TMCB is a selective, ATP-competitive CK2 (casein kinase II) inhibitor with distinct K_i values of 83 nM and 21 nM for the two different catalytic CK2 subunits α and α', respectively^[1].

The inhibition of TMCB toward the purified CK2 holoenzyme CK2α2β2 results in a K_i value of 10.1 nM. In addition, K_i values are determined with the surface displayed isoform CK2 holoenzymes and turned out to be of 31.1 nM for CK2α2β2 and 19.6 nM for CK2α'2β2. The surface display of CKα and CK2α', in the context of the corresponding holoenzymes, can be used to identify selective compounds^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

534.82

C₁₁H₉Br₄N₃O₂

905105-89-7

Room temperature in continental US; may vary elsewhere.

• [1]. Bollacke A, Nienberg C, Borgne ML, Jose J. Toward selective CK2alpha and CK2alpha' inhibitors: Development of a novel whole-cell kinase assay by Autodisplay of catalytic CK2alpha'. J Pharm Biomed Anal. 2016;121:253-260.  [Content Brief]