Fosbretabulin disodium (Synonyms: 康普瑞汀磷酸二鈉; CA 4DP; CA 4P; Combretastatin A4 disodium phosphate)

目錄號(hào): HY-17449 純度: 99.47%: FAQs
Data Sheet SDS COA 產(chǎn)品使用指南

摩爾計(jì)算器

Fosbretabulin disodium (CA 4DP) 是微管蛋白去穩(wěn)定劑。Fosbretabulin disodium 是 Combretastatin A4 前體，可選擇性靶向內(nèi)皮細(xì)胞，誘導(dǎo)新生腫瘤新血管消退，減少腫瘤血流量并引起中央腫瘤壞死。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Fosbretabulin disodium Chemical Structure

CAS No. : 168555-66-6

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規(guī)格	價(jià)格	是否有貨
1 mg	￥353	In-stock
5 mg	￥687	In-stock
10 mg	￥1100	In-stock
25 mg	￥2000	In-stock
50 mg	￥3000	In-stock
100 mg	￥4500	In-stock
200 mg		詢價(jià)
500 mg		詢價(jià)

or 大包裝詢價(jià)

* Please select Quantity before adding items.

Other Forms of Fosbretabulin disodium:

Fosbretabulin 詢價(jià)
Fosbretabulin tromethamine 詢價(jià)

Fosbretabulin disodium 相關(guān)產(chǎn)品

•相關(guān)化合物庫(kù):

•同靶點(diǎn)產(chǎn)品:

•同靶點(diǎn)蛋白產(chǎn)品:

生物活性
純度 & 產(chǎn)品資料
參考文獻(xiàn)

生物活性

Fosbretabulin disodium (CA 4DP) is a tubulin destabilizing agent. Fosbretabulin disodium is the Combretastatin A4 proagent that selectively targets endothelial cells, induces regression of nascent tumour neovessels, reduces tumour blood flow and causes central tumour necrosis^[1]^[3].

IC₅₀ & Target

tubulin^[1]

細(xì)胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A2780	GI₅₀	0.32 μM Compound: CA-4P; 3	Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay	[PMID: 30580241]
A-375	IC₅₀	0.0016 μM Compound: CA4P	Growth inhibition of human A375 cells measured after 48 hrs by MTS assay Growth inhibition of human A375 cells measured after 48 hrs by MTS assay	[PMID: 27100701]
A549	IC₅₀	0.0234 μM Compound: CA4P	Growth inhibition of human A549 cells by MTS assay Growth inhibition of human A549 cells by MTS assay	[PMID: 27100701]
A549	GI₅₀	0.16 μM Compound: CA-4P; 3	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 30580241]
A549	IC₅₀	0.4 μM Compound: CA-4P	Antiproliferative activity against human A549 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human A549 cells after 72 hrs by CCK-8 assay	[PMID: 30108925]
Bel-7402	IC₅₀	0.04 μM Compound: CA-4p	Antiproliferative activity against human Bel-7402 cells measured after 48 hrs by SRB assay Antiproliferative activity against human Bel-7402 cells measured after 48 hrs by SRB assay	[PMID: 32113125]
BXPC-3	GI₅₀	0.23 μg/mL Compound: 1b, CA4P, Fosbretabulin	Growth inhibition of human BxPC3 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human BxPC3 cells after 48 hrs by sulforhodamine B assay	[PMID: 22324723]
BXPC-3	GI₅₀	0.23 μg/mL Compound: CA4P	Antitumor activity against human BxPC3 cells by sulforhodamine B assay Antitumor activity against human BxPC3 cells by sulforhodamine B assay	[PMID: 19228038]
Caov-3 cell line	IC₅₀	13.11 nM Compound: CA4P	Antiproliferative activity against human Caov3 cells measured after 96 hrs by Celltiter-Glo assay Antiproliferative activity against human Caov3 cells measured after 96 hrs by Celltiter-Glo assay	[PMID: 27718473]
CCRF-CEM	IC₅₀	0.011 μM Compound: 7; CA-4P	Antiproliferative activity against human CEM cells measured after 96 hrs by Coulter counter method Antiproliferative activity against human CEM cells measured after 96 hrs by Coulter counter method	[PMID: 30921759]
CCRF-CEM	IC₅₀	0.011 μM Compound: 4; CA-4P	Antiproliferative activity against human CEM cells after 96 hrs by coulter counting method Antiproliferative activity against human CEM cells after 96 hrs by coulter counting method	[PMID: 29471122]
CCRF-CEM	IC₅₀	95 nM Compound: CA-4P, combretastatin A4P	Antiproliferative activity against human CEM cells after 96 hrs by Coulter counter method Antiproliferative activity against human CEM cells after 96 hrs by Coulter counter method	[PMID: 25626146]
DU-145	GI₅₀	0.0007 μg/mL Compound: CA4P	Antitumor activity against human DU145 cells by sulforhodamine B assay Antitumor activity against human DU145 cells by sulforhodamine B assay	[PMID: 19228038]
DU-145	IC₅₀	0.0014 μM Compound: CA4P	Growth inhibition of human DU145 cells measured after 48 hrs by MTS assay Growth inhibition of human DU145 cells measured after 48 hrs by MTS assay	[PMID: 27100701]
DU-145	GI₅₀	0.00323 μM Compound: CA-4P	Cytotoxicity against human DU145 cells assessed as growth inhibition measured after 48 hrs by SRB assay Cytotoxicity against human DU145 cells assessed as growth inhibition measured after 48 hrs by SRB assay	[PMID: 31059248]
DU-145	GI₅₀	0.00323 μM Compound: CA4P	Cytotoxicity against human DU145 cells after 48 hrs by SRB assay Cytotoxicity against human DU145 cells after 48 hrs by SRB assay	[PMID: 24183586]
DU-145	GI₅₀	0.0072 μg/mL Compound: 1b, CA4P, Fosbretabulin	Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay	[PMID: 22324723]
DU-145	GI₅₀	0.016 μM Compound: 3, CA4P	Cytotoxicity against human DU145 cells by SRB assay Cytotoxicity against human DU145 cells by SRB assay	[PMID: 24016002]
HCT-116	IC₅₀	0.0016 μM Compound: CA4P	Growth inhibition of human HCT116 cells measured after 48 hrs by MTS assay Growth inhibition of human HCT116 cells measured after 48 hrs by MTS assay	[PMID: 27100701]
HCT-116	IC₅₀	0.24 μM Compound: CA-4P	Antiproliferative activity against human HCT116 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human HCT116 cells after 72 hrs by CCK-8 assay	[PMID: 30108925]
HeLa	IC₅₀	0.00043 μM Compound: 2, CA4-P	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 19879758]
HeLa	IC₅₀	0.013 μM Compound: 7; CA-4P	Antiproliferative activity against human HeLa cells measured after 3 days by Coulter counter method Antiproliferative activity against human HeLa cells measured after 3 days by Coulter counter method	[PMID: 30921759]
HeLa	IC₅₀	0.013 μM Compound: 4; CA-4P	Antiproliferative activity against human HeLa cells after 3 days by coulter counting method Antiproliferative activity against human HeLa cells after 3 days by coulter counting method	[PMID: 29471122]
HeLa	GI₅₀	0.019 μM Compound: CA-4P; 3	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 30580241]
HeLa	IC₅₀	0.56 μM Compound: CA-4P	Antiproliferative activity against human HeLa cells after 72 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells after 72 hrs by CCK-8 assay	[PMID: 30108925]
HeLa	IC₅₀	79 nM Compound: CA-4P, combretastatin A4P	Antiproliferative activity against human HeLa cells after 4 days by Coulter counter method Antiproliferative activity against human HeLa cells after 4 days by Coulter counter method	[PMID: 25626146]
HepG2	IC₅₀	0.002 μM Compound: CA-4p	Antiproliferative activity against human HepG2 cells measured after 48 hrs by SRB assay Antiproliferative activity against human HepG2 cells measured after 48 hrs by SRB assay	[PMID: 32113125]
HepG2	GI₅₀	0.19 μM Compound: CA-4P; 3	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 30580241]
HepG2	IC₅₀	0.27 μM Compound: CA-4P	Antiproliferative activity against human HepG2 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human HepG2 cells after 72 hrs by CCK-8 assay	[PMID: 30108925]
HMEC-1	IC₅₀	0.0029 μM Compound: 7; CA-4P	Antiproliferative activity against human HMEC1 cells measured after 4 days by Coulter counter method Antiproliferative activity against human HMEC1 cells measured after 4 days by Coulter counter method	[PMID: 30921759]
HMEC-1	IC₅₀	0.0029 μM Compound: 4; CA-4P	Antiproliferative activity against human HMEC1 cells after 4 days by coulter counting method Antiproliferative activity against human HMEC1 cells after 4 days by coulter counting method	[PMID: 29471122]
HMEC-1	IC₅₀	2.9 nM Compound: CA-4P, combretastatin A4P	Antiproliferative activity against human HMEC1 cells after 4 days by Coulter counter method Antiproliferative activity against human HMEC1 cells after 4 days by Coulter counter method	[PMID: 25626146]
HT-29	GI₅₀	0.062 μM Compound: CA-4P; 3	Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 30580241]
HUVEC	GI₅₀	8 nM Compound: CA4P	Growth inhibition of HUVEC after 72 hrs by crystal violet staining-based assay Growth inhibition of HUVEC after 72 hrs by crystal violet staining-based assay	[PMID: 27690431]
Jurkat	EC₅₀	15 nM Compound: CA4P, Zybrestat	Cytotoxicity against human Jurkat cells assessed as cell viability after 48 hrs by trypan blue exclusion assay Cytotoxicity against human Jurkat cells assessed as cell viability after 48 hrs by trypan blue exclusion assay	[PMID: 24387982]
K562	IC₅₀	0.72 μM Compound: 7	Cytotoxicity against human K562 cells assessed as growth inhibition after 5 days by MTT assay Cytotoxicity against human K562 cells assessed as growth inhibition after 5 days by MTT assay	[PMID: 28143677]
KM-20L2	GI₅₀	0.034 μg/mL Compound: 1b, CA4P, Fosbretabulin	Growth inhibition of human KM20L2 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human KM20L2 cells after 48 hrs by sulforhodamine B assay	[PMID: 22324723]
KM-20L2	GI₅₀	0.034 μg/mL Compound: 1b, CA4P	Cytotoxicity against human KM20L2 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human KM20L2 cells after 48 hrs by sulforhodamine B assay	[PMID: 16252907]
L1210	IC₅₀	0.0021 μM Compound: 4; CA-4P	Antiproliferative activity against mouse L1210 cells after 96 hrs by coulter counting method Antiproliferative activity against mouse L1210 cells after 96 hrs by coulter counting method	[PMID: 29471122]
L1210	IC₅₀	0.013 μM Compound: 7; CA-4P	Antiproliferative activity against mouse L1210 cells measured after 96 hrs by Coulter counter method Antiproliferative activity against mouse L1210 cells measured after 96 hrs by Coulter counter method	[PMID: 30921759]
L1210	IC₅₀	82 nM Compound: CA-4P, combretastatin A4P	Antiproliferative activity against mouse L1210 cells after 48 hrs by Coulter counter method Antiproliferative activity against mouse L1210 cells after 48 hrs by Coulter counter method	[PMID: 25626146]
MCF7	IC₅₀	0.002 μM Compound: 2, CA4-P	Cytotoxicity against human MCF7 cells by MTT assay Cytotoxicity against human MCF7 cells by MTT assay	[PMID: 19879758]
MCF7	IC₅₀	0.011 μM Compound: CA-4p	Antiproliferative activity against human MCF7 cells measured after 48 hrs by SRB assay Antiproliferative activity against human MCF7 cells measured after 48 hrs by SRB assay	[PMID: 32113125]
MCF7	IC₅₀	0.96 μM Compound: CA-4P	Antiproliferative activity against human MCF7 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human MCF7 cells after 72 hrs by CCK-8 assay	[PMID: 30108925]
MDA-MB-231	IC₅₀	0.0028 μM Compound: CA4P	Growth inhibition of human MDA-MB-231 cells measured after 48 hrs by MTS assay Growth inhibition of human MDA-MB-231 cells measured after 48 hrs by MTS assay	[PMID: 27100701]
MDA-MB-231	GI₅₀	0.065 μM Compound: CA-4P; 3	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 30580241]
MDA-MB-231	IC₅₀	173.3 nM Compound: CA4P	Antiproliferative activity against human MDA-MB-231 cells measured after 96 hrs by Celltiter-Glo assay Antiproliferative activity against human MDA-MB-231 cells measured after 96 hrs by Celltiter-Glo assay	[PMID: 27718473]
MDA-MB-435	IC₅₀	8.75 nM Compound: CA4P	Antiproliferative activity against human MDA-MB-435 cells measured after 96 hrs by Celltiter-Glo assay Antiproliferative activity against human MDA-MB-435 cells measured after 96 hrs by Celltiter-Glo assay	[PMID: 27718473]
MGC-803	IC₅₀	0.47 μM Compound: CA-4P	Antiproliferative activity against human MGC803 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human MGC803 cells after 72 hrs by CCK-8 assay	[PMID: 30108925]
NCI-H460	GI₅₀	0.0004 μg/mL Compound: CA4P	Antitumor activity against human NCI-H460 cells by sulforhodamine B assay Antitumor activity against human NCI-H460 cells by sulforhodamine B assay	[PMID: 19228038]
NCI-H460	GI₅₀	0.00194 μM Compound: CA-4P	Cytotoxicity against human NCI-H460 cells assessed as growth inhibition measured after 48 hrs by SRB assay Cytotoxicity against human NCI-H460 cells assessed as growth inhibition measured after 48 hrs by SRB assay	[PMID: 31059248]
NCI-H460	GI₅₀	0.00194 μM Compound: CA4P	Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 24183586]
NCI-H460	GI₅₀	0.029 μg/mL Compound: 1b, CA4P, Fosbretabulin	Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay	[PMID: 22324723]
NCI-H460	GI₅₀	0.029 μg/mL Compound: 1b, CA4P	Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay	[PMID: 16252907]
NCI-H460	GI₅₀	0.066 μM Compound: 3, CA4P	Cytotoxicity against human NCI-H460 cells by SRB assay Cytotoxicity against human NCI-H460 cells by SRB assay	[PMID: 24016002]
P388	ED₅₀	0.0004 μg/mL Compound: 1b, CA4P	Cytotoxicity against mouse P388 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against mouse P388 cells after 48 hrs by sulforhodamine B assay	[PMID: 16252907]
P388	ED₅₀	0.0004 μg/mL Compound: 1b, CA4P, Fosbretabulin	Growth inhibition of mouse P388 cells after 48 hrs by Z1 Beckman/Coulter particle counter analysis Growth inhibition of mouse P388 cells after 48 hrs by Z1 Beckman/Coulter particle counter analysis	[PMID: 22324723]
PBMC	IC₅₀	0.17 μM Compound: CA4P	Growth inhibition of human PBMC cells measured after 48 hrs by MTS assay Growth inhibition of human PBMC cells measured after 48 hrs by MTS assay	[PMID: 27100701]
PC-3	IC₅₀	0.0062 μM Compound: CA4P	Growth inhibition of human PC3 cells measured after 48 hrs by MTS assay Growth inhibition of human PC3 cells measured after 48 hrs by MTS assay	[PMID: 27100701]
SF-268	GI₅₀	0.036 μg/mL Compound: 1b, CA4P, Fosbretabulin	Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay	[PMID: 22324723]
SF-268	GI₅₀	0.036 μg/mL Compound: 1b, CA4P	Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay	[PMID: 16252907]
SK-OV-3	GI₅₀	0.00119 μM Compound: CA-4P	Cytotoxicity against human SKOV3 cells assessed as growth inhibition measured after 48 hrs by SRB assay Cytotoxicity against human SKOV3 cells assessed as growth inhibition measured after 48 hrs by SRB assay	[PMID: 31059248]
SK-OV-3	GI₅₀	0.00119 μM Compound: CA4P	Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay	[PMID: 24183586]
SK-OV-3	IC₅₀	0.0077 μM Compound: CA4P	Growth inhibition of human SKOV3 cells measured after 48 hrs by MTS assay Growth inhibition of human SKOV3 cells measured after 48 hrs by MTS assay	[PMID: 27100701]
TOV112D	IC₅₀	30.85 nM Compound: CA4P	Antiproliferative activity against human TOV112D cells measured after 96 hrs by Celltiter-Glo assay Antiproliferative activity against human TOV112D cells measured after 96 hrs by Celltiter-Glo assay	[PMID: 27718473]

體外研究
(In Vitro)

FosbretabuLin disodium 抑制白血病 P-388、胰腺 BXPC-3、成神經(jīng)細(xì)胞 SK-N-SH、甲狀腺 SW1736、肺-NSC NCI-H460、前列腺 DU-145、咽 FADU 的生長(zhǎng)，EC₅₀ 分別為 0.0029、0.23、0.00025、0.00061、0.00035、0.00072 和 0.00045 μg/mL^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

體內(nèi)研究
(In Vivo)

FosbretabuLin disodium (100 mg/kg；ip) 在給藥后 1 小時(shí)和 6 小時(shí)增加平均動(dòng)脈血壓 (MABP)，并降低大鼠的腫瘤血流量^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male BD9 rats (7-9 weeks) bearing the s.c. implanted P22 tumor^[3]
Dosage:	100 mg/kg
Administration:	A single i.p. injections
Result:	Significantly raised the MABP by about 30%, and reduced the heart rate at 1 h after administration. Reduced the blood flow in the tumor.

Clinical Trial

分子量

440.29

Formula

C₁₈H₁₉Na₂O₈P

CAS 號(hào)

168555-66-6

性狀

固體

顏色

White to off-white

中文名稱

康普瑞汀磷酸二鈉

結(jié)構(gòu)分類

Stilbenes

初始來源

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性數(shù)據(jù)

細(xì)胞實(shí)驗(yàn)：

H₂O 中的溶解度 : 4.5 mg/mL (10.22 mM; 超聲加熱助溶)

DMF 中的溶解度 : < 1 mg/mL (insoluble)

配制儲(chǔ)備液

濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg

1 mM	2.2712 mL	11.3562 mL	22.7123 mL
5 mM	0.4542 mL	2.2712 mL	4.5425 mL
10 mM	0.2271 mL	1.1356 mL	2.2712 mL

查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

* 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

摩爾計(jì)算器
稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

濃度 _(start)

體積 _(start)

濃度 _(final)

體積 _(final)

動(dòng)物實(shí)驗(yàn)：

以下溶解方案，請(qǐng)直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶。

方案一

請(qǐng)依序添加每種溶劑： PBS
Solubility: 14.29 mg/mL (32.46 mM); 澄清溶液; 超聲助溶 (<60°C)

動(dòng)物溶解方案計(jì)算器

請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只

由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量

計(jì)算結(jié)果

工作液所需濃度 : mg/mL

您所需的儲(chǔ)備液濃度超過該產(chǎn)品的實(shí)測(cè)溶解度，如有需要，請(qǐng)與 MCE 中國(guó)技術(shù)支持聯(lián)系。

純度 & 產(chǎn)品資料

純度: 99.47%

選擇批次：

Data Sheet (626 KB) SDS (393 KB)

COA (188 KB) HNMR (165 KB) LCMS (394 KB)

產(chǎn)品使用指南 (1538 KB)

參考文獻(xiàn)

[1]. Shen CH, et, al. Combretastatin A-4 inhibits cell growth and metastasis in bladder cancer cells and retards tumour growth in a murine orthotopic bladder tumour model. Br J Pharmacol. 2010 Aug;160(8):2008-27. [Content Brief]

[2]. Pettit GR, et, al. Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41. J Med Chem. 2005 Jun 16;48(12):4087-99. [Content Brief]

[3]. Tozer GM, et, al. Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues. Cancer Res. 1999 Apr 1;59(7):1626-34. [Content Brief]

Fosbretabulin disodium 相關(guān)分類

完整儲(chǔ)備液配制表

可選溶劑	濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.2712 mL	11.3562 mL	22.7123 mL	56.7808 mL
	5 mM	0.4542 mL	2.2712 mL	4.5425 mL	11.3562 mL
	10 mM	0.2271 mL	1.1356 mL	2.2712 mL	5.6781 mL

* 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fosbretabulin disodium168555-66-6CA 4DP CA 4PCombretastatin A4 disodium康普瑞汀磷酸二鈉Microtubule/TubulinApoptosistubulindestabilizingendothelianascenttumourneovesselsInhibitorinhibitorinhibit

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Fosbretabulin disodium (Synonyms: 康普瑞汀磷酸二鈉; CA 4DP; CA 4P; Combretastatin A4 disodium phosphate)

Other Forms of Fosbretabulin disodium:

Fosbretabulin disodium 相關(guān)產(chǎn)品

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生物活性

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參考文獻(xiàn)

摩爾計(jì)算器

稀釋計(jì)算器

Fosbretabulin disodium 相關(guān)分類

完整儲(chǔ)備液配制表

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Fosbretabulin disodium (Synonyms: 康普瑞汀磷酸二鈉; CA 4DP; CA 4P; Combretastatin A4 disodium phosphate)

Other Forms of Fosbretabulin disodium:

Fosbretabulin disodium 相關(guān)抗體

Fosbretabulin disodium 相關(guān)產(chǎn)品

•相關(guān)化合物庫(kù):

•同靶點(diǎn)產(chǎn)品:

•同靶點(diǎn)蛋白產(chǎn)品:

生物活性

純度 & 產(chǎn)品資料

參考文獻(xiàn)

Fosbretabulin disodium 相關(guān)抗體:

摩爾計(jì)算器

稀釋計(jì)算器

Fosbretabulin disodium 相關(guān)分類

完整儲(chǔ)備液配制表

Keywords:

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