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  2. GPCR/G Protein TGF-beta/Smad Stem Cell/Wnt
  3. Prostaglandin Receptor TGF-beta/Smad
  4. Butaprost

Butaprost  (Synonyms: 布他前列素)

目錄號(hào): HY-100448A 純度: ≥99.0%
COA 產(chǎn)品使用指南

Butaprost 是一種選擇性前列腺素 E 受體 (EP2) 激動(dòng)劑，對(duì)鼠類 EP2 受體的 EC50 值為 33 nM，Ki 值為 2.4 μM。Butaprost 對(duì)鼠類 EP1，EP3 和 EP4 受體的活性較低。Butaprost 通過(guò)阻礙 TGF-β/Smad2 信號(hào)傳導(dǎo)來(lái)減輕纖維化。

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Butaprost Chemical Structure

Butaprost Chemical Structure

CAS No. : 69685-22-9

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg (12.24 mM * 200 μL in Methyl acetate) ￥3900
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5 mg (12.24 mM * 1 mL in Methyl acetate) 現(xiàn)貨 詢價(jià)

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Other Forms of Butaprost:

MCE 顧客使用本產(chǎn)品發(fā)表的 2 篇科研文獻(xiàn)

查看 Prostaglandin Receptor 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Butaprost is a selective prostaglandin E receptor (EP2) agonist with an EC50 of 33 nM and a Ki of 2.4 μM for murine EP2 receptor. Butaprost is less activity against murine EP1, EP3 and EP4 receptors. Butaprost attenuates fibrosis by hampering TGF-β/Smad2 signalling[1][2][3].

體外研究
(In Vitro)

Butaprost (1-100 nM；0.5-24 小時(shí)) 誘導(dǎo) hEP2-HEK293/EBNA 細(xì)胞中 Nur77 mRNA 表達(dá)，上調(diào)大約五倍，且呈劑量和時(shí)間依賴性。Butaprost 通過(guò) PKC 通路上調(diào) Nur77 基因表達(dá)[1]。
Butaprost (50 μM；24 小時(shí)) 降低 TGF-β 誘導(dǎo)的纖連蛋白 (FN) 表達(dá)、Smad2 磷酸化和上皮-間充質(zhì)Madin-Darby 犬腎 (MDCK) 細(xì)胞的轉(zhuǎn)變[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HEK 293/EBNA cells stably expressing the human EP2 receptor (hEP2-HEK 293/EBNA cells)
Concentration: 1 nM, 10 nM, 100 nM
Incubation Time: 0.5 hours, 1 hours, 6 hours, 24 hours
Result: Induced about a five-fold upregulation of Nur77 mRNA expression in hEP2-HEK293/EBNA cells.
體內(nèi)研究
(In Vivo)

Butaprost (1-4 mg/kg；腹膜內(nèi)注射；每天兩次；持續(xù) 7 天) 處理可減輕接受單側(cè)輸尿管梗阻手術(shù)的小鼠纖維化的發(fā)展，如 α-平滑肌基因和蛋白表達(dá)的減少所示肌動(dòng)蛋白、纖連蛋白和膠原蛋白 1A1[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (8 weeks of age; 21 g) bearing unilateral ureteral obstruction surgery[2]
Dosage: 1 mg/kg, 2 mg/kg, 4 mg/kg
Administration: Intraperitoneal injection; twice daily; for 7 days
Result: Attenuated the development of fibrosis in mice that underwent unilateral ureteral obstruction surgery.
分子量

408.57

Formula

C24H40O5
CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Solution, -20°C, 2 years
純度 & 產(chǎn)品資料

純度: ≥99.0%

參考文獻(xiàn)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Butaprost
目錄號(hào)：
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