Podofilox (Synonyms: 鬼臼毒素; Podophyllotoxin)

目錄號: HY-15552 純度: 99.92%: FAQs
Data Sheet SDS COA 產(chǎn)品使用指南技術支持

Podofilox (Podophyllotoxin) 是微管組裝和DNA拓撲異構酶II抑制劑。

MCE 的所有產(chǎn)品僅用作科學研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務

Podofilox Chemical Structure

CAS No. : 518-28-5

1. 客戶無需承擔相應的運輸費用。

2. 同一機構（單位）同一產(chǎn)品試用裝僅限申領一次，同一機構（單位）一年內

可免費申領三個不同產(chǎn)品的試用裝。

3. 試用裝只面向終端客戶。

規(guī)格	價格	是否有貨
10 mM * 1 mL in DMSO	￥330	In-stock
1 g	￥100	In-stock
5 g	￥260	In-stock
10 g	￥420	In-stock
25 g	￥840	In-stock
50 g	￥1350	In-stock
100 g	￥2160	In-stock
> 100 g		詢價

or 大包裝詢價

* Please select Quantity before adding items.

Customer Review

Other Forms of Podofilox:

Podofilox-d₆ 詢價
Podofilox (Standard) 詢價

MCE 顧客使用本產(chǎn)品發(fā)表的 3 篇科研文獻

•ACS Nano. 2024 Mar 4. [Abstract]
•Cancer Immunol Res. 2023 May 3;11(5):583-599. [Abstract]
•Exp Ther Med. August 23, 2021.

Podofilox 相關產(chǎn)品

•相關化合物庫:

•同靶點產(chǎn)品:

•同靶點蛋白產(chǎn)品:

生物活性
純度 & 產(chǎn)品資料
參考文獻

生物活性

Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

IC₅₀ & Target

Topoisomerase II; Microtubule/Tubulin

細胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
786-0	GI₅₀	16.9 nM Compound: PT, NSC 24818	Cytotoxicity against human 786-0 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human 786-0 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
A2780	IC₅₀	15 nM Compound: Podophyllotoxin	Cytotoxicity against human A2780 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Cytotoxicity against human A2780 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35344902]
A2780	IC₅₀	18 nM Compound: 1	Cytotoxicity against human A2780 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human A2780 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 27518758]
A2780	IC₅₀	20 nM Compound: Podophyllotoxin	Cytotoxicity against human A2780AD cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Cytotoxicity against human A2780AD cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35344902]
A-375	IC₅₀	2.62 μM Compound: 1	Anticancer activity against human A375 cells after 48 hrs by MTT assay Anticancer activity against human A375 cells after 48 hrs by MTT assay	[PMID: 22136907]
A-431	IC₅₀	> 100 μM Compound: PDT	Cytotoxicity against human A431 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay Cytotoxicity against human A431 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]
A-431	ED₅₀	1.1 x 10^-6 μg/mL Compound: podophyllotoxin	Cytotoxicity against human A431 cells by MTT assay Cytotoxicity against human A431 cells by MTT assay	[PMID: 7714533]
A498	IC₅₀	0.034 μg/mL Compound: Podophyllotoxin	Anticancer activity against human A498 cells after 24 hrs by MTT assay Anticancer activity against human A498 cells after 24 hrs by MTT assay	[PMID: 25305717]
A498	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human A498 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human A498 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
A498	ED₅₀	3.4 x 10^-7 μg/mL Compound: podophyllotoxin	Cytotoxicity against human A498 cells by MTT assay Cytotoxicity against human A498 cells by MTT assay	[PMID: 7714533]
A549	IC₅₀	< 0.1 μM Compound: Podophyllotoxin	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by SRB assay	10.1039/C0MD00263A
A549	GI₅₀	0.012 μM Compound: 1	Cytotoxicity against human A549 cells after 72 hrs by SRB assay Cytotoxicity against human A549 cells after 72 hrs by SRB assay	[PMID: 20067289]
A549	IC₅₀	0.012 μM Compound: 1	Cytotoxicity against human A549 cells after 4 days Cytotoxicity against human A549 cells after 4 days	[PMID: 17197187]
A549	IC₅₀	0.014 μM Compound: 2; PPT	Antiproliferative activity against human A549 cells assessed as growth inhibition after 72 hrs by CCK-8 assay Antiproliferative activity against human A549 cells assessed as growth inhibition after 72 hrs by CCK-8 assay	[PMID: 26615886]
A549	IC₅₀	0.059 μM Compound: PPT	Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35447432]
A549	IC₅₀	0.059 μM Compound: 2	Cytotoxicity against human A549 cells after 48 hrs by SRB assay Cytotoxicity against human A549 cells after 48 hrs by SRB assay	[PMID: 25084144]
A549	IC₅₀	0.09 μM Compound: Podophyllotoxin	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 34175586]
A549	IC₅₀	0.09 μM Compound: Podophyllotoxin	Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay	[PMID: 29525336]
A549	IC₅₀	0.09 μM Compound: Podophyllotoxin	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 28648953]
A549	IC₅₀	0.09 μM Compound: Podophyllotoxin	Growth inhibition of human A549 cells after 48 hrs by MTT assay Growth inhibition of human A549 cells after 48 hrs by MTT assay	[PMID: 28131777]
A549	IC₅₀	0.5 μM Compound: 2	Cytotoxicity against human A549 cells after 24 hrs by MTS assay Cytotoxicity against human A549 cells after 24 hrs by MTS assay	[PMID: 19880222]
A549	IC₅₀	1.36 μM Compound: Podophyllotoxin	Cytotoxicity against human A549 cells after 36 hrs by MTT assay Cytotoxicity against human A549 cells after 36 hrs by MTT assay	[PMID: 27262599]
A549	IC₅₀	105 nM Compound: PPT	Cytotoxicity against human A549 cells overexpressing NQO1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human A549 cells overexpressing NQO1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33091789]
A549	IC₅₀	12 nM Compound: Podophyllotoxin	Cytotoxicity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35344902]
A549	GI₅₀	12 nM Compound: 1a	Growth inhibition of human A549 cells after 72 hrs by SRB assay Growth inhibition of human A549 cells after 72 hrs by SRB assay	[PMID: 22607205]
A549	IC₅₀	128.61 μM Compound: Podophyllotoxin	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 26292628]
A549	IC₅₀	13.62 μM Compound: Podophyllotoxing	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 25462233]
A549	IC₅₀	13.62 μM Compound: 1	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 22687745]
A549	GI₅₀	13.8 nM Compound: PT, NSC 24818	Cytotoxicity against human A549 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human A549 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
A549	IC₅₀	15 nM Compound: 1	Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 27518758]
A549	IC₅₀	15.8 nM Compound: Ref 34, Cpd 1	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 32992133]
A549	EC₅₀	16.5 nM Compound: PT	Cell cycle arrest in human A549 cells assessed as accumulation of cells in G2/M phase after 24 hrs by propidium iodide staining-based flow cytometry Cell cycle arrest in human A549 cells assessed as accumulation of cells in G2/M phase after 24 hrs by propidium iodide staining-based flow cytometry	[PMID: 21916509]
A549	IC₅₀	2.13 μM Compound: Ref 34, Cpd 1	Antiproliferative activity against human A549 cells incubated for 24 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 24 hrs by MTT assay	[PMID: 32992133]
A549	IC₅₀	2.55 μM Compound: 1	Cytotoxicity against human A549 cells assessed as cell viability by SRB assay Cytotoxicity against human A549 cells assessed as cell viability by SRB assay	[PMID: 26022842]
A549	IC₅₀	2.6 μM Compound: PTOX	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30878833]
A549	IC₅₀	291 nM Compound: PPT	Cytotoxicity against hypoxia-induced human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against hypoxia-induced human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33091789]
A549	IC₅₀	3.06 μM Compound: Podophyllotoxin	Antiproliferative activity against human A549 cells by MTT assay Antiproliferative activity against human A549 cells by MTT assay	[PMID: 31546197]
A549	IC₅₀	3.09 μM Compound: 1	Anticancer activity against human A549 cells after 48 hrs by MTT assay Anticancer activity against human A549 cells after 48 hrs by MTT assay	[PMID: 24721832]
A549	IC₅₀	3.6 μM Compound: 1, Podo	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 23182091]
A549	IC₅₀	3.75 μM Compound: 1	Anticancer activity against human A549 cells after 48 hrs by MTT assay Anticancer activity against human A549 cells after 48 hrs by MTT assay	[PMID: 22136907]
A549	IC₅₀	3.76 μM Compound: IV	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 29289881]
A549	IC₅₀	338 nM Compound: PPT	Cytotoxicity against taxol-resistant human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against taxol-resistant human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33091789]
A549	IC₅₀	4.31 μM Compound: Ref 34, Cpd 1	Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay	[PMID: 32992133]
A549	IC₅₀	4.6 μM Compound: Podophyllotoxin	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 29289884]
A549	IC₅₀	5.37 nM Compound: PPT	Cytotoxicity in human A549 cells assessed as inhibition of cell proliferation measured by CCK-8 assay Cytotoxicity in human A549 cells assessed as inhibition of cell proliferation measured by CCK-8 assay	[PMID: 34098082]
A549	IC₅₀	5.61 μM Compound: PDT	Cytotoxicity against human A549 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay Cytotoxicity against human A549 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]
A549	IC₅₀	7.34 μM Compound: Podophyllotoxin	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 31884407]
A549	IC₅₀	7.38 μM Compound: 1, VP-16	Cytotoxicity against human A549 cells after 72 hrs by SRB method Cytotoxicity against human A549 cells after 72 hrs by SRB method	[PMID: 19324555]
A549	IC₅₀	7.47 nM Compound: PT	Cytotoxicity against human A549 cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 21916509]
A549	IC₅₀	7.63 μM Compound: 1	Cytotoxicity against human A549 cells by sulforhodamine B assay Cytotoxicity against human A549 cells by sulforhodamine B assay	[PMID: 17988764]
A549	ED₅₀	7.7 x 10^-8 μg/mL Compound: podophyllotoxin	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 7714533]
A549	IC₅₀	9.34 μM Compound: 1; PPT	Cytotoxicity against human A549 cells after 24 hrs by MTT assay Cytotoxicity against human A549 cells after 24 hrs by MTT assay	[PMID: 28757065]
ACHN	IC₅₀	1.93 μM Compound: 1	Anticancer activity against human ACHN cells after 48 hrs by MTT assay Anticancer activity against human ACHN cells after 48 hrs by MTT assay	[PMID: 24721832]
ACHN	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human ACHN cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human ACHN cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
ACHN	IC₅₀	2.12 μM Compound: 1	Anticancer activity against human ACHN cells after 48 hrs by MTT assay Anticancer activity against human ACHN cells after 48 hrs by MTT assay	[PMID: 22136907]
ACHN	IC₅₀	2.3 μM Compound: 1, Podo	Cytotoxicity against human ACHN cells after 72 hrs by MTT assay Cytotoxicity against human ACHN cells after 72 hrs by MTT assay	[PMID: 23182091]
AGS	IC₅₀	50.8 μM Compound: 1, VP-16	Cytotoxicity against human AGS cells after 72 hrs by SRB method Cytotoxicity against human AGS cells after 72 hrs by SRB method	[PMID: 19324555]
B16	IC₅₀	2.12 μM Compound: 1; PPT	Cytotoxicity against human B16 cells after 48 hrs by MTT assay Cytotoxicity against human B16 cells after 48 hrs by MTT assay	[PMID: 30108892]
B16	IC₅₀	2.5 μM Compound: 1, Podo	Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay	[PMID: 23182091]
Bel-7402	IC₅₀	0.016 μM Compound: Podo	Antiproliferative activity against human Bel7402 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human Bel7402 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]
Bel-7402	IC₅₀	0.052 μM Compound: 1; PPT	Antiproliferative activity against human Bel7402 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human Bel7402 cells after 72 hrs by CCK-8 assay	[PMID: 28301815]
Bel-7402	IC₅₀	9.1 nM Compound: podophyllotoxin	Antiproliferative activity against human Bel7402 cells after 72 hrs Antiproliferative activity against human Bel7402 cells after 72 hrs	[PMID: 17034133]
Bel7402/5-FU	IC₅₀	0.044 μM Compound: 1; PPT	Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by CCK-8 assay Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by CCK-8 assay	[PMID: 28301815]
BGC-823	IC₅₀	4.31 μM Compound: Ref 34, Cpd 1	Antiproliferative activity against human BGC-823 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human BGC-823 cells incubated for 48 hrs by MTT assay	[PMID: 32992133]
BJ	IC₅₀	> 50 μM Compound: B	Cytotoxicity against human BJ cells after 72 hrs by luminescence assay Cytotoxicity against human BJ cells after 72 hrs by luminescence assay	[PMID: 20129783]
BJ	IC₅₀	5 μM Compound: PDX	Cytotoxicity against human BJ cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay Cytotoxicity against human BJ cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay	[PMID: 30482548]
BT-549	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human BT549 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human BT549 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
Caco-2	IC₅₀	0.002 μM Compound: podophyllotoxin	Cytotoxicity against human CaCO2 cells after 24 hrs by MTT assay Cytotoxicity against human CaCO2 cells after 24 hrs by MTT assay	[PMID: 18586491]
Caco-2	IC₅₀	0.5 μM Compound: 2	Cytotoxicity against human Caco-2 cells after 24 hrs by MTS assay Cytotoxicity against human Caco-2 cells after 24 hrs by MTS assay	[PMID: 19880222]
CAKI-1	GI₅₀	89.7 nM Compound: PT, NSC 24818	Cytotoxicity against human CAKI-1 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human CAKI-1 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
Calu-1	IC₅₀	2.68 μM Compound: Ref 34, Cpd 1	Antiproliferative activity against human Calu-1 cells incubated for 24 hrs by MTT assay Antiproliferative activity against human Calu-1 cells incubated for 24 hrs by MTT assay	[PMID: 32992133]
Ca-Ski	IC₅₀	0.3 μM Compound: PDX	Antiproliferative activity against human CaSki cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay Antiproliferative activity against human CaSki cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay	[PMID: 30482548]
CCRF-CEM	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human CCRF-CEM cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human CCRF-CEM cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
COLO 205	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human COLO205 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human COLO205 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
DLD-1	IC₅₀	0.11 μM Compound: PDT	Cytotoxicity against human DLD1 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay Cytotoxicity against human DLD1 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]
DMS-79	IC₅₀	23 nM Compound: podophyllotoxin	Antiproliferative activity against human DMS79 cells after 72 hrs Antiproliferative activity against human DMS79 cells after 72 hrs	[PMID: 17034133]
DU-145	IC₅₀	< 0.1 μM Compound: Podophyllotoxin	Cytotoxicity against human DU145 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human DU145 cells assessed as growth inhibition after 48 hrs by SRB assay	10.1039/C0MD00263A
DU-145	IC₅₀	> 100 μM Compound: Podophyllotoxing	Cytotoxicity against human DU145 cells after 48 hrs by MTT assay Cytotoxicity against human DU145 cells after 48 hrs by MTT assay	[PMID: 25462233]
DU-145	IC₅₀	> 100 μM Compound: 1	Cytotoxicity against human DU145 cells after 72 hrs by MTT assay Cytotoxicity against human DU145 cells after 72 hrs by MTT assay	[PMID: 22687745]
DU-145	IC₅₀	0.01 μM Compound: PPT	Antiproliferative activity against human DU145 cells after 96 hrs by SRB assay Antiproliferative activity against human DU145 cells after 96 hrs by SRB assay	[PMID: 27187855]
DU-145	IC₅₀	0.06 μM Compound: Podophyllotoxin	Antiproliferative activity against human DU-145 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human DU-145 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 34175586]
DU-145	IC₅₀	0.063 μM Compound: Podophyllotoxin	Cytotoxicity against human DU145 cells assessed as cell growth inhibition after 48 hrs by MTT assay Cytotoxicity against human DU145 cells assessed as cell growth inhibition after 48 hrs by MTT assay	[PMID: 29525336]
DU-145	IC₅₀	0.063 μM Compound: Podophyllotoxin	Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay	[PMID: 28648953]
DU-145	IC₅₀	0.063 μM Compound: Podophyllotoxin	Growth inhibition of human DU145 cells after 48 hrs by MTT assay Growth inhibition of human DU145 cells after 48 hrs by MTT assay	[PMID: 28131777]
DU-145	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human DU145 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human DU145 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
DU-145	IC₅₀	2.97 μM Compound: 1	Cytotoxicity against human DU145 cells by sulforhodamine B assay Cytotoxicity against human DU145 cells by sulforhodamine B assay	[PMID: 17988764]
DU-145	IC₅₀	3.06 μM Compound: Podophyllotoxin	Antiproliferative activity against human DU145 cells by MTT assay Antiproliferative activity against human DU145 cells by MTT assay	[PMID: 31546197]
DU-145	IC₅₀	3.11 μM Compound: IV	Cytotoxicity against human DU145 cells after 48 hrs by MTT assay Cytotoxicity against human DU145 cells after 48 hrs by MTT assay	[PMID: 29289881]
DU-145	IC₅₀	3.21 μM Compound: 1	Anticancer activity against human DU145 cells after 48 hrs by MTT assay Anticancer activity against human DU145 cells after 48 hrs by MTT assay	[PMID: 24721832]
DU-145	IC₅₀	4.15 μM Compound: Podophyllotoxin	Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay	[PMID: 29289884]
DU-145	IC₅₀	52 nM Compound: podophyllotoxin	Antiproliferative activity against human DU145 cells after 72 hrs Antiproliferative activity against human DU145 cells after 72 hrs	[PMID: 17034133]
EKVX	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human EKVX cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human EKVX cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
FaDu	IC₅₀	7.2 nM Compound: podophyllotoxin	Antiproliferative activity against human CEM cells after 72 hrs Antiproliferative activity against human CEM cells after 72 hrs	[PMID: 17034133]
GLC4 cell line	IC₅₀	0.06 μM Compound: 20	Cytotoxic effect against GLC4 (human small cell lung carcinoma cell line) using the microculture tetrazolium (MTT) assay based on continuous incubation Cytotoxic effect against GLC4 (human small cell lung carcinoma cell line) using the microculture tetrazolium (MTT) assay based on continuous incubation	[PMID: 7783142]
GLC4 cell line	IC₅₀	0.15 μM Compound: 20	Cytotoxic effect against GLC4 (human small cell lung carcinoma cell line) using the microculture tetrazolium (MTT) assay based on 2 hr incubation Cytotoxic effect against GLC4 (human small cell lung carcinoma cell line) using the microculture tetrazolium (MTT) assay based on 2 hr incubation	[PMID: 7783142]
HCC 2998	GI₅₀	12.3 nM Compound: PT, NSC 24818	Cytotoxicity against human HCC2998 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human HCC2998 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
HCT-116	IC₅₀	> 20 μM Compound: Podophyllotoxin	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 31884407]
HCT-116	IC₅₀	0.02 μM Compound: PPT	Antiproliferative activity against human HCT116 cells after 96 hrs by SRB assay Antiproliferative activity against human HCT116 cells after 96 hrs by SRB assay	[PMID: 27187855]
HCT-116	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human HCT116 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human HCT116 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
HCT-15	IC₅₀	0.061 μM Compound: Podophyllotoxin	Antiproliferative activity against human HCT15 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT15 cells after 48 hrs by MTT assay	[PMID: 28648953]
HCT-15	IC₅₀	0.061 μM Compound: Podophyllotoxin	Growth inhibition of human HCT15 cells after 48 hrs by MTT assay Growth inhibition of human HCT15 cells after 48 hrs by MTT assay	[PMID: 28131777]
HCT-15	IC₅₀	1 μM Compound: 1	Cytotoxicity against human HCT-15 cells by sulforhodamine B assay Cytotoxicity against human HCT-15 cells by sulforhodamine B assay	[PMID: 17988764]
HCT-15	GI₅₀	13.5 nM Compound: PT, NSC 24818	Cytotoxicity against human HCT15 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human HCT15 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
HEK293	IC₅₀	0.017 μM Compound: B	Cytotoxicity against HEK293 cells after 72 hrs by luminescence assay Cytotoxicity against HEK293 cells after 72 hrs by luminescence assay	[PMID: 20129783]
HEK293	IC₅₀	0.12 μg/mL Compound: Podophyllotoxin	Cytotoxic activity against HEK293 cells after 24 hrs by MTT assay Cytotoxic activity against HEK293 cells after 24 hrs by MTT assay	[PMID: 25305717]
HEK293	IC₅₀	50 μM Compound: PDT	Cytotoxicity against human HEK293 cells after 24 hrs by MTT assay Cytotoxicity against human HEK293 cells after 24 hrs by MTT assay	[PMID: 24457094]
HEK-293T	IC₅₀	1.54 μM Compound: Podophyllotoxin	Cytotoxicity against HEK293T cells after 36 hrs by MTT assay Cytotoxicity against HEK293T cells after 36 hrs by MTT assay	[PMID: 27262599]
HeLa	IC₅₀	0.012 μM Compound: 2; PPT	Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by CCK-8 assay	[PMID: 26615886]
HeLa	GI₅₀	0.02 μM Compound: Podophyllotoxin	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 21615090]
HeLa	GI₅₀	0.02 μM Compound: 1	Growth inhibition of HeLa cells after 48 hrs by MTT assay Growth inhibition of HeLa cells after 48 hrs by MTT assay	[PMID: 17894480]
HeLa	IC₅₀	0.044 μM Compound: PPT	Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35447432]
HeLa	IC₅₀	0.069 μM Compound: 6	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 21570846]
HeLa	IC₅₀	0.1 μM Compound: Podophyllotoxin	Cytotoxicity against human HeLa cells after 2 days by MTT assay Cytotoxicity against human HeLa cells after 2 days by MTT assay	[PMID: 21821321]
HeLa	IC₅₀	0.1 μM Compound: Podophyllotoxin	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 25113878]
HeLa	IC₅₀	0.14 μM Compound: 1	Cytotoxicity against human HeLa cells after 48 hrs Cytotoxicity against human HeLa cells after 48 hrs	[PMID: 23022053]
HeLa	GI₅₀	0.71 μM Compound: 1	Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay	[PMID: 24953821]
HeLa	GI₅₀	0.74 μM Compound: 1	Antiproliferative activity against human HeLa cells assessed as growth inhibition after 48 hrs by SRB assay Antiproliferative activity against human HeLa cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 25131956]
HeLa	IC₅₀	1.45 μM Compound: Podophyllotoxin	Cytotoxicity against human HeLa cells after 36 hrs by MTT assay Cytotoxicity against human HeLa cells after 36 hrs by MTT assay	[PMID: 27262599]
HeLa	IC₅₀	1.92 μM Compound: 1	Cytotoxicity against human HeLa cells assessed as cell viability by SRB assay Cytotoxicity against human HeLa cells assessed as cell viability by SRB assay	[PMID: 26022842]
HeLa	IC₅₀	14 nM Compound: Podophyllotoxin	Cytotoxicity against human HeLa cells overexpressing tubulin beta3 assessed as inhibition of cell growth measured after 48 hrs by MTT assay Cytotoxicity against human HeLa cells overexpressing tubulin beta3 assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35344902]
HeLa	IC₅₀	17 nM Compound: Podophyllotoxin	Cytotoxicity against human HeLa cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35344902]
HeLa	IC₅₀	2.13 μM Compound: Ref 34, Cpd 1	Antiproliferative activity against human HeLa cells incubated for 24 hrs by MTT assay Antiproliferative activity against human HeLa cells incubated for 24 hrs by MTT assay	[PMID: 32992133]
HeLa	IC₅₀	2.36 μM Compound: 1; PPT	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 30108892]
HeLa	IC₅₀	2.8 μM Compound: 1, Podo	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 23182091]
HeLa	IC₅₀	2.81 μM Compound: 1	Anticancer activity against human HeLa cells after 48 hrs by MTT assay Anticancer activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 24721832]
HeLa	ED₅₀	20.5 μg/mL Compound: 3	Cytotoxicity against human HeLa cells after 4 days by trypan blue assay Cytotoxicity against human HeLa cells after 4 days by trypan blue assay	[PMID: 1602298]
HeLa	IC₅₀	3.04 μM Compound: IV	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 29289881]
HeLa	IC₅₀	3.06 μM Compound: Podophyllotoxin	Antiproliferative activity against human HeLa cells by MTT assay Antiproliferative activity against human HeLa cells by MTT assay	[PMID: 31546197]
HeLa	IC₅₀	3.14 μg/mL Compound: Podophyllotoxin	Anticancer activity against human HeLa cells after 24 hrs by MTT assay Anticancer activity against human HeLa cells after 24 hrs by MTT assay	[PMID: 25305717]
HeLa	IC₅₀	3.45 μM Compound: Podophyllotoxin	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 29289884]
HeLa	IC₅₀	6.9 μM Compound: PTOX	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30878833]
HeLa	IC₅₀	7.45 μM Compound: 1; PPT	Cytotoxicity against human HeLa cells after 24 hrs by MTT assay Cytotoxicity against human HeLa cells after 24 hrs by MTT assay	[PMID: 28757065]
HeLa	IC₅₀	7.58 μM Compound: Podophyllotoxing	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 25462233]
HeLa	IC₅₀	7.58 μM Compound: 1	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 22687745]
HEp-2	IC₅₀	1.42 μM Compound: 1	Cytotoxicity against human HEP2 cells by sulforhodamine B assay Cytotoxicity against human HEP2 cells by sulforhodamine B assay	[PMID: 17988764]
HepG2	IC₅₀	< 0.1 μM Compound: Podophyllotoxin	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by SRB assay	10.1039/C0MD00263A
HepG2	IC₅₀	> 200000 nM Compound: PPT	Cytotoxicity in human HepG2 cells assessed as inhibition of cell proliferation measured by CCK-8 assay Cytotoxicity in human HepG2 cells assessed as inhibition of cell proliferation measured by CCK-8 assay	[PMID: 34098082]
HepG2	IC₅₀	0.003 μM Compound: Podo	Antiproliferative activity against human HepG2 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human HepG2 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]
HepG2	IC₅₀	0.008 μM Compound: Podophyllotoxin	Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 29609908]
HepG2	IC₅₀	0.014 μM Compound: 2; PPT	Antiproliferative activity against human HepG2 cells assessed as growth inhibition after 72 hrs by CCK-8 assay Antiproliferative activity against human HepG2 cells assessed as growth inhibition after 72 hrs by CCK-8 assay	[PMID: 26615886]
HepG2	IC₅₀	0.024 μM Compound: B	Cytotoxicity against human HepG2 cells after 72 hrs by luminescence assay Cytotoxicity against human HepG2 cells after 72 hrs by luminescence assay	[PMID: 20129783]
HepG2	IC₅₀	0.5 μM Compound: 2	Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay	[PMID: 19880222]
HepG2	IC₅₀	0.51 μM Compound: 1	Cytotoxicity against human HepG2 cells after 48 hrs Cytotoxicity against human HepG2 cells after 48 hrs	[PMID: 23022053]
HepG2	IC₅₀	2.27 μM Compound: Podophyllotoxing	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 25462233]
HepG2	IC₅₀	2.27 μM Compound: 1	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 22687745]
HepG2	IC₅₀	2.4 μM Compound: PTOX	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30878833]
HepG2	IC₅₀	209 nM Compound: PPT	Cytotoxicity against hypoxia-induced human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against hypoxia-induced human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33091789]
HepG2	IC₅₀	3.06 μM Compound: Podophyllotoxin	Antiproliferative activity against human HepG2 cells by MTT assay Antiproliferative activity against human HepG2 cells by MTT assay	[PMID: 31546197]
HepG2	IC₅₀	4.31 μM Compound: Ref 34, Cpd 1	Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay	[PMID: 32992133]
HepG2	IC₅₀	4.8 μM Compound: podophyllotoxin	Cytotoxicity against human HEPG2 cells after 24 hrs by MTT assay Cytotoxicity against human HEPG2 cells after 24 hrs by MTT assay	[PMID: 18586491]
HepG2	IC₅₀	5.81 μM Compound: 1; PPT	Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay	[PMID: 28757065]
HepG2	IC₅₀	6.63 μM Compound: Podophyllotoxin	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 29289884]
HepG2	IC₅₀	83 nM Compound: PPT	Cytotoxicity against human HepG2 cells overexpressing NQO1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human HepG2 cells overexpressing NQO1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33091789]
HL-60	IC₅₀	0.48 μM Compound: PPT	Antiproliferative activity against human HL60 cells after 96 hrs by SRB assay Antiproliferative activity against human HL60 cells after 96 hrs by SRB assay	[PMID: 27187855]
HL-60	IC₅₀	2.75 μM Compound: 1, VP-16	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 19324555]
HL-60(TB)	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human HL-60(TB) cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human HL-60(TB) cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
HMEC	IC₅₀	1338 nM Compound: PPT	Cytotoxicity in human HMEC cells assessed as inhibition of cell proliferation measured by CCK-8 assay Cytotoxicity in human HMEC cells assessed as inhibition of cell proliferation measured by CCK-8 assay	[PMID: 34098082]
HMEC	IC₅₀	5.6 μM Compound: PTOX	Antiproliferative activity against human HMEC cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HMEC cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30878833]
HOP-62	GI₅₀	21.1 nM Compound: PT, NSC 24818	Cytotoxicity against human HOP62 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human HOP62 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
HOP-92	GI₅₀	34.1 nM Compound: PT, NSC 24818	Cytotoxicity against human HOP92 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human HOP92 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
Hs-578T	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human Hs 578T cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human Hs 578T cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
HT-29	IC₅₀	> 100 μM Compound: 1	Cytotoxicity against human HT-29 cells after 24 hrs by annexin-V-FITC/propidium iodide staining based flow cytometric method Cytotoxicity against human HT-29 cells after 24 hrs by annexin-V-FITC/propidium iodide staining based flow cytometric method	[PMID: 29670695]
HT-29	IC₅₀	0.012 μM Compound: 1	Cytotoxicity against human HT29 cells after 4 days Cytotoxicity against human HT29 cells after 4 days	[PMID: 17197187]
HT-29	IC₅₀	0.02 μM Compound: PPT	Antiproliferative activity against human HT-29 cells after 96 hrs by SRB assay Antiproliferative activity against human HT-29 cells after 96 hrs by SRB assay	[PMID: 27187855]
HT-29	IC₅₀	0.023 μM Compound: PPT	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35447432]
HT-29	GI₅₀	0.024 μM Compound: 1	Cytotoxicity against human HT-29 cells after 72 hrs by SRB assay Cytotoxicity against human HT-29 cells after 72 hrs by SRB assay	[PMID: 20067289]
HT-29	IC₅₀	0.066 μM Compound: 1	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 29670695]
HT-29	IC₅₀	0.78 μM Compound: 1	Anticancer activity against human HT-29 cells after 48 hrs by MTT assay Anticancer activity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 22136907]
HT-29	IC₅₀	1.02 μM Compound: 1, Podo	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 23182091]
HT-29	IC₅₀	1.26 μM Compound: 1; PPT	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 30108892]
HT-29	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human HT-29 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human HT-29 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
HT-29	IC₅₀	11 nM Compound: Podophyllotoxin	Antiproliferative activity against human HT-29 cells after 96 hrs by MTT assay Antiproliferative activity against human HT-29 cells after 96 hrs by MTT assay	[PMID: 2778449]
HT-29	GI₅₀	12 nM Compound: 1a	Growth inhibition of human HT-29 cells after 72 hrs by SRB assay Growth inhibition of human HT-29 cells after 72 hrs by SRB assay	[PMID: 22607205]
HT-29	IC₅₀	2.29 μM Compound: 1	Anticancer activity against human HT-29 cells after 48 hrs by MTT assay Anticancer activity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 24721832]
HT-29	IC₅₀	2.99 μM Compound: IV	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 29289881]
HT-29	ED₅₀	4.7 x 10^-8 μg/mL Compound: podophyllotoxin	Cytotoxicity against human HT-29 cells by MTT assay Cytotoxicity against human HT-29 cells by MTT assay	[PMID: 7714533]
HT-29	IC₅₀	4.78 μM Compound: Podophyllotoxin	Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 29289884]
HUVEC	IC₅₀	0.014 μM Compound: 2; PPT	Antiproliferative activity against HUVEC assessed as growth inhibition after 72 hrs by CCK-8 assay Antiproliferative activity against HUVEC assessed as growth inhibition after 72 hrs by CCK-8 assay	[PMID: 26615886]
IGROV-1	GI₅₀	13.2 nM Compound: PT, NSC 24818	Cytotoxicity against human IGROV1 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human IGROV1 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
J774	IC₅₀	0.023 μM Compound: Podophyllotoxin	Cytotoxicity against mouse J774 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against mouse J774 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31732409]
J774.A1	EC₅₀	21 nM Compound: Podophyllotoxin	Cytotoxicity against mouse J774A.1 cells assessed as inhibition of cell viability after 72 hrs by MTT assay Cytotoxicity against mouse J774A.1 cells assessed as inhibition of cell viability after 72 hrs by MTT assay	[PMID: 25749014]
J774.A1	EC₅₀	250 nM Compound: Podophyllotoxin	Cytotoxicity against mouse J774A1 cells after 72 hrs by MTT assay Cytotoxicity against mouse J774A1 cells after 72 hrs by MTT assay	[PMID: 24874647]
Jurkat	IC₅₀	25 nM Compound: PT	Cytotoxicity against human Jurkat cells assessed as cell viability after 48 hrs by trypan blue exclusion assay Cytotoxicity against human Jurkat cells assessed as cell viability after 48 hrs by trypan blue exclusion assay	[PMID: 21916509]
K562	IC₅₀	> 100 μM Compound: 1, VP-16	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 19324555]
K562	IC₅₀	0.006 μM Compound: 1; PPT	Antiproliferative activity against human K562 cells after 72 hrs by CCK8 assay Antiproliferative activity against human K562 cells after 72 hrs by CCK8 assay	[PMID: 27503681]
K562	IC₅₀	0.006 μM Compound: 2; PPT	Antiproliferative activity against human K562 cells assessed as growth inhibition after 72 hrs by CCK-8 assay Antiproliferative activity against human K562 cells assessed as growth inhibition after 72 hrs by CCK-8 assay	[PMID: 26615886]
K562	IC₅₀	0.013 μg/mL Compound: Podophyllotoxin	Anticancer activity against human K562 cells after 24 hrs by MTT assay Anticancer activity against human K562 cells after 24 hrs by MTT assay	[PMID: 25305717]
K562	IC₅₀	0.025 μM Compound: 1	Antiproliferative activity against human K562 cells after 72 hrs by CCK8 assay Antiproliferative activity against human K562 cells after 72 hrs by CCK8 assay	[PMID: 29678463]
K562	IC₅₀	0.03 μM Compound: Podophyllotoxin	Cytotoxicity against human K562 cells after 2 days by MTT assay Cytotoxicity against human K562 cells after 2 days by MTT assay	[PMID: 21821321]
K562	IC₅₀	0.03 μM Compound: Podophyllotoxin	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 25113878]
K562	IC₅₀	18.39 μM Compound: PDT	Cytotoxicity against human K562 cells incubated for 72 hrs by Sulphorhodamine assay Cytotoxicity against human K562 cells incubated for 72 hrs by Sulphorhodamine assay	[PMID: 37146520]
K562	GI₅₀	215.3 nM Compound: PT, NSC 24818	Cytotoxicity against human K562 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human K562 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
K562	IC₅₀	4.51 μM Compound: 1	Cytotoxicity against human K562 cells after 48 hrs Cytotoxicity against human K562 cells after 48 hrs	[PMID: 23022053]
K562/A02	IC₅₀	0.17 μM Compound: Podophyllotoxin	Cytotoxicity against human K562/A02 cells after 2 days by MTT assay Cytotoxicity against human K562/A02 cells after 2 days by MTT assay	[PMID: 21821321]
K562/A02	IC₅₀	0.17 μM Compound: Podophyllotoxin	Cytotoxicity against human K562/A02 cells after 48 hrs by MTT assay Cytotoxicity against human K562/A02 cells after 48 hrs by MTT assay	[PMID: 25113878]
K562/Adr	IC₅₀	0.025 μM Compound: 1; PPT	Antiproliferative activity against human K562/ADR cells after 72 hrs by CCK8 assay Antiproliferative activity against human K562/ADR cells after 72 hrs by CCK8 assay	[PMID: 27503681]
K562/Adr	IC₅₀	0.085 μM Compound: 2; PPT	Antiproliferative activity against human K562/ADR cells assessed as growth inhibition after 72 hrs by CCK-8 assay Antiproliferative activity against human K562/ADR cells assessed as growth inhibition after 72 hrs by CCK-8 assay	[PMID: 26615886]
K562/VCR	IC₅₀	0.05 μM Compound: 1	Antiproliferative activity against human K562/VCR cells after 72 hrs by CCK8 assay Antiproliferative activity against human K562/VCR cells after 72 hrs by CCK8 assay	[PMID: 29678463]
KB	ED₅₀	0.0003 μg/mL Compound: Podophyllotoxin	Cytotoxicity against human KB cells after 72 hrs Cytotoxicity against human KB cells after 72 hrs	[PMID: 8158163]
KB	IC₅₀	0.0007 μM Compound: POD	Cytotoxicity against human KB cells after 72 hrs by Alamar blue assay Cytotoxicity against human KB cells after 72 hrs by Alamar blue assay	[PMID: 24900724]
KB	IC₅₀	0.003 μM Compound: POD	Cytotoxicity against human KB cells after 48 hrs by alamar blue assay Cytotoxicity against human KB cells after 48 hrs by alamar blue assay	[PMID: 18215443]
KB	IC₅₀	0.0048 μM Compound: Podophyllotoxin	Cytotoxicity against human KB cells by alamar blue assay Cytotoxicity against human KB cells by alamar blue assay	[PMID: 12141852]
KB	IC₅₀	0.008 μM Compound: Podophyllotoxin	Cytotoxicity against human KB cells after 72 hrs Cytotoxicity against human KB cells after 72 hrs	[PMID: 11141105]
KB	IC₅₀	0.056 μM Compound: 6	Cytotoxicity against human KB cells after 72 hrs by MTT assay Cytotoxicity against human KB cells after 72 hrs by MTT assay	[PMID: 21570846]
KB	IC₅₀	0.058 μM Compound: Podophyllotoxin	Cytotoxicity against human KB cells after 72 hrs by Alamar blue assay Cytotoxicity against human KB cells after 72 hrs by Alamar blue assay	[PMID: 28189085]
KB	ED₅₀	0.07 μM Compound: podophyllotoxin	Cytotoxicity against human KB cells by Alamar blue assay Cytotoxicity against human KB cells by Alamar blue assay	[PMID: 16279799]
KB	IC₅₀	11.7 nM Compound: Podophyllotoxin	Cytotoxicity against human KB cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human KB cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 24148834]
KM12	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human KM12 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human KM12 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
L02	IC₅₀	0.022 μM Compound: 1; PPT	Antiproliferative activity against human LO2 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human LO2 cells after 72 hrs by CCK-8 assay	[PMID: 28301815]
L02	IC₅₀	2.97 μM Compound: Ref 34, Cpd 1	Cytotoxicity against human L02 cells incubated for 24 hrs by CCK8 assay Cytotoxicity against human L02 cells incubated for 24 hrs by CCK8 assay	[PMID: 32992133]
L02	IC₅₀	3.72 μM Compound: 1; PPT	Cytotoxicity against human L02 cells after 24 hrs by MTT assay Cytotoxicity against human L02 cells after 24 hrs by MTT assay	[PMID: 28757065]
L02	IC₅₀	4.31 μM Compound: Ref 34, Cpd 1	Cytotoxicity against human HL7702 cells incubated for 48 hrs by MTT assay Cytotoxicity against human HL7702 cells incubated for 48 hrs by MTT assay	[PMID: 32992133]
L02	IC₅₀	5 μM Compound: PTOX	Antiproliferative activity against human HL7702 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HL7702 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30878833]
L02	IC₅₀	85 nM Compound: PPT	Cytotoxicity against NQO1-deficient human L02 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against NQO1-deficient human L02 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33091789]
L6	IC₅₀	0.001 μM Compound: PDT	Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 24900706]
L6	IC₅₀	0.0017 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by inverted microscopy Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by inverted microscopy	[PMID: 23153330]
L6	IC₅₀	0.002 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay	[PMID: 26237241]
L6	IC₅₀	0.004 μg/mL Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay	[PMID: 22352841]
L6	IC₅₀	0.004 μg/mL Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by microplate fluorometric analysis Cytotoxicity against rat L6 cells after 72 hrs by microplate fluorometric analysis	[PMID: 20855214]
L6	IC₅₀	0.005 μg/mL Compound: Podophyllotoxin	Toxicity against rat L6 cells after 72 hrs by Alamar blue assay Toxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 23313632]
L6	EC₅₀	0.005 μg/mL Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells incubated for 72 hrs by alamar blue staining based microscopy Cytotoxicity against rat L6 cells incubated for 72 hrs by alamar blue staining based microscopy	[PMID: 26408453]
L6	IC₅₀	0.006 μg/mL Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 4 days Cytotoxicity against rat L6 cells after 4 days	[PMID: 17475370]
L6	IC₅₀	0.006 μg/mL Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 70 hrs by resazurin dye based fluorescence assay Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 70 hrs by resazurin dye based fluorescence assay	[PMID: 34091216]
L6	IC₅₀	0.006 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by fluorometric analysis Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by fluorometric analysis	[PMID: 24063369]
L6	IC₅₀	0.007 μg/mL Compound: POD	Cytotoxicity against rat L6 cells after 70 hrs by Alamar Blue-based assay Cytotoxicity against rat L6 cells after 70 hrs by Alamar Blue-based assay	[PMID: 29220797]
L6	EC₅₀	0.007 μg/mL Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay	[PMID: 24978605]
L6	IC₅₀	0.007 μg/mL Compound: podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay	[PMID: 20307077]
L6	IC₅₀	0.007 μg/mL Compound: Pod	Cytotoxicity against rat L6 cells by alamar blue assay Cytotoxicity against rat L6 cells by alamar blue assay	[PMID: 19010569]
L6	IC₅₀	0.007 μg/mL Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by resazurin assay Cytotoxicity against rat L6 cells after 72 hrs by resazurin assay	[PMID: 22217867]
L6	IC₅₀	0.007 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells measured after 72 hrs by alamar blue dye based fluorimetry analysis Cytotoxicity against rat L6 cells measured after 72 hrs by alamar blue dye based fluorimetry analysis	[PMID: 31799840]
L6	CC₅₀	0.007 μM Compound: PPT	Cytotoxicity against rat L6 cels assessed as reduction in cell viability after 72 hrs by Alamar Blue dye-based fluorometric analysis Cytotoxicity against rat L6 cels assessed as reduction in cell viability after 72 hrs by Alamar Blue dye-based fluorometric analysis	[PMID: 30615444]
L6	CC₅₀	0.007 μM Compound: PPT	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue staining based fluorescence assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue staining based fluorescence assay	[PMID: 30006174]
L6	IC₅₀	0.007 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue staining based fluorescence assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue staining based fluorescence assay	[PMID: 29244495]
L6	IC₅₀	0.008 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells after 70 hrs by microscopic analysis Cytotoxicity against rat L6 cells after 70 hrs by microscopic analysis	[PMID: 23320609]
L6	IC₅₀	0.0082 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 28537728]
L6	IC₅₀	0.009 μg/mL Compound: podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs Cytotoxicity against rat L6 cells after 72 hrs	[PMID: 17765547]
L6	IC₅₀	0.009 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay	[PMID: 30565934]
L6	EC₅₀	0.009 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 23517371]
L6	IC₅₀	0.009 μM Compound: podophyllotoxin	Cytotoxicity at rat L6 cells after 72 hrs by microplate alamar blue assay Cytotoxicity at rat L6 cells after 72 hrs by microplate alamar blue assay	[PMID: 21644541]
L6	IC₅₀	0.0097 μM Compound: PPT	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay	[PMID: 25195945]
L6	IC₅₀	0.01 μM Compound: PPT	Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay	[PMID: 19606902]
L6	IC₅₀	0.01 μM Compound: PPT	Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay	[PMID: 19267462]
L6	IC₅₀	0.01 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay	[PMID: 28840725]
L6	IC₅₀	0.01 μM Compound: PDP	Cytotoxicity against rat L6 cells assessed as cell viability after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells assessed as cell viability after 72 hrs by Alamar blue assay	[PMID: 28789893]
L6	IC₅₀	0.01 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 myoblasts after 72 hrs by alamar blue assay Cytotoxicity against rat L6 myoblasts after 72 hrs by alamar blue assay	[PMID: 22285027]
L6	IC₅₀	0.01 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay	[PMID: 21348447]
L6	IC₅₀	0.01 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 72 hrs by Alamar blue staining-based fluorometric analysis Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 72 hrs by Alamar blue staining-based fluorometric analysis	[PMID: 30302998]
L6	IC₅₀	0.012 μM Compound: pod	Cytotoxicity against rat L6 cells after 70 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 70 hrs by Alamar blue assay	[PMID: 33148495]
L6	IC₅₀	0.012 μM Compound: POD	Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by alamar blue assay Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by alamar blue assay	[PMID: 28031151]
L6	IC₅₀	0.012 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay	[PMID: 21112788]
L6	IC₅₀	0.012 μM Compound: PPT	Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay	[PMID: 20047276]
L6	IC₅₀	0.012 μM Compound: POD	Cytotoxicity in rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay Cytotoxicity in rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay	[PMID: 30962114]
L6	IC₅₀	0.012 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 28666857]
L6	IC₅₀	0.012 μM Compound: POD	Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 72 hrs by Alamar blue assay	[PMID: 27344215]
L6	IC₅₀	0.012 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 25871440]
L6	EC₅₀	0.012 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay	[PMID: 23916149]
L6	EC₅₀	0.012 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay	[PMID: 22390399]
L6	IC₅₀	0.012 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 70 hrs by Alamar blue staining-based fluorometric analysis Cytotoxicity against rat L6 cells after 70 hrs by Alamar blue staining-based fluorometric analysis	[PMID: 29172086]
L6	IC₅₀	0.012 μM Compound: POD	Cytotoxicity against rat L6 cells after 70 hrs by alamar blue staining based fluorometric assay Cytotoxicity against rat L6 cells after 70 hrs by alamar blue staining based fluorometric assay	[PMID: 28279559]
L6	IC₅₀	0.012 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue based inverted microscopy analysis Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue based inverted microscopy analysis	[PMID: 31784198]
L6	IC₅₀	0.012 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by resazurin-based spectrophotometric assay Cytotoxicity against rat L6 cells after 72 hrs by resazurin-based spectrophotometric assay	[PMID: 22061825]
L6	IC₅₀	0.012 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by microplate fluorimetry Cytotoxicity against rat L6 cells after 72 hrs by microplate fluorimetry	[PMID: 21438586]
L6	CC₅₀	0.014 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 48 hrs by Alamar Blue assay Cytotoxicity against rat L6 cells after 48 hrs by Alamar Blue assay	[PMID: 24354316]
L6	IC₅₀	0.014 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by alamar blue assay	[PMID: 28284860]
L6	IC₅₀	0.014 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 21937228]
L6	IC₅₀	0.014 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by resazurin assay Cytotoxicity against rat L6 cells after 72 hrs by resazurin assay	[PMID: 17709461]
L6	EC₅₀	0.014 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells incubated for 70 hrs by resazurin dye based assay Cytotoxicity against rat L6 cells incubated for 70 hrs by resazurin dye based assay	[PMID: 32134269]
L6	IC₅₀	0.0145 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 70 hrs by resazurin dye based fluorescence assay Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 70 hrs by resazurin dye based fluorescence assay	[PMID: 33524940]
L6	IC₅₀	0.0145 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells after 70 hrs by resazurin reduction assay Cytotoxicity against rat L6 cells after 70 hrs by resazurin reduction assay	[PMID: 23301592]
L6	IC₅₀	0.016 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay	[PMID: 28116906]
L6	IC₅₀	0.0169 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells by alamar blue assay Cytotoxicity against rat L6 cells by alamar blue assay	[PMID: 27387356]
L6	IC₅₀	0.017 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 3 days by Alamar blue assay Cytotoxicity against rat L6 cells after 3 days by Alamar blue assay	[PMID: 24956553]
L6	IC₅₀	0.017 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by Alamar Blue assay Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by Alamar Blue assay	[PMID: 24471526]
L6	IC₅₀	0.017 μM Compound: PPT	Cytotoxicity against rat L6 cells assessed as cell viability after 70 hrs by Alamar blue assay Cytotoxicity against rat L6 cells assessed as cell viability after 70 hrs by Alamar blue assay	[PMID: 24268543]
L6	EC₅₀	0.017 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 70 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 70 hrs by Alamar blue assay	[PMID: 23831695]
L6	IC₅₀	0.017 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay	[PMID: 28121440]
L6	IC₅₀	0.017 μM Compound: PPT	Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay	[PMID: 23795673]
L6	IC₅₀	0.017 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as cell growth inhibition incubated for 70 hrs by resazurin dye based assay Cytotoxicity against rat L6 cells assessed as cell growth inhibition incubated for 70 hrs by resazurin dye based assay	[PMID: 33901399]
L6	IC₅₀	0.017 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells measured after 70 hrs by alamar blue staining based fluorescence analysis Cytotoxicity against rat L6 cells measured after 70 hrs by alamar blue staining based fluorescence analysis	[PMID: 27102161]
L6	IC₅₀	0.017 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 70 hrs by resazurin staining based inverted microscopic analysis Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 70 hrs by resazurin staining based inverted microscopic analysis	[PMID: 32745819]
L6	IC₅₀	0.017 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 72 hrs by Alamar blue dye-based fluorometric analysis Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 72 hrs by Alamar blue dye-based fluorometric analysis	[PMID: 31642313]
L6	IC₅₀	0.017 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue staining based fluorescence assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue staining based fluorescence assay	[PMID: 29043798]
L6	IC₅₀	0.017 μM Compound: Podophyllotoxin	Cytotoxicity in rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue dye based assay Cytotoxicity in rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue dye based assay	[PMID: 28988153]
L6	IC₅₀	0.017 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as reduction in cell viability by resazurin dye based assay Cytotoxicity against rat L6 cells assessed as reduction in cell viability by resazurin dye based assay	[PMID: 36972793]
L6	IC₅₀	0.018 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells measured after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells measured after 72 hrs by alamar blue assay	[PMID: 31550659]
L6	IC₅₀	0.018 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells measured after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells measured after 72 hrs by alamar blue assay	[PMID: 30975502]
L6	IC₅₀	0.019 mM Compound: PPT	Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 23871911]
L6	CC₅₀	0.019 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 70 hrs by Alamar blue assay Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 70 hrs by Alamar blue assay	[PMID: 33070078]
L6	IC₅₀	0.019 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 23265884]
L6	IC₅₀	0.019 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells by Alamar blue assay Cytotoxicity against rat L6 cells by Alamar blue assay	[PMID: 17922552]
L6	IC₅₀	0.019 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells incubated for 72 hrs by Alamar Blue staining based fluorometric assay Cytotoxicity against rat L6 cells incubated for 72 hrs by Alamar Blue staining based fluorometric assay	[PMID: 21846091]
L6	IC₅₀	0.0193 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by fluorometric analysis Cytotoxicity against rat L6 cells after 72 hrs by fluorometric analysis	[PMID: 24900574]
L6	IC₅₀	0.02 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay	[PMID: 29896963]
L6	IC₅₀	0.02 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells after 70 hrs by Alamar Blue assay Cytotoxicity against rat L6 cells after 70 hrs by Alamar Blue assay	[PMID: 24900723]
L6	IC₅₀	0.02 μM Compound: PPT	Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay	[PMID: 19928900]
L6	IC₅₀	0.02 μM Compound: Podo	Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay	10.1039/C5MD00498E
L6	IC₅₀	0.02 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 70 hrs by resazurin dye based inverted microscopic analysis Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 70 hrs by resazurin dye based inverted microscopic analysis	[PMID: 33095014]
L6	IC₅₀	0.02 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells measured after 72 hrs by alamar blue dye based fluorometric analysis Cytotoxicity against rat L6 cells measured after 72 hrs by alamar blue dye based fluorometric analysis	[PMID: 33843232]
L6	IC₅₀	0.02 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by AlamarBlue dye based fluorimetric method Cytotoxicity against rat L6 cells after 72 hrs by AlamarBlue dye based fluorimetric method	[PMID: 26849852]
L6	IC₅₀	0.021 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells by MTT assay Cytotoxicity against rat L6 cells by MTT assay	[PMID: 21456549]
L6	IC₅₀	0.022 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 70 hrs by resazurin dye-based fluorometric analysis Cytotoxicity against rat L6 cells after 70 hrs by resazurin dye-based fluorometric analysis	10.1039/C4MD00406J
L6	IC₅₀	0.041 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 29560715]
L6	IC₅₀	0.041 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue staining-based fluorometric analysis Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue staining-based fluorometric analysis	[PMID: 31630523]
L6	IC₅₀	11 nM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 70 hrs by Alamar blue dye-based fluorometric analysis Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 70 hrs by Alamar blue dye-based fluorometric analysis	[PMID: 34095848]
L6	IC₅₀	14.5 nM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 70 hrs by Alamar Blue assay Cytotoxicity against rat L6 cells after 70 hrs by Alamar Blue assay	[PMID: 24721829]
L6	IC₅₀	14.5 nM Compound: Podophylotoxin	Toxicity against rat L6 cells after 72 hrs by Alamar blue assay Toxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 23360309]
L6	IC₅₀	14.5 nM Compound: Podophylotoxin	Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by Alamar blue staining-based inverted microscopic analysis Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by Alamar blue staining-based inverted microscopic analysis	[PMID: 23685569]
L929	IC₅₀	1.37 μM Compound: 1	Cytotoxicity against mouse L929 cells after 72 hrs by MTT assay Cytotoxicity against mouse L929 cells after 72 hrs by MTT assay	[PMID: 22687745]
LOX IMVI	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human LOXIMVI cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human LOXIMVI cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
M14	GI₅₀	13.1 nM Compound: PT, NSC 24818	Cytotoxicity against human M14 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human M14 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
Malme-3M	GI₅₀	47315.1 nM Compound: PT, NSC 24818	Cytotoxicity against human MALME-3M cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human MALME-3M cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
MCF7	IC₅₀	> 100 μM Compound: 1	Cytotoxicity against human MCF7 cells after 24 hrs by annexin-V-FITC/propidium iodide staining based flow cytometric method Cytotoxicity against human MCF7 cells after 24 hrs by annexin-V-FITC/propidium iodide staining based flow cytometric method	[PMID: 29670695]
MCF7	IC₅₀	> 200000 nM Compound: PPT	Cytotoxicity in human MCF7 cells assessed as inhibition of cell proliferation measured by CCK-8 assay Cytotoxicity in human MCF7 cells assessed as inhibition of cell proliferation measured by CCK-8 assay	[PMID: 34098082]
MCF7	IC₅₀	0.0001 μM Compound: 2	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 25084144]
MCF7	IC₅₀	0.0004 μM Compound: 2	Cytotoxicity against human MCF7 cells in presence of 10 mM DTT after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells in presence of 10 mM DTT after 48 hrs by SRB assay	[PMID: 25084144]
MCF7	IC₅₀	0.005 μM Compound: Podophyllotoxin	Cytotoxicity against human MCF7 cells measured after 72 hrs by sulforhodamine B assay Cytotoxicity against human MCF7 cells measured after 72 hrs by sulforhodamine B assay	[PMID: 30920216]
MCF7	GI₅₀	0.01 μM Compound: Podophyllotoxin	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 21615090]
MCF7	IC₅₀	0.01 μM Compound: PPT	Antiproliferative activity against human MCF7 cells after 96 hrs by SRB assay Antiproliferative activity against human MCF7 cells after 96 hrs by SRB assay	[PMID: 27187855]
MCF7	IC₅₀	0.017 μM Compound: podophyllotoxin	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay	[PMID: 26086179]
MCF7	IC₅₀	0.02 μM Compound: Podo	Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]
MCF7	IC₅₀	0.02 μM Compound: Podophyllotoxin	Cytotoxicity against vinblastine-sensitive human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against vinblastine-sensitive human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 28006904]
MCF7	IC₅₀	0.028 μM Compound: 1	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 29670695]
MCF7	IC₅₀	0.039 μM Compound: PPT	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35447432]
MCF7	IC₅₀	0.2 μM Compound: Podophyllotoxin	Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine free medium assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine free medium assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 28006904]
MCF7	GI₅₀	0.23 μM Compound: 1	Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 24953821]
MCF7	IC₅₀	0.23 μM Compound: 1; PT	Antiproliferative activity against human MCF7 cells after 96 hrs by propidium iodide-based monolayer assay Antiproliferative activity against human MCF7 cells after 96 hrs by propidium iodide-based monolayer assay	[PMID: 26854430]
MCF7	IC₅₀	0.28 μM Compound: PDX	Antiproliferative activity against human MCF7 cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay Antiproliferative activity against human MCF7 cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay	[PMID: 30482548]
MCF7	IC₅₀	0.3 μM Compound: Podophyllotoxin	Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine containing medium assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine containing medium assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 28006904]
MCF7	GI₅₀	0.31 μM Compound: 1	Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 25131956]
MCF7	ED₅₀	1.1 x 10^-6 μg/mL Compound: podophyllotoxin	Cytotoxicity against human MCF7 cells by MTT assay Cytotoxicity against human MCF7 cells by MTT assay	[PMID: 7714533]
MCF7	IC₅₀	1.11 μM Compound: Podophyllotoxin	Cytotoxicity against human MCF7 cells after 36 hrs by MTT assay Cytotoxicity against human MCF7 cells after 36 hrs by MTT assay	[PMID: 27262599]
MCF7	IC₅₀	1.18 μM Compound: 1	Anticancer activity against human MCF7 cells after 48 hrs by MTT assay Anticancer activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 22136907]
MCF7	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human MCF7 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human MCF7 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
MCF7	IC₅₀	10.04 μM Compound: PDT	Cytotoxicity against human MCF7 cells incubated for 72 hrs by Sulphorhodamine assay Cytotoxicity against human MCF7 cells incubated for 72 hrs by Sulphorhodamine assay	[PMID: 37146520]
MCF7	IC₅₀	10.86 μM Compound: Podophyllotoxin	Antiproliferative activity against human MCF-7 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human MCF-7 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 31884407]
MCF7	IC₅₀	15 nM Compound: podophyllotoxin	Antiproliferative activity against human MCF7 cells after 72 hrs Antiproliferative activity against human MCF7 cells after 72 hrs	[PMID: 17034133]
MCF7	IC₅₀	15.8 nM Compound: Ref 34, Cpd 1	Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 32992133]
MCF7	IC₅₀	2.13 μM Compound: Ref 34, Cpd 1	Antiproliferative activity against human MCF7 cells incubated for 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 24 hrs by MTT assay	[PMID: 32992133]
MCF7	IC₅₀	2.21 μM Compound: Podo	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 30025350]
MCF7	IC₅₀	2.4 μM Compound: PTOX	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30878833]
MCF7	IC₅₀	3.06 μM Compound: Podophyllotoxin	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 29289884]
MCF7	IC₅₀	3.06 μM Compound: Podophyllotoxin	Antiproliferative activity against human MCF7 cells by MTT assay Antiproliferative activity against human MCF7 cells by MTT assay	[PMID: 31546197]
MCF7	IC₅₀	3.34 μM Compound: 1	Cytotoxicity against human MCF7 cells assessed as cell viability by SRB assay Cytotoxicity against human MCF7 cells assessed as cell viability by SRB assay	[PMID: 26022842]
MCF7	IC₅₀	3.5 μM Compound: PDT, 4	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 22472045]
MCF7	IC₅₀	3.52 μg/mL Compound: Podophyllotoxin	Anticancer activity against human MCF7 cells after 24 hrs by MTT assay Anticancer activity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 25305717]
MCF7	IC₅₀	3.75 μM Compound: 1; PPT	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 30108892]
MCF7	IC₅₀	4.16 μM Compound: PDT	Cytotoxicity against human MCF7 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay Cytotoxicity against human MCF7 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]
MCF7	IC₅₀	64.99 μM Compound: Podophyllotoxin	Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 32731188]
MCF7	IC₅₀	64.99 μM Compound: PDT	Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 24457094]
MCF7	IC₅₀	7.13 μM Compound: 1; PPT	Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 28757065]
MCF7	IC₅₀	8.5 μM Compound: podophyllotoxin	Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 18586491]
MDA-MB-231	IC₅₀	< 0.1 μM Compound: Podophyllotoxin	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by SRB assay	10.1039/C0MD00263A
MDA-MB-231	IC₅₀	0.008 μM Compound: Podophyllotoxin	Antiproliferative activity against estrogen-independent breast cancer MDA-MB-231 cell line by MTS assay Antiproliferative activity against estrogen-independent breast cancer MDA-MB-231 cell line by MTS assay	[PMID: 16213720]
MDA-MB-231	IC₅₀	0.017 μM Compound: PPT	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35447432]
MDA-MB-231	IC₅₀	0.079 μM Compound: podophyllotoxin	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay	[PMID: 26086179]
MDA-MB-231	IC₅₀	0.12 μM Compound: PPT	Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by SRB assay	[PMID: 27187855]
MDA-MB-231	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
MDA-MB-231	IC₅₀	20.22 μM Compound: PDT	Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by Sulphorhodamine assay Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by Sulphorhodamine assay	[PMID: 37146520]
MDA-MB-231	IC₅₀	35.7 μM Compound: PDT	Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay	[PMID: 24457094]
MDA-MB-231	IC₅₀	5.73 μM Compound: Podophyllotoxin	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 31884407]
MDA-MB-231	IC₅₀	9.76 μM Compound: IV	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 29289881]
MDA-MB-435	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human MDA-MB-435 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human MDA-MB-435 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
MDA-MB-468	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human MDA-MB-468 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human MDA-MB-468 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
MG-63	IC₅₀	0.007 μM Compound: 1	Cytotoxicity against human MG63 cells after 72 hrs by MTT assay Cytotoxicity against human MG63 cells after 72 hrs by MTT assay	[PMID: 29670695]
MG-63	IC₅₀	18.3 μM Compound: 1	Cytotoxicity against human MG63 cells after 24 hrs by annexin-V-FITC/propidium iodide staining based flow cytometric method Cytotoxicity against human MG63 cells after 24 hrs by annexin-V-FITC/propidium iodide staining based flow cytometric method	[PMID: 29670695]
MIA PaCa-2	IC₅₀	0.012 μM Compound: Podo	Antiproliferative activity against human MIAPaCa2 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human MIAPaCa2 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]
MIA PaCa-2	GI₅₀	0.51 μM Compound: 1	Antiproliferative activity against human MIAPaCa2 cells assessed as growth inhibition after 48 hrs by SRB assay Antiproliferative activity against human MIAPaCa2 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 25131956]
MOLT-3	IC₅₀	14 nM Compound: podophyllotoxin	Antiproliferative activity against human Molt3 cells after 72 hrs Antiproliferative activity against human Molt3 cells after 72 hrs	[PMID: 17034133]
MOLT-4	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human MOLT4 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human MOLT4 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
MRC5	IC₅₀	10.6 μM Compound: PTOX	Antiproliferative activity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30878833]
NCI/ADR-RES	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human NCI/ADR-RES cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human NCI/ADR-RES cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
NCI-H226	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human NCI-H226 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human NCI-H226 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
NCI-H23	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human NCI-H23 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human NCI-H23 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
NCI-H322M	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human NCI-H322M cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human NCI-H322M cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
NCI-H460	GI₅₀	10.6 nM Compound: PT, NSC 24818	Cytotoxicity against human NCI-H460 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human NCI-H460 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
NCI-H522	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human NCI-H522 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human NCI-H522 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
NIH3T3	IC₅₀	0.084 μM Compound: podophyllotoxin	Antiproliferative activity against mouse NIH/3T3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay Antiproliferative activity against mouse NIH/3T3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay	[PMID: 26086179]
NIH3T3	IC₅₀	3.06 μM Compound: Podophyllotoxin	Antiproliferative activity against mouse NIH/3T3 cells by MTT assay Antiproliferative activity against mouse NIH/3T3 cells by MTT assay	[PMID: 31546197]
OVCAR-3	GI₅₀	11.3 nM Compound: PT, NSC 24818	Cytotoxicity against human OVCAR3 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human OVCAR3 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
OVCAR-4	GI₅₀	17.5 nM Compound: PT, NSC 24818	Cytotoxicity against human OVCAR4 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human OVCAR4 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
OVCAR-8	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human OVCAR8 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human OVCAR8 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
P388	ED₅₀	0.0043 μg/mL Compound: 1a	Growth inhibition of mouse P388 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of mouse P388 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 26938998]
P388	IC₅₀	0.012 μM Compound: 1	Cytotoxicity against mouse P388 cells after 4 days Cytotoxicity against mouse P388 cells after 4 days	[PMID: 17197187]
P388	IC₅₀	10.4 nM Compound: PT	Cytotoxicity against mouse P388 cells assessed as cell viability after 48 hrs by trypan blue exclusion assay Cytotoxicity against mouse P388 cells assessed as cell viability after 48 hrs by trypan blue exclusion assay	[PMID: 21916509]
P388	IC₅₀	10.4 μM Compound: 185	Cytotoxicity against mouse P388 cells measured after 48 hrs by MTT assay Cytotoxicity against mouse P388 cells measured after 48 hrs by MTT assay	[PMID: 35598527]
P388	IC₅₀	5.9 nM Compound: Podophyllotoxin	Antiproliferative activity against mouse P388 cells after 48 hrs by MTT assay Antiproliferative activity against mouse P388 cells after 48 hrs by MTT assay	[PMID: 2778449]
PBMC	IC₅₀	5.02 μM Compound: Ref 34, Cpd 1	Cytotoxicity against PBMC (unknown origin) incubated for 24 hrs by CCK8 assay Cytotoxicity against PBMC (unknown origin) incubated for 24 hrs by CCK8 assay	[PMID: 32992133]
PC-3	IC₅₀	0.013 μM Compound: Podophyllotoxin	Antiproliferative activity against androgen-independent prostate cancer PC3 cell line by MTS assay Antiproliferative activity against androgen-independent prostate cancer PC3 cell line by MTS assay	[PMID: 16213720]
PC-3	IC₅₀	0.05 μM Compound: PPT	Antiproliferative activity against human PC3 cells after 96 hrs by SRB assay Antiproliferative activity against human PC3 cells after 96 hrs by SRB assay	[PMID: 27187855]
PC-3	IC₅₀	0.06 μM Compound: Podophyllotoxin	Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 34175586]
PC-3	IC₅₀	0.07 μM Compound: Podophyllotoxin	Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 48 hrs by MTT assay Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 48 hrs by MTT assay	[PMID: 29525336]
PC-3	IC₅₀	0.07 μM Compound: Podophyllotoxin	Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay	[PMID: 28648953]
PC-3	IC₅₀	0.07 μM Compound: Podophyllotoxin	Growth inhibition of human PC3 cells after 48 hrs by MTT assay Growth inhibition of human PC3 cells after 48 hrs by MTT assay	[PMID: 28131777]
PC-3	IC₅₀	0.12 μM Compound: PDX	Antiproliferative activity against human PC3 cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay Antiproliferative activity against human PC3 cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay	[PMID: 30482548]
PC-3	IC₅₀	0.2 μM Compound: Podophyllotoxin	Cytotoxicity against human PC3 cells measured after 72 hrs by sulforhodamine B assay Cytotoxicity against human PC3 cells measured after 72 hrs by sulforhodamine B assay	[PMID: 30920216]
PC-3	ED₅₀	1.2 x 10^-7 μg/mL Compound: podophyllotoxin	Cytotoxicity against human PC3 cells by MTT assay Cytotoxicity against human PC3 cells by MTT assay	[PMID: 7714533]
PC-3	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human PC3 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human PC3 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
PC-3	IC₅₀	10 nM Compound: podophyllotoxin	Antiproliferative activity against human PC3 cells after 72 hrs Antiproliferative activity against human PC3 cells after 72 hrs	[PMID: 17034133]
PC-3	IC₅₀	15.8 nM Compound: Ref 34, Cpd 1	Antiproliferative activity against human PC3 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human PC3 cells incubated for 72 hrs by MTT assay	[PMID: 32992133]
PC-3	IC₅₀	18.9 μM Compound: 1	Cytotoxicity against human PC-3 cells by sulforhodamine B assay Cytotoxicity against human PC-3 cells by sulforhodamine B assay	[PMID: 17988764]
PC-3	IC₅₀	3.06 μM Compound: Podophyllotoxin	Antiproliferative activity against human PC3 cells by MTT assay Antiproliferative activity against human PC3 cells by MTT assay	[PMID: 31546197]
PC-3M	IC₅₀	234.9 nM Compound: PPT	Cytotoxicity in human PC-3M cells assessed as inhibition of cell proliferation measured by CCK-8 assay Cytotoxicity in human PC-3M cells assessed as inhibition of cell proliferation measured by CCK-8 assay	[PMID: 34098082]
Raji	IC₅₀	0.018 μM Compound: B	Cytotoxicity against human Raji cells after 72 hrs by luminescence assay Cytotoxicity against human Raji cells after 72 hrs by luminescence assay	[PMID: 20129783]
RKO	IC₅₀	> 0.5 μM Compound: podophyllotoxin	Cytotoxicity against cell cycle arrested RKOp27 cells after 72 hrs by alamar blue assay Cytotoxicity against cell cycle arrested RKOp27 cells after 72 hrs by alamar blue assay	[PMID: 16970401]
RKO	IC₅₀	0.029 μM Compound: podophyllotoxin	Cytotoxicity against proliferating RKOp27 cells after 72 hrs by Alamar Blue assay Cytotoxicity against proliferating RKOp27 cells after 72 hrs by Alamar Blue assay	[PMID: 16970401]
RPMI-8226	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human RPMI8226 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human RPMI8226 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
RXF 393	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human RXF393 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human RXF393 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
SF-268	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human SF268 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human SF268 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
SF-295	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human SF295 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human SF295 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
SF-295	IC₅₀	5.69 μM Compound: 1	Cytotoxicity against human SF295 cells by sulforhodamine B assay Cytotoxicity against human SF295 cells by sulforhodamine B assay	[PMID: 17988764]
SF-539	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human SF539 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human SF539 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
SGC-7901	IC₅₀	0.34 μM Compound: 1	Cytotoxicity against human SGC7901 cells after 48 hrs Cytotoxicity against human SGC7901 cells after 48 hrs	[PMID: 23022053]
SGC-7901	IC₅₀	2.95 μM Compound: 1	Cytotoxicity against human SGC7901 cells after 72 hrs by MTT assay Cytotoxicity against human SGC7901 cells after 72 hrs by MTT assay	[PMID: 22687745]
SH-SY5Y	IC₅₀	1.05 μg/mL Compound: Podophyllotoxin	Anticancer activity against human SH-SY5Y cells after 24 hrs by MTT assay Anticancer activity against human SH-SY5Y cells after 24 hrs by MTT assay	[PMID: 25305717]
SH-SY5Y	IC₅₀	2.54 μM Compound: 1	Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay	[PMID: 22687745]
SH-SY5Y	IC₅₀	7 nM Compound: 2, podophyllotoxin	Cytotoxicity against SH-SY5Y cells assessed as cell viability after 48 hrs by MTT method Cytotoxicity against SH-SY5Y cells assessed as cell viability after 48 hrs by MTT method	[PMID: 17765552]
SiHa	IC₅₀	0.1 μM Compound: Podophyllotoxin	Cytotoxicity against human SiHa cells measured after 72 hrs by sulforhodamine B assay Cytotoxicity against human SiHa cells measured after 72 hrs by sulforhodamine B assay	[PMID: 30920216]
SK-MEL-2	GI₅₀	14.9 nM Compound: PT, NSC 24818	Cytotoxicity against human SK-MEL-2 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human SK-MEL-2 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
SK-MEL-28	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human SK-MEL-28 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human SK-MEL-28 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
SK-MEL-5	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human SK-MEL-5 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human SK-MEL-5 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
SK-MEL-5	ED₅₀	4.1 x 10^-8 μg/mL Compound: podophyllotoxin	Cytotoxicity against human SK-MEL-5 cells by MTT assay Cytotoxicity against human SK-MEL-5 cells by MTT assay	[PMID: 7714533]
SK-N-SH	IC₅₀	< 0.1 μM Compound: Podophyllotoxin	Cytotoxicity against human SK-N-SH cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human SK-N-SH cells assessed as growth inhibition after 48 hrs by SRB assay	10.1039/C0MD00263A
SK-N-SH	IC₅₀	7.92 μM Compound: 1	Cytotoxicity against human SK-N-SH cells assessed as cell viability by SRB assay Cytotoxicity against human SK-N-SH cells assessed as cell viability by SRB assay	[PMID: 26022842]
SK-OV-3	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human SKOV3 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human SKOV3 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
SK-OV-3	ED₅₀	4.2 x 10^-5 μg/mL Compound: podophyllotoxin	Cytotoxicity against human SKOV3 cells by MTT assay Cytotoxicity against human SKOV3 cells by MTT assay	[PMID: 7714533]
SN12C	GI₅₀	17.1 nM Compound: PT, NSC 24818	Cytotoxicity against human SN12C cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human SN12C cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
SNB-19	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human SNB19 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human SNB19 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
SNB-75	GI₅₀	659.2 nM Compound: PT, NSC 24818	Cytotoxicity against human SNB75 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human SNB75 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
SR	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human SR cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human SR cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
SW-620	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human SW620 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human SW620 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
T47D	IC₅₀	0.25 μM Compound: PPT	Antiproliferative activity against human T47D cells after 96 hrs by SRB assay Antiproliferative activity against human T47D cells after 96 hrs by SRB assay	[PMID: 27187855]
T47D	EC₅₀	2.97 nM Compound: PPT	Inhibition of colony formation in human T47D cells after 7 days by crystal violet staining based assay Inhibition of colony formation in human T47D cells after 7 days by crystal violet staining based assay	[PMID: 27187855]
T47D	EC₅₀	8.98 μM Compound: PPT	Antimigratory activity in human T47D cells assessed as inhibition of cell migration after 12 hrs by crystal violet staining based transwell migration assay Antimigratory activity in human T47D cells assessed as inhibition of cell migration after 12 hrs by crystal violet staining based transwell migration assay	[PMID: 27187855]
T47D	GI₅₀	84527.9 nM Compound: PT, NSC 24818	Cytotoxicity against human T47D cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human T47D cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
THP-1	IC₅₀	19.55 μM Compound: Podophyllotoxin	Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 31884407]
TK-10	GI₅₀	30.5 nM Compound: PT, NSC 24818	Cytotoxicity against human TK10 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human TK10 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
U-251	GI₅₀	10.7 nM Compound: PT, NSC 24818	Cytotoxicity against human U251 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human U251 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
UACC-257	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human UACC257 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human UACC257 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
UACC-62	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human UACC62 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human UACC62 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
UO-31	GI₅₀	16.6 nM Compound: PT, NSC 24818	Cytotoxicity against human UO31 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human UO31 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
Vero	IC₅₀	0.023 μM Compound: podophyllotoxin	Cytotoxicity against african green monkey Vero cells after 3 days by tetrazolium dye based colorimetric assay Cytotoxicity against african green monkey Vero cells after 3 days by tetrazolium dye based colorimetric assay	[PMID: 19058972]
Vero	IC₅₀	1.78 μM Compound: 1	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 22687745]
Vero	CC₅₀	5.74 μM Compound: Podophyllotoxin	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 28763644]
WRL68	IC₅₀	1.989 μg/mL Compound: Podophyllotoxin	Anticancer activity against human WRL68 cells after 24 hrs by MTT assay Anticancer activity against human WRL68 cells after 24 hrs by MTT assay	[PMID: 25305717]
WRL68	IC₅₀	3.02 μM Compound: PDT	Cytotoxicity against human WRL68 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay Cytotoxicity against human WRL68 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]
WRL68	IC₅₀	4.8 μM Compound: podophyllotoxin	Cytotoxicity against human WRL68 cells after 24 hrs by MTT assay Cytotoxicity against human WRL68 cells after 24 hrs by MTT assay	[PMID: 18586491]

體外研究
(In Vitro)

Podofilox 是一種從鬼臼屬植物的根和根莖中提取的非生物堿類毒素木脂素，已被證明可抑制多種癌細胞的生長。Podofilox 是一種抑制微管蛋白聚合的天然產(chǎn)物，已成為臨床使用的多種抗腫瘤藥物開發(fā)的原型。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

414.41

Formula

C₂₂H₂₂O₈

CAS 號

518-28-5

性狀

固體

顏色

White to off-white

中文名稱

依托泊苷EP雜質M

結構分類

初始來源

運輸條件

Room temperature in continental US; may vary elsewhere.

儲存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

溶解性數(shù)據(jù)

細胞實驗：

DMSO 中的溶解度 : 100 mg/mL (241.31 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液

濃度溶劑體積質量	1 mg	5 mg	10 mg

1 mM	2.4131 mL	12.0653 mL	24.1307 mL
5 mM	0.4826 mL	2.4131 mL	4.8261 mL
10 mM	0.2413 mL	1.2065 mL	2.4131 mL

查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內使用， -20°C儲存時，請在1年內使用。

摩爾計算器
稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

濃度 _(start)

體積 _(start)

濃度 _(final)

體積 _(final)

動物實驗：

請根據(jù)您的實驗動物和給藥方式選擇適當?shù)娜芙夥桨浮?

以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
——為保證實驗結果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當保存；體內實驗的工作液，建議您現(xiàn)用現(xiàn)配，當天使用；
以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

方案一

請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (3.02 mM); 澄清溶液

此方案可獲得 ≥ 1.25 mg/mL（飽和度未知）的澄清溶液。
以 1 mL 工作液為例，取 100 μL 12.5 mg/mL 的澄清 DMSO 儲備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水定容至 1 mL。
生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
方案二

請依序添加每種溶劑： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.25 mg/mL (3.02 mM); 澄清溶液

此方案可獲得 ≥ 1.25 mg/mL（飽和度未知）的澄清溶液。
以 1 mL 工作液為例，取 100 μL 12.5 mg/mL 的澄清 DMSO 儲備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液中，混合均勻。
2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。
方案三

請依序添加每種溶劑： 10% DMSO 90% Corn Oil
Solubility: ≥ 1.25 mg/mL (3.02 mM); 澄清溶液

此方案可獲得 ≥ 1.25 mg/mL（飽和度未知）的澄清溶液，此方案實驗周期在半個月以上的動物實驗酌情使用。
以 1 mL 工作液為例，取 100 μL 12.5 mg/mL 的澄清 DMSO 儲備液加到 900 μL玉米油中，混合均勻。

動物溶解方案計算器

請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

每只動物的給藥體積

μL

動物數(shù)量

只

由于實驗過程有損耗，建議您多配一只動物的量

請輸入您的動物體內配方組成：

DMSO +

Tween-80 +

Saline

如果您的動物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過 2%。

方案所需 助溶劑 包括：DMSO，，均可在 MCE 網(wǎng)站選購。，Tween 80，均可在 MCE 網(wǎng)站選購。

計算結果

工作液所需濃度 : mg/mL

儲備液配制方法 : mg 藥物溶于 μL DMSO（母液濃度為 mg/mL）。

您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，以下方案僅供參考，如有需要，請與 MCE 中國技術支持聯(lián)系。

動物實驗體內工作液的配制方法 : 取 μL DMSO 儲備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。

連續(xù)給藥周期超過半月以上，請謹慎選擇該方案。

請確保第一步儲備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱（超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。

純度 & 產(chǎn)品資料

純度: 99.92%

選擇批次：

Data Sheet (639 KB) SDS (480 KB)

COA (295 KB) LCMS (94 KB)

產(chǎn)品使用指南 (1538 KB)

參考文獻

[1]. Wang B, Chen L, Zhen H, et al. Proteomic changes induced by podophyllotoxin in human cervical carcinoma HeLa cells. Am J Chin Med. 2013;41(1):163-75. [Content Brief]

[2]. Guerrero E, Abad A, Montenegro G, et al. Analgesic and anti-inflammatory activity of podophyllotoxin derivatives. Pharm Biol. 2013 Jan 31. [Content Brief]

[3]. Li M, Zhou L, Yang D, et al. Biochemical composition and antioxidant capacity of extracts from Podophyllum hexandrum rhizome. BMC Complement Altern Med. 2012 Dec 22;12:263. [Content Brief]

[4]. Prasad V, Chaudhuri AR, Curcio M, et al. Podophyllotoxin and nocodazole counter the effect of IKP104 on tubulin decay. J Protein Chem. 1998 Oct;17(7):663-8. [Content Brief]

[5]. Podophyllotoxin

Podofilox 相關分類

完整儲備液配制表

可選溶劑	濃度溶劑體積質量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4131 mL	12.0653 mL	24.1307 mL	60.3267 mL
	5 mM	0.4826 mL	2.4131 mL	4.8261 mL	12.0653 mL
	10 mM	0.2413 mL	1.2065 mL	2.4131 mL	6.0327 mL
	15 mM	0.1609 mL	0.8044 mL	1.6087 mL	4.0218 mL
	20 mM	0.1207 mL	0.6033 mL	1.2065 mL	3.0163 mL
	25 mM	0.0965 mL	0.4826 mL	0.9652 mL	2.4131 mL
	30 mM	0.0804 mL	0.4022 mL	0.8044 mL	2.0109 mL
	40 mM	0.0603 mL	0.3016 mL	0.6033 mL	1.5082 mL
	50 mM	0.0483 mL	0.2413 mL	0.4826 mL	1.2065 mL
	60 mM	0.0402 mL	0.2011 mL	0.4022 mL	1.0054 mL
	80 mM	0.0302 mL	0.1508 mL	0.3016 mL	0.7541 mL
	100 mM	0.0241 mL	0.1207 mL	0.2413 mL	0.6033 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Podofilox518-28-5Podophyllotoxin依托泊苷EP雜質MMicrotubule/TubulinInhibitorinhibitorinhibit

產(chǎn)品名稱：			* 需求量：
* 客戶姓名：			* Email：
* 電話：			* 公司或機構名稱：
留言給我們：

產(chǎn)品名稱：			* Lot #：
* 客戶姓名：			* Email：
電話：			* 部門：
* 公司或機構名稱：
留言給我們：

MedChemExpress (MCE) 只為有資質的科研機構、醫(yī)藥企業(yè)基于科學研究或藥證申報的用途提供醫(yī)藥研發(fā)服務，不為任何個人或者非科研性質的、非用于藥證申報使用等其他用途提供服務。	站點地圖隱私聲明
滬ICP備15051369號-4 上海工商滬公網(wǎng)安備31011502019417 滬(浦)應急管危經(jīng)許[2021]201709(QFYS) 營業(yè)執(zhí)照（三證合一）
Copyright ? 2013-2025 MedChemExpress. All Rights Reserved.

成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Podofilox (Synonyms: 鬼臼毒素; Podophyllotoxin)

Customer Review

Other Forms of Podofilox:

MCE 顧客使用本產(chǎn)品發(fā)表的 3 篇科研文獻

Podofilox 相關產(chǎn)品

•相關化合物庫:

•同靶點產(chǎn)品:

•同靶點蛋白產(chǎn)品:

生物活性

純度 & 產(chǎn)品資料

參考文獻

摩爾計算器

稀釋計算器

Podofilox 相關分類

完整儲備液配制表

Keywords:

您最近查看的產(chǎn)品:

熱門區(qū)域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
郵箱 *

Sorry, but the email address you supplied was invalid.

成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Podofilox (Synonyms: 鬼臼毒素; Podophyllotoxin)

Customer Review

Other Forms of Podofilox:

Podofilox 相關抗體

MCE 顧客使用本產(chǎn)品發(fā)表的 3 篇科研文獻

Podofilox 相關產(chǎn)品

•相關化合物庫:

•同靶點產(chǎn)品:

•同靶點蛋白產(chǎn)品:

生物活性

純度 & 產(chǎn)品資料

參考文獻

Podofilox 相關抗體:

摩爾計算器

稀釋計算器

Podofilox 相關分類

完整儲備液配制表

Keywords:

您最近查看的產(chǎn)品:

Request for HNMR Report

Request for HNMR Report

熱門區(qū)域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z