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  2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. 1-Naphthohydroxamic acid

1-Naphthohydroxamic acid 

目錄號: HY-130538 純度: 99.72%
COA 產品使用指南

1-Naphthohydroxamic acid (Compound 2) 是一種有效的，選擇性的 HDAC8 抑制劑，IC50 為 14 μM。1-Naphthohydroxamic acid 對 HDAC8 的選擇性高于 I 類 HDAC1 和 II 類 HDAC6 (IC50 >100 μM)。1-Naphthohydroxamic acid 不會增加整體組蛋白 H4 的乙酰化，也不會降低總細胞內 HDAC 的活性。1-Naphthohydroxamic acid 可誘導微管蛋白乙酰化。

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1-Naphthohydroxamic acid Chemical Structure

1-Naphthohydroxamic acid Chemical Structure

CAS No. : 6953-61-3

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥175
In-stock
5 mg ￥404
In-stock
10 mg ￥665
In-stock
25 mg ￥1396
In-stock
50 mg ￥2235
In-stock
100 mg ￥3580
In-stock
200 mg   詢價  
500 mg   詢價  

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Customer Review

MCE 顧客使用本產品發(fā)表的 1 篇科研文獻

  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM. 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity[1][2].1-Naphthohydroxamic acid can induce tubulin acetylation[3].

IC50 & Target[1]

HDAC8

14 μM (IC50)

HDAC1

>100 μM (IC50)

HDAC6

>100 μM (IC50)

體外研究
(In Vitro)

1-Naphthohydroxamic acid (compound 2; 20-40 μM; 0-144 ?hours; BE(2)-C, SK-N-BE(2) and SH-SY5Y cells) treatment reduces cell numbers in a concentration-dependent manner[2].
1-Naphthohydroxamic acid (compound 2) at concentrations in the range of its in vitro IC50 against HDAC8 results in reduced cell density and outgrowth of neurite-like structures that stained positive for neurofilament.1-Naphthohydroxamic acid reduces the formation of clones in soft-agar concentration dependently[2].
When either cell type (HeLa and HEK293 cells) is treated with 1-Naphthohydroxamic acid (compound 2; 0.8 μM, 4 μM, 20 μM or 100 μM), only tubulin becomes hyperacetylated[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: BE(2)-C, SK-N-BE(2) and SH-SY5Y cells
Concentration: 20 μM, 40 μM
Incubation Time: 0?hours, 24?hours, 48?hours, 72?hours, 96?hours, and 144 ?hours
Result: Reduced cell numbers in a concentration-dependent manner.
體內研究
(In Vivo)

Dose-limiting toxicities (DLTs) of 1-Naphthohydroxamic acid (compound 2; 0-40 mg/kg; intraperitoneal injection; daily; for 10 day; NMRI Foxn1 nude mice) include weight loss and signs of liver toxicity, as evidenced by elevated plasma liver enzymes and detection of necrotic areas on histological liver examination. 1-Naphthohydroxamic acid has the maximum tolerable doses at 50?mg/kg per day. At these concentrations, neither body weight nor blood parameters are critically changed[3].
Pharmacokinetic studies after intraperitoneal administration of the inhibitors identified the half-life of 1-Naphthohydroxamic acid to be ~15?min, with a plasma peak concentration of ~30?μM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NMRI Foxn1 nude mice[3]
Dosage: 0 mg/kg, 50 mg/kg, 100mg/kg, 200 mg/kg, 300 mg/kg 400 mg/kg
Administration: Intraperitoneal injection; daily; for 10 days
Result: Dose-limiting toxicities (DLTs) included weight loss and signs of liver toxicity, as evidenced by elevated plasma liver enzymes and detection of necrotic areas on histological liver examination.
分子量

187.19

Formula

C11H9NO2
CAS 號
性狀

固體

顏色

White to off-white

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 125 mg/mL (667.77 mM; 超聲助溶; 吸濕的 DMSO 對產品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 5.3422 mL 26.7108 mL 53.4217 mL
5 mM 1.0684 mL 5.3422 mL 10.6843 mL
查看完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內使用， -20°C儲存時，請在1年內使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
純度 & 產品資料
參考文獻

完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內使用， -20°C儲存時，請在1年內使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.3422 mL 26.7108 mL 53.4217 mL 133.5541 mL
5 mM 1.0684 mL 5.3422 mL 10.6843 mL 26.7108 mL
10 mM 0.5342 mL 2.6711 mL 5.3422 mL 13.3554 mL
15 mM 0.3561 mL 1.7807 mL 3.5614 mL 8.9036 mL
20 mM 0.2671 mL 1.3355 mL 2.6711 mL 6.6777 mL
25 mM 0.2137 mL 1.0684 mL 2.1369 mL 5.3422 mL
30 mM 0.1781 mL 0.8904 mL 1.7807 mL 4.4518 mL
40 mM 0.1336 mL 0.6678 mL 1.3355 mL 3.3389 mL
50 mM 0.1068 mL 0.5342 mL 1.0684 mL 2.6711 mL
60 mM 0.0890 mL 0.4452 mL 0.8904 mL 2.2259 mL
80 mM 0.0668 mL 0.3339 mL 0.6678 mL 1.6694 mL
100 mM 0.0534 mL 0.2671 mL 0.5342 mL 1.3355 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產品名稱：
1-Naphthohydroxamic acid
目錄號：
HY-130538
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