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  2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Droxidopa

Droxidopa  (Synonyms: 屈昔多巴; L-DOPS; DOPS; SM5688)

目錄號(hào): HY-13458 純度: 96.12%
COA 產(chǎn)品使用指南

Droxidopa (L-DOPS; SM5688) 是一種有效的口服活性去甲腎上腺素前體。Droxidopa 可增加站立血壓，改善體位性低血壓癥狀并提高站立能力。Droxidopa 具有研究神經(jīng)源性體位性低血壓（nOH）和替代性多動(dòng)癥 (注意缺陷多動(dòng)障礙) 的潛力。

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Droxidopa Chemical Structure

Droxidopa Chemical Structure

CAS No. : 23651-95-8

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥279
In-stock
5 mg ￥640
In-stock
10 mg ￥935
In-stock
25 mg ￥1563
In-stock
50 mg ￥2200
In-stock
100 mg ￥3440
In-stock
200 mg   詢價(jià)  
500 mg   詢價(jià)  

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Customer Review

Other Forms of Droxidopa:

查看 Adrenergic Receptor 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Droxidopa (L-DOPS; SM5688) is a potent, orally active norepinephrine precursor. Droxidopa increases standing blood pressure, ameliorates symptoms of orthostatic hypotension and improves standing ability. Droxidopa has the potential for the research of neurogenic orthostatic hypotension (nOH) and alternative ADHD (attention deficit hyperactivity disorder)[1][2][3][4].

體內(nèi)研究
(In Vivo)

Droxidopa (200 mg/kg；腹腔注射) 改變大鼠多巴胺神經(jīng)元和前額皮質(zhì)活動(dòng)，并改善注意力缺陷/多動(dòng)障礙樣行為[2]。Droxidopa (10、20 mg/kg；腹腔注射) 在術(shù)后第 5 周顯著增加 6-OHDA 損傷大鼠的縮爪潛伏期并抑制對(duì)熱刺激的機(jī)械超敏反應(yīng)[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 250-380g male Sprague-Dawley rats[2]
Dosage: 200 mg/kg (10 mg/kg, i.p. benserazide was given to the animals at 20 or 30 min prior to L-DOPS injection)
Administration: I.p.
Result: Significantly decreased hyperactivity of BZ-pretreated SHR/NCrl at 30 (P < 0.01) and 40 min (P < 0.05) post-injection, improved inattention-like behavior of SHR/NCrl, and ameliorated impulsive-like behavior of SHR/NCrl and Wistar rats.
Clinical Trial
分子量

213.19

Formula

C9H11NO5
CAS 號(hào)
性狀

固體

顏色

White to off-white

中文名稱

屈西多巴雜質(zhì)1
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 96.12%

參考文獻(xiàn)
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Droxidopa
目錄號(hào)：
HY-13458
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