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  2. Apoptosis Anti-infection
  3. TNF Receptor Bacterial
  4. Etanercept

Etanercept  (Synonyms: 依那西普)

目錄號(hào): HY-108847 純度: 99.20%
COA 技術(shù)支持

Etanercept 是一種結(jié)合腫瘤壞死因子 (TNF) 的二聚體融合蛋白，作為 TNF 抑制劑。Etanercept 競(jìng)爭(zhēng)性地抑制 TNF-α 和 TNF-β 與細(xì)胞表面 TNF 受體的結(jié)合，使腫瘤壞死因子在生物學(xué)上失去活性。Etanercept 對(duì)風(fēng)濕性關(guān)節(jié)炎、幼年特發(fā)性關(guān)節(jié)炎和斑塊性銀屑病有效。

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CAS No. : 185243-69-0

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥4000
In-stock
5 mg   詢價(jià)  
10 mg   詢價(jià)  

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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis[1][2][3].

種屬

Human
IC50 & Target[1][2]

Fas

 

體內(nèi)研究
(In Vivo)

Etanercept（10 mg/kg；皮下注射；每 3 天一次，持續(xù) 3 周）顯著降低平均關(guān)節(jié)炎評(píng)分和放射學(xué)評(píng)分[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old male Lewis rats (adjuvant-induced arthritis (AIA) model)[4]
Dosage: 10 mg/kg
Administration: S.c.; every 3 days for 3 weeks
Result: Significantly decreased the mean arthritis scores; Significant decreased in radiological score at the end of the treatment period.
Clinical Trial
分子量

150000 (Average)

CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

中文名稱

依那西普
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • [TNFRSF1B (tumor necrosis factor receptor (TNFR)superfamily member 1B, TNFBR, p75, CD120b)]2-IGHG1 Fc (Fragment constant)
Biological Activity
  • Immobilized TNF-alpha/TNFSF2 Protein, Human (His, HY-P7416) can bind Etanercept. The EC50 for this effect is 9.44 ng/mL.
純度 & 產(chǎn)品資料

純度: 99.20%

參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Etanercept
目錄號(hào)：
HY-108847
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