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  2. Metabolic Enzyme/Protease Anti-infection Protein Tyrosine Kinase/RTK
  3. Phosphatase Parasite SHP2
  4. Sodium stibogluconate

Sodium stibogluconate  (Synonyms: 葡萄糖酸銻鈉; Stibogluconate trisodium nonahydrate)

目錄號(hào): HY-100595 純度: 98.27%
COA 產(chǎn)品使用指南

Sodium stibogluconate (Stibogluconate trisodium nonahydrate) 是蛋白酪氨酸磷酸酶 (phosphatase) 的有效抑制劑。 Sodium stibogluconate 在10，100 和 100 μg/mL 時(shí)分別抑制 99% 的 SHP-1，SHP-2 和 PTP1B 活性。

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Sodium stibogluconate Chemical Structure

Sodium stibogluconate Chemical Structure

CAS No. : 16037-91-5

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規(guī)格 價(jià)格 是否有貨 數(shù)量
500 mg ￥550
In-stock
1 g ￥800
In-stock
5 g   詢價(jià)  
10 g   詢價(jià)  

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Customer Review

  • 生物活性

  • 實(shí)驗(yàn)參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent inhibitor of protein tyrosine phosphatase. Sodium stibogluconate inhibits 99% of SHP-1, SHP-2 and PTP1B activity at 10, 100, 100 μg/mL, respectively.

IC50 & Target

Phosphatase[1]
體外研究
(In Vitro)

Sodium stibogluconate (Stibogluconate trisodium nonahydrate) 在 10 μg/mL (利什曼病藥物的處理濃度) 下抑制 99% 的 SHP-1 活性。類似程度的 SHP-2 和 PTP1B 抑制需要 100 μg/mL Sodium stibogluconate。Sodium stibogluconate 對(duì)細(xì)胞 PTPases 的抑制作用是通過(guò)其快速誘導(dǎo) Baf3 細(xì)胞中細(xì)胞蛋白的酪氨酸磷酸化及其增強(qiáng) IL-3 誘導(dǎo)的 Janus 家族激酶 2/Stat5 酪氨酸磷酸化和 Baf3 細(xì)胞增殖來(lái)表明的。Sodium stibogluconate 增強(qiáng)了 GM-CSF 和 IFN-α 對(duì) TF-1 細(xì)胞生長(zhǎng)的相反作用，表明其在各種細(xì)胞因子信號(hào)轉(zhuǎn)導(dǎo)中具有廣泛的活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Sodium stibogluconate (Stibogluconate trisodium nonahydrate) 在 BALB/c 小鼠中誘導(dǎo) 61% 的 Renca 腫瘤生長(zhǎng)抑制，同時(shí)腫瘤浸潤(rùn)性巨噬細(xì)胞增加 (2 倍)。Sodium stibogluconate 和 IL-2 的組合在抑制腫瘤生長(zhǎng) (91%) 和誘導(dǎo)腫瘤浸潤(rùn) (4 倍) 方面更有效，而單獨(dú)使用 IL-2 幾乎沒有效果[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

910.90

Formula

C12H38Na3O26Sb2
CAS 號(hào)
性狀

固體

顏色

White to off-white

中文名稱

葡萄糖酸銻鈉
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

H2O 中的溶解度 : 3 mg/mL (3.29 mM; 超聲助溶 (<60°C))

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 1.0978 mL 5.4891 mL 10.9782 mL
5 mM --- --- ---
查看完整儲(chǔ)備液配制表

* 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
您所需的儲(chǔ)備液濃度超過(guò)該產(chǎn)品的實(shí)測(cè)溶解度，如有需要，請(qǐng)與 MCE 中國(guó)技術(shù)支持聯(lián)系。
純度 & 產(chǎn)品資料

純度: 98.27%

參考文獻(xiàn)
Cell Assay
[1]

Human myeloid cell line TF-1 is maintained in RPMI 1640 supplemented with 10% FCS and 40 ng/mL recombinant human GM-CSF. For cell proliferation assays, cells are washed in 10% FCS medium twice, resuspended in 10% FCS medium, incubated at 37°C for 16 h, and then cultured at 37°C in 10% FCS medium containing various amounts of cytokines, sodium stibogluconate, or potassium antimonyl tartrate for 3-6 days. The cell numbers in proliferation assays are determined by an MTT assay or by microscopic cell counting[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[2]

BALB/c and athymic nude BALB/c mice are inoculated (s.c.) at the flanks with Renca cells (106 cells/site). Four days after inoculation, the mice are subjected to no treatment (control) or treatment with IL-2 (105 IU/day for 5 days i.p.), Stibogluconate sodium (12 mg/day i.m. at hip regions), or the combination of the two agents for 2 wk. Tumor volume is measured during the study period and calculated using the formula for a prolate spheroid[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻(xiàn)

完整儲(chǔ)備液配制表

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.0978 mL 5.4891 mL 10.9782 mL 27.4454 mL

* 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Sodium stibogluconate
目錄號(hào)：
HY-100595
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