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  2. Epigenetics PI3K/Akt/mTOR Protein Tyrosine Kinase/RTK
  3. AMPK VEGFR PDGFR
  4. 10Z-Hymenialdisine

10Z-Hymenialdisine  (Synonyms: (Z)-Hymenialdisine; Hymenialdisine)

目錄號: HY-N6794 純度: 97.0%
COA 產(chǎn)品使用指南 技術(shù)支持

10Z-Hymenialdisine ((Z)-Hymenialdisine) 是一種天然的生物活性吡咯生物堿。10Z-Hymenialdisine 是一種泛激酶抑制劑，具有抗癌活性。

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10Z-Hymenialdisine Chemical Structure

10Z-Hymenialdisine Chemical Structure

CAS No. : 82005-12-7

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規(guī)格 價格 是否有貨 數(shù)量
500 μg ￥5700
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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

10Z-Hymenialdisine ((Z)-Hymenialdisine) is a natural bioactive pyrrole alkaloid. 10Z-Hymenialdisine is a pan kinase inhibitor, and has anticancer activities[1].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
Jurkat IC50
2.41 μM
Compound: 1 (Hymenialdisine)
Inhibition of IL-2 production was determined in Jurkat cells after PMA/PHA activation by Enzyme immunoassay
Inhibition of IL-2 production was determined in Jurkat cells after PMA/PHA activation by Enzyme immunoassay
[PMID: 15214798]
Jurkat IC50
4 μM
Compound: 8; 55, 63
Antiinflammatory activity in PMA induced human Jurkat cells assessed as inhibition of IL-2 production by EIA assay
Antiinflammatory activity in PMA induced human Jurkat cells assessed as inhibition of IL-2 production by EIA assay
[PMID: 36496202]
KB 3-1 IC50
3.1 μM
Compound: HMD; 1a
Cytotoxicity against human KB-3-1 cells by MTT assay
Cytotoxicity against human KB-3-1 cells by MTT assay
[PMID: 33901899]
L5178Y EC50
3.5 μg/mL
Compound: HMD; 1a
Cytotoxicity against mouse L5178Y cells by MTT assay
Cytotoxicity against mouse L5178Y cells by MTT assay
[PMID: 33901899]
LoVo IC50
6 nM
Compound: 8; 55, 63
Inhibition of cell growth in human LoVo cells by SRB assay
Inhibition of cell growth in human LoVo cells by SRB assay
[PMID: 36496202]
MONO-MAC-6 IC50
0.2 μg/mL
Compound: 6
Cytotoxicity against human MONO-MAC 6 cells assessed as [3H]thymidine incorporation after 48 hrs
Cytotoxicity against human MONO-MAC 6 cells assessed as [3H]thymidine incorporation after 48 hrs
[PMID: 9917317]
MONO-MAC-6 IC50
0.61 μM
Compound: 8; 55, 63
Cytotoxicity against human MONO-MAC-6 cells incubated for 48 hrs by [3H]-thymidine incorporation based liquid scintillation counter analysis
Cytotoxicity against human MONO-MAC-6 cells incubated for 48 hrs by [3H]-thymidine incorporation based liquid scintillation counter analysis
[PMID: 36496202]
SW-620 IC50
2 μM
Compound: HMD; 1a
Cytotoxicity against human SW620 cells by MTT assay
Cytotoxicity against human SW620 cells by MTT assay
[PMID: 33901899]
THP-1 IC50
1.36 μM
Compound: 1 (Hymenialdisine)
Inhibition of TNF-alpha production was determined in THP-1cells after LPS activation by Enzyme immunoassay
Inhibition of TNF-alpha production was determined in THP-1cells after LPS activation by Enzyme immunoassay
[PMID: 15214798]
THP-1 IC50
1.4 μM
Compound: 8; 55, 63
Antiinflammatory activity in LPS induced human THP-1 cells assessed as inhibition of TNF-alpha production by EIA assay
Antiinflammatory activity in LPS induced human THP-1 cells assessed as inhibition of TNF-alpha production by EIA assay
[PMID: 36496202]
體外研究
(In Vitro)

10Z-Hymenialdisine displays a moderate effect on (ARK5, VEGFR-2, SAK and PDGFR) protein kinases. 10Z-Hymenialdisine shows a potent inhibition of RAF/MEK-1/MAPK cascade with an IC50 value of 6 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

324.13

Formula

C11H10BrN5O2
CAS 號
性狀

固體

顏色

White to light yellow

中文名稱

2,5-已炔二醇；已炔二醇
結(jié)構(gòu)分類
初始來源

marine sponge Axinella carteri
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實驗： 

DMSO 中的溶解度 : 3.24 mg/mL (10.00 mM; 超聲加熱助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 3.0852 mL 15.4259 mL 30.8518 mL
5 mM 0.6170 mL 3.0852 mL 6.1704 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: ≥97.0%

參考文獻(xiàn)

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0852 mL 15.4259 mL 30.8518 mL 77.1295 mL
5 mM 0.6170 mL 3.0852 mL 6.1704 mL 15.4259 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
10Z-Hymenialdisine
目錄號：
HY-N6794
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