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  2. Apoptosis
  3. Apoptosis
  4. (Rac)-Idroxioleic acid

(Rac)-Idroxioleic acid  (Synonyms: 2-Hydroxyoleic acid; 2-OHOA; LAM561)

目錄號: HY-129467 純度: ≥98.0%
COA 產(chǎn)品使用指南

(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) 是一種合成油酸 (OA) 衍生物，能與質(zhì)膜結(jié)合改變脂質(zhì)組織。(Rac)-Idroxioleic acid 具有抗腫瘤作用。

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(Rac)-Idroxioleic acid Chemical Structure

(Rac)-Idroxioleic acid Chemical Structure

CAS No. : 56472-29-8

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2.  同一機構(gòu)（單位）同一產(chǎn)品試用裝僅限申領(lǐng)一次，同一機構(gòu)（單位）一年內(nèi)

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥2134
In-stock
1 mg ￥650
In-stock
5 mg ￥1300
In-stock
10 mg ￥2100
In-stock
25 mg ￥4300
In-stock
50 mg 現(xiàn)貨 詢價
100 mg   詢價  
200 mg   詢價  

* Please select Quantity before adding items.

Customer Review

Other Forms of (Rac)-Idroxioleic acid:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. (Rac)-Idroxioleic acid has anti-tumor effect[1].

體外研究
(In Vitro)

(Rac)-Idroxioleic acid (25-75 μM; 72 hours) impairs Jurkat cell growth in a time- and concentration-dependent manner, with an IC50 of ~40 μM[1].
(Rac)-Idroxioleic acid (25-50 μM; 72 hours) also induces a marked and concentration-dependent increase in the proteolytic cleavage of PARP, a molecular marker of apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Jurkat cells
Concentration: 25 μM, 50 μM, 75 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Impaired Jurkat cell growth in a time- and concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: Jurkat cells
Concentration: 25 μM, 50 μM
Incubation Time: 72 hours
Result: Induced a marked and concentration-dependent increase in the proteolytic cleavage of PARP.
體內(nèi)研究
(In Vivo)

(Rac)-Idroxioleic acid markedly and significantly inhibits tumour growth in nude mice infected with Jurkat cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old nude male mice (Jurkat cells xenograft model)[1]
Dosage: 600 mg/kg
Administration: Oral administration; daily; for 21 days
Result: Markedly and significantly inhibited tumour growth.
分子量

298.46

Formula

C18H34O3
CAS 號
性狀

固體

顏色

White to off-white

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 100 mg/mL (335.05 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 3.3505 mL 16.7527 mL 33.5053 mL
5 mM 0.6701 mL 3.3505 mL 6.7011 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: ≥98.0%

參考文獻

(Rac)-Idroxioleic acid 相關(guān)分類

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3505 mL 16.7527 mL 33.5053 mL 83.7633 mL
5 mM 0.6701 mL 3.3505 mL 6.7011 mL 16.7527 mL
10 mM 0.3351 mL 1.6753 mL 3.3505 mL 8.3763 mL
15 mM 0.2234 mL 1.1168 mL 2.2337 mL 5.5842 mL
20 mM 0.1675 mL 0.8376 mL 1.6753 mL 4.1882 mL
25 mM 0.1340 mL 0.6701 mL 1.3402 mL 3.3505 mL
30 mM 0.1117 mL 0.5584 mL 1.1168 mL 2.7921 mL
40 mM 0.0838 mL 0.4188 mL 0.8376 mL 2.0941 mL
50 mM 0.0670 mL 0.3351 mL 0.6701 mL 1.6753 mL
60 mM 0.0558 mL 0.2792 mL 0.5584 mL 1.3961 mL
80 mM 0.0419 mL 0.2094 mL 0.4188 mL 1.0470 mL
100 mM 0.0335 mL 0.1675 mL 0.3351 mL 0.8376 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
(Rac)-Idroxioleic acid
目錄號：
HY-129467
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