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  1. Apoptosis Cell Cycle/DNA Damage Anti-infection Autophagy NF-κB Metabolic Enzyme/Protease
  2. Apoptosis Topoisomerase HIV Autophagy Mitophagy NF-κB Endogenous Metabolite Parasite
  3. Betulinic acid

Betulinic acid  (Synonyms: 白樺脂酸; Lupatic acid; Betulic acid)

目錄號(hào): HY-10529 純度: ≥98.0%
COA 產(chǎn)品使用指南 技術(shù)支持

Betulinic acid 是一種天然的五環(huán)三萜類化合物,為真核細(xì)胞拓?fù)洚悩?gòu)酶 I (topoisomerase I) 的抑制劑,IC50 值為 5 μM,具有抗炎,抗瘧疾,抗艾滋病和抗腫瘤等活性。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào),我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Betulinic acid Chemical Structure

Betulinic acid Chemical Structure

CAS No. : 472-15-1

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Other Forms of Betulinic acid:

    Betulinic acid purchased from MCE. Usage Cited in: Front Pharmacol. 2019 Sep 13;10:1017.  [Abstract]

    Immunofluorescence is performed to determine the LC3II expression level to show the autophagosomes in the cells of the skin flaps: autophagosomes (green) in the dermis in area II; nuclei counterstained with DAPI (blue).

    查看 Topoisomerase 亞型特異性產(chǎn)品:

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    • 生物活性

    • 實(shí)驗(yàn)參考方法

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties[1][2][3][4].

    IC50 & Target[1][4][5]

    Topoisomerase I

    5 μM (IC50)

    HIV-1

    1.4 μM (EC50)

    NF-κB

     

    細(xì)胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    4T1 IC50
    14.04 μM
    Compound: BA
    Cytotoxicity against mouse 4T1 cells assessed as growth inhibition after 96 hrs by SRB assay
    Cytotoxicity against mouse 4T1 cells assessed as growth inhibition after 96 hrs by SRB assay
    [PMID: 25817774]
    518A2 IC50
    0.33 μM
    Compound: 1
    Antitumor activity against human 518A2 cells by SRB assay
    Antitumor activity against human 518A2 cells by SRB assay
    [PMID: 31499360]
    518A2 EC50
    11.9 μM
    Compound: BA
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    [PMID: 27142753]
    518A2 IC50
    11.9 μM
    Compound: BA
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    [PMID: 24161703]
    518A2 IC50
    11.9 μM
    Compound: 2, BA
    Cytotoxicity against human 518A2 cells assessed as cell viability after 96 hrs by SRB assay
    Cytotoxicity against human 518A2 cells assessed as cell viability after 96 hrs by SRB assay
    [PMID: 23245801]
    518A2 IC50
    11.9 μM
    Compound: BA
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    [PMID: 20034802]
    518A2 EC50
    11.9 μM
    Compound: BA
    Anticancer activity against human 518A2 cells measured after 96 hrs by sulforhodamine B assay
    Anticancer activity against human 518A2 cells measured after 96 hrs by sulforhodamine B assay
    [PMID: 31330447]
    518A2 EC50
    11.9 μM
    Compound: Betulinic acid
    Cytotoxicity against human 518A2 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human 518A2 cells after 96 hrs by sulforhodamine B assay
    [PMID: 26211461]
    518A2 IC50
    11.9 μM
    Compound: BA
    Cytotoxicity against human 518A2 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human 518A2 cells after 96 hrs by sulforhodamine B assay
    [PMID: 20846866]
    518A2 IC50
    11.9 μM
    Compound: BA
    Cytotoxicity against human 518A2 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human 518A2 cells after 96 hrs by sulforhodamine B assay
    [PMID: 20299226]
    518A2 EC50
    13.6 μM
    Compound: BA
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    [PMID: 28169163]
    518A2 IC50
    14.8 μM
    Compound: 1
    Cytotoxicity against human 518A2 cells assessed as cell viability after 96 hrs by SRB assay
    Cytotoxicity against human 518A2 cells assessed as cell viability after 96 hrs by SRB assay
    [PMID: 23973824]
    518A2 IC50
    8.13 μM
    Compound: 1
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB colorimetric assay
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB colorimetric assay
    [PMID: 20472329]
    518A2 IC50
    8.13 μM
    Compound: 1
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    [PMID: 20451375]
    518A2 EC50
    9.4 μM
    Compound: 5
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    [PMID: 28033541]
    518A2 EC50
    9.4 μM
    Compound: BA
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    [PMID: 27017553]
    518A2 EC50
    9.4 μM
    Compound: BA
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    [PMID: 26750249]
    518A2 EC50
    9.4 μM
    Compound: 1
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    [PMID: 26547057]
    518A2 EC50
    9.4 μM
    Compound: BA
    Cytotoxicity against human 518A2 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human 518A2 cells after 96 hrs by sulforhodamine B assay
    [PMID: 30278332]
    518A2 EC50
    9.4 μM
    Compound: 4; BA
    Cytotoxicity against human 518A2 cells assessed as reduction in cell proliferation after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human 518A2 cells assessed as reduction in cell proliferation after 96 hrs by sulforhodamine B assay
    [PMID: 27149037]
    8505C IC50
    0.33 μM
    Compound: 1
    Antitumor activity against human 8505C cells by SRB assay
    Antitumor activity against human 8505C cells by SRB assay
    [PMID: 31499360]
    8505C IC50
    12.63 μM
    Compound: 1
    Cytotoxicity against human 8505C cells assessed as cell viability after 96 hrs by SRB assay
    Cytotoxicity against human 8505C cells assessed as cell viability after 96 hrs by SRB assay
    [PMID: 23973824]
    8505C IC50
    6.7 μM
    Compound: BA
    Cytotoxicity against human 8505C cells after 96 hrs by SRB assay
    Cytotoxicity against human 8505C cells after 96 hrs by SRB assay
    [PMID: 24161703]
    8505C IC50
    6.7 μM
    Compound: 2, BA
    Cytotoxicity against human 8505C cells assessed as cell viability after 96 hrs by SRB assay
    Cytotoxicity against human 8505C cells assessed as cell viability after 96 hrs by SRB assay
    [PMID: 23245801]
    8505C IC50
    6.7 μM
    Compound: BA
    Cytotoxicity against human 8505C cells after 96 hrs by SRB assay
    Cytotoxicity against human 8505C cells after 96 hrs by SRB assay
    [PMID: 20034802]
    8505C EC50
    6.7 μM
    Compound: BA
    Anticancer activity against human 8505C cells measured after 96 hrs by sulforhodamine B assay
    Anticancer activity against human 8505C cells measured after 96 hrs by sulforhodamine B assay
    [PMID: 31330447]
    8505C EC50
    6.7 μM
    Compound: Betulinic acid
    Cytotoxicity against human 8505C cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human 8505C cells after 96 hrs by sulforhodamine B assay
    [PMID: 26211461]
    8505C IC50
    6.7 μM
    Compound: BA
    Cytotoxicity against human 8505C cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human 8505C cells after 96 hrs by sulforhodamine B assay
    [PMID: 20846866]
    8505C IC50
    6.7 μM
    Compound: BA
    Cytotoxicity against human 8505C cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human 8505C cells after 96 hrs by sulforhodamine B assay
    [PMID: 20299226]
    8505C IC50
    7.26 μM
    Compound: 1
    Cytotoxicity against human 8505C cells after 96 hrs by SRB assay
    Cytotoxicity against human 8505C cells after 96 hrs by SRB assay
    [PMID: 20451375]
    A253 cell line IC50
    11.1 μM
    Compound: 2, BA
    Cytotoxicity against human A253 cells assessed as cell viability after 96 hrs by SRB assay
    Cytotoxicity against human A253 cells assessed as cell viability after 96 hrs by SRB assay
    [PMID: 23245801]
    A253 cell line IC50
    11.1 μM
    Compound: BA
    Cytotoxicity against human A253 cells after 96 hrs by SRB assay
    Cytotoxicity against human A253 cells after 96 hrs by SRB assay
    [PMID: 20034802]
    A253 cell line IC50
    11.1 μM
    Compound: BA
    Cytotoxicity against human A253 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human A253 cells after 96 hrs by sulforhodamine B assay
    [PMID: 20846866]
    A253 cell line IC50
    11.1 μM
    Compound: BA
    Cytotoxicity against human A253 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human A253 cells after 96 hrs by sulforhodamine B assay
    [PMID: 20299226]
    A253 cell line IC50
    9.18 μM
    Compound: 1
    Cytotoxicity against human A253 cells after 96 hrs by SRB colorimetric assay
    Cytotoxicity against human A253 cells after 96 hrs by SRB colorimetric assay
    [PMID: 20472329]
    A253 cell line IC50
    9.18 μM
    Compound: 1
    Cytotoxicity against human A253 cells after 96 hrs by SRB assay
    Cytotoxicity against human A253 cells after 96 hrs by SRB assay
    [PMID: 20451375]
    A2780 EC50
    > 30 μM
    Compound: 1
    Cytotoxicity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
    Cytotoxicity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
    [PMID: 32956968]
    A2780 IC50
    0.33 μM
    Compound: 1
    Antitumor activity against human A2780 cells by SRB assay
    Antitumor activity against human A2780 cells by SRB assay
    [PMID: 31499360]
    A2780 EC50
    11 μM
    Compound: BA
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    [PMID: 29960206]
    A2780 EC50
    11 μM
    Compound: BA
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    [PMID: 27142753]
    A2780 IC50
    11 μM
    Compound: BA
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    [PMID: 24161703]
    A2780 IC50
    11 μM
    Compound: 2, BA
    Cytotoxicity against human A2780 cells assessed as cell viability after 96 hrs by SRB assay
    Cytotoxicity against human A2780 cells assessed as cell viability after 96 hrs by SRB assay
    [PMID: 23245801]
    A2780 IC50
    11 μM
    Compound: BA
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    [PMID: 20034802]
    A2780 EC50
    11 μM
    Compound: Betulinic acid
    Cytotoxicity against human A2780 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human A2780 cells after 96 hrs by sulforhodamine B assay
    [PMID: 26211461]
    A2780 IC50
    11 μM
    Compound: BA
    Cytotoxicity against human A2780 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human A2780 cells after 96 hrs by sulforhodamine B assay
    [PMID: 20846866]
    A2780 IC50
    11 μM
    Compound: BA
    Cytotoxicity against human A2780 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human A2780 cells after 96 hrs by sulforhodamine B assay
    [PMID: 20299226]
    A2780 IC50
    11.07 μM
    Compound: 1
    Cytotoxicity against human A2780 cells after 96 hrs by SRB colorimetric assay
    Cytotoxicity against human A2780 cells after 96 hrs by SRB colorimetric assay
    [PMID: 20472329]
    A2780 IC50
    11.07 μM
    Compound: 1
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    [PMID: 20451375]
    A2780 EC50
    12.7 μM
    Compound: BA
    Cytotoxicity against human A2780 cells assessed as reduction in cell viability after 96 hrs by SRB assay
    Cytotoxicity against human A2780 cells assessed as reduction in cell viability after 96 hrs by SRB assay
    [PMID: 30840925]
    A2780 EC50
    12.7 μM
    Compound: BA
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    [PMID: 28169163]
    A2780 EC50
    12.7 μM
    Compound: BA
    Cytotoxicity against human A2780 cells assessed as reduction in cell viability incubated fro 96 hrs by SRB assay
    Cytotoxicity against human A2780 cells assessed as reduction in cell viability incubated fro 96 hrs by SRB assay
    [PMID: 29024910]
    A2780 EC50
    12.7 μM
    Compound: BA
    Anticancer activity against human A2780 cells measured after 96 hrs by sulforhodamine B assay
    Anticancer activity against human A2780 cells measured after 96 hrs by sulforhodamine B assay
    [PMID: 31330447]
    A2780 IC50
    8.75 μM
    Compound: 1
    Cytotoxicity against human A2780 cells assessed as cell viability after 96 hrs by SRB assay
    Cytotoxicity against human A2780 cells assessed as cell viability after 96 hrs by SRB assay
    [PMID: 23973824]
    A2780 EC50
    8.8 μM
    Compound: BA
    Cytotoxicity against human A2780 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay
    Cytotoxicity against human A2780 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay
    [PMID: 31718946]
    A2780 EC50
    8.8 μM
    Compound: 5
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    [PMID: 28033541]
    A2780 EC50
    8.8 μM
    Compound: BA
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    [PMID: 27017553]
    A2780 EC50
    8.8 μM
    Compound: BA
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    [PMID: 26750249]
    A2780 EC50
    8.8 μM
    Compound: 1
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    [PMID: 26547057]
    A2780 EC50
    8.8 μM
    Compound: BA
    Cytotoxicity against human A2780 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human A2780 cells after 96 hrs by sulforhodamine B assay
    [PMID: 30278332]
    A2780 EC50
    8.8 μM
    Compound: 4; BA
    Cytotoxicity against human A2780 cells assessed as reduction in cell proliferation after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human A2780 cells assessed as reduction in cell proliferation after 96 hrs by sulforhodamine B assay
    [PMID: 27149037]
    A2780 EC50
    9.7 μM
    Compound: BA
    Cytotoxicity against human A2780 cells after 96 hrs by sulforhodamine-B assay
    Cytotoxicity against human A2780 cells after 96 hrs by sulforhodamine-B assay
    [PMID: 30056282]
    A-375 EC50
    > 30 μM
    Compound: 1
    Cytotoxicity against human A-375 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
    Cytotoxicity against human A-375 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
    [PMID: 32956968]
    A-375 EC50
    12 μM
    Compound: BA
    Cytotoxicity against human A375 cells assessed as reduction in cell viability incubated fro 96 hrs by SRB assay
    Cytotoxicity against human A375 cells assessed as reduction in cell viability incubated fro 96 hrs by SRB assay
    [PMID: 29024910]
    A-375 EC50
    17.1 μM
    Compound: BA
    Cytotoxicity against human A375 cells after 96 hrs by SRB assay
    Cytotoxicity against human A375 cells after 96 hrs by SRB assay
    [PMID: 29960206]
    A-375 IC50
    22 μM
    Compound: 1
    Cytotoxicity against human A375 cells after 72 hrs by MTS assay
    Cytotoxicity against human A375 cells after 72 hrs by MTS assay
    [PMID: 20719505]
    A-375 IC50
    43.7 μM
    Compound: BA
    Cytotoxicity against human A375 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human A375 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    [PMID: 28368586]
    A-375 IC50
    51 μM
    Compound: 7
    Antiproliferative activity against human A375 cells after 72 hrs by MTS assay
    Antiproliferative activity against human A375 cells after 72 hrs by MTS assay
    [PMID: 19286375]
    A-431 IC50
    12.6 μM
    Compound: 1
    Cytotoxicity against human A431 cells after 96 hrs by SRB colorimetric assay
    Cytotoxicity against human A431 cells after 96 hrs by SRB colorimetric assay
    [PMID: 20472329]
    A-431 IC50
    12.6 μM
    Compound: 1
    Cytotoxicity against human A431 cells after 96 hrs by SRB assay
    Cytotoxicity against human A431 cells after 96 hrs by SRB assay
    [PMID: 20451375]
    A-431 IC50
    15.4 μM
    Compound: BA
    Cytotoxicity against human A431 cells after 96 hrs by SRB assay
    Cytotoxicity against human A431 cells after 96 hrs by SRB assay
    [PMID: 20034802]
    A-431 IC50
    15.4 μM
    Compound: BA
    Cytotoxicity against human A431 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human A431 cells after 96 hrs by sulforhodamine B assay
    [PMID: 20846866]
    A-431 IC50
    15.4 μM
    Compound: BA
    Cytotoxicity against human A431 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human A431 cells after 96 hrs by sulforhodamine B assay
    [PMID: 20299226]
    A549 ED50
    > 10 μg/mL
    Compound: Betulinic acid
    Cytotoxic activity against human A549 cell line was measured after 72 hr using MTT assay
    Cytotoxic activity against human A549 cell line was measured after 72 hr using MTT assay
    [PMID: 15225732]
    A549 IC50
    > 10 μM
    Compound: 1
    Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by SRB assay
    Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by SRB assay
    [PMID: 28500966]
    A549 IC50
    > 20 μM
    Compound: BetA
    Cytotoxicity against human A549 cells assessed as cell killing effect after 72 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as cell killing effect after 72 hrs by MTT assay
    [PMID: 26005543]
    A549 IC50
    > 200 μM
    Compound: 1
    Cell membrane permeabilization in human A549 cells assessed as drug level causing decrease in calcein fluorescence
    Cell membrane permeabilization in human A549 cells assessed as drug level causing decrease in calcein fluorescence
    [PMID: 19200744]
    A549 IC50
    0.33 μM
    Compound: 1
    Antitumor activity against human A549 cells by SRB assay
    Antitumor activity against human A549 cells by SRB assay
    [PMID: 31499360]
    A549 IC50
    10.3 μM
    Compound: 2
    Cytotoxicity against human A549 cells after 48 hrs
    Cytotoxicity against human A549 cells after 48 hrs
    [PMID: 19115839]
    A549 IC50
    10.3 μM
    Compound: 1
    Cytotoxicity against human A549 cells after 48 hrs by resazurin reduction test
    Cytotoxicity against human A549 cells after 48 hrs by resazurin reduction test
    [PMID: 19200744]
    A549 IC50
    10.3 μM
    Compound: 3
    Cytotoxicity against human A549 cells by resazurin reduction test
    Cytotoxicity against human A549 cells by resazurin reduction test
    [PMID: 19285391]
    A549 IC50
    10.82 μM
    Compound: 7
    Cytotoxicity against human A549 cells by SRB assay
    Cytotoxicity against human A549 cells by SRB assay
    [PMID: 20176479]
    A549 IC50
    11.1 μM
    Compound: 1
    Cytotoxicity against human A549 cells after 96 hrs by SRB colorimetric assay
    Cytotoxicity against human A549 cells after 96 hrs by SRB colorimetric assay
    [PMID: 20472329]
    A549 IC50
    11.1 μM
    Compound: 1
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    [PMID: 20451375]
    A549 IC50
    13.3 μM
    Compound: 1
    Cytotoxicity against human A549 cells assessed as cell viability after 96 hrs by SRB assay
    Cytotoxicity against human A549 cells assessed as cell viability after 96 hrs by SRB assay
    [PMID: 23973824]
    A549 EC50
    14.8 μM
    Compound: Betulinic acid
    Cytotoxicity against human A549 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human A549 cells after 96 hrs by sulforhodamine B assay
    [PMID: 26211461]
    A549 EC50
    14.9 μM
    Compound: BA
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    [PMID: 27142753]
    A549 IC50
    14.9 μM
    Compound: BA
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    [PMID: 24161703]
    A549 IC50
    14.9 μM
    Compound: 2, BA
    Cytotoxicity against human A549 cells assessed as cell viability after 96 hrs by SRB assay
    Cytotoxicity against human A549 cells assessed as cell viability after 96 hrs by SRB assay
    [PMID: 23245801]
    A549 IC50
    14.9 μM
    Compound: BA
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    [PMID: 20034802]
    A549 EC50
    14.9 μM
    Compound: BA
    Anticancer activity against human A549 cells measured after 96 hrs by sulforhodamine B assay
    Anticancer activity against human A549 cells measured after 96 hrs by sulforhodamine B assay
    [PMID: 31330447]
    A549 IC50
    14.9 μM
    Compound: BA
    Cytotoxicity against human A549 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human A549 cells after 96 hrs by sulforhodamine B assay
    [PMID: 20846866]
    A549 IC50
    14.9 μM
    Compound: BA
    Cytotoxicity against human A549 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human A549 cells after 96 hrs by sulforhodamine B assay
    [PMID: 20299226]
    A549 IC50
    146 μM
    Compound: 1
    Cytotoxicity against human A549 cells after 72 hrs by MTT assay
    Cytotoxicity against human A549 cells after 72 hrs by MTT assay
    [PMID: 15270560]
    A549 EC50
    17.1 μM
    Compound: 5
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    [PMID: 28033541]
    A549 EC50
    17.1 μM
    Compound: BA
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    [PMID: 27017553]
    A549 EC50
    17.1 μM
    Compound: BA
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    [PMID: 26750249]
    A549 EC50
    17.1 μM
    Compound: 1
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    [PMID: 26547057]
    A549 EC50
    17.1 μM
    Compound: BA
    Cytotoxicity against human A549 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human A549 cells after 96 hrs by sulforhodamine B assay
    [PMID: 30278332]
    A549 EC50
    17.1 μM
    Compound: 4; BA
    Cytotoxicity against human A549 cells assessed as reduction in cell proliferation after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human A549 cells assessed as reduction in cell proliferation after 96 hrs by sulforhodamine B assay
    [PMID: 27149037]
    A549 IC50
    17.13 μM
    Compound: 2
    Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay
    [PMID: 28671831]
    A549 IC50
    2.8 μg/mL
    Compound: 9
    Cytotoxicity against human A549 cells by MTT assay
    Cytotoxicity against human A549 cells by MTT assay
    [PMID: 18590313]
    A549 IC50
    29.5 μM
    Compound: 1; BA
    Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 72 hrs by sulforhodamine B assay
    [PMID: 31126820]
    A549 IC50
    3 μg/mL
    Compound: 1
    Cytotoxicity against human A549 cells after 72 hrs by MTT assay
    Cytotoxicity against human A549 cells after 72 hrs by MTT assay
    [PMID: 18752941]
    A549 IC50
    3.1 μM
    Compound: 17
    Cytotoxicity against human A549 cells assessed as inhibition of cell growth by SRB assay
    Cytotoxicity against human A549 cells assessed as inhibition of cell growth by SRB assay
    [PMID: 28358502]
    A549 IC50
    31 μM
    Compound: 1
    Cytotoxicity against human A549 cells after 48 hrs by SRB assay
    Cytotoxicity against human A549 cells after 48 hrs by SRB assay
    [PMID: 23584541]
    A549 IC50
    43.7 μM
    Compound: BA
    Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    [PMID: 28368586]
    A549 IC50
    43.97 μM
    Compound: Betulinic acid
    Cytotoxicity against human A549 cells after 72 hrs ny MTT assay
    Cytotoxicity against human A549 cells after 72 hrs ny MTT assay
    [PMID: 23974020]
    A549 IC50
    6.65 μM
    Compound: 3
    Cytotoxicity against human A549 cells after 1 hr by MTT assay
    Cytotoxicity against human A549 cells after 1 hr by MTT assay
    [PMID: 18343122]
    A549 EC50
    7.6 μM
    Compound: BA
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    [PMID: 28169163]
    A549 IC50
    72.8 μM
    Compound: 12
    Antiinflammatory activity against human A549 cells assessed as inhibition of IL-1-alpha-induced ICAM1 expression treated after 1 hr before IL1alpha challenge
    Antiinflammatory activity against human A549 cells assessed as inhibition of IL-1-alpha-induced ICAM1 expression treated after 1 hr before IL1alpha challenge
    [PMID: 15730243]
    A549 IC50
    8 μM
    Compound: 1
    Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay
    [PMID: 26629862]
    A549 IC50
    85.3 μM
    Compound: 12
    Cytotoxicity against human A549 cells assessed as cell viability after 24 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as cell viability after 24 hrs by MTT assay
    [PMID: 15730243]
    A549 IC50
    97.51 μM
    Compound: BA
    Cytotoxicity against human A549 cells by MTT assay
    Cytotoxicity against human A549 cells by MTT assay
    [PMID: 17275295]
    B16 ED50
    4.1 μM
    Compound: 11
    Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days
    Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days
    [PMID: 12027734]
    B16 IC50
    53.46 μM
    Compound: BA
    Cytotoxicity against mouse B16 cells by MTT assay
    Cytotoxicity against mouse B16 cells by MTT assay
    [PMID: 17275295]
    B16 IC50
    7.9 μM
    Compound: 11
    Growth inhibition of mouse B16 2F2 cells after 3 days
    Growth inhibition of mouse B16 2F2 cells after 3 days
    [PMID: 12027734]
    B16-F10 IC50
    > 20 μM
    Compound: BetA
    Cytotoxicity against mouse B16F10 cells assessed as cell killing effect after 72 hrs by MTT assay
    Cytotoxicity against mouse B16F10 cells assessed as cell killing effect after 72 hrs by MTT assay
    [PMID: 26005543]
    Bel-7402 IC50
    43.39 μM
    Compound: BA
    Cytotoxicity against human BEL-7402 cells by MTT assay
    Cytotoxicity against human BEL-7402 cells by MTT assay
    [PMID: 17275295]
    BMDC IC50
    19.45 μM
    Compound: 24
    Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated TNF-alpha production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA
    Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated TNF-alpha production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA
    [PMID: 23484668]
    BMDC IC50
    21.27 μM
    Compound: 24
    Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated IL12 production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA
    Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated IL12 production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA
    [PMID: 23484668]
    BMDC IC50
    3.61 μM
    Compound: 24
    Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated IL-12p40 production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA
    Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated IL-12p40 production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA
    [PMID: 23484668]
    BRISTOL8 ED50
    0.84 μg/mL
    Compound: Betulinic acid
    Cytotoxic activity against human BRISTOL8 cell line was measured after 72 hr using MTT assay
    Cytotoxic activity against human BRISTOL8 cell line was measured after 72 hr using MTT assay
    [PMID: 15225732]
    BV-2 IC50
    4.5 μM
    Compound: 17
    Anti-inflammatory in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production pre-incubated before LPS challenge for 24 hrs by Griess reagent based assay
    Anti-inflammatory in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production pre-incubated before LPS challenge for 24 hrs by Griess reagent based assay
    [PMID: 28358502]
    C3H 10T1/2 IC50
    82 μM
    Compound: 2
    Cytotoxicity against mouse C3H10T1/2 cells after 24 hrs by fluorometric microculture cytotoxicity assay
    Cytotoxicity against mouse C3H10T1/2 cells after 24 hrs by fluorometric microculture cytotoxicity assay
    [PMID: 18842418]
    C6 IC50
    90.69 μM
    Compound: BA
    Cytotoxicity against mouse C6 cells by MTT assay
    Cytotoxicity against mouse C6 cells by MTT assay
    [PMID: 17275295]
    Ca9-22 IC50
    > 20 μg/mL
    Compound: 9
    Cytotoxicity against human sCa9-22 cells by MTT assay
    Cytotoxicity against human sCa9-22 cells by MTT assay
    [PMID: 18590313]
    CCD-18Co IC50
    43.6 μM
    Compound: 1
    Cytotoxicity against human CCD-18Co cells assessed as cell viability after 96 hrs by SRB assay
    Cytotoxicity against human CCD-18Co cells assessed as cell viability after 96 hrs by SRB assay
    [PMID: 23973824]
    CCRF-CEM ED50
    0.98 μg/mL
    Compound: Betulinic acid
    Cytotoxic activity against human CEM.CM3 cell line was measured after 72 hr using MTT assay
    Cytotoxic activity against human CEM.CM3 cell line was measured after 72 hr using MTT assay
    [PMID: 15225732]
    CCRF-CEM IC50
    27 μM
    Compound: 1
    Cytotoxicity against human CEM cells after 72 hrs by MTT assay
    Cytotoxicity against human CEM cells after 72 hrs by MTT assay
    [PMID: 15270560]
    CCRF-CEM IC50
    30 μM
    Compound: 2
    Cytotoxicity against human CCRF-CEM cells after 72 hrs by MTT assay
    Cytotoxicity against human CCRF-CEM cells after 72 hrs by MTT assay
    [PMID: 22551630]
    CCRF-CEM IC50
    30 μM
    Compound: 1a
    Cytotoxicity against human CEM cells after 72 hrs by MTT assay
    Cytotoxicity against human CEM cells after 72 hrs by MTT assay
    [PMID: 17371067]
    CEM-SS ED50
    2 μM
    Compound: 5
    Antiviral activity against HIV1 3B infected in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect after 6 days by MTS assay
    Antiviral activity against HIV1 3B infected in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect after 6 days by MTS assay
    [PMID: 15217281]
    CEM-SS CC50
    5.9 μM
    Compound: 5
    Cytotoxicity against human CEM-SS cells after 6 days by MTS assay
    Cytotoxicity against human CEM-SS cells after 6 days by MTS assay
    [PMID: 15217281]
    CHO IC50
    > 20 μM
    Compound: BetA
    Cytotoxicity against CHO cells assessed as cell killing effect after 72 hrs by MTT assay
    Cytotoxicity against CHO cells assessed as cell killing effect after 72 hrs by MTT assay
    [PMID: 26005543]
    CHO EC50
    1.04 μM
    Compound: 1
    Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
    Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
    [PMID: 19911773]
    COS-1 EC50
    0 μM
    Compound: 1
    Agonist activity at human FXR expressed in COS1 cells by luciferase reporter gene assay
    Agonist activity at human FXR expressed in COS1 cells by luciferase reporter gene assay
    [PMID: 19911773]
    Daoy IC50
    11 μM
    Compound: 1
    Cytotoxicity against human DaOY cells after 72 hrs by MTS assay
    Cytotoxicity against human DaOY cells after 72 hrs by MTS assay
    [PMID: 20719505]
    Daoy IC50
    31 μM
    Compound: 7
    Antiproliferative activity against human DaOY cells after 72 hrs by MTS assay
    Antiproliferative activity against human DaOY cells after 72 hrs by MTS assay
    [PMID: 19286375]
    DLD-1 IC50
    > 200 μM
    Compound: 1
    Cell membrane permeabilization in human DLD1 cells assessed as drug level causing decrease in calcein fluorescence
    Cell membrane permeabilization in human DLD1 cells assessed as drug level causing decrease in calcein fluorescence
    [PMID: 19200744]
    DLD-1 IC50
    11.87 μM
    Compound: 1
    Cytotoxicity against human DLD1 cells after 96 hrs by SRB assay
    Cytotoxicity against human DLD1 cells after 96 hrs by SRB assay
    [PMID: 20451375]
    DLD-1 IC50
    15 μM
    Compound: 2
    Cytotoxicity against human DLD1 cells after 48 hrs
    Cytotoxicity against human DLD1 cells after 48 hrs
    [PMID: 19115839]
    DLD-1 IC50
    15 μM
    Compound: 1
    Cytotoxicity against human DLD1 cells after 48 hrs by resazurin reduction test
    Cytotoxicity against human DLD1 cells after 48 hrs by resazurin reduction test
    [PMID: 19200744]
    DLD-1 IC50
    15 μM
    Compound: 3
    Cytotoxicity against human DLD1 cells by resazurin reduction test
    Cytotoxicity against human DLD1 cells by resazurin reduction test
    [PMID: 19285391]
    DLD-1 IC50
    17.5 μM
    Compound: 2, BA
    Cytotoxicity against human DLD1 cells assessed as cell viability after 96 hrs by SRB assay
    Cytotoxicity against human DLD1 cells assessed as cell viability after 96 hrs by SRB assay
    [PMID: 23245801]
    DLD-1 IC50
    17.5 μM
    Compound: BA
    Cytotoxicity against human DLD1 cells after 96 hrs by SRB assay
    Cytotoxicity against human DLD1 cells after 96 hrs by SRB assay
    [PMID: 20034802]
    DLD-1 IC50
    17.5 μM
    Compound: BA
    Cytotoxicity against human DLD1 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human DLD1 cells after 96 hrs by sulforhodamine B assay
    [PMID: 20846866]
    DLD-1 IC50
    17.5 μM
    Compound: BA
    Cytotoxicity against human DLD1 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human DLD1 cells after 96 hrs by sulforhodamine B assay
    [PMID: 20299226]
    DU-145 IC50
    > 20 μg/mL
    Compound: 1
    Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
    Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
    [PMID: 18752941]
    DU-145 CC50
    > 500 μM
    Compound: 5
    Cytotoxic activity in human DU145 cells by sulforhodamine B assay
    Cytotoxic activity in human DU145 cells by sulforhodamine B assay
    [PMID: 29120172]
    DU-145 IC50
    > 500 μM
    Compound: 5
    Antiproliferative activity in human DU145 cells by sulforhodamine B assay
    Antiproliferative activity in human DU145 cells by sulforhodamine B assay
    [PMID: 29120172]
    DU-145 ED50
    1.13 μg/mL
    Compound: Betulinic acid
    Cytotoxic activity against human DU145 cell line was measured after 72 hr using MTT assay
    Cytotoxic activity against human DU145 cell line was measured after 72 hr using MTT assay
    [PMID: 15225732]
    DU-145 IC50
    196 μM
    Compound: 1
    Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
    Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
    [PMID: 15270560]
    DU-145 IC50
    22 μM
    Compound: 1
    Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
    Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
    [PMID: 23584541]
    DU-145 IC50
    36.16 μM
    Compound: BA
    Cytotoxicity against human DU145 cells assessed as growth inhibition after 96 hrs by SRB assay
    Cytotoxicity against human DU145 cells assessed as growth inhibition after 96 hrs by SRB assay
    [PMID: 25817774]
    DU-145 IC50
    37 μM
    Compound: 2
    Cytotoxicity against human DU145 cells after 24 hrs by fluorometric microculture cytotoxicity assay
    Cytotoxicity against human DU145 cells after 24 hrs by fluorometric microculture cytotoxicity assay
    [PMID: 18842418]
    ECa-109 cell line IC50
    28.07 μM
    Compound: 2
    Cytotoxicity against human ECA109 cells assessed as cell growth inhibition after 48 hrs by MTT assay
    Cytotoxicity against human ECA109 cells assessed as cell growth inhibition after 48 hrs by MTT assay
    [PMID: 28671831]
    Ehrlich IC50
    54 μM
    Compound: 1
    Cytotoxicity against mouse Ehrlich carcinoma cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against mouse Ehrlich carcinoma cells assessed as reduction in cell viability after 48 hrs by MTT assay
    [PMID: 31499360]
    Epithelial cell IC50
    > 20 μM
    Compound: betulinic acid
    Antiproliferative activity against mouse +SA mammary epithelial cells after 4 days by MTT assay
    Antiproliferative activity against mouse +SA mammary epithelial cells after 4 days by MTT assay
    [PMID: 18826277]
    FaDu EC50
    > 30 μM
    Compound: 1
    Cytotoxicity against human FaDu cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
    Cytotoxicity against human FaDu cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
    [PMID: 32956968]
    FaDu IC50
    10.19 μM
    Compound: 1
    Cytotoxicity against human FADU cells after 96 hrs by SRB assay
    Cytotoxicity against human FADU cells after 96 hrs by SRB assay
    [PMID: 20451375]
    FaDu IC50
    10.4 μM
    Compound: BA
    Cytotoxicity against human FADU cells after 96 hrs by SRB assay
    Cytotoxicity against human FADU cells after 96 hrs by SRB assay
    [PMID: 20034802]
    FaDu IC50
    10.4 μM
    Compound: BA
    Cytotoxicity against human FADU cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human FADU cells after 96 hrs by sulforhodamine B assay
    [PMID: 20846866]
    FaDu IC50
    10.4 μM
    Compound: BA
    Cytotoxicity against human FADU cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human FADU cells after 96 hrs by sulforhodamine B assay
    [PMID: 20299226]
    FaDu EC50
    10.7 μM
    Compound: BA
    Cytotoxicity against human FADU cells after 96 hrs by sulforhodamine-B assay
    Cytotoxicity against human FADU cells after 96 hrs by sulforhodamine-B assay
    [PMID: 30056282]
    FaDu EC50
    13.4 μM
    Compound: BA
    Cytotoxicity against human FADU cells assessed as reduction in cell viability after 96 hrs by SRB assay
    Cytotoxicity against human FADU cells assessed as reduction in cell viability after 96 hrs by SRB assay
    [PMID: 30840925]
    FaDu EC50
    13.4 μM
    Compound: BA
    Cytotoxicity against human FADU cells assessed as reduction in cell viability incubated fro 96 hrs by SRB assay
    Cytotoxicity against human FADU cells assessed as reduction in cell viability incubated fro 96 hrs by SRB assay
    [PMID: 29024910]
    FaDu EC50
    13.7 μM
    Compound: BA
    Cytotoxicity against human FADU cells after 96 hrs by SRB assay
    Cytotoxicity against human FADU cells after 96 hrs by SRB assay
    [PMID: 28169163]
    FaDu EC50
    15.3 μM
    Compound: BA
    Cytotoxicity against human FADU cells after 96 hrs by SRB assay
    Cytotoxicity against human FADU cells after 96 hrs by SRB assay
    [PMID: 26750249]
    FaDu EC50
    15.3 μM
    Compound: 4; BA
    Cytotoxicity against human FADU cells assessed as reduction in cell proliferation after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human FADU cells assessed as reduction in cell proliferation after 96 hrs by sulforhodamine B assay
    [PMID: 27149037]
    Fibroblast IC50
    20.81 μM
    Compound: 1
    Cytotoxicity against human fibroblast after 96 hrs by SRB assay
    Cytotoxicity against human fibroblast after 96 hrs by SRB assay
    [PMID: 20451375]
    H9 EC50
    1.4 μM
    Compound: 1
    Antiviral activity against HIV1 3B in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay
    Antiviral activity against HIV1 3B in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay
    [PMID: 8176401]
    H9 EC50
    1.4 μM
    Compound: 130
    Antiviral activity against HIV1 infected in human H9 cells after 4 days by p24 antigen ELISA
    Antiviral activity against HIV1 infected in human H9 cells after 4 days by p24 antigen ELISA
    [PMID: 20187635]
    H9 EC50
    1.4 μM
    Compound: 130
    Antiviral activity against HIV1 3B infected in H9 cells assessed as inhibition of viral replication by p24 antigen ELISA
    Antiviral activity against HIV1 3B infected in H9 cells assessed as inhibition of viral replication by p24 antigen ELISA
    [PMID: 20187635]
    H9 EC50
    1.4 μM
    Compound: 1
    Anti-HIV activity against acutely infected H9 lymphocytes. Activity expressed as concentration of compound able to suppress HIV replication by 50%.
    Anti-HIV activity against acutely infected H9 lymphocytes. Activity expressed as concentration of compound able to suppress HIV replication by 50%.
    [PMID: 9804704]
    H9 IC50
    12.9 μM
    Compound: 1
    Antiviral activity against HIV1 3B isolate replication in human H9 cells assessed as decrease in viral p24 level after 4 days
    Antiviral activity against HIV1 3B isolate replication in human H9 cells assessed as decrease in viral p24 level after 4 days
    [PMID: 11141100]
    H9 IC50
    13 μM
    Compound: 130
    Cytotoxicity against human H9 cells after 4 days by coulter counter
    Cytotoxicity against human H9 cells after 4 days by coulter counter
    [PMID: 20187635]
    H9 IC50
    13 μM
    Compound: 1
    Cytotoxicity against human H9 cells after 3 days
    Cytotoxicity against human H9 cells after 3 days
    [PMID: 8176401]
    HaCaT IC50
    32 μM
    Compound: 2
    Inhibition of GLI1-mediated transcriptional activity in human HaCaT cells by luciferase based reporter gene assay
    Inhibition of GLI1-mediated transcriptional activity in human HaCaT cells by luciferase based reporter gene assay
    [PMID: 18842418]
    HBL-100 IC50
    5.02 μg/mL
    Compound: 1
    Cytotoxicity against human HBL100 cells after 72 hrs by MTT assay
    Cytotoxicity against human HBL100 cells after 72 hrs by MTT assay
    [PMID: 18752941]
    HCT-116 IC50
    > 10 μM
    Compound: 1
    Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by SRB assay
    Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by SRB assay
    [PMID: 28500966]
    HCT-116 IC50
    10.8 μM
    Compound: 1
    Cytotoxicity against human HCT116 cells after 96 hrs by SRB assay
    Cytotoxicity against human HCT116 cells after 96 hrs by SRB assay
    [PMID: 20451375]
    HCT-116 IC50
    13.3 μM
    Compound: BA
    Cytotoxicity against human HCT116 cells after 96 hrs by SRB assay
    Cytotoxicity against human HCT116 cells after 96 hrs by SRB assay
    [PMID: 20034802]
    HCT-116 IC50
    13.3 μM
    Compound: BA
    Cytotoxicity against human HCT116 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human HCT116 cells after 96 hrs by sulforhodamine B assay
    [PMID: 20846866]
    HCT-116 IC50
    13.3 μM
    Compound: BA
    Cytotoxicity against human HCT116 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human HCT116 cells after 96 hrs by sulforhodamine B assay
    [PMID: 20299226]
    HCT-116 IC50
    13.46 μM
    Compound: 1
    Antiproliferative activity against human HCT116 cells after 3 days by XTT assay
    Antiproliferative activity against human HCT116 cells after 3 days by XTT assay
    [PMID: 19691293]
    HCT-116 GI50
    2.7 μM
    Compound: 1
    Cytotoxicity of compound against human colon carcinoma (HCT116) using MTT assay
    Cytotoxicity of compound against human colon carcinoma (HCT116) using MTT assay
    [PMID: 11527742]
    HCT-116 IC50
    22.13 μM
    Compound: BA
    Cytotoxicity against human HCT116 cells assessed as growth inhibition after 96 hrs by SRB assay
    Cytotoxicity against human HCT116 cells assessed as growth inhibition after 96 hrs by SRB assay
    [PMID: 25817774]
    HCT-15 IC50
    12 μM
    Compound: 1
    Cytotoxicity against human HCT15 cells after 48 hrs by SRB assay
    Cytotoxicity against human HCT15 cells after 48 hrs by SRB assay
    [PMID: 23584541]
    HCT-15 IC50
    14.25 μM
    Compound: 7
    Cytotoxicity against human HCT15 cells by SRB assay
    Cytotoxicity against human HCT15 cells by SRB assay
    [PMID: 20176479]
    HCT-15 IC50
    8.7 μM
    Compound: 17
    Cytotoxicity against human HCT15 cells assessed as inhibition of cell growth by SRB assay
    Cytotoxicity against human HCT15 cells assessed as inhibition of cell growth by SRB assay
    [PMID: 28358502]
    HCT-8 IC50
    13.1 μM
    Compound: 1
    Cytotoxicity against human HCT8 cells after 96 hrs by SRB assay
    Cytotoxicity against human HCT8 cells after 96 hrs by SRB assay
    [PMID: 20451375]
    HCT-8 IC50
    17.8 μM
    Compound: BA
    Cytotoxicity against human HCT8 cells after 96 hrs by SRB assay
    Cytotoxicity against human HCT8 cells after 96 hrs by SRB assay
    [PMID: 20034802]
    HCT-8 IC50
    17.8 μM
    Compound: BA
    Cytotoxicity against human HCT8 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human HCT8 cells after 96 hrs by sulforhodamine B assay
    [PMID: 20846866]
    HCT-8 IC50
    17.8 μM
    Compound: BA
    Cytotoxicity against human HCT8 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human HCT8 cells after 96 hrs by sulforhodamine B assay
    [PMID: 20299226]
    HEK293 EC50
    > 100 μM
    Compound: 19
    Agonist activity at mouse PPARgamma expressed in HEK293 cells co-expressing with Gal4 reporter vector after 24 hrs by dual-luciferase reporter assay
    Agonist activity at mouse PPARgamma expressed in HEK293 cells co-expressing with Gal4 reporter vector after 24 hrs by dual-luciferase reporter assay
    [PMID: 24955889]
    HEK293 IC50
    336.2 μM
    Compound: 5
    Antiproliferative activity in HEK293 cells by sulforhodamine B assay
    Antiproliferative activity in HEK293 cells by sulforhodamine B assay
    [PMID: 29120172]
    HEK293 CC50
    80 μM
    Compound: 5
    Cytotoxic activity in HEK293 cells by sulforhodamine B assay
    Cytotoxic activity in HEK293 cells by sulforhodamine B assay
    [PMID: 29120172]
    HeLa IC50
    0.8 μg/mL
    Compound: betulinicacidbetulinic acid
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    [PMID: 9834149]
    HeLa IC50
    26 nM
    Compound: 2
    Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
    [PMID: 19674909]
    HeLa IC50
    26 μM
    Compound: 2
    Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
    [PMID: 20494586]
    HeLa CC50
    32.6 μM
    Compound: 5
    Cytotoxic activity in human HeLa cells by sulforhodamine B assay
    Cytotoxic activity in human HeLa cells by sulforhodamine B assay
    [PMID: 29120172]
    HeLa IC50
    47.6 μM
    Compound: 5
    Antiproliferative activity in human HeLa cells by sulforhodamine B assay
    Antiproliferative activity in human HeLa cells by sulforhodamine B assay
    [PMID: 29120172]
    HeLa EC50
    8.8 μM
    Compound: BA
    Cytotoxicity against human HeLa cells after 96 hrs by SRB assay
    Cytotoxicity against human HeLa cells after 96 hrs by SRB assay
    [PMID: 27142753]
    Hep 3B2 IC50
    1.7 μg/mL
    Compound: 9
    Cytotoxicity against human Hep3B cells by MTT assay
    Cytotoxicity against human Hep3B cells by MTT assay
    [PMID: 18590313]
    HEp-2 IC50
    > 500 μM
    Compound: 5
    Antiproliferative activity in human Hep2 cells by sulforhodamine B assay
    Antiproliferative activity in human Hep2 cells by sulforhodamine B assay
    [PMID: 29120172]
    HEp-2 IC50
    16 μM
    Compound: 1
    Cytotoxicity against human Hep2 cells after 48 hrs by SRB assay
    Cytotoxicity against human Hep2 cells after 48 hrs by SRB assay
    [PMID: 23584541]
    HEp-2 CC50
    48.2 μM
    Compound: 5
    Cytotoxic activity in human Hep2 cells by sulforhodamine B assay
    Cytotoxic activity in human Hep2 cells by sulforhodamine B assay
    [PMID: 29120172]
    HepG2 CC50
    > 400 μM
    Compound: BA
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    [PMID: 29326018]
    HepG2 IC50
    21 μM
    Compound: 12
    Cytotoxicity against human Hep G2 cells after 48 hrs by WST-8 assay
    Cytotoxicity against human Hep G2 cells after 48 hrs by WST-8 assay
    [PMID: 15730243]
    HepG2 IC50
    25.3 μM
    Compound: 2
    Cytotoxicity against human HepG2 cells assessed as cell growth inhibition after 48 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as cell growth inhibition after 48 hrs by MTT assay
    [PMID: 28671831]
    HepG2 IC50
    3.1 μg/mL
    Compound: 9
    Cytotoxicity against human HepG2 cells by MTT assay
    Cytotoxicity against human HepG2 cells by MTT assay
    [PMID: 18590313]
    HepG2 IC50
    36.4 nM
    Compound: 2
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    [PMID: 19674909]
    HepG2 IC50
    36.4 μM
    Compound: 2
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    [PMID: 20494586]
    HepG2 IC50
    5.9 μM
    Compound: 25
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    [PMID: 27617953]
    HL-60 IC50
    17 μM
    Compound: 1
    Cytotoxicity against human HL60 cells after 48 hrs by SRB assay
    Cytotoxicity against human HL60 cells after 48 hrs by SRB assay
    [PMID: 23584541]
    HL-60 IC50
    18.47 μM
    Compound: 2
    Cytotoxicity against human HL60 cells assessed as cell growth inhibition after 48 hrs by MTT assay
    Cytotoxicity against human HL60 cells assessed as cell growth inhibition after 48 hrs by MTT assay
    [PMID: 28671831]
    HL-60 IC50
    2 μg/mL
    Compound: 9
    Cytotoxicity against human HL60 cells by MTT assay
    Cytotoxicity against human HL60 cells by MTT assay
    [PMID: 18590313]
    HL-60 IC50
    8 μM
    Compound: 1
    Cytotoxicity against human HL60 cells assessed as cell growth inhibition after 48 hrs by MTT assay
    Cytotoxicity against human HL60 cells assessed as cell growth inhibition after 48 hrs by MTT assay
    [PMID: 26629862]
    HT-29 IC50
    > 10 μM
    Compound: 9
    Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
    Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
    [PMID: 30057155]
    HT-29 EC50
    > 30 μM
    Compound: 1
    Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
    Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
    [PMID: 32956968]
    HT-29 IC50
    12.8 μM
    Compound: 2
    Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
    Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
    [PMID: 20494586]
    HT-29 EC50
    13.1 μM
    Compound: Betulinic acid
    Cytotoxicity against human HT-29 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human HT-29 cells after 96 hrs by sulforhodamine B assay
    [PMID: 26211461]
    HT-29 IC50
    13.93 μM
    Compound: 1
    Cytotoxicity against human HT-29 cells after 96 hrs by SRB colorimetric assay
    Cytotoxicity against human HT-29 cells after 96 hrs by SRB colorimetric assay
    [PMID: 20472329]
    HT-29 IC50
    13.93 μM
    Compound: 1
    Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay
    Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay
    [PMID: 20451375]
    HT-29 EC50
    14.4 μM
    Compound: BA
    Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay
    Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay
    [PMID: 31718946]
    HT-29 EC50
    14.4 μM
    Compound: BA
    Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay
    Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay
    [PMID: 29960206]
    HT-29 EC50
    14.4 μM
    Compound: 5
    Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay
    Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay
    [PMID: 28033541]
    HT-29 EC50
    14.4 μM
    Compound: BA
    Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay
    Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay
    [PMID: 27142753]
    HT-29 EC50
    14.4 μM
    Compound: BA
    Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay
    Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay
    [PMID: 27017553]
    HT-29 EC50
    14.4 μM
    Compound: BA
    Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay
    Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay
    [PMID: 26750249]
    HT-29 EC50
    14.4 μM
    Compound: BA
    Cytotoxicity against human HT-29 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human HT-29 cells after 96 hrs by sulforhodamine B assay
    [PMID: 30278332]
    HT-29 EC50
    14.4 μM
    Compound: 4; BA
    Cytotoxicity against human HT-29 cells assessed as reduction in cell proliferation after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human HT-29 cells assessed as reduction in cell proliferation after 96 hrs by sulforhodamine B assay
    [PMID: 27149037]
    HT-29 EC50
    16 μM
    Compound: BA
    Cytotoxicity against human HT-29 cells after 96 hrs by sulforhodamine-B assay
    Cytotoxicity against human HT-29 cells after 96 hrs by sulforhodamine-B assay
    [PMID: 30056282]
    HT-29 IC50
    16.1 μM
    Compound: BA
    Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay
    Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay
    [PMID: 20034802]
    HT-29 IC50
    16.1 μM
    Compound: BA
    Cytotoxicity against human HT-29 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human HT-29 cells after 96 hrs by sulforhodamine B assay
    [PMID: 20846866]
    HT-29 IC50
    16.1 μM
    Compound: BA
    Cytotoxicity against human HT-29 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human HT-29 cells after 96 hrs by sulforhodamine B assay
    [PMID: 20299226]
    HT-29 IC50
    17.32 μM
    Compound: BA
    Cytotoxicity against human HT-29 cells assessed as growth inhibition after 96 hrs by SRB assay
    Cytotoxicity against human HT-29 cells assessed as growth inhibition after 96 hrs by SRB assay
    [PMID: 25817774]
    HT-29 EC50
    18.4 μM
    Compound: BA
    Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 96 hrs by SRB assay
    Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 96 hrs by SRB assay
    [PMID: 30840925]
    HT-29 EC50
    18.4 μM
    Compound: BA
    Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay
    Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay
    [PMID: 28169163]
    HT-29 EC50
    18.4 μM
    Compound: BA
    Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated fro 96 hrs by SRB assay
    Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated fro 96 hrs by SRB assay
    [PMID: 29024910]
    HT-29 EC50
    18.4 μM
    Compound: BA
    Anticancer activity against human HT-29 cells measured after 96 hrs by sulforhodamine B assay
    Anticancer activity against human HT-29 cells measured after 96 hrs by sulforhodamine B assay
    [PMID: 31330447]
    HT-29 IC50
    3.5 μM
    Compound: 9
    Inhibition of mitochondrial membrane potential in human HT-29 cells after 3 hrs by JC-1 staining based fluorescence assay
    Inhibition of mitochondrial membrane potential in human HT-29 cells after 3 hrs by JC-1 staining based fluorescence assay
    [PMID: 30057155]
    HT-29 IC50
    31 μM
    Compound: 1
    Cytotoxicity against human HT-29 cells after 72 hrs by MTS assay
    Cytotoxicity against human HT-29 cells after 72 hrs by MTS assay
    [PMID: 20719505]
    HT-29 IC50
    37 μM
    Compound: 7
    Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay
    Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay
    [PMID: 19286375]
    HT-29 IC50
    89 μM
    Compound: 1
    Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
    Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
    [PMID: 15270560]
    J774 IC50
    44 μM
    Compound: 9
    Cytotoxicity against mouse J774 cells by alamar blue assay
    Cytotoxicity against mouse J774 cells by alamar blue assay
    [PMID: 17637068]
    Jurkat ED50
    0.65 μg/mL
    Compound: Betulinic acid
    Cytotoxic activity against human JurkatE6.1 cell line was measured after 72 h using MTT assay
    Cytotoxic activity against human JurkatE6.1 cell line was measured after 72 h using MTT assay
    [PMID: 15225732]
    Jurkat IC50
    26.9 nM
    Compound: 2
    Cytotoxicity against human Jurkat cells after 72 hrs by XTT assay
    Cytotoxicity against human Jurkat cells after 72 hrs by XTT assay
    [PMID: 19674909]
    Jurkat IC50
    26.9 μM
    Compound: 2
    Cytotoxicity against human Jurkat cells after 72 hrs by XTT assay
    Cytotoxicity against human Jurkat cells after 72 hrs by XTT assay
    [PMID: 20494586]
    K562 IC50
    112 μM
    Compound: 1
    Cytotoxicity against paclitaxel-resistant human K562 cells after 72 hrs by MTT assay
    Cytotoxicity against paclitaxel-resistant human K562 cells after 72 hrs by MTT assay
    [PMID: 15270560]
    K562 IC50
    21.96 μM
    Compound: 2
    Cytotoxicity against human K562 cells assessed as cell growth inhibition after 48 hrs by MTT assay
    Cytotoxicity against human K562 cells assessed as cell growth inhibition after 48 hrs by MTT assay
    [PMID: 28671831]
    K562 IC50
    3.25 μg/mL
    Compound: 1
    Cytotoxicity against human K-562 cells after 72 hrs by MTT assay
    Cytotoxicity against human K-562 cells after 72 hrs by MTT assay
    [PMID: 18752941]
    K562 IC50
    56 μM
    Compound: 1
    Cytotoxicity against human K562 cells after 72 hrs by MTT assay
    Cytotoxicity against human K562 cells after 72 hrs by MTT assay
    [PMID: 15270560]
    KB CC50
    15.6 μM
    Compound: 5
    Cytotoxic activity in human KB cells by sulforhodamine B assay
    Cytotoxic activity in human KB cells by sulforhodamine B assay
    [PMID: 29120172]
    KB IC50
    28.1 μM
    Compound: 5
    Antiproliferative activity in human KB cells by sulforhodamine B assay
    Antiproliferative activity in human KB cells by sulforhodamine B assay
    [PMID: 29120172]
    KB IC50
    28.7 μM
    Compound: 1; BA
    Antiproliferative activity against human KB cells assessed as cell growth inhibition after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human KB cells assessed as cell growth inhibition after 72 hrs by sulforhodamine B assay
    [PMID: 31126820]
    L02 IC50
    35.07 μM
    Compound: 2
    Cytotoxicity against human HL-7702 cells assessed as cell growth inhibition after 48 hrs by MTT assay
    Cytotoxicity against human HL-7702 cells assessed as cell growth inhibition after 48 hrs by MTT assay
    [PMID: 28671831]
    L132 ED50
    1.3 μg/mL
    Compound: Betulinic acid
    Cytotoxic activity against human L132 cell line was measured after 72 hr using MTT assay
    Cytotoxic activity against human L132 cell line was measured after 72 hr using MTT assay
    [PMID: 15225732]
    LN-229 IC50
    29 μM
    Compound: 1
    Cytotoxicity against human LN229 cells after 72 hrs by MTS assay
    Cytotoxicity against human LN229 cells after 72 hrs by MTS assay
    [PMID: 20719505]
    LN-229 IC50
    61 μM
    Compound: 7
    Antiproliferative activity against human LN229 cells after 72 hrs by MTS assay
    Antiproliferative activity against human LN229 cells after 72 hrs by MTS assay
    [PMID: 19286375]
    M14 GI50
    2.7 μM
    Compound: 1
    Cytotoxicity of compound against human melanoma cell lines (M14-MEL) using MTT assay
    Cytotoxicity of compound against human melanoma cell lines (M14-MEL) using MTT assay
    [PMID: 11527742]
    M14 IC50
    50 μM
    Compound: 4
    Cytotoxicity against human M14 cells after 48 hrs by MTT assay
    Cytotoxicity against human M14 cells after 48 hrs by MTT assay
    [PMID: 21954959]
    MCF7 IC50
    > 10 μM
    Compound: 1
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay
    [PMID: 28500966]
    MCF7 IC50
    > 25 μM
    Compound: BA
    Cytotoxicity against human MCF7 cells assessed as decrease in cell viability by trypan blue test
    Cytotoxicity against human MCF7 cells assessed as decrease in cell viability by trypan blue test
    [PMID: 30108714]
    MCF7 EC50
    > 30 μM
    Compound: 1
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
    [PMID: 32956968]
    MCF7 IC50
    > 40 μM
    Compound: 1; BA
    Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by sulforhodamine B assay
    [PMID: 31126820]
    MCF7 IC50
    0.33 μM
    Compound: 1
    Antitumor activity against human MCF7 cells by SRB assay
    Antitumor activity against human MCF7 cells by SRB assay
    [PMID: 31499360]
    MCF7 EC50
    10.2 μM
    Compound: BA
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay
    [PMID: 31718946]
    MCF7 EC50
    10.2 μM
    Compound: 5
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    [PMID: 28033541]
    MCF7 EC50
    10.2 μM
    Compound: BA
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    [PMID: 27017553]
    MCF7 EC50
    10.2 μM
    Compound: BA
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    [PMID: 26750249]
    MCF7 EC50
    10.2 μM
    Compound: 1
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    [PMID: 26547057]
    MCF7 EC50
    10.2 μM
    Compound: BA
    Cytotoxicity against human MCF7 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human MCF7 cells after 96 hrs by sulforhodamine B assay
    [PMID: 30278332]
    MCF7 EC50
    10.2 μM
    Compound: 4; BA
    Cytotoxicity against human MCF7 cells assessed as reduction in cell proliferation after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell proliferation after 96 hrs by sulforhodamine B assay
    [PMID: 27149037]
    MCF7 IC50
    10.527 μM
    Compound: BetA
    Cytotoxicity against human MCF7 cells assessed as cell killing effect after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as cell killing effect after 72 hrs by MTT assay
    [PMID: 26005543]
    MCF7 EC50
    10.6 μM
    Compound: BA
    Cytotoxicity against human MCF7 cells after 96 hrs by sulforhodamine-B assay
    Cytotoxicity against human MCF7 cells after 96 hrs by sulforhodamine-B assay
    [PMID: 30056282]
    MCF7 GI50
    11.3 μM
    Compound: Betulinic acid
    Cytotoxicity in human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
    Cytotoxicity in human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
    [PMID: 28754470]
    MCF7 EC50
    11.4 μM
    Compound: BA
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    [PMID: 28169163]
    MCF7 EC50
    12 μM
    Compound: BA
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 96 hrs by SRB assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 96 hrs by SRB assay
    [PMID: 30840925]
    MCF7 EC50
    12 μM
    Compound: BA
    Anticancer activity against human MCF7 cells measured after 96 hrs by sulforhodamine B assay
    Anticancer activity against human MCF7 cells measured after 96 hrs by sulforhodamine B assay
    [PMID: 31330447]
    MCF7 IC50
    12.27 μM
    Compound: 1
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB colorimetric assay
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB colorimetric assay
    [PMID: 20472329]
    MCF7 IC50
    12.27 μM
    Compound: 1
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    [PMID: 20451375]
    MCF7 IC50
    14.03 μM
    Compound: 1
    Cytotoxicity against human MCF7 cells assessed as cell viability after 96 hrs by SRB assay
    Cytotoxicity against human MCF7 cells assessed as cell viability after 96 hrs by SRB assay
    [PMID: 23973824]
    MCF7 EC50
    14.8 μM
    Compound: BA
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    [PMID: 29960206]
    MCF7 EC50
    14.8 μM
    Compound: BA
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    [PMID: 27142753]
    MCF7 IC50
    14.8 μM
    Compound: BA
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    [PMID: 24161703]
    MCF7 IC50
    14.8 μM
    Compound: 2, BA
    Cytotoxicity against human MCF7 cells assessed as cell viability after 96 hrs by SRB assay
    Cytotoxicity against human MCF7 cells assessed as cell viability after 96 hrs by SRB assay
    [PMID: 23245801]
    MCF7 IC50
    14.9 μM
    Compound: BA
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    [PMID: 20034802]
    MCF7 EC50
    14.9 μM
    Compound: Betulinic acid
    Cytotoxicity against human MCF7 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human MCF7 cells after 96 hrs by sulforhodamine B assay
    [PMID: 26211461]
    MCF7 IC50
    14.9 μM
    Compound: BA
    Cytotoxicity against human MCF7 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human MCF7 cells after 96 hrs by sulforhodamine B assay
    [PMID: 20846866]
    MCF7 IC50
    14.9 μM
    Compound: BA
    Cytotoxicity against human MCF7 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human MCF7 cells after 96 hrs by sulforhodamine B assay
    [PMID: 20299226]
    MCF7 IC50
    143 μM
    Compound: 1
    Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
    [PMID: 15270560]
    MCF7 IC50
    22.61 μM
    Compound: BA
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 96 hrs by SRB assay
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 96 hrs by SRB assay
    [PMID: 25817774]
    MCF7 IC50
    30 μM
    Compound: 1
    Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay
    Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay
    [PMID: 20719505]
    MCF7 IC50
    37 μM
    Compound: 1
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    [PMID: 23584541]
    MCF7 IC50
    4 μg/mL
    Compound: 9
    Cytotoxicity against human MCF7 cells by MTT assay
    Cytotoxicity against human MCF7 cells by MTT assay
    [PMID: 18590313]
    MCF7 IC50
    41 μM
    Compound: 2
    Cytotoxicity against human MCF7 cells after 48 hrs
    Cytotoxicity against human MCF7 cells after 48 hrs
    [PMID: 19115839]
    MCF7 IC50
    41 μM
    Compound: 3
    Cytotoxicity against human MCF7 cells by resazurin reduction test
    Cytotoxicity against human MCF7 cells by resazurin reduction test
    [PMID: 19285391]
    MCF7 CC50
    49.6 μM
    Compound: 5
    Cytotoxic activity in human MCF7 cells by sulforhodamine B assay
    Cytotoxic activity in human MCF7 cells by sulforhodamine B assay
    [PMID: 29120172]
    MCF7 IC50
    50 μM
    Compound: 7
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay
    [PMID: 19286375]
    MCF7 IC50
    56.3 μM
    Compound: 5
    Antiproliferative activity in human MCF7 cells by sulforhodamine B assay
    Antiproliferative activity in human MCF7 cells by sulforhodamine B assay
    [PMID: 29120172]
    MDA-MB-231 IC50
    > 10 μM
    Compound: 9
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
    [PMID: 30057155]
    MDA-MB-231 IC50
    > 20 μM
    Compound: BetA
    Cytotoxicity against human MDA-MB-231 cells assessed as cell killing effect after 72 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as cell killing effect after 72 hrs by MTT assay
    [PMID: 26005543]
    MDA-MB-231 IC50
    > 40 μM
    Compound: 1; BA
    Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition after 72 hrs by sulforhodamine B assay
    [PMID: 31126820]
    MDA-MB-231 IC50
    > 500 μM
    Compound: 5
    Antiproliferative activity in human MDA-MB-231 cells by sulforhodamine B assay
    Antiproliferative activity in human MDA-MB-231 cells by sulforhodamine B assay
    [PMID: 29120172]
    MDA-MB-231 IC50
    15.24 μM
    Compound: 1
    Antiproliferative activity against human MDA-MB-231 cells after 3 days by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 3 days by MTT assay
    [PMID: 19691293]
    MDA-MB-231 IC50
    19.13 μM
    Compound: Betulinic acid
    Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
    Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
    [PMID: 35217359]
    MDA-MB-231 GI50
    22.9 μM
    Compound: Betulinic acid
    Cytotoxicity in human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
    Cytotoxicity in human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
    [PMID: 28754470]
    MDA-MB-231 IC50
    3.5 μg/mL
    Compound: 9
    Cytotoxicity against human MDA-MB-231 cells by MTT assay
    Cytotoxicity against human MDA-MB-231 cells by MTT assay
    [PMID: 18590313]
    MDA-MB-231 IC50
    34.57 μM
    Compound: BA
    Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 96 hrs by SRB assay
    Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 96 hrs by SRB assay
    [PMID: 25817774]
    MDA-MB-231 CC50
    94.3 μM
    Compound: 5
    Cytotoxic activity in human MDA-MB-231 cells by sulforhodamine B assay
    Cytotoxic activity in human MDA-MB-231 cells by sulforhodamine B assay
    [PMID: 29120172]
    MIA PaCa-2 IC50
    > 10 μM
    Compound: 1
    Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 hrs by SRB assay
    Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 hrs by SRB assay
    [PMID: 28500966]
    MIA PaCa-2 IC50
    > 20 μg/mL
    Compound: 1
    Cytotoxicity against human MIA PaCa2 cells after 72 hrs by MTT assay
    Cytotoxicity against human MIA PaCa2 cells after 72 hrs by MTT assay
    [PMID: 18752941]
    MIA PaCa-2 IC50
    26.7 μM
    Compound: Betulinic acid
    Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
    Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
    [PMID: 35217359]
    MIA PaCa-2 IC50
    7 μM
    Compound: 1
    Cytotoxicity against human MIAPaCa2 cells assessed as cell growth inhibition after 48 hrs by MTT assay
    Cytotoxicity against human MIAPaCa2 cells assessed as cell growth inhibition after 48 hrs by MTT assay
    [PMID: 26629862]
    MOLT-4 ED50
    1.23 μg/mL
    Compound: Betulinic acid
    Cytotoxic activity against human MOLT-4 cell line was measured after 72 hr using MTT assay
    Cytotoxic activity against human MOLT-4 cell line was measured after 72 hr using MTT assay
    [PMID: 15225732]
    MRC5 IC50
    32.8 μM
    Compound: BA
    Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    [PMID: 28368586]
    NCI/ADR-RES IC50
    38.5 μM
    Compound: BA
    Cytotoxicity against human MCF7/ADR cells assessed as growth inhibition after 96 hrs by SRB assay
    Cytotoxicity against human MCF7/ADR cells assessed as growth inhibition after 96 hrs by SRB assay
    [PMID: 25817774]
    Neutrophil IC50
    11.12 μg/mL
    Compound: 2
    Immunomodulatory activity in neutrophils assessed as decrease in oxidative burst after 30 min by luminol-enhanced chemiluminescence assay
    Immunomodulatory activity in neutrophils assessed as decrease in oxidative burst after 30 min by luminol-enhanced chemiluminescence assay
    10.1007/s00044-012-0183-y
    NIH3T3 IC50
    > 20 μM
    Compound: BetA
    Cytotoxicity against mouse NIH/3T3 cells assessed as cell killing effect after 72 hrs by MTT assay
    Cytotoxicity against mouse NIH/3T3 cells assessed as cell killing effect after 72 hrs by MTT assay
    [PMID: 26005543]
    NIH3T3 EC50
    > 30 μM
    Compound: 1
    Cytotoxicity against mouse NIH3T3 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
    Cytotoxicity against mouse NIH3T3 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
    [PMID: 32956968]
    NIH3T3 IC50
    10 μM
    Compound: BA
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
    [PMID: 24161703]
    NIH3T3 IC50
    10 μM
    Compound: 2, BA
    Cytotoxicity against mouse NIH/3T3 cells assessed as cell viability after 96 hrs by SRB assay
    Cytotoxicity against mouse NIH/3T3 cells assessed as cell viability after 96 hrs by SRB assay
    [PMID: 23245801]
    NIH3T3 EC50
    10 μM
    Compound: Betulinic acid
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by sulforhodamine B assay
    [PMID: 26211461]
    NIH3T3 EC50
    12.9 μM
    Compound: BA
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by sulforhodamine-B assay
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by sulforhodamine-B assay
    [PMID: 30056282]
    NIH3T3 EC50
    13.1 μM
    Compound: BA
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
    [PMID: 29960206]
    NIH3T3 EC50
    13.1 μM
    Compound: BA
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
    [PMID: 28169163]
    NIH3T3 EC50
    16.1 μM
    Compound: BA
    Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay
    Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay
    [PMID: 31718946]
    NIH3T3 EC50
    16.1 μM
    Compound: BA
    Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 96 hrs by SRB assay
    Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 96 hrs by SRB assay
    [PMID: 30840925]
    NIH3T3 EC50
    16.1 μM
    Compound: 5
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
    [PMID: 28033541]
    NIH3T3 EC50
    16.1 μM
    Compound: BA
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
    [PMID: 27017553]
    NIH3T3 EC50
    16.1 μM
    Compound: BA
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
    [PMID: 26750249]
    NIH3T3 EC50
    16.1 μM
    Compound: 1
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
    [PMID: 26547057]
    NIH3T3 EC50
    16.1 μM
    Compound: BA
    Cytotoxicity against mouse NIH/3T3 cells measured after 96 hrs by sulforhodamine B assay
    Cytotoxicity against mouse NIH/3T3 cells measured after 96 hrs by sulforhodamine B assay
    [PMID: 31330447]
    NIH3T3 EC50
    16.1 μM
    Compound: BA
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by sulforhodamine B assay
    [PMID: 30278332]
    NIH3T3 EC50
    16.1 μM
    Compound: 4; BA
    Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell proliferation after 96 hrs by sulforhodamine B assay
    Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell proliferation after 96 hrs by sulforhodamine B assay
    [PMID: 27149037]
    NIH3T3 IC50
    4.37 μg/mL
    Compound: 1
    Cytotoxicity against mouse NIH3T3 cells after 72 hrs by MTT assay
    Cytotoxicity against mouse NIH3T3 cells after 72 hrs by MTT assay
    [PMID: 18752941]
    OVCAR-3 IC50
    0.9 μg/mL
    Compound: betulinicacidbetulinic acid
    Cytotoxicity against human OVCAR-3 cells after 48 hrs by MTT assay
    Cytotoxicity against human OVCAR-3 cells after 48 hrs by MTT assay
    [PMID: 9834149]
    OVCAR-3 IC50
    40 μM
    Compound: 1
    Cytotoxicity against human OVCAR-3 cells after 72 hrs by MTS assay
    Cytotoxicity against human OVCAR-3 cells after 72 hrs by MTS assay
    [PMID: 20719505]
    OVCAR-3 IC50
    59 μM
    Compound: 7
    Antiproliferative activity against human OVCAR-3 cells after 120 hrs by MTS assay
    Antiproliferative activity against human OVCAR-3 cells after 120 hrs by MTS assay
    [PMID: 19286375]
    OVCAR-3 IC50
    8.366 μM
    Compound: BetA
    Cytotoxicity against human OVCAR3 cells assessed as cell killing effect after 72 hrs by MTT assay
    Cytotoxicity against human OVCAR3 cells assessed as cell killing effect after 72 hrs by MTT assay
    [PMID: 26005543]
    P815 IC50
    41 μM
    Compound: 1
    Cytotoxicity against mouse P815 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against mouse P815 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    [PMID: 31499360]
    PA-1 ED50
    > 10 μg/mL
    Compound: Betulinic acid
    Cytotoxic activity against human PA-1 cell line was measured after 72 hr using MTT assay
    Cytotoxic activity against human PA-1 cell line was measured after 72 hr using MTT assay
    [PMID: 15225732]
    PA-1 IC50
    11.53 μg/mL
    Compound: 1
    Cytotoxicity against human PA-1 cells after 72 hrs by MTT assay
    Cytotoxicity against human PA-1 cells after 72 hrs by MTT assay
    [PMID: 18752941]
    PANC-1 IC50
    10.223 μM
    Compound: BetA
    Cytotoxicity against human PANC1 cells assessed as cell killing effect after 72 hrs by MTT assay
    Cytotoxicity against human PANC1 cells assessed as cell killing effect after 72 hrs by MTT assay
    [PMID: 26005543]
    PANC-1 IC50
    44 μM
    Compound: 2
    Cytotoxicity against human PANC1 after 24 hrs by fluorometric microculture cytotoxicity assay
    Cytotoxicity against human PANC1 after 24 hrs by fluorometric microculture cytotoxicity assay
    [PMID: 18842418]
    PC-3 IC50
    > 10 μM
    Compound: 1
    Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by SRB assay
    Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by SRB assay
    [PMID: 28500966]
    PC-3 EC50
    1.9 mM
    Compound: 1
    Cytotoxicity of compound against human prostate adenocarcinoma (PC3) using SRB assay
    Cytotoxicity of compound against human prostate adenocarcinoma (PC3) using SRB assay
    [PMID: 11527742]
    PC-3 IC50
    21.5 μM
    Compound: 2
    Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
    Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
    [PMID: 20494586]
    PC-3 IC50
    27.51 μM
    Compound: BA
    Cytotoxicity against human PC3 cells assessed as growth inhibition after 96 hrs by SRB assay
    Cytotoxicity against human PC3 cells assessed as growth inhibition after 96 hrs by SRB assay
    [PMID: 25817774]
    PC-3 IC50
    37 μM
    Compound: 1
    Cytotoxicity against human PC3 cells after 48 hrs by SRB assay
    Cytotoxicity against human PC3 cells after 48 hrs by SRB assay
    [PMID: 23584541]
    PC-3 IC50
    40 μM
    Compound: 2
    Cytotoxicity against human PC3 cells after 48 hrs
    Cytotoxicity against human PC3 cells after 48 hrs
    [PMID: 19115839]
    PC-3 IC50
    40 μM
    Compound: 3
    Cytotoxicity against human PC3 cells by resazurin reduction test
    Cytotoxicity against human PC3 cells by resazurin reduction test
    [PMID: 19285391]
    PC-3 IC50
    7 μM
    Compound: 1
    Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 48 hrs by MTT assay
    Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 48 hrs by MTT assay
    [PMID: 26629862]
    PC-3 IC50
    91 μM
    Compound: 1
    Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
    Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
    [PMID: 15270560]
    RAW264.7 IC50
    > 100 μM
    Compound: 4
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of HMGB1-induced NO production pretreated with compounds for 15 mins followed by HMGB1 stimulation measured after 24 hrs by Griess reagent based assay
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of HMGB1-induced NO production pretreated with compounds for 15 mins followed by HMGB1 stimulation measured after 24 hrs by Griess reagent based assay
    [PMID: 34800877]
    RAW264.7 IC50
    32.38 μM
    Compound: BA
    Inhibition of RANKL/M-CSF-induced osteoclastogenesis in mouse RAW264.7 cells measured for 4 days by TRAP staining based assay
    Inhibition of RANKL/M-CSF-induced osteoclastogenesis in mouse RAW264.7 cells measured for 4 days by TRAP staining based assay
    [PMID: 34491054]
    RAW264.7 CC50
    50.64 μM
    Compound: BA
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured for 96 hrs by MTT assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured for 96 hrs by MTT assay
    [PMID: 34491054]
    RD IC50
    23.95 μM
    Compound: Betulinic acid
    Cytotoxicity against human TE-32 cells after 72 hrs ny MTT assay
    Cytotoxicity against human TE-32 cells after 72 hrs ny MTT assay
    [PMID: 23974020]
    SF-295 IC50
    22 μM
    Compound: 1
    Cytotoxicity against human SF295 cells after 48 hrs by SRB assay
    Cytotoxicity against human SF295 cells after 48 hrs by SRB assay
    [PMID: 23584541]
    SH-SY5Y EC50
    4.3 μM
    Compound: Betulinic acid
    Neuroprotective activity in human SH-SY5Y cells assessed as reduction in 1-methyl-4-phenylpyridinium ion-induced cell death after 48 hrs by MTT assay
    Neuroprotective activity in human SH-SY5Y cells assessed as reduction in 1-methyl-4-phenylpyridinium ion-induced cell death after 48 hrs by MTT assay
    [PMID: 27420919]
    SiHa CC50
    28.9 μM
    Compound: 5
    Cytotoxic activity in human SiHa cells by sulforhodamine B assay
    Cytotoxic activity in human SiHa cells by sulforhodamine B assay
    [PMID: 29120172]
    SiHa IC50
    70.1 μM
    Compound: 5
    Antiproliferative activity in human SiHa cells by sulforhodamine B assay
    Antiproliferative activity in human SiHa cells by sulforhodamine B assay
    [PMID: 29120172]
    SK-MEL-2 IC50
    > 10 μM
    Compound: 17
    Cytotoxicity against human SK-MEL-2 cells assessed as inhibition of cell growth by SRB assay
    Cytotoxicity against human SK-MEL-2 cells assessed as inhibition of cell growth by SRB assay
    [PMID: 28358502]
    SK-MEL-2 IC50
    17.44 μM
    Compound: 7
    Cytotoxicity against human SK-MEL-2 cells by SRB assay
    Cytotoxicity against human SK-MEL-2 cells by SRB assay
    [PMID: 20176479]
    SK-MEL-2 EC50
    2.2 mM
    Compound: 1
    Cytotoxicity of compound against SK-MEL-2 using SRB assay
    Cytotoxicity of compound against SK-MEL-2 using SRB assay
    [PMID: 11527742]
    SK-MEL-2 IC50
    21 μM
    Compound: 1
    Cytotoxicity against human SK-MEL-2 cells after 72 hrs by MTT assay
    Cytotoxicity against human SK-MEL-2 cells after 72 hrs by MTT assay
    [PMID: 15270560]
    SK-MEL-2 GI50
    3.2 μM
    Compound: 1
    Cytotoxicity of compound against human melanoma cell lines (SK-MEL-2) using MTT assay
    Cytotoxicity of compound against human melanoma cell lines (SK-MEL-2) using MTT assay
    [PMID: 11527742]
    SK-MEL-2 IC50
    33 μM
    Compound: 7
    Antiproliferative activity against human SK-MEL-2 cells after 72 hrs by MTS assay
    Antiproliferative activity against human SK-MEL-2 cells after 72 hrs by MTS assay
    [PMID: 19286375]
    SK-MEL-2 IC50
    7 μM
    Compound: 1
    Cytotoxicity against human SK-MEL-2 cells after 72 hrs by MTS assay
    Cytotoxicity against human SK-MEL-2 cells after 72 hrs by MTS assay
    [PMID: 20719505]
    SK-OV-3 IC50
    > 10 μM
    Compound: 17
    Cytotoxicity against human SKOV3 cells assessed as inhibition of cell growth by SRB assay
    Cytotoxicity against human SKOV3 cells assessed as inhibition of cell growth by SRB assay
    [PMID: 28358502]
    SK-OV-3 IC50
    17.68 μM
    Compound: 7
    Cytotoxicity against human SKOV3 cells by SRB assay
    Cytotoxicity against human SKOV3 cells by SRB assay
    [PMID: 20176479]
    SW-1736 IC50
    11.6 μM
    Compound: 2, BA
    Cytotoxicity against human SW1736 cells assessed as cell viability after 96 hrs by SRB assay
    Cytotoxicity against human SW1736 cells assessed as cell viability after 96 hrs by SRB assay
    [PMID: 23245801]
    SW-1736 IC50
    11.6 μM
    Compound: BA
    Cytotoxicity against human SW1736 cells after 96 hrs by SRB assay
    Cytotoxicity against human SW1736 cells after 96 hrs by SRB assay
    [PMID: 20034802]
    SW-1736 IC50
    11.6 μM
    Compound: BA
    Cytotoxicity against human SW1736 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human SW1736 cells after 96 hrs by sulforhodamine B assay
    [PMID: 20846866]
    SW-1736 IC50
    11.6 μM
    Compound: BA
    Cytotoxicity against human SW1736 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human SW1736 cells after 96 hrs by sulforhodamine B assay
    [PMID: 20299226]
    SW-1736 IC50
    13.09 μM
    Compound: 1
    Cytotoxicity against human SW1736 cells after 96 hrs by SRB colorimetric assay
    Cytotoxicity against human SW1736 cells after 96 hrs by SRB colorimetric assay
    [PMID: 20472329]
    SW-1736 IC50
    13.09 μM
    Compound: 1
    Cytotoxicity against human SW1736 cells after 96 hrs by SRB assay
    Cytotoxicity against human SW1736 cells after 96 hrs by SRB assay
    [PMID: 20451375]
    SW-1736 EC50
    14.8 μM
    Compound: BA
    Cytotoxicity against human SW1736 cells after 96 hrs by sulforhodamine-B assay
    Cytotoxicity against human SW1736 cells after 96 hrs by sulforhodamine-B assay
    [PMID: 30056282]
    SW-1736 EC50
    16.4 μM
    Compound: BA
    Cytotoxicity against human SW1736 cells assessed as reduction in cell viability after 96 hrs by SRB assay
    Cytotoxicity against human SW1736 cells assessed as reduction in cell viability after 96 hrs by SRB assay
    [PMID: 30840925]
    SW-1736 EC50
    16.4 μM
    Compound: BA
    Cytotoxicity against human SW1736 cells assessed as reduction in cell viability incubated fro 96 hrs by SRB assay
    Cytotoxicity against human SW1736 cells assessed as reduction in cell viability incubated fro 96 hrs by SRB assay
    [PMID: 29024910]
    SW-1736 EC50
    16.4 μM
    Compound: BA
    Anticancer activity against human SW1736 cells measured after 96 hrs by sulforhodamine B assay
    Anticancer activity against human SW1736 cells measured after 96 hrs by sulforhodamine B assay
    [PMID: 31330447]
    SW-1736 EC50
    18.3 μM
    Compound: BA
    Cytotoxicity against human SW1736 cells after 96 hrs by SRB assay
    Cytotoxicity against human SW1736 cells after 96 hrs by SRB assay
    [PMID: 29960206]
    SW480 IC50
    6.4 μM
    Compound: BA
    Cytotoxicity against human SW480 cells after 96 hrs by SRB assay
    Cytotoxicity against human SW480 cells after 96 hrs by SRB assay
    [PMID: 20034802]
    SW480 IC50
    6.4 μM
    Compound: BA
    Cytotoxicity against human SW480 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human SW480 cells after 96 hrs by sulforhodamine B assay
    [PMID: 20846866]
    SW480 IC50
    6.4 μM
    Compound: BA
    Cytotoxicity against human SW480 cells after 96 hrs by sulforhodamine B assay
    Cytotoxicity against human SW480 cells after 96 hrs by sulforhodamine B assay
    [PMID: 20299226]
    SW480 IC50
    6.48 μM
    Compound: 1
    Cytotoxicity against human SW480 cells after 96 hrs by SRB assay
    Cytotoxicity against human SW480 cells after 96 hrs by SRB assay
    [PMID: 20451375]
    SW-620 IC50
    13.26 μg/mL
    Compound: 1
    Cytotoxicity against human SW620 cells after 72 hrs by MTT assay
    Cytotoxicity against human SW620 cells after 72 hrs by MTT assay
    [PMID: 18752941]
    SW948 IC50
    10.5 μM
    Compound: 1
    Antiproliferative activity against human SW948 cells after 3 days by XTT assay
    Antiproliferative activity against human SW948 cells after 3 days by XTT assay
    [PMID: 19691293]
    T47D IC50
    15.56 μM
    Compound: BA
    Cytotoxicity against human T47D cells assessed as growth inhibition after 96 hrs by SRB assay
    Cytotoxicity against human T47D cells assessed as growth inhibition after 96 hrs by SRB assay
    [PMID: 25817774]
    THP-1 IC50
    20 μM
    Compound: 1
    Cytotoxicity against human THP1 cells after 48 hrs by SRB assay
    Cytotoxicity against human THP1 cells after 48 hrs by SRB assay
    [PMID: 23584541]
    U-937 ED50
    0.69 μg/mL
    Compound: Betulinic acid
    Cytotoxic activity against human U937 cell line was measured after 72 hr using MTT assay
    Cytotoxic activity against human U937 cell line was measured after 72 hr using MTT assay
    [PMID: 15225732]
    UACC-257 GI50
    1.5 μM
    Compound: 1
    Cytotoxicity of compound against human melanoma cell lines (UACC-257) using MTT assay
    Cytotoxicity of compound against human melanoma cell lines (UACC-257) using MTT assay
    [PMID: 11527742]
    Vero EC50
    > 10 μM
    Compound: 13
    Antiviral activity against SARS coronavirus in Vero E6 cells assessed as inhibition of viral replication by ELISA
    Antiviral activity against SARS coronavirus in Vero E6 cells assessed as inhibition of viral replication by ELISA
    [PMID: 17663539]
    Vero CC50
    > 100 μM
    Compound: 1, Betulinic acid
    Cytotoxicity against African green monkey Vero cells assessed as cell viability after 48 hrs by Alamar Blue assay
    Cytotoxicity against African green monkey Vero cells assessed as cell viability after 48 hrs by Alamar Blue assay
    [PMID: 26112446]
    Vero CC50
    > 400 μM
    Compound: BA
    Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay
    Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay
    [PMID: 29326018]
    Vero IC50
    1.6 μM
    Compound: 1, Betulinic acid
    Antiviral activity against HSV-2 186 infected in African green monkey Vero cells assessed as inhibition of viral yield after 48 hrs by crystal violet staining
    Antiviral activity against HSV-2 186 infected in African green monkey Vero cells assessed as inhibition of viral yield after 48 hrs by crystal violet staining
    [PMID: 26112446]
    Vero CC50
    150 μM
    Compound: 13
    Cytotoxicity against Vero E6 cells by MTT assay
    Cytotoxicity against Vero E6 cells by MTT assay
    [PMID: 17663539]
    Vero CC50
    38.1 μM
    Compound: 5
    Cytotoxic activity in African green monkey Vero cells by sulforhodamine B assay
    Cytotoxic activity in African green monkey Vero cells by sulforhodamine B assay
    [PMID: 29120172]
    Vero IC50
    72.1 μM
    Compound: 5
    Antiproliferative activity in African green monkey Vero cells by sulforhodamine B assay
    Antiproliferative activity in African green monkey Vero cells by sulforhodamine B assay
    [PMID: 29120172]
    WI-38 IC50
    1.3 μM
    Compound: 12
    Cytotoxicity against human WI 38 cells after 48 hrs by WST-8 assay
    Cytotoxicity against human WI 38 cells after 48 hrs by WST-8 assay
    [PMID: 15730243]
    WI-38 VA13 IC50
    11.6 μM
    Compound: 12
    Cytotoxicity against human VA13 cells after 48 hrs by WST-8 assay
    Cytotoxicity against human VA13 cells after 48 hrs by WST-8 assay
    [PMID: 15730243]
    體外研究
    (In Vitro)

    Betulinic acid is a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and prevents topoisomerase I-DNA interaction[1]. Betulinic acid (10, 20, 40, 80, and 160 μM) significantly suppresses MDA-MB-231 cell viability in a time- and dose-dependent manner after treatment for 24 or 48 h.? Betulinic acid (20, 40 μM) causes decrease in Bcl-2 expression of MDA-MB-231 cells. Betulinic acid also induces morphological changes of MDA-MB-231 cells at 20 μM, and leads to ultrastructure changes of MDA-MB-231 cells at 40 μM[2]. Betulinic acid shows anti-HIV activities, with an EC50 of 1.4 μM in acutely infected H9 lymphocytes[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    體內(nèi)研究
    (In Vivo)

    Betulinic acid (10 and 30 mg/kg, p.o.) significantly abrogates colon shortening, and reduces malondialdehyde (MDA) and lipid hydroperoxide levels in dextran sulfate sodium (DSS)-induced colitis in mice. Betulinic acid (30 mg/kg, p.o.) restores superoxide dismutase (SOD), catalase activity and glutathione (GSH) content to control levels in DSS-induced colitis in mice. Betulinic acid (30 mg/kg, p.o.) also inhibits the DSS-induced increase in inflammatory markers. Betulinic acid (3, 10, 30 mg/kg, p.o.) suppresses acetic acid-induced writhing responses and mustard oil (MO)-induced visceral nociception in mice[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    分子量

    456.70

    Formula

    C30H48O3

    CAS 號(hào)
    性狀

    固體

    顏色

    White to off-white

    中文名稱

    白樺脂酸;樺木酸;香檸檬烯;白樺酯酸;白樺酸

    結(jié)構(gòu)分類
    初始來(lái)源
    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.

    儲(chǔ)存方式

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    溶解性數(shù)據(jù)
    細(xì)胞實(shí)驗(yàn): 

    DMSO 中的溶解度 : 13.33 mg/mL (29.19 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響,請(qǐng)使用新開(kāi)封的 DMSO)

    H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

    配制儲(chǔ)備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 2.1896 mL 10.9481 mL 21.8962 mL
    5 mM 0.4379 mL 2.1896 mL 4.3792 mL
    查看完整儲(chǔ)備液配制表

    * 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液;一旦配成溶液,請(qǐng)分裝保存,避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí),請(qǐng)?jiān)?個(gè)月內(nèi)使用,-20°C儲(chǔ)存時(shí),請(qǐng)?jiān)?個(gè)月內(nèi)使用。

    • 摩爾計(jì)算器

    • 稀釋計(jì)算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動(dòng)物實(shí)驗(yàn):

    請(qǐng)根據(jù)您的 實(shí)驗(yàn)動(dòng)物和給藥方式 選擇適當(dāng)?shù)娜芙夥桨浮?

    以下溶解方案都請(qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液,再依次添加助溶劑:
    ——為保證實(shí)驗(yàn)結(jié)果的可靠性,澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件,適當(dāng)保存;體內(nèi)實(shí)驗(yàn)的工作液,建議您現(xiàn)用現(xiàn)配,當(dāng)天使用;
    以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比;如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象,可以通過(guò)加熱和/或超聲的方式助溶

    • 方案 一

      請(qǐng)依序添加每種溶劑: 10% DMSO    90% Corn Oil

      Solubility: ≥ 1.33 mg/mL (2.91 mM); 澄清溶液

      此方案可獲得 ≥ 1.33 mg/mL(飽和度未知)的澄清溶液,此方案實(shí)驗(yàn)周期在半個(gè)月以上的動(dòng)物實(shí)驗(yàn)酌情使用。

      1 mL 工作液為例,取 100 μL 13.3 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 900 μL玉米油中,混合均勻。

    以下溶解方案,請(qǐng)直接配制工作液。建議現(xiàn)用現(xiàn)配,在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比; 如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象,可以通過(guò)加熱和/或超聲的方式助溶。

    • 方案 一

      請(qǐng)依序添加每種溶劑: 50% PEG300    50% Saline

      Solubility: 4 mg/mL (8.76 mM); 懸濁液; 超聲助溶

    • 方案 二

      請(qǐng)依序添加每種溶劑: 0.5% CMC-Na/saline water

      Solubility: 2 mg/mL (4.38 mM); 懸濁液; 超聲助溶

    動(dòng)物溶解方案計(jì)算器
    請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息:

    給藥劑量

    mg/kg

    動(dòng)物的平均體重

    g

    每只動(dòng)物的給藥體積

    μL

    動(dòng)物數(shù)量

    由于實(shí)驗(yàn)過(guò)程有損耗,建議您多配一只動(dòng)物的量
    請(qǐng)輸入您的動(dòng)物體內(nèi)配方組成:
    %
    DMSO +
    +
    %
    Tween-80 +
    %
    Saline
    如果您的動(dòng)物是免疫缺陷鼠或者體弱鼠,建議 DMSO 中的在最后工作液體系中的占比盡量不超過(guò) 2%。
    方案所需 助溶劑 包括:DMSO, ,均可在 MCE 網(wǎng)站選購(gòu)。 Tween 80,均可在 MCE 網(wǎng)站選購(gòu)。
    計(jì)算結(jié)果
    工作液所需濃度 : mg/mL
    儲(chǔ)備液配制方法 : mg 藥物溶于 μL  DMSO(母液濃度為 mg/mL)。

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    您所需的儲(chǔ)備液濃度超過(guò)該產(chǎn)品的實(shí)測(cè)溶解度,以下方案僅供參考,如有需要,請(qǐng)與 MCE 中國(guó)技術(shù)支持聯(lián)系。
    動(dòng)物實(shí)驗(yàn)體內(nèi)工作液的配制方法 : 取 μL DMSO 儲(chǔ)備液,加入 μL 。 μL ,混合均勻至澄清,再加 μL Tween 80,混合均勻至澄清,再加 μL 生理鹽水。
    連續(xù)給藥周期超過(guò)半月以上,請(qǐng)謹(jǐn)慎選擇該方案。
    請(qǐng)確保第一步儲(chǔ)備液溶解至澄清狀態(tài),從左到右依次添加助溶劑。您可采用超聲加熱 (超聲清洗儀,建議頻次 20-40 kHz),渦旋吹打等方式輔助溶解。
    純度 & 產(chǎn)品資料

    純度: 98.43%

    參考文獻(xiàn)
    Cell Assay
    [2]

    CCK-8 is used in the assay. MDA-MB-231 cells are cultured in 96-well plates at a density of 2 × 103 cells/well and then treated with DMSO vehicle or various concentrations of Betulinic acid ranging from 5 μM to 160 μM in 100 μL of medium for the indicated times. After the treatment period, the medium in each well is replaced with 110 μL of medium containing 10 μL of the CCK-8 mixture, and the plates are incubated for 1 h and 30 min at 37°C. The absorbance at a wavelength of 450 nm is measured with a microplate reader[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Administration
    [3]

    Female Swiss albino mice are administered vehicle (5% v/v DMSO in peanut oil) or Betulinic acid (3, 10 or 30 mg/kg) in vehicle, orally. After 1 h, acetic acid (300 mg/kg) is administered by intraperitoneal route and number of writhing response of each animal is counted for 20 min by an observer who is blind to the treatments. Writhing response is when animal rubs its abdomen on surface of table/floor with elongation of the body and extension of the hind limbs[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    參考文獻(xiàn)

    完整儲(chǔ)備液配制表

    * 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液;一旦配成溶液,請(qǐng)分裝保存,避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí),請(qǐng)?jiān)?個(gè)月內(nèi)使用,-20°C儲(chǔ)存時(shí),請(qǐng)?jiān)?個(gè)月內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.1896 mL 10.9481 mL 21.8962 mL 54.7405 mL
    5 mM 0.4379 mL 2.1896 mL 4.3792 mL 10.9481 mL
    10 mM 0.2190 mL 1.0948 mL 2.1896 mL 5.4741 mL
    15 mM 0.1460 mL 0.7299 mL 1.4597 mL 3.6494 mL
    20 mM 0.1095 mL 0.5474 mL 1.0948 mL 2.7370 mL
    25 mM 0.0876 mL 0.4379 mL 0.8758 mL 2.1896 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Inquiry Information

    產(chǎn)品名稱:
    Betulinic acid
    目錄號(hào):
    HY-10529
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