotoxicity against CHO cells by MTT assay
    Cytotoxicity against CHO cells by MTT assay
    		[PMID: 29559277]
    Erythrocyte CC50
    > 100 μg/mL
    Compound: Chloroquine
    Hemolytic activity in human erythrocytes measured after 1 hr by microtiter plate method
    Hemolytic activity in human erythrocytes measured after 1 hr by microtiter plate method
    		[PMID: 27667552]
    FM3A EC50
    32000 nM
    Compound: 1
    Cytotoxicity against mouse FM3A cells assessed as inhibition of increase in cell density after 48 hrs
    Cytotoxicity against mouse FM3A cells assessed as inhibition of increase in cell density after 48 hrs
    		[PMID: 18479926]
    HCA1 IC50
    > 10 μM
    Compound: CQ
    Cytotoxicity against mouse HCA1 cells assessed as cell viability by MTT assay
    Cytotoxicity against mouse HCA1 cells assessed as cell viability by MTT assay
    		[PMID: 34558909]
    HCC827 IC50
    76 μM
    Compound: CQ, Lys01
    Antiproliferative activity against human HCC827 cells after 72 hrs by SRB method
    Antiproliferative activity against human HCC827 cells after 72 hrs by SRB method
    		[PMID: 25699157]
    HCT-116 IC50
    33.7 μM
    Compound: 70
    Cytotoxicity against human HCT116 cells after 72 hrs by WST1 assay
    Cytotoxicity against human HCT116 cells after 72 hrs by WST1 assay
    		[PMID: 12398531]
    HCT-8 IC50
    27 nM
    Compound: chloroquine
    Antimicrobial activity against Cryptosporidium parvum infected in human HCT-8 cells after 48 hrs by ELISA
    Antimicrobial activity against Cryptosporidium parvum infected in human HCT-8 cells after 48 hrs by ELISA
    		[PMID: 18591280]
    HEK293 IC50
    > 10 μM
    Compound: Chloroquine
    Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue dye based fluorescence assay
    Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue dye based fluorescence assay
    		[PMID: 36799121]
    HEK293 IC50
    > 1000 μM
    Compound: CQ
    Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 24 hrs by neutral red dye based analysis
    Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 24 hrs by neutral red dye based analysis
    		[PMID: 33666415]
    HEK293 IC50
    > 120 nM
    Compound: Chloroquine
    Cytotoxicity against HEK293 cells by alamar blue assay
    Cytotoxicity against HEK293 cells by alamar blue assay
    		[PMID: 27212070]
    HEK293 IC50
    > 40 μM
    Compound: Chloroquine
    Cytotoxicity against HEK293 cells incubated for 72 hrs by resazurin dye based assay
    Cytotoxicity against HEK293 cells incubated for 72 hrs by resazurin dye based assay
    		[PMID: 31961680]
    HEK293 CC50
    ≥ 20 μM
    Compound: Chloroquine
    Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye based assay
    Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye based assay
    		[PMID: 30537832]
    HEK293 IC50
    0.49 μM
    Compound: Chloroquine
    Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye based assay
    Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye based assay
    		[PMID: 29236492]
    HEK293 IC50
    101.19 μM
    Compound: Chloroquine
    Cytotoxicity against human HEK293 cells incubated for 48 hrs by MTT assay
    Cytotoxicity against human HEK293 cells incubated for 48 hrs by MTT assay
    		[PMID: 33744688]
    HEK293 IC50
    12 μM
    Compound: chloroquine
    Cytotoxicity against human HEK293 cells after 72 hrs by alamar blue assay
    Cytotoxicity against human HEK293 cells after 72 hrs by alamar blue assay
    		[PMID: 21155593]
    HEK293 CC50
    20 μM
    Compound: Chloroquine
    Cytotoxicity against human HEK293 cells assessed as cell viability measured for 24 hrs by MTT assay
    Cytotoxicity against human HEK293 cells assessed as cell viability measured for 24 hrs by MTT assay
    		[PMID: 34303874]
    HEK293 IC50
    40 μM
    Compound: Chloroquine
    Cytotoxicity against HEK293 cells assessed as cell growth inhibition after 72 hrs by Alamar blue assay
    Cytotoxicity against HEK293 cells assessed as cell growth inhibition after 72 hrs by Alamar blue assay
    		[PMID: 28774427]
    HEK293 IC50
    48 μM
    Compound: Chloroquine
    Cytotoxicity against HEK293 cells after 72 hrs by Alamar Blue assay
    Cytotoxicity against HEK293 cells after 72 hrs by Alamar Blue assay
    		[PMID: 21190857]
    HEK-293T IC50
    > 50 μM
    Compound: 1, CQ
    Cytotoxicity against HEK293T cells assessed as cell viability after 48 hrs by MTT assay
    Cytotoxicity against HEK293T cells assessed as cell viability after 48 hrs by MTT assay
    		[PMID: 24077527]
    HEL CC50
    58.5 μM
    Compound: 1, CQ
    Cytotoxicity against human HEL cells assessed as inhibition of cell viability by colorimetric formazan-based MTS assay
    Cytotoxicity against human HEL cells assessed as inhibition of cell viability by colorimetric formazan-based MTS assay
    		[PMID: 26114811]
    HEL 299 CC50
    33.6 μM
    Compound: CQ
    Cytotoxicity against HEL 299 cells assessed as reduction in cell viability measured after 1 to 2 hrs by MTS colorimetric assay
    Cytotoxicity against HEL 299 cells assessed as reduction in cell viability measured after 1 to 2 hrs by MTS colorimetric assay
    		[PMID: 35571875]
    HeLa IC50
    > 100 μM
    Compound: CQ
    Cytotoxicity against human HeLa cells by MTT assay
    Cytotoxicity against human HeLa cells by MTT assay
    		[PMID: 22858300]
    HeLa EC50
    > 100 μM
    Compound: 1, CQ
    Antiviral activity against Vesicular stomatitis virus infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect by visual scoring analysis
    Antiviral activity against Vesicular stomatitis virus infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect by visual scoring analysis
    		[PMID: 26114811]
    HeLa EC50
    > 100 μM
    Compound: 1, CQ
    Antiviral activity against Coxsackievirus B4 infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect by visual scoring analysis
    Antiviral activity against Coxsackievirus B4 infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect by visual scoring analysis
    		[PMID: 26114811]
    HeLa EC50
    > 100 μM
    Compound: 1, CQ
    Antiviral activity against Respiratory syncytial virus infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect by visual scoring analysis
    Antiviral activity against Respiratory syncytial virus infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect by visual scoring analysis
    		[PMID: 26114811]
    HeLa CC50
    > 1000 μg/mL
    Compound: CQ
    Cytotoxic activity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    Cytotoxic activity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    		[PMID: 25920564]
    HeLa IC50
    > 1000 μM
    Compound: CQ
    Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 24 hrs by neutral red dye based analysis
    Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 24 hrs by neutral red dye based analysis
    		[PMID: 33666415]
    HeLa IC50
    12.48 μM
    Compound: CQ
    Antiviral activity against VSV-G pseudotyped HIV1 lentiviral particles infected in human HeLa cells incubated for 48 hrs by spectrofluorometry
    Antiviral activity against VSV-G pseudotyped HIV1 lentiviral particles infected in human HeLa cells incubated for 48 hrs by spectrofluorometry
    		[PMID: 22858300]
    HeLa IC50
    18 μM
    Compound: 1, CQ
    Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation by Coulter counter analysis
    Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation by Coulter counter analysis
    		[PMID: 26114811]
    HeLa GI50
    18.6 μM
    Compound: CQ
    Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 10% FBS supplemented DMEM medium
    Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 10% FBS supplemented DMEM medium
    		[PMID: 19748786]
    HeLa EC50
    19.6 μM
    Compound: Chloroquine
    Inhibition of lysosomal acidification in human HeLa cells incubated for 3 hrs by LysoTracker Red DND-99 staining based array scan method
    Inhibition of lysosomal acidification in human HeLa cells incubated for 3 hrs by LysoTracker Red DND-99 staining based array scan method
    		[PMID: 32356659]
    HeLa GI50
    2.1 μM
    Compound: CQ
    Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 100 uM ZnCl2
    Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 100 uM ZnCl2
    		[PMID: 19748786]
    HeLa IC50
    29.96 μM
    Compound: Chloroquine
    Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay
    Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay
    		[PMID: 26602827]
    HeLa GI50
    4.4 μM
    Compound: CQ
    Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 50 uM CuCl2
    Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 50 uM CuCl2
    		[PMID: 19748786]
    HeLa GI50
    5.3 μM
    Compound: CQ
    Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 10 uM CuCl2
    Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 10 uM CuCl2
    		[PMID: 19748786]
    HeLa GI50
    5.6 μM
    Compound: CQ
    Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 50 uM ZnCl2
    Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 50 uM ZnCl2
    		[PMID: 19748786]
    HeLa GI50
    6.1 μM
    Compound: CQ
    Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 1 uM CuCl2
    Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 1 uM CuCl2
    		[PMID: 19748786]
    HeLa IC50
    9.665 μM
    Compound: CQ
    Cytotoxicity against human HeLa cells assessed as cell survival after 7 hrs by MTT assay
    Cytotoxicity against human HeLa cells assessed as cell survival after 7 hrs by MTT assay
    		[PMID: 17768052]
    HeLa IC50
    9.67 μM
    Compound: Chloroquine
    Cytotoxicity against human HeLa cells after 7 days by MTT assay
    Cytotoxicity against human HeLa cells after 7 days by MTT assay
    		[PMID: 21489789]
    Hep 3B2 IC50
    > 10 μM
    Compound: CQ
    Cytotoxicity against human Hep3B cells assessed as cell viability by MTT assay
    Cytotoxicity against human Hep3B cells assessed as cell viability by MTT assay
    		[PMID: 34558909]
    HepG2 IC50
    > 10 μM
    Compound: CQ
    Cytotoxicity against human HepG2 cells assessed as cell viability by MTT assay
    Cytotoxicity against human HepG2 cells assessed as cell viability by MTT assay
    		[PMID: 34558909]
    HepG2 IC50
    > 10 μM
    Compound: CQ
    Cytotoxicity against human HepG2 cells after 48 hrs
    Cytotoxicity against human HepG2 cells after 48 hrs
    		[PMID: 24904967]
    HepG2 IC50
    > 10 μM
    Compound: CQ
    Antimalarial activity against exo-erythrocytic form of Plasmodium berghei infected in human HepG2 cells after 48 hrs
    Antimalarial activity against exo-erythrocytic form of Plasmodium berghei infected in human HepG2 cells after 48 hrs
    		[PMID: 24904967]
    HepG2 CC50
    > 1000 μg/mL
    Compound: CQ
    Cytotoxic activity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    Cytotoxic activity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    		[PMID: 25920564]
    HepG2 EC50
    > 10000 nM
    Compound: 36
    Antimicrobial activity against Plasmodium berghei sporozoites infected in 12 hrs compound pretreated human HepG2 cells assessed as reduction in viability of exoerythrocytic forms measured after 48 hrs of incubation by luciferase bioluminescence assay
    Antimicrobial activity against Plasmodium berghei sporozoites infected in 12 hrs compound pretreated human HepG2 cells assessed as reduction in viability of exoerythrocytic forms measured after 48 hrs of incubation by luciferase bioluminescence assay
    		[PMID: 24641010]
    HepG2 CC50
    > 30 μM
    Compound: CQ
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo assay
    		[PMID: 33620219]
    HepG2 CC50
    1.6 μM
    Compound: Chloroquine
    Cytotoxicity against human HepG2 cells expressing CD81 assessed as cell viability after 72 hrs by CellTiter-glo assay
    Cytotoxicity against human HepG2 cells expressing CD81 assessed as cell viability after 72 hrs by CellTiter-glo assay
    		[PMID: 25791675]
    HepG2 EC50
    10.1 μM
    Compound: Chloroquine
    Cytotoxicity against human HepG2 cells after 48 hrs by CellTiter-Glo assay
    Cytotoxicity against human HepG2 cells after 48 hrs by CellTiter-Glo assay
    		[PMID: 29800827]
    HepG2 EC50
    10430 nM
    Compound: CQ
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTS assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTS assay
    		[PMID: 32959656]
    HepG2 IC50
    116 μM
    Compound: CHL, CLQ
    Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay
    Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay
    		[PMID: 22380766]
    HepG2 IC50
    116 μM
    Compound: CQ
    Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay
    Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay
    		[PMID: 22321992]
    HepG2 IC50
    12.9 μM
    Compound: Chloroquine
    Cytotoxicity against human HepG2 cells after 72 hrs by Alamar Blue assay
    Cytotoxicity against human HepG2 cells after 72 hrs by Alamar Blue assay
    		[PMID: 21190857]
    HepG2 IC50
    12020 ng/mL
    Compound: CQ
    Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 25654185]
    HepG2 CC50
    137.42 μM
    Compound: CQ
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 30199706]
    HepG2 IC50
    1650 nM
    Compound: Chloroquine
    Antiplasmodial activity against liver stage of Plasmodium yoelii 17X NL sporozoites infected in human HepG2 cells expressing CD81 after 48 hrs by DAPI staining-based immunofluorescence analysis
    Antiplasmodial activity against liver stage of Plasmodium yoelii 17X NL sporozoites infected in human HepG2 cells expressing CD81 after 48 hrs by DAPI staining-based immunofluorescence analysis
    		[PMID: 25791675]
    HepG2 GI50
    22.16 μM
    Compound: CQ
    Cytotoxicity against human HepG2 cells after 48 hrs by lactate dehydrogenase assay
    Cytotoxicity against human HepG2 cells after 48 hrs by lactate dehydrogenase assay
    		[PMID: 21882831]
    HepG2 EC50
    25 μM
    Compound: CQ
    Cytotoxicity against human HepG2 cells assessed as intracellular ATP level after 72 hrs by Celltiter-Glo luminescent assay
    Cytotoxicity against human HepG2 cells assessed as intracellular ATP level after 72 hrs by Celltiter-Glo luminescent assay
    		[PMID: 21910466]
    HepG2 IC50
    25 μM
    Compound: CQ, chloroquine
    Cytotoxicity against human HepG2 cells assessed as reduction in cell number incubated for 72 hrs
    Cytotoxicity against human HepG2 cells assessed as reduction in cell number incubated for 72 hrs
    		[PMID: 26135471]
    HepG2 CC50
    30 μM
    Compound: Chloroquine
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    		[PMID: 34364164]
    HepG2 CC50
    30 μM
    Compound: Chloroquine
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
    		[PMID: 27654395]
    HepG2 CC50
    30 μM
    Compound: Chloroquine
    Cytotoxicity against human HepG2 cells measured after 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells measured after 72 hrs by MTT assay
    		[PMID: 27155463]
    HepG2 CC50
    30 μM
    Compound: Chloroquine
    Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay
    		[PMID: 25791675]
    HepG2 CC50
    30 μM
    Compound: Chloroquine
    Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay
    		[PMID: 25282267]
    HepG2 CC50
    30 μM
    Compound: Chloroquine
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    		[PMID: 24946216]
    HepG2 CC50
    30 μM
    Compound: Chloroquine
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    		[PMID: 24858543]
    HepG2 CC50
    30 μM
    Compound: Chloroquine
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    		[PMID: 22889559]
    HepG2 CC50
    30 μM
    Compound: Chloroquine
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    		[PMID: 22608675]
    HepG2 CC50
    30 μM
    Compound: Chloroquine
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    		[PMID: 21852132]
    HepG2 CC50
    30 μM
    Compound: Chloroquine
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    		[PMID: 21741131]
    HepG2 IC50
    30 μM
    Compound: chloroquine
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    		[PMID: 19926173]
    HepG2 IC50
    30 μM
    Compound: Chloroquine
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    		[PMID: 19482476]
    HepG2 IC50
    30 μM
    Compound: chloroquine
    Cytotoxicity against human HepG2 cells by MTT assay
    Cytotoxicity against human HepG2 cells by MTT assay
    		[PMID: 17981462]
    HepG2 IC50
    37577 nM
    Compound: CQ
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 34111350]
    HepG2 IC50
    37577 nM
    Compound: CQ
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 32390431]
    HepG2 IC50
    37577 nM
    Compound: CQ
    Cytotoxicity against human HepG2 cells measured after 24 to 36 hrs by resazurin dye based fluorescence assay
    Cytotoxicity against human HepG2 cells measured after 24 to 36 hrs by resazurin dye based fluorescence assay
    		[PMID: 30852885]
    HepG2 EC50
    384 μM
    Compound: Chloroquine
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay
    		[PMID: 29879353]
    HepG2 IC50
    384 μM
    Compound: Chloroquine
    Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay
    		[PMID: 33158577]
    HepG2 CC50
    393 μM
    Compound: 4
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay
    		[PMID: 29324340]
    HepG2 GI50
    43.09 μM
    Compound: CQ
    Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth after 48 hrs by LDH assay
    Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth after 48 hrs by LDH assay
    		[PMID: 25684422]
    HepG2 IC50
    49.02 μM
    Compound: Chloroquine
    Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured for 72 hrs by MTT assay
    Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured for 72 hrs by MTT assay
    		[PMID: 34303874]
    HepG2 CC50
    504.1 μM
    Compound: Chloroquine
    Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
    		[PMID: 23353738]
    HepG2 IC50
    73.7 μM
    Compound: CQ
    Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 24 hrs by neutral red dye based analysis
    Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 24 hrs by neutral red dye based analysis
    		[PMID: 33666415]
    HepG2 IC50
    8.3 μM
    Compound: chloroquine
    Cytotoxicity against human HepG2 cells after 72 hrs by alamar blue assay
    Cytotoxicity against human HepG2 cells after 72 hrs by alamar blue assay
    		[PMID: 21155593]
    HepG2 CC50
    810 μM
    Compound: 1
    Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
    		[PMID: 24469080]
    HFF-1 GI50
    > 100 μM
    Compound: CQ, 1
    Antiproliferative activity against human HFF1 cells after 2 days by sulforhodamine B assay
    Antiproliferative activity against human HFF1 cells after 2 days by sulforhodamine B assay
    		[PMID: 24184076]
    HL-60 IC50
    > 100 μM
    Compound: CQ
    Cytotoxicity against human HL60 cells after 24 hrs by MTT assay
    Cytotoxicity against human HL60 cells after 24 hrs by MTT assay
    		[PMID: 29398445]
    HL-60 GI50
    128 μM
    Compound: CQ
    Cytotoxicity against human HL60 cells by alamar blue assay
    Cytotoxicity against human HL60 cells by alamar blue assay
    		[PMID: 23266185]
    HMEC-1 IC50
    > 100 μM
    Compound: CQ
    Antiproliferative activity against SV40 large T-antigen 38 immortalized HMEC1 cells after 72 hrs by MTT assay
    Antiproliferative activity against SV40 large T-antigen 38 immortalized HMEC1 cells after 72 hrs by MTT assay
    		[PMID: 28128956]
    HMEC-1 IC50
    > 20 μM
    Compound: CQ
    Cytotoxicity against HMEC1 assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    Cytotoxicity against HMEC1 assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    		[PMID: 26081764]
    HMEC-1 CC50
    > 32000 nM
    Compound: CQ
    Cytotoxicity against HMEC1 cells after 72 hrs by MTT assay
    Cytotoxicity against HMEC1 cells after 72 hrs by MTT assay
    		[PMID: 20797868]
    HMEC-1 IC50
    > 32000 nM
    Compound: CQ
    Cytotoxicity against HMEC1 cells by MTT assay
    Cytotoxicity against HMEC1 cells by MTT assay
    		[PMID: 18562202]
    HMEC-1 IC50
    > 38 μM
    Compound: CQ
    Cytotoxicity against HMEC1 cells after 72 hrs by MTT assay
    Cytotoxicity against HMEC1 cells after 72 hrs by MTT assay
    		[PMID: 25497962]
    HMEC-1 CC50
    > 38 μM
    Compound: Chloroquine
    Cytotoxicity against HMEC1 assessed as cell growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against HMEC1 assessed as cell growth inhibition after 72 hrs by MTT assay
    		[PMID: 25311562]
    HMEC-1 IC50
    > 38000 nM
    Compound: CQ
    Cytotoxicity against human HMEC1 cells after 72 hrs by MTT assay
    Cytotoxicity against human HMEC1 cells after 72 hrs by MTT assay
    		[PMID: 22917857]
    HMEC-1 IC50
    > 38000 nM
    Compound: CQ
    Cytotoxicity against human HMEC1 cells after 72 hrs by MTT assay
    Cytotoxicity against human HMEC1 cells after 72 hrs by MTT assay
    		[PMID: 22901673]
    HMEC-1 IC50
    > 40 μM
    Compound: CQ
    Cytotoxicity in human HMEC1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxicity in human HMEC1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 30996801]
    HT-1080 ED50
    6.5 μg/mL
    Compound: chloroquine
    Cytotoxicity against human HT1080 cells after 3 days by sulforhodamine B assay
    Cytotoxicity against human HT1080 cells after 3 days by sulforhodamine B assay
    		[PMID: 8450319]
    HT-29 IC50
    3.6 μM
    Compound: CQ, Lys01
    Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
    Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
    		[PMID: 25699157]
    HT-29 IC50
    58000 ng/mL
    Compound: chloroquine
    Cytotoxicity against human HT-29 cells after 72 hrs by Alamar blue assay
    Cytotoxicity against human HT-29 cells after 72 hrs by Alamar blue assay
    		[PMID: 9644053]
    Huh-7 CC50
    > 100 μg/mL
    Compound: CQ
    Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 36306538]
    Huh-7 IC50
    > 15 μM
    Compound: CQ
    Antiplasmodial activity against liver stage of Plasmodium berghei expressing GFP-Luc infected in HuH7 cells incubated at 1 hr prior to infection followed by compound replenisment at 24 hrs post-infection measured after 48 hrs by Alamar blue assay
    Antiplasmodial activity against liver stage of Plasmodium berghei expressing GFP-Luc infected in HuH7 cells incubated at 1 hr prior to infection followed by compound replenisment at 24 hrs post-infection measured after 48 hrs by Alamar blue assay
    		[PMID: 23290049]
    Huh-7 CC50
    > 50 μM
    Compound: 1; CQ
    Cytotoxicity against human Huh-7 cells incubated for 1 hr by MTS assay
    Cytotoxicity against human Huh-7 cells incubated for 1 hr by MTS assay
    		[PMID: 32845145]
    Huh-7 IC50
    15.9 μM
    Compound: 1, CQ
    Antiplasmodial activity against Plasmodium berghei liver stage form transfected in human Huh-7 cells assessed as cell viability after 48 hrs by luciferase reporter gene assay
    Antiplasmodial activity against Plasmodium berghei liver stage form transfected in human Huh-7 cells assessed as cell viability after 48 hrs by luciferase reporter gene assay
    		[PMID: 23273038]
    J774 EC50
    47.2 μM
    Compound: CQ
    Cytotoxicity against mouse J774 cells after 72 hrs by CellTiter-96 aqueous one solution cell proliferation assay
    Cytotoxicity against mouse J774 cells after 72 hrs by CellTiter-96 aqueous one solution cell proliferation assay
    		[PMID: 29215279]
    J774.1 IC50
    18.4 μM
    Compound: Chloroquine
    Cytotoxicity against mouse J774.1 cells after 24 hrs by AlamarBlue based cytotoxicity assay
    Cytotoxicity against mouse J774.1 cells after 24 hrs by AlamarBlue based cytotoxicity assay
    		[PMID: 27316542]
    Jurkat IC50
    95 μM
    Compound: CQ
    Cytotoxicity against human Jurkat cells after 20 hrs by propidium iodide staining based flow cytometry
    Cytotoxicity against human Jurkat cells after 20 hrs by propidium iodide staining based flow cytometry
    		[PMID: 29398445]
    Jurkat E6.1 IC50
    83.64 μM
    Compound: CQ
    Cytotoxicity against human Jurkat E6-1 cells after 24 hrs by MTT assay
    Cytotoxicity against human Jurkat E6-1 cells after 24 hrs by MTT assay
    		[PMID: 29398445]
    K562 CC50
    > 25000 nM
    Compound: CQ
    Cytotoxicity against human K562 cells after 72 hrs by MTT assay
    Cytotoxicity against human K562 cells after 72 hrs by MTT assay
    		[PMID: 20797868]
    K562 IC50
    25.3 μM
    Compound: Chloroquine
    Toxicity in human K562 cells assessed as effect on cell growth measured after 24 hrs by [3H]thymidine incorporation based assay
    Toxicity in human K562 cells assessed as effect on cell growth measured after 24 hrs by [3H]thymidine incorporation based assay
    		[PMID: 32687714]
    K562 IC50
    29030 nM
    Compound: CQ
    Cytotoxicity against human K562 cells by MTT assay
    Cytotoxicity against human K562 cells by MTT assay
    		[PMID: 18562202]
    K562 IC50
    32 μM
    Compound: chloroquine
    Cytotoxicity against human K562 cells after 72 hrs by flow cytometry
    Cytotoxicity against human K562 cells after 72 hrs by flow cytometry
    		[PMID: 19926173]
    K562 IC50
    32 μM
    Compound: Chloroquine
    Cytotoxicity against human K562 cells after 72 hrs by flow cytometry
    Cytotoxicity against human K562 cells after 72 hrs by flow cytometry
    		[PMID: 19482476]
    K562 IC50
    43.8 μg/mL
    Compound: Chloroquine
    Cytotoxicity against Homo sapiens (human) K562 cells by Sulphorhodamine B assay
    Cytotoxicity against Homo sapiens (human) K562 cells by Sulphorhodamine B assay
    		10.1007/s00044-011-9694-1
    K562 CC50
    9.7 μM
    Compound: chloroquine
    Cytotoxicity against human K562 cells assessed as radioactive thymidine incorporation after 24 hrs
    Cytotoxicity against human K562 cells assessed as radioactive thymidine incorporation after 24 hrs
    		[PMID: 18680278]
    KB IC50
    110 μM
    Compound: CQ
    Cytotoxicity against human KB cells after 48 hrs by alamar blue assay
    Cytotoxicity against human KB cells after 48 hrs by alamar blue assay
    		[PMID: 18215443]
    KB ED50
    17.4 μg/mL
    Compound: chloroquine
    Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay
    Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay
    		[PMID: 8450319]
    KB ED50
    17.4 μg/mL
    Compound: chloroquine
    Cytotoxicity against human KB cells after 72 hrs
    Cytotoxicity against human KB cells after 72 hrs
    		[PMID: 11421741]
    KB IC50
    20.4 μM
    Compound: chloroquine
    Cytotoxicity against human KB cells after 48 hrs by MTT assay
    Cytotoxicity against human KB cells after 48 hrs by MTT assay
    		[PMID: 11809075]
    KB IC50
    22.5 μM
    Compound: chloroquine
    Cytotoxicity against human KB cells after 72 hrs by MTS assay
    Cytotoxicity against human KB cells after 72 hrs by MTS assay
    		[PMID: 19879150]
    KB ED50
    30.8 μM
    Compound: chloroquine
    Cytotoxicity against human KB cells by SRB assay
    Cytotoxicity against human KB cells by SRB assay
    		[PMID: 16562832]
    KB ED50
    33700 nM
    Compound: chloroquine
    Cytotoxicity against human KB cells after 72 hrs by SRB assay
    Cytotoxicity against human KB cells after 72 hrs by SRB assay
    		[PMID: 9917283]
    KB IC50
    34 μM
    Compound: CQ
    Cytotoxicity against human KB cells after 72 hrs by Alamar blue assay
    Cytotoxicity against human KB cells after 72 hrs by Alamar blue assay
    		[PMID: 24900724]
    KB CC50
    44 μM
    Compound: Chloroquine
    Cytotoxicity against human KB cells after 72 hrs by alamar blue assay
    Cytotoxicity against human KB cells after 72 hrs by alamar blue assay
    		[PMID: 20014857]
    KB IC50
    97725.5 nM
    Compound: Chloroquine
    Cytotoxicity against human KB cells assessed as cell viability after 24 hrs by MTT assay
    Cytotoxicity against human KB cells assessed as cell viability after 24 hrs by MTT assay
    		[PMID: 24148834]
    KB-V1 ED50
    7.8 μg/mL
    Compound: chloroquine
    Cytotoxicity against human KBV1 cells after 3 days by sulforhodamine B assay
    Cytotoxicity against human KBV1 cells after 3 days by sulforhodamine B assay
    		[PMID: 8450319]
    L02 IC50
    15 μM
    Compound: Chloroquine
    Anticancer activity against human L02 cells assessed as cell growth inhibition measured for 72 hrs by MTT assay
    Anticancer activity against human L02 cells assessed as cell growth inhibition measured for 72 hrs by MTT assay
    		[PMID: 34303874]
    L1210 IC50
    15 μM
    Compound: 1, CQ
    Cytotoxicity against mouse L1210 cells assessed as inhibition of cell proliferation by Coulter counter analysis
    Cytotoxicity against mouse L1210 cells assessed as inhibition of cell proliferation by Coulter counter analysis
    		[PMID: 26114811]
    L6 IC50
    0.007 μg/mL
    Compound: chloroquine
    Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay
    Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay
    		[PMID: 24056020]
    L6 IC50
    0.11 μg/mL
    Compound: Chloroquine
    Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 infected in rat L6 cells assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting
    Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 infected in rat L6 cells assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting
    		[PMID: 22352841]
    L6 IC50
    0.178 μM
    Compound: Chloroquine
    Antiparasitic activity against Plasmodium falciparum K1 infected in rat L6 cells assessed as inhibition of parasite growth preincubated for 48 hrs before [3H]hypoxanthine addition measured after 24 hrs by [3H]hypoxanthine incorporation assay
    Antiparasitic activity against Plasmodium falciparum K1 infected in rat L6 cells assessed as inhibition of parasite growth preincubated for 48 hrs before [3H]hypoxanthine addition measured after 24 hrs by [3H]hypoxanthine incorporation assay
    		[PMID: 21937228]
    L6 IC50
    116.9 μM
    Compound: chl
    Cytotoxicity against rat L6 cells after 70 hrs by Alamar blue assay
    Cytotoxicity against rat L6 cells after 70 hrs by Alamar blue assay
    		[PMID: 33148495]
    L6 IC50
    117 mM
    Compound: CQ
    Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay
    Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay
    		[PMID: 23871911]
    L6 IC50
    117 μM
    Compound: CQ
    Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay
    Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay
    		[PMID: 19928900]
    L6 IC50
    117 μM
    Compound: CQ
    Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay
    Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay
    		[PMID: 19606902]
    L6 IC50
    117 μM
    Compound: CQ
    Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay
    Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay
    		[PMID: 19267462]
    L6 IC50
    188.5 nM
    Compound: Chloroquine
    Cytotoxicity against rat L6 cells by alamar blue assay
    Cytotoxicity against rat L6 cells by alamar blue assay
    		[PMID: 17178177]
    L6 IC50
    188.5 μM
    Compound: CQ
    Cytotoxicity in rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay
    Cytotoxicity in rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay
    		[PMID: 30962114]
    L6 IC50
    188.5 μM
    Compound: CQ
    Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 72 hrs by Alamar blue assay
    Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 72 hrs by Alamar blue assay
    		[PMID: 27344215]
    L6 IC50
    188.5 μM
    Compound: Ch
    Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
    Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
    		[PMID: 25746816]
    L6 IC50
    188.5 μM
    Compound: Chl
    Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
    Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
    		[PMID: 19395265]
    L6 IC50
    188.5 μM
    Compound: Chl
    Cytotoxicity against rat L6 cells after 72 hrs by microplate fluorometry
    Cytotoxicity against rat L6 cells after 72 hrs by microplate fluorometry
    		[PMID: 23880082]
    L6 IC50
    188.5 μM
    Compound: chloroquine (chl)
    Cytotoxicity against rat L6 cells after 72 hrs by microplate alamar blue assay
    Cytotoxicity against rat L6 cells after 72 hrs by microplate alamar blue assay
    		[PMID: 18502136]
    L6 IC50
    188.5 μM
    Compound: chl
    Cytotoxicity against rat L6 cells after 72 hrs by microplate assay
    Cytotoxicity against rat L6 cells after 72 hrs by microplate assay
    		[PMID: 17544672]
    L6 IC50
    76.5 μM
    Compound: Chloroquine
    Cytotoxicity against rat L6 cells after 3 days by Alamar blue assay
    Cytotoxicity against rat L6 cells after 3 days by Alamar blue assay
    		[PMID: 24956553]
    L6 IC50
    76.5 μM
    Compound: CQ
    Cytotoxicity against rat L6 cells assessed as cell viability after 70 hrs by Alamar blue assay
    Cytotoxicity against rat L6 cells assessed as cell viability after 70 hrs by Alamar blue assay
    		[PMID: 24268543]
    L6 IC50
    76.5 μM
    Compound: CQ
    Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay
    Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay
    		[PMID: 23795673]
    L6 IC50
    78 μM
    Compound: CQ
    Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
    Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
    		[PMID: 25195945]
    L6 IC50
    90.92 μM
    Compound: CQ
    Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by alamar blue assay
    Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by alamar blue assay
    		[PMID: 28031151]
    L6 IC50
    90.92 μM
    Compound: CQ
    Cytotoxicity against rat L6 cells after 70 hrs by alamar blue staining based fluorometric assay
    Cytotoxicity against rat L6 cells after 70 hrs by alamar blue staining based fluorometric assay
    		[PMID: 28279559]
    L6 IC50
    91 μM
    Compound: Chloroquine
    Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by alamar blue assay
    Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by alamar blue assay
    		[PMID: 28284860]
    L6 IC50
    91 μM
    Compound: Chloroquine
    Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue based inverted microscopy analysis
    Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue based inverted microscopy analysis
    		[PMID: 31784198]
    L6 CC50
    92.8 μM
    Compound: CHQ
    Cytotoxicity against rat L6 cels assessed as reduction in cell viability after 72 hrs by Alamar Blue dye-based fluorometric analysis
    Cytotoxicity against rat L6 cels assessed as reduction in cell viability after 72 hrs by Alamar Blue dye-based fluorometric analysis
    		[PMID: 30615444]
    L929 IC50
    14 μg/mL
    Compound: Chloroquine
    Cytotoxicity against mouse L929 cells after 5 days by MTT assay
    Cytotoxicity against mouse L929 cells after 5 days by MTT assay
    		[PMID: 18922036]
    L929 EC50
    18.6 μg/mL
    Compound: chloroquine
    Cytotoxicity against mouse L929 cells by MTT assay
    Cytotoxicity against mouse L929 cells by MTT assay
    		[PMID: 16854076]
    LN-229 IC50
    3.6 μM
    Compound: CQ, Lys01
    Cytotoxicity against human LN229 cells after 72 hrs by MTT assay
    Cytotoxicity against human LN229 cells after 72 hrs by MTT assay
    		[PMID: 25699157]
    LNCaP ED50
    14.3 μg/mL
    Compound: chloroquine
    Cytotoxicity against human LNCAP cells after 3 days by sulforhodamine B assay
    Cytotoxicity against human LNCAP cells after 3 days by sulforhodamine B assay
    		[PMID: 8450319]
    LNCaP IC50
    32.87 μM
    Compound: CQ, chloroquine
    Cytotoxicity against human LNCAP cells assessed as reduction in cell number incubated for 72 hrs
    Cytotoxicity against human LNCAP cells assessed as reduction in cell number incubated for 72 hrs
    		[PMID: 26135471]
    Lymphocyte IC50
    > 100 μM
    Compound: CQ
    Cytotoxicity against human lymphocytes after 24 to 48 hrs by MTT assay
    Cytotoxicity against human lymphocytes after 24 to 48 hrs by MTT assay
    		[PMID: 29398445]
    Lymphocyte IC50
    12000 nM
    Compound: Chloroquine
    Cytotoxicity against C57B1/6J mouse splenic lymphocyte after 24 hrs by alamar blue assay
    Cytotoxicity against C57B1/6J mouse splenic lymphocyte after 24 hrs by alamar blue assay
    		[PMID: 20088608]
    Mahlavu IC50
    > 10 μM
    Compound: CQ
    Cytotoxicity against human Mahlavu cells assessed as cell viability by MTT assay
    Cytotoxicity against human Mahlavu cells assessed as cell viability by MTT assay
    		[PMID: 34558909]
    MCF-10A GI50
    81.26 μM
    Compound: CQ
    Antiproliferative activity against human MCF10A cells after 48 hrs by SRB assay
    Antiproliferative activity against human MCF10A cells after 48 hrs by SRB assay
    		[PMID: 20561720]
    MCF-10A GI50
    81.26 μM
    Compound: Chloroquine
    Cytotoxicity against human MCF10A cells after 48 hrs by SRB assay
    Cytotoxicity against human MCF10A cells after 48 hrs by SRB assay
    		[PMID: 20106668]
    MCF-10A GI50
    81.26 μM
    Compound: CQ
    Cytotoxicity against human MCF10A cells after 48 hrs by SRB assay
    Cytotoxicity against human MCF10A cells after 48 hrs by SRB assay
    		[PMID: 19804979]
    MCF7 IC50
    > 100 μg/mL
    Compound: chloroquine
    Cytotoxicity against human MCF7 cells assessed as [3H]hypoxanthin incorporation after 24 to 72 hrs
    Cytotoxicity against human MCF7 cells assessed as [3H]hypoxanthin incorporation after 24 to 72 hrs
    		[PMID: 19296616]
    MCF7 IC50
    13.2 μM
    Compound: 8
    Antiproliferative activity against human MCF7 cells measured after 2 days by SRB assay
    Antiproliferative activity against human MCF7 cells measured after 2 days by SRB assay
    		[PMID: 35231830]
    MCF7 CC50
    19.4 μM
    Compound: Chloroquine
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 20014857]
    MCF7 CC50
    19.4 μM
    Compound: Chloroquine
    Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 48 hrs by XTT assay
    Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 48 hrs by XTT assay
    		[PMID: 24594524]
    MCF7 CC50
    19.4 μM
    Compound: Chloroquine
    Cytotoxicity against human MCF7 cells after 48 hrs by XTT reduction assay
    Cytotoxicity against human MCF7 cells after 48 hrs by XTT reduction assay
    		[PMID: 24686013]
    MCF7 IC50
    23.43 μM
    Compound: CQ, chloroquine
    Cytotoxicity against human MCF7 cells assessed as reduction in cell number incubated for 72 hrs
    Cytotoxicity against human MCF7 cells assessed as reduction in cell number incubated for 72 hrs
    		[PMID: 26135471]
    MCF7 IC50
    36.1 μM
    Compound: CQ
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 19892554]
    MCF7 IC50
    38.44 μM
    Compound: CQ
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 28586716]
    MCF7 GI50
    38.44 μM
    Compound: CQ
    Antiproliferative activity against human p53+/- MCF7 cells after 48 hrs by SRB assay
    Antiproliferative activity against human p53+/- MCF7 cells after 48 hrs by SRB assay
    		[PMID: 20561720]
    MCF7 GI50
    38.44 μM
    Compound: Chloroquine
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    		[PMID: 20106668]
    MCF7 GI50
    38.44 μM
    Compound: CQ
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    		[PMID: 19804979]
    MCF7 GI50
    64.35 μM
    Compound: CQ, 1
    Antiproliferative activity against human MCF7 cells after 2 days by sulforhodamine B assay
    Antiproliferative activity against human MCF7 cells after 2 days by sulforhodamine B assay
    		[PMID: 24184076]
    MDA-MB-231 IC50
    22.52 μM
    Compound: CQ
    Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 28586716]
    MDA-MB-231 GI50
    22.52 μM
    Compound: CQ
    Antiproliferative activity against human p53, pRB mutant and estrogen receptor deficient MDA-MB-231 cells after 48 hrs by SRB assay
    Antiproliferative activity against human p53, pRB mutant and estrogen receptor deficient MDA-MB-231 cells after 48 hrs by SRB assay
    		[PMID: 20561720]
    MDA-MB-231 GI50
    22.52 μM
    Compound: CQ
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay
    		[PMID: 19804979]
    MDA-MB-231 IC50
    36.53 μM
    Compound: Chloroquine
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay
    		[PMID: 26602827]
    MDA-MB-361 IC50
    97 μM
    Compound: CQ, chloroquine
    Cytotoxicity against human MDA-MB-361 cells assessed as reduction in cell number incubated for 72 hrs
    Cytotoxicity against human MDA-MB-361 cells assessed as reduction in cell number incubated for 72 hrs
    		[PMID: 26135471]
    MDA-MB-468 IC50
    10.6 μM
    Compound: CQ
    Cytotoxicity against human MDA-MB-468 cells measured after 72 hrs by Celltiter-Glo assay
    Cytotoxicity against human MDA-MB-468 cells measured after 72 hrs by Celltiter-Glo assay
    		[PMID: 33200929]
    MDA-MB-468 IC50
    19.86 μM
    Compound: Chloroquine
    Antiproliferative activity against human MDA-MB-468 cells after 72 hrs by SRB assay
    Antiproliferative activity against human MDA-MB-468 cells after 72 hrs by SRB assay
    		[PMID: 26602827]
    MDA-MB-468 IC50
    28.58 μM
    Compound: CQ
    Cytotoxicity against human MDA-MB-468 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human MDA-MB-468 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 28586716]
    MDA-MB-468 GI50
    28.58 μM
    Compound: Chloroquine
    Cytotoxicity against human MDA-MB-468 cells after 48 hrs by SRB assay
    Cytotoxicity against human MDA-MB-468 cells after 48 hrs by SRB assay
    		[PMID: 20106668]
    MDA-MB-468 GI50
    28.58 μM
    Compound: CQ
    Cytotoxicity against human MDA-MB-468 cells after 48 hrs by SRB assay
    Cytotoxicity against human MDA-MB-468 cells after 48 hrs by SRB assay
    		[PMID: 19804979]
    MDCK CC50
    55.6 μM
    Compound: 1, CQ
    Cytotoxicity against MDCK cells assessed as inhibition of cell viability by colorimetric formazan-based MTS assay
    Cytotoxicity against MDCK cells assessed as inhibition of cell viability by colorimetric formazan-based MTS assay
    		[PMID: 26114811]
    MIA PaCa-2 EC50
    14 μM
    Compound: Chloroquine
    Antiproliferative activity against human MIA PaCa-2 cells assessed as cell viability measured after 72 hrs by MTT assay
    Antiproliferative activity against human MIA PaCa-2 cells assessed as cell viability measured after 72 hrs by MTT assay
    		[PMID: 28105281]
    MKN-28 GI50
    44.44 μM
    Compound: CQ, 1
    Antiproliferative activity against human MKN28 cells after 2 days by sulforhodamine B assay
    Antiproliferative activity against human MKN28 cells after 2 days by sulforhodamine B assay
    		[PMID: 24184076]
    MRC5 CC50
    50 μM
    Compound: CQ
    Cytotoxicity against human MRC5 cells after 7 days by MTT assay
    Cytotoxicity against human MRC5 cells after 7 days by MTT assay
    		[PMID: 18226428]
    MRC5 CC50
    50 μM
    Compound: chloroquine(CQ)
    Cytotoxic effect on human diploid embryonic lung cell line (MRC-5) using the colorimetric MTT assay
    Cytotoxic effect on human diploid embryonic lung cell line (MRC-5) using the colorimetric MTT assay
    		[PMID: 15357968]
    MRC5 CC50
    50 μM
    Compound: Chloroquine
    Cytotoxicity against human diploid embryonic lung cell line (MRC5 cells) using the colorimetric MTT assay
    Cytotoxicity against human diploid embryonic lung cell line (MRC5 cells) using the colorimetric MTT assay
    		[PMID: 14552779]
    MRC5 IC50
    50 μM
    Compound: Chloroquine
    Cytotoxicity tests were performed on a human diploid embryonic lung cell line (MRC5) using the colorimetric MTT assay
    Cytotoxicity tests were performed on a human diploid embryonic lung cell line (MRC5) using the colorimetric MTT assay
    		[PMID: 12182868]
    MRC5 CC50
    50 μM
    Compound: CQ
    Cytotoxicity against human diploid embryonic lung MRC5 cells by colorimetric MTT assay
    Cytotoxicity against human diploid embryonic lung MRC5 cells by colorimetric MTT assay
    		[PMID: 16263280]
    MRC5 IC50
    50000 nM
    Compound: CQ
    Cytotoxicity against human MRC5 cells after 5 days by MTT assay
    Cytotoxicity against human MRC5 cells after 5 days by MTT assay
    		[PMID: 18819813]
    MRC5 IC50
    58.2 μM
    Compound: Chloroquine
    Cytotoxicity against human MRC5 cells assessed as cell growth inhibition and measured after 2 days by WST-8 assay
    Cytotoxicity against human MRC5 cells assessed as cell growth inhibition and measured after 2 days by WST-8 assay
    		[PMID: 35512262]
    MRC5 IC50
    64 nM
    Compound: CQ
    Cytotoxicity against human MRC5 after 3 days
    Cytotoxicity against human MRC5 after 3 days
    		[PMID: 20329733]
    NCH89 IC50
    41.2 μM
    Compound: CQ
    Antiproliferative activity against human carmustine-resistant NCH-89 cells assessed as BrdU incorporation after 48 hrs
    Antiproliferative activity against human carmustine-resistant NCH-89 cells assessed as BrdU incorporation after 48 hrs
    		[PMID: 20329733]
    NCI-H460 IC50
    52 μM
    Compound: CQ, Lys01
    Antiproliferative activity against human H460 cells after 72 hrs by SRB method
    Antiproliferative activity against human H460 cells after 72 hrs by SRB method
    		[PMID: 25699157]
    NFF IC50
    > 1000 μM
    Compound: CQ
    Cytotoxicity against human NFF cells after 3 days by SRB assay
    Cytotoxicity against human NFF cells after 3 days by SRB assay
    		[PMID: 24084158]
    NFF IC50
    34 μM
    Compound: Chloroquine
    Cytotoxicity against human NFF assessed as growth inhibition after 3 days by sulforhodamine B assay
    Cytotoxicity against human NFF assessed as growth inhibition after 3 days by sulforhodamine B assay
    		[PMID: 22269277]
    NFF IC50
    37.3 μM
    Compound: Chloroquine
    Cytotoxicity against human NFF cells after 3 days by sulforhodamine B assay
    Cytotoxicity against human NFF cells after 3 days by sulforhodamine B assay
    		[PMID: 23117170]
    NFF IC50
    45900 nM
    Compound: chloroquine
    Cytotoxicity against human NFF after 72 hrs by SRB assay
    Cytotoxicity against human NFF after 72 hrs by SRB assay
    		[PMID: 24900794]
    NIH3T3 IC50
    > 50 μM
    Compound: 1, CQ
    Cytotoxicity against mouse NIH/3T3 cells assessed as cell viability after 48 hrs by MTT assay
    Cytotoxicity against mouse NIH/3T3 cells assessed as cell viability after 48 hrs by MTT assay
    		[PMID: 24077527]
    NIH3T3 IC50
    71954 nM
    Compound: CQ
    Cytotoxicity against mouse 3T3 cells after 48 hrs by MTT assay
    Cytotoxicity against mouse 3T3 cells after 48 hrs by MTT assay
    		[PMID: 22055713]
    NSC CC50
    94.95 μM
    Compound: 38
    Cytotoxicity against human NSC after 5 days by CellTiter Blue assay
    Cytotoxicity against human NSC after 5 days by CellTiter Blue assay
    		[PMID: 31549836]
    P388 ED50
    > 5 μg/mL
    Compound: chloroquine
    Cytotoxicity against mouse P388 cells after 2 days by sulforhodamine B assay
    Cytotoxicity against mouse P388 cells after 2 days by sulforhodamine B assay
    		[PMID: 8450319]
    PBMC IC50
    5.1 μM
    Compound: chloroquine
    Antiproliferative activity against PHA-stimulated human PBMC after 72 hrs by MTT assay
    Antiproliferative activity against PHA-stimulated human PBMC after 72 hrs by MTT assay
    		[PMID: 18222568]
    Peritoneal macrophage cell CC50
    88.6 μM
    Compound: CQ
    Cytotoxicity against mouse peritoneal macrophages after 48 hrs by trypan blue exclusion method
    Cytotoxicity against mouse peritoneal macrophages after 48 hrs by trypan blue exclusion method
    		[PMID: 21724395]
    SH-SY5Y CC50
    30 μM
    Compound: CQ
    Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay
    Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay
    		[PMID: 29559198]
    SK-BR-3 IC50
    50.37 μM
    Compound: CQ, chloroquine
    Cytotoxicity against human SKBR3 cells assessed as reduction in cell number incubated for 72 hrs
    Cytotoxicity against human SKBR3 cells assessed as reduction in cell number incubated for 72 hrs
    		[PMID: 26135471]
    SK-MEL-2 ED50
    > 20 μg/mL
    Compound: chloroquine
    Cytotoxicity against human SK-MEL-2 cells after 3 days by sulforhodamine B assay
    Cytotoxicity against human SK-MEL-2 cells after 3 days by sulforhodamine B assay
    		[PMID: 8450319]
    Splenocyte IC50
    3.46 μM
    Compound: CQ
    Cytotoxicity against concanavalin-stimulated BALB/c mouse splenocytes after 72 hrs by resazurin dye reduction method
    Cytotoxicity against concanavalin-stimulated BALB/c mouse splenocytes after 72 hrs by resazurin dye reduction method
    		[PMID: 19908867]
    SW480 IC50
    14.7 μM
    Compound: 8
    Antiproliferative activity against human SW480 cells measured after 3 days by SRB assay
    Antiproliferative activity against human SW480 cells measured after 3 days by SRB assay
    		[PMID: 35231830]
    THP-1 IC50
    40 μM
    Compound: Chloroquine
    Cytotoxicity against human THP1 cells assessed as cell viability after 72 hrs by Alamar blue assay
    Cytotoxicity against human THP1 cells assessed as cell viability after 72 hrs by Alamar blue assay
    		[PMID: 19914747]
    THP-1 IC50
    40 μM
    Compound: Chloroquine
    Cytotoxicity against human THP1 cells using propidium iodide staining after 72 hrs by flow cytometry
    Cytotoxicity against human THP1 cells using propidium iodide staining after 72 hrs by flow cytometry
    		[PMID: 20638854]
    THP-1 IC50
    40 μM
    Compound: chloroquine
    Cytotoxicity against human THP1 cells by MTT assay
    Cytotoxicity against human THP1 cells by MTT assay
    		[PMID: 17981462]
    THP-1 IC50
    40 μM
    Compound: Chloroquine
    Cytotoxicity against human THP1 cells after 72 hrs by propidium iodide staining-based flow cytometry
    Cytotoxicity against human THP1 cells after 72 hrs by propidium iodide staining-based flow cytometry
    		[PMID: 19748781]
    Vero CC50
    > 100 μM
    Compound: 4
    Cytotoxicity against african green monkey Vero cells incubated for 3 days
    Cytotoxicity against african green monkey Vero cells incubated for 3 days
    		[PMID: 32539378]
    Vero IC50
    > 14.88 μM
    Compound: CQ
    Cytotoxicity against African green monkey Vero cells after 48 hrs by neutral red uptake assay
    Cytotoxicity against African green monkey Vero cells after 48 hrs by neutral red uptake assay
    		[PMID: 27936446]
    Vero CC50
    > 150 μM
    Compound: Chloroquine
    Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr
    Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr
    		10.1101/2020.03.20.999730
    Vero CC50
    > 25 μM
    Compound: Chloroquine
    Cytotoxicity against African green monkey Vero cells infected with SARS-CoV-2 betaCoV/KOR/KCDC03/2020 assessed as reduction in cell viability measured after 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
    Cytotoxicity against African green monkey Vero cells infected with SARS-CoV-2 betaCoV/KOR/KCDC03/2020 assessed as reduction in cell viability measured after 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
    		[PMID: 33160024]
    Vero CC50
    > 500 μM
    Compound: CQ
    Cytotoxicity against African green monkey Vero cells measured after 72 hrs by resazurin assay
    Cytotoxicity against African green monkey Vero cells measured after 72 hrs by resazurin assay
    		[PMID: 30469040]
    Vero CC50
    > 500 μM
    Compound: Chloroquine
    Cytotoxicity against African green monkey Vero cells after 3 days by resazurin dye based fluorescence assay
    Cytotoxicity against African green monkey Vero cells after 3 days by resazurin dye based fluorescence assay
    		[PMID: 29940466]
    Vero EC50
    10 μM
    Compound: chloroquine
    Antiviral activity against Chikungunya virus 899 infected in African green monkey Vero cells assessed as inhibition of virus-induced cell death after 6 to 7 days by MTS assay
    Antiviral activity against Chikungunya virus 899 infected in African green monkey Vero cells assessed as inhibition of virus-induced cell death after 6 to 7 days by MTS assay
    		[PMID: 24926807]
    Vero EC50
    10 μM
    Compound: chloroquine
    Antiviral activity against chikungunya virus Indian ocean strain 899 infected in Vero cells assessed as virus-induced cytopathic effect after 6 to 7 days
    Antiviral activity against chikungunya virus Indian ocean strain 899 infected in Vero cells assessed as virus-induced cytopathic effect after 6 to 7 days
    		[PMID: 25970561]
    Vero EC50
    11 μM
    Compound: chloroquine
    Antiviral activity against Sindbis virus HRsp infected in African green monkey Vero cells assessed as inhibition of virus-induced cell death after 6 to 7 days by MTS assay
    Antiviral activity against Sindbis virus HRsp infected in African green monkey Vero cells assessed as inhibition of virus-induced cell death after 6 to 7 days by MTS assay
    		[PMID: 24926807]
    Vero EC50
    11 μM
    Compound: Chloroquine
    Antiviral activity against Sindbis virus HRsp infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 6 to 7 days by MTS assay
    Antiviral activity against Sindbis virus HRsp infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 6 to 7 days by MTS assay
    		[PMID: 23215460]
    Vero EC50
    11 μM
    Compound: Chloroquine
    Antiviral activity against Chikungunya virus 899 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 6 to 7 days by MTS assay
    Antiviral activity against Chikungunya virus 899 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 6 to 7 days by MTS assay
    		[PMID: 23215460]
    Vero EC50
    11 μM
    Compound: chloroquine
    Antiviral activity against Chikungunya virus Indian Ocean strain 899 infected in African green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 7 days by MTS/PMS method
    Antiviral activity against Chikungunya virus Indian Ocean strain 899 infected in African green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 7 days by MTS/PMS method
    		[PMID: 24800626]
    Vero EC50
    11 μM
    Compound: chloroquine
    Antiviral activity against Chikungunya virus strain 899 infected in african green monkey Vero cells assessed as inhibition of virus induced cell death measured after 7 days
    Antiviral activity against Chikungunya virus strain 899 infected in african green monkey Vero cells assessed as inhibition of virus induced cell death measured after 7 days
    		[PMID: 25946116]
    Vero EC50
    11 μM
    Compound: chloroquine
    Antiviral activity against Sindbis virus strain HRsp infected in african green monkey Vero cells assessed as inhibition of virus induced cell death measured after 7 days
    Antiviral activity against Sindbis virus strain HRsp infected in african green monkey Vero cells assessed as inhibition of virus induced cell death measured after 7 days
    		[PMID: 25946116]
    Vero IC50
    125 ng/mL
    Compound: Chloroquine
    Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method
    Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method
    		[PMID: 19914074]
    Vero CC50
    125 μM
    Compound: Chloroquine
    Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
    Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
    		[PMID: 26338359]
    Vero CC50
    125.9 μM
    Compound: Chloroquine
    Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
    Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
    		[PMID: 23354072]
    Vero EC50
    13.8 μM
    Compound: chloroquine
    Antiviral activity against Semliki forest virus Vietnam infected in African green monkey Vero cells assessed as inhibition of virus-induced cell death after 6 to 7 days by MTS assay
    Antiviral activity against Semliki forest virus Vietnam infected in African green monkey Vero cells assessed as inhibition of virus-induced cell death after 6 to 7 days by MTS assay
    		[PMID: 24926807]
    Vero EC50
    14 μM
    Compound: Chloroquine
    Antiviral activity against Semliki forest virus infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 6 to 7 days by MTS assay
    Antiviral activity against Semliki forest virus infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 6 to 7 days by MTS assay
    		[PMID: 23215460]
    Vero EC50
    14 μM
    Compound: chloroquine
    Antiviral activity against Semliki forest virus strain Vietnam infected in african green monkey Vero cells assessed as inhibition of virus induced cell death measured after 7 days
    Antiviral activity against Semliki forest virus strain Vietnam infected in african green monkey Vero cells assessed as inhibition of virus induced cell death measured after 7 days
    		[PMID: 25946116]
    Vero IC50
    17 ng/mL
    Compound: Chloroquine
    Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method
    Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method
    		[PMID: 19914074]
    Vero IC50
    21 μM
    Compound: Chloroquine
    Cytotoxicity against african green monkey Vero cells assessed as growth inhibition after 72 hrs by MTS assay
    Cytotoxicity against african green monkey Vero cells assessed as growth inhibition after 72 hrs by MTS assay
    		[PMID: 23727538]
    Vero CC50
    226 μM
    Compound: Chloroquine
    Cytotoxicity against African green monkey Vero cells measured after 3 days by resazurin dye based fluorescence assay
    Cytotoxicity against African green monkey Vero cells measured after 3 days by resazurin dye based fluorescence assay
    		[PMID: 28319782]
    Vero IC50
    234.47 μM
    Compound: CQ
    Cytotoxicity against African green monkey Vero cells by MTS assay
    Cytotoxicity against African green monkey Vero cells by MTS assay
    		[PMID: 26748697]
    Vero CC50
    235109 nM
    Compound: Chloroquine
    Cytotoxicity against african green monkey Vero C1008 cells after 72 hrs by MTT assay
    Cytotoxicity against african green monkey Vero C1008 cells after 72 hrs by MTT assay
    		[PMID: 23270565]
    Vero CC50
    412 μM
    Compound: Chloroquine
    Cytotoxicity against African green monkey Vero cells after 72 hrs by XTT assay
    Cytotoxicity against African green monkey Vero cells after 72 hrs by XTT assay
    		[PMID: 28092859]
    Vero CC50
    412 μM
    Compound: Chloroquine
    Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by XTT assay
    Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by XTT assay
    		[PMID: 28068604]
    Vero IC50
    48.5 μg/mL
    Compound: Chloroquinec
    Cytotoxicity against african green monkey Vero cells by MTT assay
    Cytotoxicity against african green monkey Vero cells by MTT assay
    		[PMID: 18855442]
    Vero IC50
    484 nM
    Compound: Chloroquine
    Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in African green monkey (Cercopithecus aethiops) (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs
    Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in African green monkey (Cercopithecus aethiops) (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs
    		[PMID: 19833520]
    Vero IC50
    5.2 ng/mL
    Compound: CQ
    Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in African green monkey (Cercopithecus aethiops) Vero cells after 72 hrs by twofold serial dilution method
    Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in African green monkey (Cercopithecus aethiops) Vero cells after 72 hrs by twofold serial dilution method
    		[PMID: 19665899]
    Vero IC50
    50 nM
    Compound: Chloroquine
    Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs
    Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs
    		[PMID: 19833520]
    Vero CC50
    684.68 μM
    Compound: 16, CQ
    Cytotoxicity against african green monkey Vero cells after 2 days by resazurin assay
    Cytotoxicity against african green monkey Vero cells after 2 days by resazurin assay
    		[PMID: 25147607]
    Vero IC50
    7.28 μM
    Compound: Chloroquine
    Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr
    Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr
    		10.1101/2020.03.20.999730
    Vero CC50
    75 μM
    Compound: Chloroquine
    Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay
    Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay
    		[PMID: 28763644]
    Vero CC50
    75000 ng/mL
    Compound: CQ
    Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
    Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
    		[PMID: 23182089]
    Vero CC50
    89 μM
    Compound: chloroquine
    Cytotoxicity against African green monkey Vero cells assessed as inhibition of overall cell metabolism after 6 to 7 days by MTS assay
    Cytotoxicity against African green monkey Vero cells assessed as inhibition of overall cell metabolism after 6 to 7 days by MTS assay
    		[PMID: 24926807]
    Vero CC50
    89 μM
    Compound: chloroquine
    Cytotoxicity against african green monkey Vero cells assessed as inhibition of cell metabolism after 72 hrs by MTS assay
    Cytotoxicity against african green monkey Vero cells assessed as inhibition of cell metabolism after 72 hrs by MTS assay
    		[PMID: 25946116]
    Vero CC50
    89 μM
    Compound: Chloroquine
    Cytotoxicity against African green monkey Vero cells by MTS assay
    Cytotoxicity against African green monkey Vero cells by MTS assay
    		[PMID: 30681849]
    Vero CC50
    89 μM
    Compound: Chloroquine
    Cytotoxicity against african green monkey Vero cells by MTS assay
    Cytotoxicity against african green monkey Vero cells by MTS assay
    		[PMID: 23215460]
    Vero CC50
    89 μM
    Compound: Chloroquine
    Cytotoxicity against African green monkey Vero cells assessed as decrease in cell viability after 5 days by MTS/PMS method
    Cytotoxicity against African green monkey Vero cells assessed as decrease in cell viability after 5 days by MTS/PMS method
    		[PMID: 29336951]
    Vero CC50
    89 μM
    Compound: chloroquine
    Cytotoxicity against non-infected African green monkey Vero cells after 7 days by MTS/PMS method
    Cytotoxicity against non-infected African green monkey Vero cells after 7 days by MTS/PMS method
    		[PMID: 24800626]
    Vero CC50
    89 μM
    Compound: Chloroquine
    Cytotoxicity against African green monkey Vero cells by MTS/PMS assay
    Cytotoxicity against African green monkey Vero cells by MTS/PMS assay
    		[PMID: 29499487]
    Vero CC50
    94.95 μM
    Compound: 38
    Cytotoxicity against African green monkey Vero cells after 5 days by CellTiter Blue assay
    Cytotoxicity against African green monkey Vero cells after 5 days by CellTiter Blue assay
    		[PMID: 31549836]
    Vero C1008 CC50
    > 100 μM
    Compound: CQ
    Cytotoxicity against African green monkey Vero E6 cells assessed as cell growth inhibition incubated for 48 hrs by CCK8 assay
    Cytotoxicity against African green monkey Vero E6 cells assessed as cell growth inhibition incubated for 48 hrs by CCK8 assay
    		[PMID: 32771797]
    Vero C1008 CC50
    > 100 μM
    Compound: CQ
    Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability measured after 48 hrs by CCK-8 assay
    Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability measured after 48 hrs by CCK-8 assay
    		[PMID: 32563814]
    Vero C1008 CC50
    > 100 μM
    Compound: 1
    Cytotoxicity against African green monkey Vero E6 cells by CCK-8 assay
    Cytotoxicity against African green monkey Vero E6 cells by CCK-8 assay
    		[PMID: 33486200]
    Vero C1008 CC50
    > 100 μM
    Compound: 1; CQ
    Cytotoxicity against African green monkey Vero E6 cells by the CCK8 assay
    Cytotoxicity against African green monkey Vero E6 cells by the CCK8 assay
    		[PMID: 32845145]
    Vero C1008 CC50
    > 128 μM
    Compound: 1; CQ
    Cytotoxicity against African green monkey Vero E6 cells incubated for 3 days by the MTS assay
    Cytotoxicity against African green monkey Vero E6 cells incubated for 3 days by the MTS assay
    		[PMID: 32845145]
    Vero C1008 CC50
    249.5 μM
    Compound: Chloroquine
    Cytotoxicity against african green monkey Vero E6 cells by CCK8 assay
    Cytotoxicity against african green monkey Vero E6 cells by CCK8 assay
    		[PMID: 33609889]
    Vero C1008 CC50
    261 μM
    Compound: 1; CQ
    Cytotoxicity against African green monkey Vero E6 cells by the MTS assay
    Cytotoxicity against African green monkey Vero E6 cells by the MTS assay
    		[PMID: 32845145]
    Vero C1008 CC50
    83.4 μM
    Compound: CQ
    Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability measured after 1 to 2 hrs by MTS colorimetric assay
    Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability measured after 1 to 2 hrs by MTS colorimetric assay
    		[PMID: 35571875]
    WEHI ED50
    9.7 μM
    Compound: 1
    Cytotoxicity against mouse WEHI cell line by MTT assay
    Cytotoxicity against mouse WEHI cell line by MTT assay
    		[PMID: 16890433]
    WI-38 EC50
    1.7 μM
    Compound: Chloroquine
    Antiviral activity against BKV Gardner ATCC VR837 infected in human WI38 cells assessed as reduction in viral DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay
    Antiviral activity against BKV Gardner ATCC VR837 infected in human WI38 cells assessed as reduction in viral DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay
    		[PMID: 17893158]
    WI-38 IC50
    3.63 μM
    Compound: CQ
    Cytotoxicity against human WI38 cells assessed as inhibition of proliferation after 24 hrs by SRB assay
    Cytotoxicity against human WI38 cells assessed as inhibition of proliferation after 24 hrs by SRB assay
    		[PMID: 25461309]
    WI-38 CC50
    8.5 μM
    Compound: Chloroquine
    Cytotoxicity against human WI38 cells assessed as reduction in cellular DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay
    Cytotoxicity against human WI38 cells assessed as reduction in cellular DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay
    		[PMID: 17893158]
    ZR-75-1 ED50
    1.2 μg/mL
    Compound: chloroquine
    Cytotoxicity against human ZR-75-1 cells after 3 days by sulforhodamine B assay
    Cytotoxicity against human ZR-75-1 cells after 3 days by sulforhodamine B assay
    		[PMID: 8450319]
    體外研究
    (In Vitro)

    Chloroquine (CHQ, 20 μM) 抑制 IL-12p70 釋放并降低活化的人單核細(xì)胞衍生的朗格漢斯樣細(xì)胞 (MoLC) 的 Th1 啟動(dòng)能力。
    Chloroquine (20 μM) 增強(qiáng) MoLC 中 IL-1 誘導(dǎo)的 IL-23 分泌，隨后增加 CD4+ T 細(xì)胞釋放 IL-17A[1]。
    Chloroquine (25 μM) 在親本 MDA-MB-231 細(xì)胞中抑制常氧和缺氧條件下的 MMP-9 mRNA 表達(dá)。Chloroquine 對(duì) MMP-2、MMP-9 和 MMP-13 mRNA 表達(dá)具有細(xì)胞、劑量和缺氧依賴性作用[2]。
    使用 IRS-954 或 Chloroquine 抑制 TLR7 和 TLR9 在體外顯著降低 HuH7 細(xì)胞增殖[3]。
    Chloroquine (0.01-100 μM；48 小時(shí)) 有效阻斷病毒感染 vero E6 細(xì)胞，抑制 SARS-CoV-2 感染具有低微摩爾濃度 (EC50=1.13 μM)。
    Chloroquine 通過增加病毒/細(xì)胞融合所需的內(nèi)體 pH 值以及干擾 SARS-CoV 細(xì)胞受體的糖基化來阻斷病毒感染[4]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    體內(nèi)研究
    (In Vivo)

    Chloroquine (80 mg/kg，ip) 不會(huì)阻止原位小鼠模型中具有高或低 TLR9 表達(dá)水平的三陰性 MDA-MB-231 細(xì)胞的生長(zhǎng)[2]。
    使用 IRS-954 或 Chloroquine 抑制 TLR7 和 TLR9 可顯著抑制小鼠異種移植模型中的腫瘤生長(zhǎng)。Chloroquine也顯著抑制了 DEN/NMOR 大鼠模型中 HCC 的發(fā)展[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    319.87

    Formula

    C18H26ClN3
    CAS 號(hào)
    性狀

    固體

    顏色

    White to light yellow

    中文名稱

    氯喹
    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲(chǔ)存方式

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    溶解性數(shù)據(jù)
    細(xì)胞實(shí)驗(yàn)： 

    Ethanol 中的溶解度 : 100 mg/mL (312.63 mM; 超聲助溶)

    DMSO 中的溶解度 : 50 mg/mL (156.31 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

    配制儲(chǔ)備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 3.1263 mL 15.6314 mL 31.2627 mL
    5 mM 0.6253 mL 3.1263 mL 6.2525 mL
    查看完整儲(chǔ)備液配制表

    * 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

    • 摩爾計(jì)算器

    • 稀釋計(jì)算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動(dòng)物實(shí)驗(yàn)：

    請(qǐng)根據(jù)您的 實(shí)驗(yàn)動(dòng)物和給藥方式 選擇適當(dāng)?shù)娜芙夥桨浮?

    以下溶解方案都請(qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：
    ——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
    以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

    • 方案 一

      請(qǐng)依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (7.82 mM); 澄清溶液

      此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

      以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水 定容至 1 mL。

      生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
    • 方案 二

      請(qǐng)依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (7.82 mM); 澄清溶液

      此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

      以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液 中，混合均勻。

      2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。

    以下溶解方案，請(qǐng)直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶。

    • 方案 一

      請(qǐng)依序添加每種溶劑： 50% PEG300    50% Saline

      Solubility: 10 mg/mL (31.26 mM); 懸濁液; Need ultrasonic and warming and heat to 44°C

    • 方案 二

      請(qǐng)依序添加每種溶劑： 15% Cremophor EL    85% Saline

      Solubility: 10 mg/mL (31.26 mM); 澄清溶液; 超聲助溶

    動(dòng)物溶解方案計(jì)算器
    請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

    給藥劑量

    mg/kg

    動(dòng)物的平均體重

    g

    每只動(dòng)物的給藥體積

    μL

    動(dòng)物數(shù)量

    只
    由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量
    請(qǐng)輸入您的動(dòng)物體內(nèi)配方組成：
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    如果您的動(dòng)物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過 2%。
    方案所需 助溶劑 包括：DMSO， ，均可在 MCE 網(wǎng)站選購。 ，Tween 80，均可在 MCE 網(wǎng)站選購。
    計(jì)算結(jié)果
    工作液所需濃度 : mg/mL
    儲(chǔ)備液配制方法 : mg 藥物溶于 μL  DMSO（母液濃度為 mg/mL）。

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    您所需的儲(chǔ)備液濃度超過該產(chǎn)品的實(shí)測(cè)溶解度，以下方案僅供參考，如有需要，請(qǐng)與 MCE 中國技術(shù)支持聯(lián)系。
    動(dòng)物實(shí)驗(yàn)體內(nèi)工作液的配制方法 : 取 μL DMSO 儲(chǔ)備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。
    連續(xù)給藥周期超過半月以上，請(qǐng)謹(jǐn)慎選擇該方案。
    請(qǐng)確保第一步儲(chǔ)備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱 （超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。
    純度 & 產(chǎn)品資料

    純度: 99.50%

    參考文獻(xiàn)

    完整儲(chǔ)備液配制表

    * 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    DMSO / Ethanol 1 mM 3.1263 mL 15.6314 mL 31.2627 mL 78.1568 mL
    5 mM 0.6253 mL 3.1263 mL 6.2525 mL 15.6314 mL
    10 mM 0.3126 mL 1.5631 mL 3.1263 mL 7.8157 mL
    15 mM 0.2084 mL 1.0421 mL 2.0842 mL 5.2105 mL
    20 mM 0.1563 mL 0.7816 mL 1.5631 mL 3.9078 mL
    25 mM 0.1251 mL 0.6253 mL 1.2505 mL 3.1263 mL
    30 mM 0.1042 mL 0.5210 mL 1.0421 mL 2.6052 mL
    40 mM 0.0782 mL 0.3908 mL 0.7816 mL 1.9539 mL
    50 mM 0.0625 mL 0.3126 mL 0.6253 mL 1.5631 mL
    60 mM 0.0521 mL 0.2605 mL 0.5210 mL 1.3026 mL
    80 mM 0.0391 mL 0.1954 mL 0.3908 mL 0.9770 mL
    100 mM 0.0313 mL 0.1563 mL 0.3126 mL 0.7816 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Inquiry Information

    產(chǎn)品名稱：
    Chloroquine
    目錄號(hào)：
    HY-17589A
    需求量：