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  2. Anti-infection Apoptosis PI3K/Akt/mTOR Immunology/Inflammation
  3. Bacterial Apoptosis Fungal PI3K Akt TNF Receptor Interleukin Related
  4. Beauvericin

Beauvericin  (Synonyms: 白僵菌素)

目錄號: HY-N6739 純度: 99.83%
COA 產(chǎn)品使用指南 技術(shù)支持

Beauvericin 是一種環(huán)六肽鐮刀菌毒素，具有殺蟲、抗菌、抗癌、抗病毒和細胞毒活性。Beauvericin 通過產(chǎn)生 DNA 斷裂、染色體畸變和微核，造成細胞的遺傳毒性，并抑制 PI3K/AKT 通路誘導(dǎo)細胞凋亡 (apoptosis)，從而抑制 HCC 的生長。此外，Beauvericin 通過抑制淋巴細胞增殖和干擾人單核細胞向巨噬細胞的分化過程，來影響免疫功能。

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Beauvericin Chemical Structure

Beauvericin Chemical Structure

CAS No. : 26048-05-5

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規(guī)格 價格 是否有貨 數(shù)量
5 mg ￥1900
In-stock
10 mg ￥2945
In-stock
50 mg   詢價  
100 mg   詢價  

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Customer Review

Other Forms of Beauvericin:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Beauvericin is a cyclohexapeptide Fusarium toxin with insecticidal, antibacterial, anticancer, antiviral and cytotoxic activities. Beauvericin causes cellular genotoxicity by producing DNA breaks, chromosomal aberrations and micronuclei, and inhibits the PI3K/AKT pathway to induce apoptosis, thereby inhibiting the growth of HCC. In addition, Beauvericin affects immune function by inhibiting lymphocyte proliferation and interfering with the differentiation process of human monocytes into macrophages[1][2][3][4][5][6][7][8][9].

IC50 & Target

ACAT

 

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 IC50
1 μM
Compound: 12
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hr by CCK-8 assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hr by CCK-8 assay
[PMID: 36288556]
Huh-7 IC50
4.3 μM
Compound: 12
Antiproliferative activity against human Huh-7 cells assessed as reduction in cell viability after 48 hr by CCK-8 assay
Antiproliferative activity against human Huh-7 cells assessed as reduction in cell viability after 48 hr by CCK-8 assay
[PMID: 36288556]
體外研究
(In Vitro)

Beauvericin (0-20 μM；12、24 和 36 h) 對 H22 肝癌細胞具有較強的抗增殖活性并促進 H22 肝癌細胞凋亡[5]。
Beauvericin (50 μM; 72 h) 誘導(dǎo)火雞外周單核細胞發(fā)生凋亡[6]。
Beauvericin (0.3-100 μM) 以濃度依賴性的方式可逆地抑制 NG108-15 神經(jīng)元細胞中 L 型電壓依賴性 Ca2+ 電流 (ICa,L)，IC50 值為 4 μM[7]。
Beauvericin 對未成熟樹突狀細胞、成熟樹突狀細胞和巨噬細胞的 IC50 分別為 1.0 μM、2.9 μM 和 2.5 μM[8]。
Beauvericin (1.6 和 2.4 μM；2 d) 使成熟過程中的樹突狀細胞 CCR7 表達降低，IL-10 分泌增加[8]。
Beauvericin 是大鼠肝微粒體中 CYP3A1/2 的有效抑制劑 (IC50=1.3 μM)[9]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[5]

Cell Line: H22 liver cancer cells
Concentration: 0, 1, 3, 5,10,15 and 20 μM
Incubation Time: 12、24 and 36 h
Result: Inhibited the growth of H22 cells in a dose-dependent manner.

Western Blot Analysis[5]

Cell Line: H22 liver cancer cells
Concentration: 0, 1, 3, 5,10,15 and 20 μM
Incubation Time: 12、24 and 36 h
Result: Upregulated the Bax/Bcl-2 ratio and the levels of cleaved caspase-9 and cleaved caspase-3, and downregulated the p-PI3K/PI3K ratio and p-AKT/AKT ratio.
體內(nèi)研究
(In Vivo)

Beauvericin (5 mg/kg；i.p.；完成第一個給藥周期后，觀察兩天后，繼續(xù)第二個給藥周期) 使同種異體移植模型小鼠中腫瘤體積減小和壞死增加[3]。
Beauvericin (3、5、7 mg/kg；i.p.；每周一次持續(xù)三周) 能顯著抑制 H22 異體移植模型小鼠的生長，同時升高小鼠體內(nèi) TNF-α 和 IL-2 的水平[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice injected subcutaneously with mouse CT-26 colon cancer cells on the right side[3]
Dosage: 5 mg/kg
Administration: ntraperitoneal injection (i.p.)；The drug was administered on the third day after the injection of colon cancer cells and continued once a day for five days, then stopped for two days of observation, and continued on the tenth day after the injection of colon cancer cells, and continued once a day for four days.
Result: Reduced the average tumor volume by 52.8 % and the average tumor weight by 60 %.
Animal Model: Human cervical cancer KB-3-1 xenograft mouse model[3]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection (i.p.)； The drug was administered once a day starting on the fifth day after cervical cancer injection for five days, followed by two days of observation. The drug was administered once a day starting on the twelfth day after cervical cancer cell injection for four days.
Result: Reduced the average tumor volume by 31.3 % and the average tumor weight by 31.2 %.
分子量

783.95

Formula

C45H57N3O9
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

白僵菌素
結(jié)構(gòu)分類
初始來源

Fusarium proliferatum,F. semitectum, and?F. subglutinans
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 100 mg/mL (127.56 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 1.2756 mL 6.3780 mL 12.7559 mL
5 mM 0.2551 mL 1.2756 mL 2.5512 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.95%

參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2756 mL 6.3780 mL 12.7559 mL 31.8898 mL
5 mM 0.2551 mL 1.2756 mL 2.5512 mL 6.3780 mL
10 mM 0.1276 mL 0.6378 mL 1.2756 mL 3.1890 mL
15 mM 0.0850 mL 0.4252 mL 0.8504 mL 2.1260 mL
20 mM 0.0638 mL 0.3189 mL 0.6378 mL 1.5945 mL
25 mM 0.0510 mL 0.2551 mL 0.5102 mL 1.2756 mL
30 mM 0.0425 mL 0.2126 mL 0.4252 mL 1.0630 mL
40 mM 0.0319 mL 0.1594 mL 0.3189 mL 0.7972 mL
50 mM 0.0255 mL 0.1276 mL 0.2551 mL 0.6378 mL
60 mM 0.0213 mL 0.1063 mL 0.2126 mL 0.5315 mL
80 mM 0.0159 mL 0.0797 mL 0.1594 mL 0.3986 mL
100 mM 0.0128 mL 0.0638 mL 0.1276 mL 0.3189 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Beauvericin
目錄號：
HY-N6739
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