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  2. Anti-infection NF-κB Cell Cycle/DNA Damage PI3K/Akt/mTOR Autophagy Apoptosis
  3. Bacterial Antibiotic NF-κB PERK Akt Autophagy Apoptosis
  4. Bavachalcone

Bavachalcone  (Synonyms: 補(bǔ)骨脂查耳酮; Broussochalcone B)

目錄號(hào): HY-N0231 純度: 99.95%
COA 產(chǎn)品使用指南 技術(shù)支持

Bavachalcone 是有效的凋亡 (apoptosis) 誘導(dǎo)劑。Bavachalcone 通過(guò)促進(jìn) HepG2 細(xì)胞的自噬 (autophagy) 和凋亡發(fā)揮抗癌活性。Bavachalcone 通過(guò) NF-κB 通路發(fā)揮抗神經(jīng)炎癥和抗抑郁的作用。Bavachalcone 通過(guò)干擾 ERK 和 Akt 信號(hào)通路以及 c-Fos 和 NFATc1 的表達(dá)抑制破骨細(xì)胞的發(fā)生。Bavachalcone 在體外對(duì)桿狀病毒表達(dá)的 BACE-1 有顯著的抑制作用。

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Bavachalcone Chemical Structure

Bavachalcone Chemical Structure

CAS No. : 28448-85-3

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥650
In-stock
5 mg ￥1600
In-stock
10 mg ￥2480
In-stock
50 mg   詢價(jià)  
100 mg   詢價(jià)  

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Customer Review

Other Forms of Bavachalcone:

MCE 顧客使用本產(chǎn)品發(fā)表的 2 篇科研文獻(xiàn)

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Bavachalcone is a potent inducer of apoptosis. Bavachalcone exerts anticancer activity by promoting autophagy and apoptosis in HepG2 cells. Bavachalcone acts as an anti-neuroinflammatory and antidepressant through the NF-κB pathway. Bavachalcone inhibits osteoclasts by interfering with ERK and Akt signaling pathways and the expression of c-Fos and NFATc1. Bavachalcone exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro[1][2][3][4].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 10 μM
Compound: 9
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 25710081]
HUVEC IC50
39.73 μM
Compound: 1a
Toxicity against HUVEC incubated for 48 hrs by MTT assay
Toxicity against HUVEC incubated for 48 hrs by MTT assay
[PMID: 25590864]
K562 IC50
> 10 μM
Compound: 9
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
[PMID: 25710081]
K562 IC50
2.77 μM
Compound: 1a
Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay
Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay
[PMID: 25590864]
體外研究
(In Vitro)

Bavachalcone (5 μg/mL; 1-48 小時(shí)) 通過(guò)干擾 ERK 和 Akt 信號(hào)通路以及 c-Fos 和 NFATc1 的表達(dá)抑制破骨細(xì)胞的發(fā)生[1]。
Bavachalcone (0-100 μg/mL; 24 小時(shí)) 對(duì) HepG2 細(xì)胞有毒性， IC50 為 20 μg/mL[3]。
Bavachalcone (20 μg/mL; 24 小時(shí)) 在 HepG2 中可誘導(dǎo)細(xì)胞凋亡[3]。
Bavachalcone (0-20 μg/mL; 24 小時(shí)) 在 HepG2 細(xì)胞中引起細(xì)胞周期阻滯[3]。
Bavachalcone (0-20 μg/mL; 24 小時(shí)) 通過(guò) Akt-mTOR 信號(hào)通路誘導(dǎo)細(xì)胞自噬[3]。
Bavachalcone (5-10 μM; 2 小時(shí)) 在 LPS (HY-D1056) 誘導(dǎo)的 BV2 細(xì)胞中抑制 NF-κB 通路活化，上調(diào) A20 和 TAX1BP1 的表達(dá)并增強(qiáng)其相互作用[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: RANKL treated bone marrow-derived macrophages
Concentration: 5 μg/mL
Incubation Time: 0, 12, 24 and 48 h;
1 h
Result: Reduced the levels of c-Fos and NFATc1.
Reduced the phosphorylation levels of ERK and Akt.

Western Blot Analysis[3]

Cell Line: HepG2 cell
Concentration: 20 μg/mL
Incubation Time: 24 h
Result: Significantly increased the levels of caspase-3.

Western Blot Analysis[3]

Cell Line: HepG2 cell
Concentration: 0, 5, 10 and 20 μg/mL
Incubation Time: 24 h
Result: Decreased the levels of early cell cycle regulatory proteins cdk4 and cdk2.
Increased the levels of p21 and p27.
Inhibited the phosphorylation and expression of both Akt and mTOR.

Western Blot Analysis[4]

Cell Line: LPS (HY-D1056) treated BV2 cells
Concentration: 5 μM and 10 μM
Incubation Time: 2 h
Result: Significantly decreased the expression of TRAF6 and phosphorylation of P65 and IκBα.
Increased the expression of A20 and TAX1BP1
體內(nèi)研究
(In Vivo)

Bavachalcone (30-60 mg/kg; 腹腔注射; 4 天) 在脂多糖 (HY-D1056) 誘導(dǎo)的小鼠模型中發(fā)揮抗神經(jīng)炎癥和抗抑郁的作用[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS (HY-D1056) treated male C57BL/6 mice (8 weeks, 20 ± 2 g)
Dosage: 30 mg/kg and 60 mg/kg
Administration: Intraperitoneal injection (i.p.); 4 days
Result: Attenuated LPS-induced depression-like behaviors in mice.
Inhibited LPS-induced activation of microglia in the brain of mice.
Inhibited LPS-induced NF-κB pathway activation and upregulated the expression of A20 and TAX1BP1 in the cortex of mice.
Weakened the production of TNF-α and IL-6 in the cortex of mice.
分子量

324.37

Formula

C20H20O4
CAS 號(hào)
性狀

固體

顏色

Yellow to orange

中文名稱

補(bǔ)骨脂查耳酮
結(jié)構(gòu)分類
初始來(lái)源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : ≥ 34 mg/mL (104.82 mM; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 3.0829 mL 15.4145 mL 30.8290 mL
5 mM 0.6166 mL 3.0829 mL 6.1658 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.95%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0829 mL 15.4145 mL 30.8290 mL 77.0725 mL
5 mM 0.6166 mL 3.0829 mL 6.1658 mL 15.4145 mL
10 mM 0.3083 mL 1.5414 mL 3.0829 mL 7.7072 mL
15 mM 0.2055 mL 1.0276 mL 2.0553 mL 5.1382 mL
20 mM 0.1541 mL 0.7707 mL 1.5414 mL 3.8536 mL
25 mM 0.1233 mL 0.6166 mL 1.2332 mL 3.0829 mL
30 mM 0.1028 mL 0.5138 mL 1.0276 mL 2.5691 mL
40 mM 0.0771 mL 0.3854 mL 0.7707 mL 1.9268 mL
50 mM 0.0617 mL 0.3083 mL 0.6166 mL 1.5414 mL
60 mM 0.0514 mL 0.2569 mL 0.5138 mL 1.2845 mL
80 mM 0.0385 mL 0.1927 mL 0.3854 mL 0.9634 mL
100 mM 0.0308 mL 0.1541 mL 0.3083 mL 0.7707 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Bavachalcone
目錄號(hào)：
HY-N0231
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