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  2. Inhibitory Antibodies
  3. Vopratelimab

Vopratelimab  (Synonyms: 伏派利單抗; JTX 2011)

目錄號(hào): HY-P99382 純度: 95.00%
COA

Vopratelimab (JTX-2011) 是一種人源化免疫球蛋白 G1-kappa 激動(dòng)劑單克隆抗體，特異性結(jié)合到誘導(dǎo)型 T 細(xì)胞 CO 刺激因子 (ICOS)。Vopratelimab 保留了物種交叉反應(yīng)性，對(duì) hICOS 的親和力為 0.93 nM，對(duì)大鼠 ICOS 的親和力為 3.7 nM，對(duì) mICOS 的親和力為 0.64 nM。Vopratelimab 具有抗腫瘤免疫反應(yīng)。

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CAS No. : 2039148-04-2

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥4000
In-stock
5 mg ￥9800
In-stock
10 mg ￥13625
In-stock
50 mg   詢(xún)價(jià)  
100 mg   詢(xún)價(jià)  

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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Vopratelimab (JTX-2011) is a humanized immunoglobulin G1-kappa agonist monoclonal antibody that pecifically binds to the Inducible CO-Stimulator of T cells (ICOS). Vopratelimab retains species cross-reactivity with affinities of 0.93 nM to hICOS, 0.46 nM to cynomolgus ICOS, 3.7 nM to rat ICOS, and 0.64 nM to mICOS. Vopratelimab has antitumor immune response[1].

同型

Human IgG1 kappa
推薦同型對(duì)照抗體
種屬

Humanized
體外研究
(In Vitro)

Vopratelimab (JTX-2011; 0.001-10 μg/mL; 3 d; CD4 T 細(xì)胞) 具有激活原代人 T 細(xì)胞的活性，驅(qū)動(dòng) IFNγ、IL-17a、IL-10、IL-9、GM-CSF、TNFα 和 IL-21 分泌[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Vopratelimab (JTX-2011; 0.25-0.3 mg/kg; i.p.; 每周兩次，持續(xù) 2 周) 促進(jìn) Sa1/N 小鼠同基因腫瘤模型中的腫瘤消退[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female A/J, Balb/c and C57BL/6 mice with Sa1/N murine syngeneic tumor model[1]
Dosage: 0.25-0.3 mg/kg
Administration: Intraperitoneal injection; twice a week, for 2 weeks
Result: Regressed tumor and protected long-term in the Sa1/N murine syngeneic tumor model.
Clinical Trial
CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

中文名稱(chēng)

伏派利單抗
運(yùn)輸條件

Shipping with dry ice.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
純度 & 產(chǎn)品資料
參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱(chēng)：
Vopratelimab
目錄號(hào)：
HY-P99382
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