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  2. Apoptosis
  3. Apoptosis
  4. Fusicoccin

Fusicoccin  (Synonyms: Fusicoccin A)

目錄號: HY-122815 純度: 96.20%
COA 產品使用指南

Fusicoccin (Fusicoccin A)，一種真菌化膿毒素，14-3-3 蛋白相互作用的穩(wěn)定劑。Fusicoccin 使 H+-ATPase/14-3-3 復合物在植物中穩(wěn)定，保持酶的激活狀態(tài)。Fusicoccin 還穩(wěn)定 14-3-3 蛋白與含有 C-末端 14-3-3 識別基序的結合伙伴的相互作用，如 ERα、GPIbα、TASK3、CTFR 和 p53。Fusicoccin 誘導一些癌細胞調亡，并具有抗癌活性。

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Fusicoccin Chemical Structure

Fusicoccin Chemical Structure

CAS No. : 20108-30-9

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥8900
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  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

Fusicoccin (Fusicoccin A), a fungal pytotoxin, is a stabilizer of specific 14-3-3 protein-protein interactions. Fusicoccin sabilizes H+-ATPase/14-3-3 cmplex in pants, maintaining the enzyme in activated state. Fusicoccin also stabilizes 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif (a mode 3 motif), such as ERα, GPIbα, TASK3, CTFR, and p53. Fusicoccin induces apoptosis in cancer cells and has anticancer activity[1][2][3][4].

體外研究
(In Vitro)

Fusicoccin (Fusicoccin A) stabilizes a complex between 14-3-3 and the stress response regulator GCN1, inducing GCN1 turnover and neurite outgrowth (EC50=29 mM)[3].
Fusicoccin A activates the plasma membrane H+-ATPase by stabilizing its binding to 14-3-3 proteins, which results in water loss and the wilting of infected plants. Fusicoccin A decreases the proliferation and migration of human GBM cell lines in vitro, including several cell lines that exhibit varying degrees of resistance to pro-apoptotic stimuli. The IC50 growth inhibitory concentration of fusicoccin A is 92 μM in the U373-MG cells and 83 μM in the Hs683 glioma cells[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

680.82

Formula

C36H56O12
CAS 號
性狀

固體

顏色

White to off-white

結構分類
初始來源

Fusicoccum amygdali
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產品資料

純度: 96.20%

參考文獻

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Fusicoccin
目錄號：
HY-122815
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