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  2. Neuronal Signaling Autophagy PI3K/Akt/mTOR Apoptosis Metabolic Enzyme/Protease
  3. PINK1/Parkin mTOR Apoptosis Prolyl Endopeptidase (PREP)
  4. Salidroside

Salidroside  (Synonyms: 紅景天苷; Rhodioloside)

目錄號: HY-N0109 純度: 99.90%
COA 產(chǎn)品使用指南 技術(shù)支持

Salidroside (Rhodioloside) 是一種脯氨酰內(nèi)肽酶 (prolyl endopeptidase) 抑制劑。Salidroside 可通過激活 mTOR 信號緩解腫瘤惡病質(zhì)小鼠模型中的惡病質(zhì)癥狀。Salidroside 還能通過增強(qiáng) PINK1/Parkin 介導(dǎo)的線粒體自噬來保護(hù)多巴胺能神經(jīng)元。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Salidroside Chemical Structure

Salidroside Chemical Structure

CAS No. : 10338-51-9

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥363
In-stock
1 mg ￥250
In-stock
5 mg ￥550
In-stock
10 mg ￥880
In-stock
25 mg ￥1525
In-stock
50 mg ￥2238
In-stock
100 mg ￥3363
In-stock
500 mg 現(xiàn)貨 詢價(jià)
1 g   詢價(jià)  
5 g   詢價(jià)  

* Please select Quantity before adding items.

Customer Review

Other Forms of Salidroside:

    Salidroside purchased from MCE. Usage Cited in: Int J Oncol. 2019 Jun;54(6):1969-1980.  [Abstract]

    Apoptosis?related protein expression in MG63 cells in response to various concentrations of Salidroside is detected via western blot analysis.

    查看 mTOR 亞型特異性產(chǎn)品:

    • 生物活性

    • 實(shí)驗(yàn)參考方法

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.

    IC50 & Target[2]

    mTOR

     

    細(xì)胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    HeLa IC50
    10.493 μM
    Compound: Sal
    Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
    Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
    		[PMID: 34978808]
    MDA-MB-231 IC50
    40 μM
    Compound: 2
    Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
    Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
    		[PMID: 33650861]
    PC-12 EC50
    0.3 μM
    Compound: Cpd i
    Neuroprotective activity against CoCl2-induced cytotoxicity in rat PC12 cells assessed as increase in cell viability pretreated with CoCl2 for 8 hrs followed by incubation with drug and measured after 24 hrs by MTT assay
    Neuroprotective activity against CoCl2-induced cytotoxicity in rat PC12 cells assessed as increase in cell viability pretreated with CoCl2 for 8 hrs followed by incubation with drug and measured after 24 hrs by MTT assay
    		[PMID: 33097301]
    體外研究
    (In Vitro)

    Salidroside (100 μM) 抑制脯氨酰內(nèi)肽酶 (PEP) 活性 (10.6±1.9%)。脯氨酰內(nèi)肽酶是一種在含脯氨酸神經(jīng)肽酶的代謝中發(fā)揮作用的酶，該酶被認(rèn)為與學(xué)習(xí)和記憶有關(guān)[1]。
    Salidroside 是在紅景天中發(fā)現(xiàn)的主要苯丙素苷之一。在許多國家，Salidroside 幾乎每天都作為營養(yǎng)補(bǔ)充劑食用，并已被確定具有潛在的抗疲勞和缺氧、抗衰老和抗阿爾茨海默病活性。Salidroside 可通過增加 mTOR、p-mTOR 和 MyHC 表達(dá)來改善肌肉營養(yǎng)[2]。
    SH-SY5Y 細(xì)胞暴露于 0-600μM MPP+ 12-48 小時(shí)，結(jié)果表明 MPP+ 導(dǎo)致細(xì)胞活力以濃度和時(shí)間依賴性方式顯著降低。將細(xì)胞用 25-100 μM Salidroside (Sal) 預(yù)處理 24 小時(shí)，然后再暴露于 500 μM MPP+ 24 小時(shí)。Salidroside 濃度依賴性地防止 MPP+ 誘導(dǎo)的細(xì)胞活力下降。膜聯(lián)蛋白 V/PI 染色是檢測凋亡細(xì)胞的常用方法。Salidroside 顯著減少 MPP+ 處理的膜聯(lián)蛋白 V/PI 染色細(xì)胞的數(shù)量，且呈濃度依賴性。凋亡細(xì)胞也可以通過 Hoechs t染色進(jìn)行形態(tài)學(xué)評估。在 Hoechst 染色中，凋亡細(xì)胞的特征是核尺寸減小、染色質(zhì)濃縮、熒光強(qiáng)烈和核碎裂。Salidroside 顯著抑制 MPP+ 誘導(dǎo)的 SH-SY5Y 細(xì)胞中染色質(zhì)濃縮、強(qiáng)熒光和核碎裂的增加[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    體內(nèi)研究
    (In Vivo)

    Salidroside 是從藥用食品植物紅景天中提取的天然抗氧化劑。Salidroside (100 mg/kg/day) 對 db/db 小鼠表現(xiàn)出強(qiáng)烈的降血糖作用，與 Metformin (200 mg/kg/day) 的作用相似[4]。
    Salidroside (10/20/40 mg/kg/day) 可誘導(dǎo)的小鼠睪丸損傷模型[6]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    300.30

    Formula

    C14H20O7
    CAS 號
    性狀

    固體

    顏色

    White to off-white

    中文名稱

    紅景天苷；毛柳甙；紅景天甙
    結(jié)構(gòu)分類
    初始來源
    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲存方式

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    溶解性數(shù)據(jù)
    細(xì)胞實(shí)驗(yàn)： 

    H2O 中的溶解度 : 125 mg/mL (416.25 mM; 超聲助溶)

    DMSO 中的溶解度 : 100 mg/mL (333.00 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

    配制儲備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 3.3300 mL 16.6500 mL 33.3000 mL
    5 mM 0.6660 mL 3.3300 mL 6.6600 mL
    查看完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲存時(shí)，請?jiān)?個(gè)月內(nèi)使用，-20°C儲存時(shí)，請?jiān)?個(gè)月內(nèi)使用。

    * 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

    • 摩爾計(jì)算器

    • 稀釋計(jì)算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動物實(shí)驗(yàn)：

    以下溶解方案，請直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶。

    • 方案 一

      請依序添加每種溶劑： PBS

      Solubility: 100 mg/mL (333.00 mM); 澄清溶液; 超聲助溶

    動物溶解方案計(jì)算器
    請輸入動物實(shí)驗(yàn)的基本信息：

    給藥劑量

    mg/kg

    動物的平均體重

    g

    每只動物的給藥體積

    μL

    動物數(shù)量

    只
    由于實(shí)驗(yàn)過程有損耗，建議您多配一只動物的量
    計(jì)算結(jié)果
    工作液所需濃度 : mg/mL
    該產(chǎn)品水溶性佳，請具體參考實(shí)測 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
    您所需的儲備液濃度超過該產(chǎn)品的實(shí)測溶解度，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
    純度 & 產(chǎn)品資料

    純度: 99.90%

    參考文獻(xiàn)
    Cell Assay
    [3]

    SH-SY5Y cells are seeded in 96-well plates at 1×104 cells per well. After the treatment with Salidroside (25-100?μM) and MPP+, cell viability is measured by MTT assay. Briefly, cells are incubated with 500?μg/mL MTT at 37°C for 4?h. After that, the medium is removed and 150?μL DMSO is added and shaking is conducted for 10?min. Absorbance is measured at 570?nm in a microplate reader and the results are expressed as folds of control[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [4]

    Mice[4]
    The 4-week-old male C57BL/6 mice are fed a high-fat diet (HFD) (n=16) or normal chow diet (n=8). After 10 weeks of the HFD, salidroside intervention (100 mg/kg/day) is initiated by gavage once a day for 5 weeks. The control groups are given vehicle (saline). The 4-week-old male C57Bl/KsJ (BKS) mice (wild type, n=8) and BKS.Cg-Dock7m +/+ Leprdb/J (db/db) mice (n=16) are used. Salidroside (100 mg/kg/day) is administrated orally by gavage once a day for 5 weeks. The control groups are given vehicle (saline). Fasting blood glucose and body weight of mice are monitored every 5 days. Glucose measurements are performed on blood drawn from the tail vein using a Glucometer.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    參考文獻(xiàn)

    完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲存時(shí)，請?jiān)?個(gè)月內(nèi)使用，-20°C儲存時(shí)，請?jiān)?個(gè)月內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 3.3300 mL 16.6500 mL 33.3000 mL 83.2501 mL
    5 mM 0.6660 mL 3.3300 mL 6.6600 mL 16.6500 mL
    10 mM 0.3330 mL 1.6650 mL 3.3300 mL 8.3250 mL
    15 mM 0.2220 mL 1.1100 mL 2.2200 mL 5.5500 mL
    20 mM 0.1665 mL 0.8325 mL 1.6650 mL 4.1625 mL
    25 mM 0.1332 mL 0.6660 mL 1.3320 mL 3.3300 mL
    30 mM 0.1110 mL 0.5550 mL 1.1100 mL 2.7750 mL
    40 mM 0.0833 mL 0.4163 mL 0.8325 mL 2.0813 mL
    50 mM 0.0666 mL 0.3330 mL 0.6660 mL 1.6650 mL
    60 mM 0.0555 mL 0.2775 mL 0.5550 mL 1.3875 mL
    80 mM 0.0416 mL 0.2081 mL 0.4163 mL 1.0406 mL
    100 mM 0.0333 mL 0.1665 mL 0.3330 mL 0.8325 mL

    * 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

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    產(chǎn)品名稱：
    Salidroside
    目錄號：
    HY-N0109
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