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  2. Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Thyroid Hormone Receptor Endogenous Metabolite
  4. Protirelin

Protirelin  (Synonyms: 普羅瑞林; Thyrotropin-releasing-hormone; TRH)

目錄號: HY-P0002 純度: 99.51%
COA 產品使用指南 技術支持

Protirelin 是一種高度保守的神經肽，發(fā)揮促甲狀腺激素 (TSH) 水平的激素控制作用，及神經調節(jié)功能。

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Custom Peptide Synthesis

Protirelin Chemical Structure

Protirelin Chemical Structure

CAS No. : 24305-27-9

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規(guī)格 價格 是否有貨 數(shù)量
5 mg ￥600
In-stock
10 mg ￥1000
In-stock
25 mg ￥1700
In-stock
50 mg ￥2700
In-stock
100 mg   詢價  
200 mg   詢價  

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Customer Review

Other Forms of Protirelin:

  • 生物活性

  • 實驗參考方法

  • 純度 & 產品資料

  • 參考文獻

生物活性

Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

IC50 & Target

Thyroid hormone receptor
細胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
0.0005 μM
Compound: TRH
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay
[PMID: 26854379]
HEK293 EC50
0.00052 μM
Compound: TRH
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR method
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR method
[PMID: 26216015]
HEK293 EC50
0.001 μM
Compound: TRH
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay
[PMID: 26854379]
HEK293 EC50
0.001 μM
Compound: TRH
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR method
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR method
[PMID: 26216015]
HEK293 IC50
0.0026 μM
Compound: TRH
Displacement of [3H]-1-MeHis-TRH from mouse TRH-R1 expressed in HEK293 cells incubated up to 4 hrs by scintillation counting method
Displacement of [3H]-1-MeHis-TRH from mouse TRH-R1 expressed in HEK293 cells incubated up to 4 hrs by scintillation counting method
[PMID: 26216015]
HEK293 EC50
0.003 μM
Compound: TRH
Signaling (activation) potency for thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubation with the compound for 6 hr at 37 degree C and pH 7.8
Signaling (activation) potency for thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubation with the compound for 6 hr at 37 degree C and pH 7.8
[PMID: 16162016]
HEK293 EC50
0.003 μM
Compound: TRH
Signaling (activation) potency for thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubation with the compound for 6 hr at 37 degree C and pH 7.8; Range = 0.002-0.004 uM
Signaling (activation) potency for thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubation with the compound for 6 hr at 37 degree C and pH 7.8; Range = 0.002-0.004 uM
[PMID: 16162016]
HEK293 EC50
0.0031 μM
Compound: TRH
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA
[PMID: 26854379]
HEK293 EC50
0.0032 μM
Compound: TRH
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA
[PMID: 26854379]
HEK293 IC50
0.007 μM
Compound: TRH
Displacement of [3H]-1-MeHis-TRH from mouse TRH-R2 expressed in HEK293 cells incubated up to 4 hrs by scintillation counting method
Displacement of [3H]-1-MeHis-TRH from mouse TRH-R2 expressed in HEK293 cells incubated up to 4 hrs by scintillation counting method
[PMID: 26216015]
HEK293 IC50
0.007 μM
Compound: TRH
Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs
Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs
[PMID: 26854379]
HEK293 IC50
0.026 μM
Compound: TRH
Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs
Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs
[PMID: 26854379]
體內研究
(In Vivo)

Protirelin (TRH) is an evolutionarily ancient neuropeptide, having its origin before the divergence of protostomes and deuterostomes, and may ancestrally have been involved in the control of postembryonic growth and reproduction[1]. The effect of the thyrotropin-releasing hormone (Protirelin, TRH), one of the hypothalamic releasing hormones, on body temperature is investigated in the rat. Protirelin, in doses of 1, 5, 10 and 20 mg/kg, is injected intraperitoneally to male Wistar rats weighing 200-250 g. Protirelin causes a temporary rise in body temperature dose-dependently. The thyroidectomized rats injected 20 mg/kg of Protirelin which induces a significant hyperthermia in the sham-operated animals, fail to show a rise in body temperature. The present results suggest that a release of thyroid hormone might participate in the hyperthermic action of Protirelin[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

362.38

Formula

C16H22N6O4
CAS 號
性狀

固體

顏色

White to off-white

Sequence

{pGlu}-His-Pro-NH2
Sequence Shortening

{pGlu}-HP-NH2
中文名稱

普羅瑞林
結構分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 250 mg/mL (689.88 mM; 超聲助溶; 吸濕的 DMSO 對產品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 2.7595 mL 13.7977 mL 27.5953 mL
5 mM 0.5519 mL 2.7595 mL 5.5191 mL
查看完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
純度 & 產品資料
參考文獻
Animal Administration
[2]

Rats[2]
Ninety male Wistar rats weighing 200-250 g are subjected to the study. In the first experiment, 50 rats are divided into five groups randomly. Four doses of Protirelin dissolved in physiological saline, i. e., 1 mg/kg, 5mg/kg, 10 mg/kg and 20 mg/kg, are administered intraperitoneally to the four groups and saline to the remaining control group. Rectal temperature is measured at the place 5 cm inner from the anus with the electronic thermister before and after treatment with Protirelin or saline. In the second experiment, 40 rats are thyroidectomized or sham-operated under the anesthesia by thiopental sodium. Ten days after the operation, 20 mg/kg of Protirelin or saline is administered to the thyroidectomized and sham-operated animals by i. p. and rectal temperature is measured using the same method as used in the first experiment. These two experiments are undertaken from 1 p, m, to 4 p. m. and the room temperature is kept at 24±1°C through the experiments including the breeding period. For a statistical analysis, Student's t test (two-tailed) is adopted.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻

完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7595 mL 13.7977 mL 27.5953 mL 68.9884 mL
5 mM 0.5519 mL 2.7595 mL 5.5191 mL 13.7977 mL
10 mM 0.2760 mL 1.3798 mL 2.7595 mL 6.8988 mL
15 mM 0.1840 mL 0.9198 mL 1.8397 mL 4.5992 mL
20 mM 0.1380 mL 0.6899 mL 1.3798 mL 3.4494 mL
25 mM 0.1104 mL 0.5519 mL 1.1038 mL 2.7595 mL
30 mM 0.0920 mL 0.4599 mL 0.9198 mL 2.2996 mL
40 mM 0.0690 mL 0.3449 mL 0.6899 mL 1.7247 mL
50 mM 0.0552 mL 0.2760 mL 0.5519 mL 1.3798 mL
60 mM 0.0460 mL 0.2300 mL 0.4599 mL 1.1498 mL
80 mM 0.0345 mL 0.1725 mL 0.3449 mL 0.8624 mL
100 mM 0.0276 mL 0.1380 mL 0.2760 mL 0.6899 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產品名稱：
Protirelin
目錄號：
HY-P0002
需求量：