Hederagenin (Synonyms: 常春藤皂苷元)

目錄號(hào): HY-N0256 純度: 99.95%: FAQs
Data Sheet SDS COA 產(chǎn)品使用指南

摩爾計(jì)算器

Hederagenin 是三萜皂苷，具有口服活性和抗腫瘤活性。Hederagenin 能夠抑制細(xì)胞中由于 LPS 刺激引起的 iNOS，COX-2，和 NF-κB 的表達(dá)。Hederagenin 還增加癌細(xì)胞中 ROS 產(chǎn)生，破壞線粒體膜電位，誘導(dǎo)細(xì)胞凋亡 (apoptosis)。Hederagenin 還增加癌細(xì)胞對(duì) Cisplatin (HY-17394) 和 Paclitaxel (HY-B0015) 敏感，增強(qiáng)誘導(dǎo)的細(xì)胞凋亡。Hederagenin 對(duì)酒精性肝損傷也有預(yù)防潛力。

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Hederagenin Chemical Structure

CAS No. : 465-99-6

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規(guī)格	價(jià)格	是否有貨
10 mM * 1 mL in DMSO	￥550	In-stock
5 mg	￥250	In-stock
10 mg	￥400	In-stock
25 mg	￥790	In-stock
50 mg	￥1300	In-stock
100 mg		詢價(jià)
200 mg		詢價(jià)

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Customer Review

Other Forms of Hederagenin:

Hederagenin (Standard) 詢價(jià)

MCE 顧客使用本產(chǎn)品發(fā)表的 3 篇科研文獻(xiàn)

•Bioengineered. 2022 Apr;13(4):8689-8698. [Abstract]
•Biochem Biophys Res Commun. 2024 May 8:718:150085. [Abstract]
•Ann Med Surg (Lond). 2024 Apr 23.

Hederagenin 相關(guān)產(chǎn)品

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

生物活性
純度 & 產(chǎn)品資料
參考文獻(xiàn)

生物活性

Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin also has preventive potential against alcoholic liver injury^[1]^[2]^[3]^[4]^[5]^[6].

細(xì)胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
518A2	EC₅₀	> 30 μM Compound: He; Hederagenin	Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay	[PMID: 27017553]
518A2	EC₅₀	34.9 μM Compound: He	Cytotoxicity against human 518A2 cells assessed as cell survival after 96 hrs by sulforhodamine B assay Cytotoxicity against human 518A2 cells assessed as cell survival after 96 hrs by sulforhodamine B assay	[PMID: 26476750]
8505C	EC₅₀	> 30 μM Compound: He; Hederagenin	Cytotoxicity against human 8505C cells after 96 hrs by SRB assay Cytotoxicity against human 8505C cells after 96 hrs by SRB assay	[PMID: 27017553]
8505C	EC₅₀	38 μM Compound: He	Cytotoxicity against human 8505C cells assessed as cell survival after 96 hrs by sulforhodamine B assay Cytotoxicity against human 8505C cells assessed as cell survival after 96 hrs by sulforhodamine B assay	[PMID: 26476750]
A2780	EC₅₀	> 30 μM Compound: He	Cytotoxicity against human A2780 cells assessed as reduction in cell viability after 96 hrs by SRB assay Cytotoxicity against human A2780 cells assessed as reduction in cell viability after 96 hrs by SRB assay	[PMID: 30840925]
A2780	EC₅₀	> 30 μM Compound: He; Hederagenin	Cytotoxicity against human A2780 cells after 96 hrs by SRB assay Cytotoxicity against human A2780 cells after 96 hrs by SRB assay	[PMID: 27017553]
A2780	EC₅₀	> 60 μM Compound: He	Cytotoxicity against human A2780 cells assessed as reduction in cell viability incubated fro 96 hrs by SRB assay Cytotoxicity against human A2780 cells assessed as reduction in cell viability incubated fro 96 hrs by SRB assay	[PMID: 29024910]
A2780	EC₅₀	19.9 μM Compound: He	Cytotoxicity against human A2780 cells assessed as cell survival after 96 hrs by sulforhodamine B assay Cytotoxicity against human A2780 cells assessed as cell survival after 96 hrs by sulforhodamine B assay	[PMID: 26476750]
A-375	EC₅₀	> 60 μM Compound: He	Cytotoxicity against human A375 cells assessed as reduction in cell viability incubated fro 96 hrs by SRB assay Cytotoxicity against human A375 cells assessed as reduction in cell viability incubated fro 96 hrs by SRB assay	[PMID: 29024910]
A549	IC₅₀	> 10 μM Compound: Hederagenin	Antiproliferative activity against human A549 cells harbouring wild type EGFR incubated for 72 hrs by SRB assay Antiproliferative activity against human A549 cells harbouring wild type EGFR incubated for 72 hrs by SRB assay	[PMID: 31718182]
A549	IC₅₀	> 10 μM Compound: Hederagenin	Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay	[PMID: 29131631]
A549	IC₅₀	> 100 μM Compound: alpha-hederagenin	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 29040953]
A549	IC₅₀	> 200 μM Compound: 3	Cell membrane permeabilization in human A549 cells assessed as drug level causing decrease in calcein fluorescence Cell membrane permeabilization in human A549 cells assessed as drug level causing decrease in calcein fluorescence	[PMID: 19200744]
A549	EC₅₀	> 30 μM Compound: He; Hederagenin	Cytotoxicity against human A549 cells after 96 hrs by SRB assay Cytotoxicity against human A549 cells after 96 hrs by SRB assay	[PMID: 27017553]
A549	IC₅₀	10.249 μM Compound: Hederagenin	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 28237662]
A549	EC₅₀	29 μM Compound: He	Cytotoxicity against human A549 cells assessed as cell survival after 96 hrs by sulforhodamine B assay Cytotoxicity against human A549 cells assessed as cell survival after 96 hrs by sulforhodamine B assay	[PMID: 26476750]
A549	IC₅₀	38.64 μM Compound: HE	Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 23992864]
A549	IC₅₀	39 μM Compound: 3	Cytotoxicity against human A549 cells after 48 hrs by resazurin reduction test Cytotoxicity against human A549 cells after 48 hrs by resazurin reduction test	[PMID: 19200744]
AGS	IC₅₀	36.14 μM Compound: alpha-hederagenin	Antiproliferative activity against human AGS cells after 72 hrs by MTT assay Antiproliferative activity against human AGS cells after 72 hrs by MTT assay	[PMID: 29040953]
BC	IC₅₀	> 5 μg/mL Compound: Hederagenin	Cytotoxicity against human BC cells by colorimetric method Cytotoxicity against human BC cells by colorimetric method	[PMID: 16038539]
BGC-823	IC₅₀	52.07 μM Compound: alpha-hederagenin	Antiproliferative activity against human BGC823 cells after 72 hrs by MTT assay Antiproliferative activity against human BGC823 cells after 72 hrs by MTT assay	[PMID: 29040953]
DLD-1	IC₅₀	> 100 μM Compound: 3	Cytotoxicity against human DLD1 cells after 48 hrs by resazurin reduction test Cytotoxicity against human DLD1 cells after 48 hrs by resazurin reduction test	[PMID: 19200744]
DLD-1	IC₅₀	> 200 μM Compound: 3	Cell membrane permeabilization in human DLD1 cells assessed as drug level causing decrease in calcein fluorescence Cell membrane permeabilization in human DLD1 cells assessed as drug level causing decrease in calcein fluorescence	[PMID: 19200744]
FaDu	EC₅₀	> 30 μM Compound: He	Cytotoxicity against human FADU cells assessed as reduction in cell viability after 96 hrs by SRB assay Cytotoxicity against human FADU cells assessed as reduction in cell viability after 96 hrs by SRB assay	[PMID: 30840925]
FaDu	EC₅₀	> 60 μM Compound: He	Cytotoxicity against human FADU cells assessed as reduction in cell viability incubated fro 96 hrs by SRB assay Cytotoxicity against human FADU cells assessed as reduction in cell viability incubated fro 96 hrs by SRB assay	[PMID: 29024910]
HeLa	IC₅₀	42.27 μM Compound: HE	Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 23992864]
HeLa	IC₅₀	53.96 μM Compound: alpha-hederagenin	Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay	[PMID: 29040953]
HepG2	CC₅₀	> 1000 μM Compound: He	Cytotoxicity in human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity in human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 29024910]
HepG2	IC₅₀	> 20 μM Compound: 15	Inhibition of TNF-alpha-induced NFkappaB activation in human HepG2 cells after 1 hr by luciferase reporter assay Inhibition of TNF-alpha-induced NFkappaB activation in human HepG2 cells after 1 hr by luciferase reporter assay	[PMID: 21870831]
HepG2	IC₅₀	28.05 μM Compound: HE	Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 23992864]
HL-60	IC₅₀	27.52 μM Compound: HE	Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 23992864]
HT-29	EC₅₀	> 30 μM Compound: He	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 96 hrs by SRB assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 96 hrs by SRB assay	[PMID: 30840925]
HT-29	EC₅₀	> 30 μM Compound: He; Hederagenin	Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay	[PMID: 27017553]
HT-29	EC₅₀	> 60 μM Compound: He	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated fro 96 hrs by SRB assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated fro 96 hrs by SRB assay	[PMID: 29024910]
HT-29	EC₅₀	50 μM Compound: He	Cytotoxicity against human HT-29 cells assessed as cell survival after 96 hrs by sulforhodamine B assay Cytotoxicity against human HT-29 cells assessed as cell survival after 96 hrs by sulforhodamine B assay	[PMID: 26476750]
KB	IC₅₀	> 10 μM Compound: Hederagenin	Antiproliferative activity against human KB cells incubated for 72 hrs by SRB assay Antiproliferative activity against human KB cells incubated for 72 hrs by SRB assay	[PMID: 31718182]
KB	IC₅₀	> 10 μM Compound: Hederagenin	Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay	[PMID: 29131631]
KB	IC₅₀	> 5 μg/mL Compound: Hederagenin	Cytotoxicity against human KB cells by colorimetric method Cytotoxicity against human KB cells by colorimetric method	[PMID: 16038539]
KB	IC₅₀	14.631 μM Compound: Hederagenin	Cytotoxicity against human KB cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human KB cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 28237662]
KB	IC₅₀	54.43 μM Compound: alpha-hederagenin	Antiproliferative activity against human KB cells after 72 hrs by MTT assay Antiproliferative activity against human KB cells after 72 hrs by MTT assay	[PMID: 29040953]
M14	IC₅₀	58 μM Compound: 6	Cytotoxicity against human M14 cells after 48 hrs by MTT assay Cytotoxicity against human M14 cells after 48 hrs by MTT assay	[PMID: 21954959]
MCF7	IC₅₀	> 10 μM Compound: Hederagenin	Antiproliferative activity against human MCF7 cells incubated for 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells incubated for 72 hrs by SRB assay	[PMID: 31718182]
MCF7	IC₅₀	> 10 μM Compound: Hederagenin	Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay	[PMID: 29131631]
MCF7	EC₅₀	> 30 μM Compound: He	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 96 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 96 hrs by SRB assay	[PMID: 30840925]
MCF7	EC₅₀	> 30 μM Compound: He; Hederagenin	Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay	[PMID: 27017553]
MCF7	EC₅₀	25.7 μM Compound: He	Cytotoxicity against human MCF7 cells assessed as cell survival after 96 hrs by sulforhodamine B assay Cytotoxicity against human MCF7 cells assessed as cell survival after 96 hrs by sulforhodamine B assay	[PMID: 26476750]
MCF7	IC₅₀	39.389 μM Compound: Hederagenin	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 28237662]
MDA-MB-231	IC₅₀	> 10 μM Compound: Hederagenin	Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by SRB assay	[PMID: 31718182]
MDA-MB-231	IC₅₀	> 10 μM Compound: Hederagenin	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay	[PMID: 29131631]
MDA-MB-231	IC₅₀	36.609 μM Compound: Hederagenin	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 28237662]
MKN-45	IC₅₀	53.69 μM Compound: alpha-hederagenin	Antiproliferative activity against human MKN45 cells after 72 hrs by MTT assay Antiproliferative activity against human MKN45 cells after 72 hrs by MTT assay	[PMID: 29040953]
NCI-H187	IC₅₀	> 5 μg/mL Compound: Hederagenin	Cytotoxicity against human NCI-H187 cells by colorimetric method Cytotoxicity against human NCI-H187 cells by colorimetric method	[PMID: 16038539]
NCI-H1975	IC₅₀	> 10 μM Compound: Hederagenin	Antiproliferative activity against human NCI-H1975 cells incubated for 72 hrs by MTS assay Antiproliferative activity against human NCI-H1975 cells incubated for 72 hrs by MTS assay	[PMID: 31718182]
NCI-H1975	IC₅₀	> 10 μM Compound: Hederagenin	Antiproliferative activity against human NCI-H1975 cells harbouring EGFR L858R/T790M/C797S mutant incubated for 72 hrs by MTS assay Antiproliferative activity against human NCI-H1975 cells harbouring EGFR L858R/T790M/C797S mutant incubated for 72 hrs by MTS assay	[PMID: 31718182]
NIH3T3	EC₅₀	> 30 μM Compound: He	Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 96 hrs by SRB assay Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 96 hrs by SRB assay	[PMID: 30840925]
NIH3T3	EC₅₀	> 30 μM Compound: He; Hederagenin	Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay	[PMID: 27017553]
Sf9	IC₅₀	> 20 μM Compound: Hederagenin	Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell expression system using poly-EY as substrate incubated for 30 mins by ADP-Glo kinase assay Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell expression system using poly-EY as substrate incubated for 30 mins by ADP-Glo kinase assay	[PMID: 31718182]
Sf9	IC₅₀	> 20 μM Compound: Hederagenin	Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M double mutant (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell expression system using poly-EY as substrate incubated for 30 mins by ADP-Glo k Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M double mutant (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell expression system using poly-EY as substrate incubated for 30 mins by ADP-Glo k	[PMID: 31718182]
Sf9	IC₅₀	> 20 μM Compound: Hederagenin	Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell expression system using poly-EY as substrate incubated for 30 mins by ADP-Glo ki Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell expression system using poly-EY as substrate incubated for 30 mins by ADP-Glo ki	[PMID: 31718182]
SW-1736	EC₅₀	> 30 μM Compound: He	Cytotoxicity against human SW1736 cells assessed as reduction in cell viability after 96 hrs by SRB assay Cytotoxicity against human SW1736 cells assessed as reduction in cell viability after 96 hrs by SRB assay	[PMID: 30840925]
SW-1736	EC₅₀	> 60 μM Compound: He	Cytotoxicity against human SW1736 cells assessed as reduction in cell viability incubated fro 96 hrs by SRB assay Cytotoxicity against human SW1736 cells assessed as reduction in cell viability incubated fro 96 hrs by SRB assay	[PMID: 29024910]
U-87MG ATCC	IC₅₀	35.95 μM Compound: HE	Cytotoxicity against human U87MG cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against human U87MG cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 23992864]

體外研究
(In Vitro)

Hederagenin (1 μM, 2 μM; 48 h) 破壞線粒體膜電位，增加細(xì)胞內(nèi)活性氧 (ROS) 含量，對(duì)癌細(xì)胞具有細(xì)胞毒作用^[4]。
Hederagenin (1 μM, 2 μM; 48 h) 誘導(dǎo)人結(jié)腸癌 LoVo 細(xì)胞凋亡，上調(diào)凋亡相關(guān)蛋白 (Bax)，并降低凋亡抑制蛋白 (Bcl-2、Bcl-xL 和 Survivin) 水平^[4]。
Hederagenin (50 μM; 4 h) 還阻斷自噬流誘導(dǎo)的 ROS 積累，增強(qiáng)了 Cisplatin 和 Paclitaxel 在肺癌細(xì)胞中的細(xì)胞毒性^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

體內(nèi)研究
(In Vivo)

Hederagenin (25 mg/kg; 口服; 共 11 天) 單獨(dú)處理 NCI-H1299 異種異植的小鼠，不影響腫瘤生長(zhǎng)。但與 Cisplatin (1 mg/kg) 具有協(xié)同作用，共同抑制腫瘤生長(zhǎng)^[4]。
Hederagenin (50 mg/kg; 口服; 每天 1 次，共 21 天) 發(fā)揮抗炎和抗凋亡活性，減輕小鼠受 25% 乙醇引起的肝損傷^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

472.70

Formula

C₃₀H₄₈O₄

CAS 號(hào)

465-99-6

性狀

固體

顏色

White to off-white

中文名稱

常春藤皂苷元

結(jié)構(gòu)分類

初始來(lái)源

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

溶解性數(shù)據(jù)

細(xì)胞實(shí)驗(yàn)：

DMSO 中的溶解度 : 50 mg/mL (105.78 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

配制儲(chǔ)備液

濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg

1 mM	2.1155 mL	10.5775 mL	21.1551 mL
5 mM	0.4231 mL	2.1155 mL	4.2310 mL
10 mM	0.2116 mL	1.0578 mL	2.1155 mL

查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用。

摩爾計(jì)算器
稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

濃度 _(start)

體積 _(start)

濃度 _(final)

體積 _(final)

動(dòng)物實(shí)驗(yàn)：

請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥方式選擇適當(dāng)?shù)娜芙夥桨浮?

以下溶解方案都請(qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：
——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的方式助溶

方案一

請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.29 mM); 澄清溶液

此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。
以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液中，混合均勻。
2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。
方案二

請(qǐng)依序添加每種溶劑： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.29 mM); 澄清溶液

此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液，此方案實(shí)驗(yàn)周期在半個(gè)月以上的動(dòng)物實(shí)驗(yàn)酌情使用。
以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 900 μL玉米油中，混合均勻。

動(dòng)物溶解方案計(jì)算器

請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只

由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量

請(qǐng)輸入您的動(dòng)物體內(nèi)配方組成：

DMSO +

Tween-80 +

Saline

如果您的動(dòng)物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過(guò) 2%。

方案所需 助溶劑 包括：DMSO，，均可在 MCE 網(wǎng)站選購(gòu)。，Tween 80，均可在 MCE 網(wǎng)站選購(gòu)。

計(jì)算結(jié)果

工作液所需濃度 : mg/mL

儲(chǔ)備液配制方法 : mg 藥物溶于 μL DMSO（母液濃度為 mg/mL）。

您所需的儲(chǔ)備液濃度超過(guò)該產(chǎn)品的實(shí)測(cè)溶解度，以下方案僅供參考，如有需要，請(qǐng)與 MCE 中國(guó)技術(shù)支持聯(lián)系。

動(dòng)物實(shí)驗(yàn)體內(nèi)工作液的配制方法 : 取 μL DMSO 儲(chǔ)備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。

連續(xù)給藥周期超過(guò)半月以上，請(qǐng)謹(jǐn)慎選擇該方案。

請(qǐng)確保第一步儲(chǔ)備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱（超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。

純度 & 產(chǎn)品資料

純度: 99.95%

選擇批次：

Data Sheet (644 KB) SDS (392 KB)

COA (197 KB) HNMR (299 KB) RP-HPLC (212 KB)

產(chǎn)品使用指南 (1538 KB)

參考文獻(xiàn)

[1]. Su-Hong Lu et al. Experimental Study of Antiatherosclerosis Effects with Hederagenin in Rats. Evid Based Complement Alternat Med, 2015, Oct 19 [Content Brief]

[2]. Diego Rodríguez-Hernández et al. Hederagenin as a triterpene template for the development of new antitumor compounds. Eur J Med Chem, 2015 Nov 13, 105:57-62 [Content Brief]

[3]. Chul Won Lee et al. Hederagenin, a major component of Clematis mandshurica Ruprecht root, attenuates inflammatory responses in RAW 264.7 cells and in mice. Int Immunopharmacol, 2015 Dec, 29(2):528-37. [Content Brief]

[4]. Liu BX, et al. Hederagenin from the leaves of ivy (Hedera helix L.) induces apoptosis in human LoVo colon cells through the mitochondrial pathway. BMC Complement Altern Med. 2014 Oct 24;14:412. [Content Brief]

[5]. Kim GJ, et al. Hederagenin Supplementation Alleviates the Pro-Inflammatory and Apoptotic Response to Alcohol in Rats. Nutrients. 2017 Jan 6;9(1):41. [Content Brief]

[6]. Wang K, et al. Hederagenin potentiated cisplatin- and paclitaxel-mediated cytotoxicity by impairing autophagy in lung cancer cells. Cell Death Dis. 2020 Aug 13;11(8):611. [Content Brief]

Hederagenin 相關(guān)分類

完整儲(chǔ)備液配制表

可選溶劑	濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1155 mL	10.5775 mL	21.1551 mL	52.8877 mL
	5 mM	0.4231 mL	2.1155 mL	4.2310 mL	10.5775 mL
	10 mM	0.2116 mL	1.0578 mL	2.1155 mL	5.2888 mL
	15 mM	0.1410 mL	0.7052 mL	1.4103 mL	3.5258 mL
	20 mM	0.1058 mL	0.5289 mL	1.0578 mL	2.6444 mL
	25 mM	0.0846 mL	0.4231 mL	0.8462 mL	2.1155 mL
	30 mM	0.0705 mL	0.3526 mL	0.7052 mL	1.7629 mL
	40 mM	0.0529 mL	0.2644 mL	0.5289 mL	1.3222 mL
	50 mM	0.0423 mL	0.2116 mL	0.4231 mL	1.0578 mL
	60 mM	0.0353 mL	0.1763 mL	0.3526 mL	0.8815 mL
	80 mM	0.0264 mL	0.1322 mL	0.2644 mL	0.6611 mL
	100 mM	0.0212 mL	0.1058 mL	0.2116 mL	0.5289 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hederagenin465-99-6常春藤皂苷元COXNF-κBCyclooxygenaseNuclear factor-κBNuclear factor-kappaBALDH2alcoholapoptosishederagenininflammatoryliver diseaseInhibitorinhibitorinhibit

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Hederagenin (Synonyms: 常春藤皂苷元)

Customer Review

Other Forms of Hederagenin:

MCE 顧客使用本產(chǎn)品發(fā)表的 3 篇科研文獻(xiàn)

Hederagenin 相關(guān)產(chǎn)品

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•同靶點(diǎn)產(chǎn)品:

•同靶點(diǎn)蛋白產(chǎn)品:

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查看 NF-κB 亞型特異性產(chǎn)品:

生物活性

純度 & 產(chǎn)品資料

參考文獻(xiàn)

摩爾計(jì)算器

稀釋計(jì)算器

Hederagenin 相關(guān)分類

完整儲(chǔ)備液配制表

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Hederagenin (Synonyms: 常春藤皂苷元)

Customer Review

Other Forms of Hederagenin:

Hederagenin 相關(guān)抗體

MCE 顧客使用本產(chǎn)品發(fā)表的 3 篇科研文獻(xiàn)

Hederagenin 相關(guān)產(chǎn)品

•相關(guān)化合物庫(kù):

•同靶點(diǎn)產(chǎn)品:

•同靶點(diǎn)蛋白產(chǎn)品:

查看 COX 亞型特異性產(chǎn)品:

查看 NF-κB 亞型特異性產(chǎn)品:

生物活性

純度 & 產(chǎn)品資料

參考文獻(xiàn)

Hederagenin 相關(guān)抗體:

摩爾計(jì)算器

稀釋計(jì)算器

Hederagenin 相關(guān)分類

完整儲(chǔ)備液配制表

Keywords:

您最近查看的產(chǎn)品:

Request for HNMR Report

Request for HNMR Report

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