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  2. 多肽產(chǎn)品
  3. 多肽及其衍生物
  4. 多肽藥物遞送 激素肽與神經(jīng)肽 抑制劑與底物肽 藥物肽
  5. 靶向肽
  6. Cyclic somatostatin

Cyclic somatostatin  (Synonyms: 環(huán)狀生長激素抑制素; SRIF-14; Somatostatin-14)

目錄號: HY-P0084 純度: 99.77%
COA 產(chǎn)品使用指南

Cyclic somatostatin (SRIF-14) 是一種生長激素釋放抑制因子，用于研究嚴(yán)重急性胃十二指腸潰瘍出血。Cyclic somatostatin 是一種與乙酰膽堿共存儲于心臟副交感神經(jīng)支配的神經(jīng)肽，直接影響心室心肌細(xì)胞的收縮。Cyclic somatostatin 抑制異丙腎上腺素的收縮反應(yīng)，IC50 值為 13 nM。Cyclic somatostatin 可用于心血管疾病的研究。

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Custom Peptide Synthesis

Cyclic somatostatin Chemical Structure

Cyclic somatostatin Chemical Structure

CAS No. : 38916-34-6

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥200
In-stock
5 mg ￥320
In-stock
10 mg ￥450
In-stock
25 mg ￥750
In-stock
50 mg ￥990
In-stock
100 mg ￥1480
In-stock
500 mg ￥3713
In-stock
1 g   詢價  
5 g   詢價  

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Customer Review

Other Forms of Cyclic somatostatin:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC50 value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease[1][2][3].

IC50 & Target

IC50: 13 nM (contractile response of isoprenaline)[1]
細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
AtT20 IC50
7.4 x 10-11 M
Compound: Somatostatin-14
Displacement of [125I]Tyr11-somatostatin-14 from Sst receptor in mouse AtT-20 cells measured after 60 mins by scintillation counting method
Displacement of [125I]Tyr11-somatostatin-14 from Sst receptor in mouse AtT-20 cells measured after 60 mins by scintillation counting method
[PMID: 27876250]
CHO IC50
1.6 nM
Compound: 1, Somatostatin, SRIF
Displacement of 125I-[LTT]-SRIF-28 from human sst1 receptor in CHO cells after 2 hrs by autoradiography
Displacement of 125I-[LTT]-SRIF-28 from human sst1 receptor in CHO cells after 2 hrs by autoradiography
[PMID: 21806016]
CHO IC50
1.9 nM
Compound: SS14
Displacement of [125I]-[LTT]-SS28 from human SST1 receptor expressed in CHO cells after 2 hrs by autoradiographic analysis
Displacement of [125I]-[LTT]-SS28 from human SST1 receptor expressed in CHO cells after 2 hrs by autoradiographic analysis
[PMID: 24378707]
HEK293 IC50
4.2 nM
Compound: SS14
Displacement of [125I]-[LTT]-SS28 from human SST5 receptor expressed in HEK293 cells after 2 hrs by autoradiographic analysis
Displacement of [125I]-[LTT]-SS28 from human SST5 receptor expressed in HEK293 cells after 2 hrs by autoradiographic analysis
[PMID: 24378707]
HEK293 IC50
4.2 nM
Compound: 1, Somatostatin, SRIF
Displacement of 125I-[LTT]-SRIF-28 from human sst5 receptor in HEK293 cells after 2 hrs by autoradiography
Displacement of 125I-[LTT]-SRIF-28 from human sst5 receptor in HEK293 cells after 2 hrs by autoradiography
[PMID: 21806016]
體外研究
(In Vitro)

Cyclic somatostatin (0-10 μM; 15 min) dose-dependently inhibits the contractile response to isoprenaline in rat ventricular cardiomyocytes with an IC50 value of 13 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Cyclic somatostatin (5 μg/kg; i.v. per hour once for 18-22 hours) affects visceral metabolism in ruminants[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Polypay sheeps[3]
Dosage: 5 μg/kg
Administration: Intravenous injection; 5 μg/kg per hour once; for 18-22 hours
Result: Decreased net portal-drained viscera release of glucose, a-amino N, ammonia N, b-hydrox ybutyrate, oxygen consumption, liver oxygen consumption, and total splanchnic a-amino N release and oxygen consumption. Increased lactate release and net hepatic glucose output.
分子量

1637.88

Formula

C76H104N18O19S2
CAS 號
性狀

固體

顏色

White to off-white

Sequence

Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys (Disulfide bridge: Cys3-Cys14)
Sequence Shortening

AGCKNFFWKTFTSC (Disulfide bridge: Cys3-Cys14)
中文名稱

環(huán)狀生長激素抑制素
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light)

溶解性數(shù)據(jù)
細(xì)胞實驗： 

H2O 中的溶解度 : 100 mg/mL (61.05 mM; 超聲助溶)

DMF 中的溶解度 : 100 mg/mL (61.05 mM; 超聲助溶)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 0.6105 mL 3.0527 mL 6.1055 mL
5 mM 0.1221 mL 0.6105 mL 1.2211 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light)。-80°C儲存時，請在1年內(nèi)使用， -20°C儲存時，請在6個月內(nèi)使用。

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
該產(chǎn)品水溶性佳，請具體參考實測 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
純度 & 產(chǎn)品資料

純度: 99.77%

參考文獻(xiàn)

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light)。-80°C儲存時，請在1年內(nèi)使用， -20°C儲存時，請在6個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
H2O / DMF 1 mM 0.6105 mL 3.0527 mL 6.1055 mL 15.2636 mL
5 mM 0.1221 mL 0.6105 mL 1.2211 mL 3.0527 mL
10 mM 0.0611 mL 0.3053 mL 0.6105 mL 1.5264 mL
15 mM 0.0407 mL 0.2035 mL 0.4070 mL 1.0176 mL
20 mM 0.0305 mL 0.1526 mL 0.3053 mL 0.7632 mL
25 mM 0.0244 mL 0.1221 mL 0.2442 mL 0.6105 mL
30 mM 0.0204 mL 0.1018 mL 0.2035 mL 0.5088 mL
40 mM 0.0153 mL 0.0763 mL 0.1526 mL 0.3816 mL
50 mM 0.0122 mL 0.0611 mL 0.1221 mL 0.3053 mL
60 mM 0.0102 mL 0.0509 mL 0.1018 mL 0.2544 mL

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Cyclic somatostatin
目錄號：
HY-P0084
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