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  2. Stem Cell/Wnt
  3. Wnt β-catenin
  4. KY1220

KY1220作用于 Wnt/β-catenin 靶點(diǎn)，使β-catenin 和 Ras不穩(wěn)定。在HEK293報(bào)告細(xì)胞中的IC50 值為2.1 μM。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

KY1220 Chemical Structure

KY1220 Chemical Structure

CAS No. : 292168-79-7

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥1380
In-stock
2 mg ￥800
In-stock
5 mg ￥1500
In-stock
10 mg ￥1900
In-stock
50 mg ￥4800
In-stock
100 mg 現(xiàn)貨 詢價(jià)
200 mg   詢價(jià)  
500 mg   詢價(jià)  

* Please select Quantity before adding items.

Customer Review

    KY1220 purchased from MCE. Usage Cited in: Cancer Lett. 2018 Sep 28;432:121-131.  [Abstract]

    The capability of ASPP2 in regulating epithelial–mesenchymal transition (EMT) is completely abolished by specific Wnt/β-catenin inhibitor KY1220.

    KY1220 purchased from MCE. Usage Cited in: Life Sci. 2018 Nov 1;212:129-137.  [Abstract]

    KY1220 reverses the increasing expression of β-Catenin after upregulating Cry1 (P<0.05).

    • 生物活性

    • 實(shí)驗(yàn)參考方法

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells.

    IC50 & Target

    IC50: 2.1 μM (HEK293 reporter cells)[1]
    體外研究
    (In Vitro)

    KY1220 shows an IC50 of 2.1 μM in HEK293 reporter cells. KY1220 dose dependently decreases Wnt3a-CM-induced TOPflash reporter activation and mRNA expression of Wnt target genes CCND1 and MYC in HEK293 cells. In HEK293 cells, both β-catenin and panRas protein levels are similarly reduced in a dose-dependent manner after treatment with KY1220, whereas the mRNA levels of CTNNB1 (which encodes β-catenin), NRAS, KRAS and HRAS remain unchanged. K-Ras, which has a critical role in progression of CRCs, is also destabilized by KY1220 via polyubiquitin-dependent proteasomal degradation. KY1220 accelerates the degradation rates of both β-catenin and Ras in SW480 cell lines. Ras destabilization by KY1220 consequently inhibits the activities of both ERK and Akt, which are downstream effectors of Ras in SW480 cells harboring a KRAS mutation. The proliferation and transformation of the HCT15, SW480, D-WT and D-MT CRC cells are efficiently inhibited after treatment with KY1220[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    314.32

    Formula

    C14H10N4O3S
    CAS 號
    性狀

    固體

    顏色

    Light yellow to yellow

    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    溶解性數(shù)據(jù)
    細(xì)胞實(shí)驗(yàn)： 

    DMSO 中的溶解度 : 50 mg/mL (159.07 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

    配制儲備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 3.1815 mL 15.9074 mL 31.8147 mL
    5 mM 0.6363 mL 3.1815 mL 6.3629 mL
    查看完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時(shí)，請?jiān)?年內(nèi)使用， -20°C儲存時(shí)，請?jiān)?年內(nèi)使用。

    • 摩爾計(jì)算器

    • 稀釋計(jì)算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動物溶解方案計(jì)算器
    請輸入動物實(shí)驗(yàn)的基本信息：

    給藥劑量

    mg/kg

    動物的平均體重

    g

    每只動物的給藥體積

    μL

    動物數(shù)量

    只
    由于實(shí)驗(yàn)過程有損耗，建議您多配一只動物的量
    計(jì)算結(jié)果
    工作液所需濃度 : mg/mL
    純度 & 產(chǎn)品資料
    參考文獻(xiàn)
    Cell Assay
    [1]

    HCT15 or SW480 cells are treated with 25 μM KY1220 or KYA1797K or with control (DMSO) for 72 h. Cell proliferation is measured using the MTT assay. The absorbance of the formazan product is determined at 590 nm every 24 h[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    參考文獻(xiàn)

    完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時(shí)，請?jiān)?年內(nèi)使用， -20°C儲存時(shí)，請?jiān)?年內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.1815 mL 15.9074 mL 31.8147 mL 79.5368 mL
    5 mM 0.6363 mL 3.1815 mL 6.3629 mL 15.9074 mL
    10 mM 0.3181 mL 1.5907 mL 3.1815 mL 7.9537 mL
    15 mM 0.2121 mL 1.0605 mL 2.1210 mL 5.3025 mL
    20 mM 0.1591 mL 0.7954 mL 1.5907 mL 3.9768 mL
    25 mM 0.1273 mL 0.6363 mL 1.2726 mL 3.1815 mL
    30 mM 0.1060 mL 0.5302 mL 1.0605 mL 2.6512 mL
    40 mM 0.0795 mL 0.3977 mL 0.7954 mL 1.9884 mL
    50 mM 0.0636 mL 0.3181 mL 0.6363 mL 1.5907 mL
    60 mM 0.0530 mL 0.2651 mL 0.5302 mL 1.3256 mL
    80 mM 0.0398 mL 0.1988 mL 0.3977 mL 0.9942 mL
    100 mM 0.0318 mL 0.1591 mL 0.3181 mL 0.7954 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Inquiry Information

    產(chǎn)品名稱：
    KY1220
    目錄號：
    HY-102028
    需求量：