Cas No.: | 26921-17-5 |
Chemical Name: | (S)-1-(tert-butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol maleate |
Synonyms: | L 714,465; L-714,465; L714,465; MK 950; MK-950; MK950; Optimol; Timacar; Timolol maleate; brand name: Betimol, Blocadren, Istalol, Timoptic, Timoptic-XE, Timoptic OcuDose. |
SMILES: | C1(=NSN=C1OC[C@@H](O)CNC(C)(C)C)N1CCOCC1.O=C(O)/C=C\C(O)=O |
Formula: | C17H28N4O7S |
M.Wt: | 432.492 |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | (S)-Timolol maleate, is a potent non-selective β-adrenergic receptor antagonist (Ki values are 1.97 and 2.0 nM for β1 and β2 receptor subtypes respectively).(S)-Timolol, 50% bioavailability following oral administration. Does not cross the blood brain barrier. Timolol maleate does appear to have some local anesthetic properties in human cornea after chronic use by susceptible individuals. |