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  2. Metabolic Enzyme/Protease Apoptosis
  3. HIF/HIF Prolyl-Hydroxylase Apoptosis
  4. EL-102

EL-102 是 hypoxia-induced factor 1 (Hif1α) 的抑制劑。EL-102 誘導(dǎo)細(xì)胞凋亡，抑制微管蛋白聚合，并顯示抗前列腺癌活性。EL-102 可用于癌癥的研究。

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EL-102 Chemical Structure

EL-102 Chemical Structure

CAS No. : 1233948-61-2

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥2368
In-stock
1 mg ￥900
In-stock
5 mg ￥2400
In-stock
10 mg ￥3800
In-stock
25 mg ￥6000
In-stock
50 mg 現(xiàn)貨 詢價
100 mg   詢價  
200 mg   詢價  

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Customer Review

查看 HIF/HIF Prolyl-Hydroxylase 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

EL-102 is a hypoxia-induced factor 1 (Hif1α) inhibitor. EL-102 induces apoptosis, inhibits tubulin polymerisation and shows activities against prostate cancer. EL-102 can be used for the research of cancer[1].

IC50 & Target

IC50: 24 nM (CWR22), 21.7 nM (22Rv1), 40.3 nM (DU145), 37.0 nM (PC-3), 14.4 nM (DLKP), 16.3 nM (DLKPA)[1]
體外研究
(In Vitro)

EL-102 (0-120 nM; 72 h) inhibits prostate cancer cells proliferation in vitro[1].
EL-102 (0-100 nM; 72 h) shows cytotoxicity to prostate cancer cell lines[1].
EL-102 (10-100 nM; 24-72 h) induces cellular apoptosis and affects cell cycle[1].
EL-102 (10-100 nM; 24-48 h) affects PARP cleavage in DU145 cells[1].
EL-102 (5 nM; 0-60 min) inhibits tubulin polymerisation activity[1].
EL-102 (0-100 nM; 1 hour) inhibits Hif1α protein expression[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: CWR22, 22Rv1, DU145, PC-3, DLKP and DLKPA cell lines
Concentration: 0-120 nM
Incubation Time: 72 hours
Result: Inhibited proliferation of CWR22, 22Rv1, DU145, PC-3, DLKP and doxorubicin-selected variant DLKPA cells with IC50s of 24, 21.7, 40.3, 37.0, 14.4 and 16.3 nM, respectively.

Cell Cytotoxicity Assay[1]

Cell Line: CWR22, 22Rv1, DU145 and PC-3 cell lines
Concentration: 0-100 nM
Incubation Time: 72 hours
Result: Exibited cytotoxicity to prostate cancer cell lines, and showed no additive effect on the inhibition of cell viability with docetaxel.

Apoptosis Analysis[1]

Cell Line: CWR22, 22Rv1, DU145, PC-3, DLKP and DLKPA cell lines
Concentration: 10 and 100 nM
Incubation Time: 24, 48 and 72 hours
Result: Induced cell apoptosis to inhibits cell viability with a dose of 100 nM.

Western Blot Analysis[1]

Cell Line: DU145 cell line
Concentration: 10 and 100 nM
Incubation Time: 24 and 48 hours
Result: Increased PARP cleavage in DU145 cells and showed a more dramatic effect with docetaxel adding.

Cell Cycle Analysis[1]

Cell Line: DU145 cell line
Concentration: 10 and 100 nM
Incubation Time: 24, 48 and 72 hours
Result: Increased loss of cells from G1 phase and accumulated cells in G2/M phase.

Western Blot Analysis[1]

Cell Line: Prostate cancer cells
Concentration: 10 , 50 and 100 nM
Incubation Time: 24 and 48 hours
Result: Modestly inhibited Hif1α expression at doses of 50 and 100 nM in normoxia.
體內(nèi)研究
(In Vivo)

EL-102 (12 and 15 mg/kg; p.o. 5-day on and 2-day off, from 13 to 37 days after tumour transplantation) potentiates effects of docetaxel in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice with CWR22 xenografts[1]
Dosage: 12 and 15 mg/kg
Administration: Oral gavage; 12 and 15 mg/kg 5-day on and 2-day off; from 13 to 37 days after tumour transplantation
Result: Showed no effect on tumor growth, but enhanced the effect of docetaxel on tumor .
分子量

384.47

Formula

C19H16N2O3S2
CAS 號
性狀

固體

顏色

Light yellow to yellow

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細(xì)胞實驗： 

DMSO 中的溶解度 : ≥ 36 mg/mL (93.64 mM; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.6010 mL 13.0049 mL 26.0098 mL
5 mM 0.5202 mL 2.6010 mL 5.2020 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻(xiàn)

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6010 mL 13.0049 mL 26.0098 mL 65.0246 mL
5 mM 0.5202 mL 2.6010 mL 5.2020 mL 13.0049 mL
10 mM 0.2601 mL 1.3005 mL 2.6010 mL 6.5025 mL
15 mM 0.1734 mL 0.8670 mL 1.7340 mL 4.3350 mL
20 mM 0.1300 mL 0.6502 mL 1.3005 mL 3.2512 mL
25 mM 0.1040 mL 0.5202 mL 1.0404 mL 2.6010 mL
30 mM 0.0867 mL 0.4335 mL 0.8670 mL 2.1675 mL
40 mM 0.0650 mL 0.3251 mL 0.6502 mL 1.6256 mL
50 mM 0.0520 mL 0.2601 mL 0.5202 mL 1.3005 mL
60 mM 0.0433 mL 0.2167 mL 0.4335 mL 1.0837 mL
80 mM 0.0325 mL 0.1626 mL 0.3251 mL 0.8128 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
EL-102
目錄號：
HY-16187
需求量：