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  2. Metabolic Enzyme/Protease Anti-infection Autophagy Apoptosis
  3. MMP Influenza Virus Autophagy Apoptosis
  4. Arctigenin

Arctigenin  (Synonyms: 牛蒡子苷元; (-)-Arctigenin)

目錄號: HY-N0035 純度: 99.69%
COA 產(chǎn)品使用指南

Arctigenin ((-)-Arctigenin) 是一種具有生物活性的木脂素，可用作抗腫瘤劑。Arctigenin 具有有效的抗氧化、抗炎和抗病毒 (influenza A virus) 活性。Arctigenin 可用于代謝紊亂和中樞神經(jīng)系統(tǒng)功能障礙的研究。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Arctigenin Chemical Structure

Arctigenin Chemical Structure

CAS No. : 7770-78-7

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥500
In-stock
1 mg ￥130
In-stock
5 mg ￥261
In-stock
10 mg ￥418
In-stock
50 mg ￥900
In-stock
100 mg ￥1200
In-stock
200 mg   詢價(jià)  
500 mg   詢價(jià)  

* Please select Quantity before adding items.

Customer Review

Other Forms of Arctigenin:

    Arctigenin purchased from MCE. Usage Cited in: Pharmacol Res. 2020 May;155:104721.  [Abstract]

    The Western blotting results show that incubating LA795 cells with 100 μM arctigenin led to a decrease in phospho-MEK1/2, phospho-ERK1/2 and cyclin D1 expression (n = 3).

    Arctigenin purchased from MCE. Usage Cited in: Life Sci. 2020 Sep 1;256:117983.  [Abstract]

    The indicated cell lines are treated with 5 μM Arc (Arctigenin) for 10 h and then harvested for extraction of total cellular RNA and subsequent qRT-PCR.

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions[1][2][3].

    細(xì)胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    A549 IC50
    > 50 μM
    Compound: ATG
    Cytotoxicity against human A549 cells after 4 days under normal conditions by MTT assay
    Cytotoxicity against human A549 cells after 4 days under normal conditions by MTT assay
    		[PMID: 25571795]
    A549 IC50
    0.8 μg/mL
    Compound: 9
    Antiproliferative activity against human A549 cells assessed as inhibition of cell viability by MTT assay
    Antiproliferative activity against human A549 cells assessed as inhibition of cell viability by MTT assay
    		[PMID: 32223924]
    A549 IC50
    6.57 μM
    Compound: ATG
    Cytotoxicity against human A549 cells after 4 days under glucose-starved conditions by MTT assay
    Cytotoxicity against human A549 cells after 4 days under glucose-starved conditions by MTT assay
    		[PMID: 25571795]
    HeLa EC50
    > 100 μM
    Compound: 1
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by WST-8 assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by WST-8 assay
    		[PMID: 28754364]
    HeLa IC50
    572.7 μM
    Compound: Arctigenin
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability by MTT assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability by MTT assay
    		[PMID: 30237124]
    HepG2 IC50
    2.8 μg/mL
    Compound: 9
    Antiproliferative activity against human HepG2 cells assessed as inhibition of cell viability by MTT assay
    Antiproliferative activity against human HepG2 cells assessed as inhibition of cell viability by MTT assay
    		[PMID: 32223924]
    HL-60 EC50
    12 μM
    Compound: 1
    Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by WST-8 assay
    Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by WST-8 assay
    		[PMID: 28754364]
    MDA-MB-231 IC50
    1.1 μg/mL
    Compound: 9
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability by MTT assay
    		[PMID: 32223924]
    MRC5 IC50
    2.1 μM
    Compound: 7
    Antiviral activity against HCMV in MRC5 cells by plaque reduction assay
    Antiviral activity against HCMV in MRC5 cells by plaque reduction assay
    		[PMID: 17239594]
    PANC-1 IC50
    2.2 μM
    Compound: Arctigenin
    Growth inhibition of human PANC1 cells in nutrient-deprived medium incubated for 24 hrs by MTT assay
    Growth inhibition of human PANC1 cells in nutrient-deprived medium incubated for 24 hrs by MTT assay
    		[PMID: 30878830]
    RAW264.7 IC50
    0.26 mM
    Compound: 10
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
    		[PMID: 18986199]
    體外研究
    (In Vitro)

    Arctigenin (0.01-1 μg/mL; 0.5-24 h) shows preferential cytotoxicity against the PANC-1 cell line under nutrient-deprived conditions in a concentration- and time-dependent manner[1].
    ? Arctigenin (0.01-1 μg/mL; 0.5-24 h) inhibits the survival of various cancer cell lines (ASPC-1, BXPC-3, Alexander, and PSN-1 cells) under nutrient-deprived conditions[1].
    ? Arctigenin (0.1-1 μg/mL; 24 h) completely inhibits Akt phosphorylation stimulated by glucose deprivation in PANC-1 cells[1].
    ? Arctigenin (5-25 μM) shows potent in vitro antiviral activities (IC50=2.9 μM) against influenza A virus[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    體內(nèi)研究
    (In Vivo)

    Arctigenin (250 μg/mL; 0.2 mL; i.p. 6 times a week for 9 weeks) suppress the PANC-1 tumor growth in nude mice[1].
    ? Arctigenin (10 mg/kg; i.p. daily for 30 days) relieves experimental autoimmune encephalomyelitis (EAE) symptoms of mice[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female SPF/VAF BALB/cAn Ncrj-nu/nu mice were injected with PANC-1 cells[1]
    Dosage: 250 μg/mL, 0.2 mL
    Administration: I.p. 6 times a week for 9 weeks
    Result: Reduced the tumor weight and volume.
    No significant body weight loss was recognized.
    Clinical Trial
    分子量

    372.41

    Formula

    C21H24O6
    CAS 號
    性狀

    固體

    顏色

    White to off-white

    中文名稱

    牛蒡子苷元；牛蒡苷元；牛蒡甙元
    結(jié)構(gòu)分類
    初始來源
    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲存方式
    Powder -20°C 3 years
    In solvent -80°C 1 year
    -20°C 6 months
    溶解性數(shù)據(jù)
    細(xì)胞實(shí)驗(yàn)： 

    DMSO 中的溶解度 : 100 mg/mL (268.52 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

    配制儲備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 2.6852 mL 13.4261 mL 26.8521 mL
    5 mM 0.5370 mL 2.6852 mL 5.3704 mL
    查看完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C儲存時(shí)，請?jiān)?年內(nèi)使用， -20°C儲存時(shí)，請?jiān)?個(gè)月內(nèi)使用。

    • 摩爾計(jì)算器

    • 稀釋計(jì)算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動物實(shí)驗(yàn)：

    請根據(jù)您的 實(shí)驗(yàn)動物和給藥方式 選擇適當(dāng)?shù)娜芙夥桨浮?

    以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
    ——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
    以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

    • 方案 一

      請依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (6.71 mM); 澄清溶液

      此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

      以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水 定容至 1 mL。

      生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
    • 方案 二

      請依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (6.71 mM); 澄清溶液

      此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

      以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液 中，混合均勻。

      2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。
    動物溶解方案計(jì)算器
    請輸入動物實(shí)驗(yàn)的基本信息：

    給藥劑量

    mg/kg

    動物的平均體重

    g

    每只動物的給藥體積

    μL

    動物數(shù)量

    只
    由于實(shí)驗(yàn)過程有損耗，建議您多配一只動物的量
    請輸入您的動物體內(nèi)配方組成：
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    如果您的動物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過 2%。
    方案所需 助溶劑 包括：DMSO， ，均可在 MCE 網(wǎng)站選購。 ，Tween 80，均可在 MCE 網(wǎng)站選購。
    計(jì)算結(jié)果
    工作液所需濃度 : mg/mL
    儲備液配制方法 : mg 藥物溶于 μL  DMSO（母液濃度為 mg/mL）。
    您所需的儲備液濃度超過該產(chǎn)品的實(shí)測溶解度，以下方案僅供參考，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
    動物實(shí)驗(yàn)體內(nèi)工作液的配制方法 : 取 μL DMSO 儲備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。
    連續(xù)給藥周期超過半月以上，請謹(jǐn)慎選擇該方案。
    請確保第一步儲備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱 （超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。
    純度 & 產(chǎn)品資料

    純度: 99.69%

    參考文獻(xiàn)

    完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C儲存時(shí)，請?jiān)?年內(nèi)使用， -20°C儲存時(shí)，請?jiān)?個(gè)月內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.6852 mL 13.4261 mL 26.8521 mL 67.1303 mL
    5 mM 0.5370 mL 2.6852 mL 5.3704 mL 13.4261 mL
    10 mM 0.2685 mL 1.3426 mL 2.6852 mL 6.7130 mL
    15 mM 0.1790 mL 0.8951 mL 1.7901 mL 4.4754 mL
    20 mM 0.1343 mL 0.6713 mL 1.3426 mL 3.3565 mL
    25 mM 0.1074 mL 0.5370 mL 1.0741 mL 2.6852 mL
    30 mM 0.0895 mL 0.4475 mL 0.8951 mL 2.2377 mL
    40 mM 0.0671 mL 0.3357 mL 0.6713 mL 1.6783 mL
    50 mM 0.0537 mL 0.2685 mL 0.5370 mL 1.3426 mL
    60 mM 0.0448 mL 0.2238 mL 0.4475 mL 1.1188 mL
    80 mM 0.0336 mL 0.1678 mL 0.3357 mL 0.8391 mL
    100 mM 0.0269 mL 0.1343 mL 0.2685 mL 0.6713 mL
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    產(chǎn)品名稱：
    Arctigenin
    目錄號：
    HY-N0035
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