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  2. Apoptosis Anti-infection
  3. TNF Receptor Bacterial
  4. Etanercept

Etanercept  (Synonyms: 依那西普)

目錄號: HY-108847 純度: 99.20%
COA

Etanercept 是一種結(jié)合腫瘤壞死因子 (TNF) 的二聚體融合蛋白，作為 TNF 抑制劑。Etanercept 競爭性地抑制 TNF-α 和 TNF-β 與細(xì)胞表面 TNF 受體的結(jié)合，使腫瘤壞死因子在生物學(xué)上失去活性。Etanercept 對風(fēng)濕性關(guān)節(jié)炎、幼年特發(fā)性關(guān)節(jié)炎和斑塊性銀屑病有效。

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CAS No. : 185243-69-0

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥4000
In-stock
5 mg   詢價(jià)  
10 mg   詢價(jià)  

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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis[1][2][3].

種屬

Human
IC50 & Target[1][2]

Fas

 

體內(nèi)研究
(In Vivo)

Etanercept (10 mg/kg; s.c.; every 3 days for 3 weeks) significantly decreases the mean arthritis scores and radiological score[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old male Lewis rats (adjuvant-induced arthritis (AIA) model)[4]
Dosage: 10 mg/kg
Administration: S.c.; every 3 days for 3 weeks
Result: Significantly decreased the mean arthritis scores; Significant decreased in radiological score at the end of the treatment period.
Clinical Trial
分子量

150000 (Average)

CAS 號
性狀

液體

顏色

Colorless to light yellow

中文名稱

依那西普
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • [TNFRSF1B (tumor necrosis factor receptor (TNFR)superfamily member 1B, TNFBR, p75, CD120b)]2-IGHG1 Fc (Fragment constant)
純度 & 產(chǎn)品資料

純度: 99.20%

參考文獻(xiàn)

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  • 稀釋計(jì)算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Etanercept
目錄號：
HY-108847
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