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  2. 誘導(dǎo)疾病模型產(chǎn)品 Membrane Transporter/Ion Channel
  3. 神經(jīng)系統(tǒng)疾病模型 Potassium Channel
  4. 震顫模型
  5. Penitrem A

Penitrem A  (Synonyms: 青霉震顫素)

目錄號(hào): HY-N6776 純度: 98.57%
COA 產(chǎn)品使用指南

Penitrem A 是由青霉菌產(chǎn)生的吲哚二萜神經(jīng)毒性生物堿，是一種選擇性的 BK 通道拮抗劑，對多種惡性腫瘤具有抗增殖、抗侵襲作用。Penitrem A 能刺激腦皮質(zhì)突觸體增加內(nèi)源性谷氨酸、GABA 和天門冬氨酸的自發(fā)釋放，能誘發(fā)動(dòng)物產(chǎn)生震顫綜合征。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Penitrem A Chemical Structure

Penitrem A Chemical Structure

CAS No. : 12627-35-9

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥2240
In-stock
5 mg ￥5600
In-stock
10 mg   詢價(jià)  
50 mg   詢價(jià)  

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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Penitrem A is an indole diterpene neurotoxic alkaloid produced by Penicillium, acts as a selective BK channel antagonist with antiproliferative and anti-invasive activities against multiple malignancies. Penitrem A increases the spontaneous release of endogenous glutamate, gamma-aminobutyric acid (GABA) and aspartate from cerebrocortical synaptosomes, and induces tremorgenic syndromes in animals[1][2].

IC50 & Target

BK channel[1]
細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
8.4 μM
Compound: 9
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
[PMID: 27462726]
HL-60 IC50
7 μM
Compound: 9
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
[PMID: 27462726]
體內(nèi)研究
(In Vivo)

Penitrem A 可用于動(dòng)物建模，構(gòu)建震顫綜合征模型。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

634.20

Formula

C37H44ClNO6
CAS 號(hào)
性狀

固體

顏色

White to light brown

中文名稱

青霉震顫素
結(jié)構(gòu)分類
初始來源

Penicillium
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料

純度: ≥99.0%

參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Penitrem A
目錄號(hào)：
HY-N6776
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