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  2. Anti-infection Apoptosis Stem Cell/Wnt JAK/STAT Signaling Cell Cycle/DNA Damage MAPK/ERK Pathway Protein Tyrosine Kinase/RTK NF-κB
  3. Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB
  4. Nitidine chloride

Nitidine chloride  (Synonyms: 氯化兩面針堿)

目錄號(hào): HY-N0498 純度: 99.75%
COA 產(chǎn)品使用指南

Nitidine chloride 是從 Zanthoxylum nitidum (Roxb) DC 中分離得到一種具有抗瘧疾活性的化合物。Nitidine chloride 通過(guò)多個(gè)靶點(diǎn)通路，發(fā)揮抗癌活性，如誘導(dǎo)凋亡，抑制 STAT3，DNA 拓?fù)洚悩?gòu)酶 1 和 2A，ERK 和 c-Src/FAK 相關(guān)信號(hào)通路，具有抗炎活性。Nitidine chloride 通過(guò) MAPK 和 NF-kB 途徑抑制 LPS (HY-D1056) 誘導(dǎo)的炎性細(xì)胞因子的產(chǎn)生。

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Nitidine chloride Chemical Structure

Nitidine chloride Chemical Structure

CAS No. : 13063-04-2

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥304
In-stock
5 mg ￥800
In-stock
10 mg ￥1400
In-stock
50 mg   詢(xún)價(jià)  
100 mg   詢(xún)價(jià)  

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Customer Review

Other Forms of Nitidine chloride:

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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway, also has anti-inflammatory activity. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway[1][2][3][4][5].

IC50 & Target

Plasmodium

 

體外研究
(In Vitro)

Nitidine chloride (0-32 μM，24-48 h) 抑制 A498 和 768-O 細(xì)胞增殖[1]。
Nitidine chloride (8-16 μM，24 h)誘導(dǎo) A498 和 768-O 細(xì)胞凋亡[1]。
Nitidine chloride (0-16 μM，48 h) 誘導(dǎo) A498 細(xì)胞凋亡，誘導(dǎo)細(xì)胞周期阻滯，抑制 ERK 通路[1]。
Nitidine chloride (0-10 μM，24 h) 誘導(dǎo) HSC3 和 HSC4 細(xì)胞凋亡，在 OSCC 細(xì)胞中通過(guò) STAT3 去磷酸化誘導(dǎo)凋亡[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: 768-O, A498
Concentration: 0, 4, 6, 8, 16, 32 μM
Incubation Time: 24, 48 h
Result: Inhibited cell proliferation in a time- and dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: 768-O, A498
Concentration: 8, 16 μM
Incubation Time: 24 h
Result: Increased apoptosis rate in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: A498
Concentration: 0, 8, 16 μM
Incubation Time: 48 h
Result: Increased Bax expression, decreased Bcl-2 expression, increased p53 expression, decreased pro-caspase-3 expression, increased cleaved caspase-3 expression and PARP cleavage level, inhibited ERK1/2, p38 and Akt phosphorylation.

Cell Viability Assay[2]

Cell Line: HSC3, HSC4
Concentration: 0, 0.1, 5, 10 μM
Incubation Time: 24 h
Result: Reduced cell viability.

Western Blot Analysis[2]

Cell Line: HSC3, HSC4, OSCC
Concentration: 0, 0.1, 5, 10 μM
Incubation Time: 24 h
Result: Dephosphorylated STAT3 and induced the cleavage of PARP and caspase-3 in a concentration- and time-dependent manner.
體內(nèi)研究
(In Vivo)

Nitidine chloride (5 mg/kg，腹腔注射，每日一次，5 周) 抑制小鼠腫瘤生長(zhǎng)，誘導(dǎo)體內(nèi)腎癌細(xì)胞凋亡[1]。
Nitidine chloride (0.375-10 mg/kg，腹腔注射，每日一次，3 周) 通過(guò) AGT4B 介導(dǎo)的自噬下調(diào)誘導(dǎo)小鼠心肌肥厚[3]。
Nitidine chloride (5-10 mg/kg，腹腔注射，單次劑量) 在內(nèi)毒素小鼠中通過(guò) Akt 介導(dǎo)的 IL-10 產(chǎn)生發(fā)揮抗炎作用[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A549 nude mouse xenograft model[1]
Dosage: 5 mg/kg; daily; 5 weeks
Administration: Intraperitoneal injection (i.p.)
Result: Showed non-toxic effects, reduced tumor growth, and induced apoptosis in renal cancer cells in vivo.
Animal Model: Mice, beagles[3]
Dosage: 2.5, 5, 10 mg/kg; 0.375, 0.75, 1.5 mg/kg; daily; 4 weeks
Administration: Intraperitoneal injection (i.p.)
Result: Both induced dose-dependent cardiac hypertrophy and dysfunction, while medium and high doses led to death in beagle dogs. Cardiac autophagy levels in cardiomyocytes were reduced. Overexpression of ATG4B reversed cardiac hypertrophy and reduced autophagy levels.
Animal Model: LPS induced endotoxemic mice[4]
Dosage: 5, 10 mg/kg; single dose
Administration: Intraperitoneal injection (i.p.)
Result: Increased IL-10 production, inhibited inflammatory response, reduced mortality, and enhanced Akt activation.
分子量

383.82

Formula

C21H18ClNO4
CAS 號(hào)
性狀

固體

顏色

Light yellow to yellow

中文名稱(chēng)

氯化兩面針堿
結(jié)構(gòu)分類(lèi)
初始來(lái)源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 2 mg/mL (5.21 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

*Nitidine chloride is usually formulated as a suspension.

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.6054 mL 13.0269 mL 26.0539 mL
5 mM 0.5211 mL 2.6054 mL 5.2108 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物實(shí)驗(yàn)：

以下溶解方案，請(qǐng)直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的方式助溶。

  • 方案 一

    請(qǐng)依序添加每種溶劑： 0.5% CMC-Na/0.5% Tween-80 in Saline water

    Solubility: 1 mg/mL (2.61 mM); 懸濁液; 超聲助溶

  • 方案 二

    請(qǐng)依序添加每種溶劑： 15% Cremophor EL    85% Saline

    Solubility: 2 mg/mL (5.21 mM); 懸濁液; 超聲助溶

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.75%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6054 mL 13.0269 mL 26.0539 mL 65.1347 mL
5 mM 0.5211 mL 2.6054 mL 5.2108 mL 13.0269 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱(chēng)：
Nitidine chloride
目錄號(hào)：
HY-N0498
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